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Spinocerebellar ataxia 19 (SCA19) represents a rare autosomal dominant genetic disorder resulting in progressive ataxia and cerebellar atrophy. SCA19 is caused by variants in the KCND3 gene, which encodes a voltage-gated potassium channel subunit essential for cerebellar Purkinje cell function. We describe six cases from Chile and Mexico, representing the largest report on SCA19 in Latin America. These cases encompass a range of clinical presentations, highlighting the phenotypic variability within SCA19 from an early-onset, severe disease to a late-onset, slowly progressive condition with normal lifespan. While some patients present with pure ataxia, others also show cognitive impairment, dystonia, and other neurological symptoms. The correlations between specific KCND3 variants and phenotypic outcomes are complex and warrant further investigation. As the genomic landscape of spinocerebellar ataxias evolves, comprehensive genetic testing is becoming pivotal in improving diagnostic accuracy. This study contributes to a better understanding of the clinical spectrum of SCA19, laying the groundwork for further genotype-phenotype correlations and functional studies to elucidate the underlying pathophysiology.

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Abstract Introduction: This paper aims to examine the psychometric properties, i.e., validity, reliability, factorial invariance, and latent mean differences based on gender, of the Perfectionistic Self-Presentation Scale, PSPS, in the Ecuadorian context. Method: A sample consisting of 597 Ecuadorian undergraduates participated in the study. Results: Confirmatory Factor Analysis supported a 14-item and three-dimensional model of the scale: Perfectionistic Self-Promotion, Nondisplay of Imperfection, and Nondisclosure of Imperfection. This model presented configural; measurement, i.e., metric, strong, and strict; as well as structural invariance across genders. Discriminant validity was observed by analysing correlations between PSPS factors and perfectionism traits. Males exhibited higher latent means of Perfectionistic Self-Promotion and also Nondisplay of Imperfection than females. Conclusions: The Spanish-translated and brief version of the PSPS represents a reliable and valid tool for assessing perfectionistic self-presentation in Ecuador.

Resumen Introducción: Este artículo tiene como objetivo examinar las propiedades psicométricas, i.e., validez, fiabilidad, invarianza factorial y diferencias de medias latentes en función del género, de la Escala de Autopresentación Perfeccionista, PSPS, en el contexto de Ecuador. Método: La muestra se compuso de 597 universitarios ecuatorianos. Resultados: El análisis factorial confirmatorio apoyó una estructura de la escala compuesta por 14 ítems y tres dimensiones: autopromoción perfeccionista, no-divulgación de la imperfección, y no-verbalización de la imperfección. Este modelo mostró invarianza configural; de medida, métrica, escalar y estricta; y estructural a través del género. El análisis de correlaciones entre los factores de la PSPS y los rasgos perfeccionistas evidenció la validez discriminante de la escala. Los hombres obtuvieron medias latentes significativamente más altas en comparación con las mujeres en los factores autopromoción perfeccionista y no-divulgación de la imperfección. Conclusiones: La versión de la PSPS abreviada y traducida al español representa una medida fiable y válida para evaluar la autopresentación perfeccionista en Ecuador.

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Airline pilots are frequently exposed to numerous flights per week, changes in their circadian rhythms, and extended periods away from home. All these stressors make pilots susceptible to developing psychiatric disorders. Recently, emphasis has been placed on the need for molecular tests that help in the diagnosis of depression. The genes SLC6A4 and S100A10 encode serotonin transporter (SERT) and p11 protein, respectively. Their expression has been frequently associated with stress and depression. In this work, we quantified, by quantitative PCR, the expression of SERT and p11 in peripheral mononuclear cells of airline pilots compared to patients with depression and healthy volunteers. Moreover, by mass spectrometry, we quantified the serum serotonin levels in the same three groups. We found that SERT and p11 were overexpressed in the mononuclear cells of airline pilots and depressed patients compared to healthy volunteers. Although serum serotonin was not different between healthy volunteers and airline pilots, a decreasing trend was observed in the latter. As expected, serum serotonin in the patients was significantly lower. Alterations in SERT and p11 in airline pilots could be related to professional stress, a condition that could potentially affect their long-term mental health.

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Introducción: La macrosomía fetal, de manera tradicional, ha sido definida por un peso arbitrario al nacer; la misma, ya sea definida por un límite de peso o grande para la edad gestacional, se asocia con numerosas complicaciones perinatales y maternas. Objetivo: Describir los factores de riesgo asociados a la macrosomía fetal en los partos del Hospital Universitario Ginecobstétrico Provincial Ana Betancourt de Mora durante el año 2019. Métodos: Se realizó un estudio observacional descriptivo de corte transversal. El universo quedó constituido por la totalidad de gestantes que tuvieron recién nacidos con peso al nacimiento mayor o igual a 4 000 gramos, el cual ascendió a 526 gestantes. Se utilizó estadística descriptiva. Se calculó media y desviación estándar a las variables cuantitativas. Resultados: Las gestantes estudiadas tenían una media de edad de 27,86 años y un IMC a la captación como promedio de 26,77 con un valor medio de ganancia de peso de 13,68 Kg. Entre los 26 y 35 años hubo 290 gestantes con recién nacidos macrosómicos, respecto a la paridad las que paren sin experiencia de este reunió a 222 grávidas. En las embarazadas catalogadas de sobrepeso con ganancia de 10 a 15 kg se reúnen 104 de los recién nacidos macrosómicos. Respecto al tipo de parto la cesárea representó el 61,4 %. Se observó en 40 gestantes la presencia de diabetes gestacional o pregestacional y preeclampsia respectivamente. Conclusiones: La ganancia excesiva de peso en gestantes con evaluación nutricional de sobrepeso u obesas tuvo la mayor incidencia en la génesis de la macrosomía en los recién nacidos.

Introduction: Fetal macrosomia has traditionally been defined by an arbitrary birth weight. Fetal macrosomia, whether defined by borderline weight or large for gestational age, is associated with numerous perinatal and maternal complications. Objective: To describe the risk factors associated with fetal macrosomia in deliveries at Ana Betancourt de Mora Provincial Gyneco-Obstetric University Hospital during 2019. Methods: A cross-sectional descriptive observational study was carried out. The study universe was made up of all pregnant women who had newborns with a birth weight greater than or equal to 4 000 grams, which amounted to 526 pregnant women. Descriptive statistics were used. Average and standard deviation were calculated for the quantitative variables. Results: The studied pregnant women had an average age of 27.86 years and an average BMI at uptake of 26.77 with an average value of weight gain of 13.68 Kg. Between 26 and 35 years there were 290 pregnant women with newborn macrosomic births, with respect to parity those who give birth without experience of this brought together 222 gravid women. In pregnant women classified as overweight with a gain of 10 to 15 kg, 104 of the macrosomic newborns are gathered. Regarding the type of delivery, cesarean section represented 61.4%. The presence of gestational or pregestational diabetes and preeclampsia, respectively, was observed in 40 pregnant women. Conclusions: The excessive weight gain in pregnant women with nutritional evaluation of overweight or obese were those that had the highest incidence in the genesis of macrosomia in newborns.

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Perfectionistic Automatic Thoughts (PATs) are currently being studied due to their association with maladaptive variables. This study aims to validate the Spanish version of the Perfectionism Cognitions Inventory (PCI) in a sample of Ecuadorian undergraduates as well as to analyze latent mean differences across sex. The sample was composed by 3060 undergraduates (Mage = 22.7, SD = 2.46). The Spanish model of the PCI composed by 17 items divided into three first-order dimensions (perfectionistic concerns, strivings, and demands) and a second-order factor was supported by confirmatory factor analysis. Acceptable levels of reliability and factorial invariance across sex were observed. Higher latent mean scores for males in comparison with females in the second-order factor of the PCI were found. The three dimensions of the PCI significantly and positively correlated with interpersonal difficulties. Overall, results demonstrate that the Spanish version of the PCI is a valid and reliable measure to evaluate PATs in Ecuadorian undergraduates.

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Resumen La relevancia psicológica, social y educativa del presente estudio reside en la escasez de trabajos previos que hayan evaluado el rechazo escolar en Latinoamérica y las elevadas tasas de deserción a las que se enfrentan en esta región. El objetivo de esta investigación consistió en examinar las diferencias en las puntuaciones medias de rechazo escolar y la formación de perfiles en adolescentes ecuatorianos y chilenos. Un total de 4266 estudiantes, entre 13 y 17 años de edad, procedentes de Ecuador (. = 14.83; SD = 1.86) y Chile (. = 15.23; SD = 1.26) fueron seleccionados mediante un muestreo aleatorio por conglomerados. El instrumento empleado para evaluar el rechazo escolar fue la School Refusal Assessment Scale-Revised. Las puntuaciones medias de rechazo escolar para Ecuador y Chile revelaron diferencias estadísticamente significativas de pequeña magnitud. Entre los estudiantes chilenos se registraron puntuaciones medias más altas de rechazo escolar, con el fin de captar la atención de sus seres queridos y obtener reforzadores tangibles externos a la escuela, en comparación con sus iguales procedentes de Ecuador. Los análisis de conglomerados confirmaron cuatro perfiles de rechazo escolar en ambos países: Rechazo Escolar Bajo, Rechazo Escolar Alto, Rechazo Escolar Ansioso y Rechazo Escolar Absentista. A pesar de que los adolescentes chilenos obtuvieron puntuaciones medias significativamente más altas que los ecuatorianos en algunas dimensiones del rechazo escolar, los resultados revelaron una pequeña variabilidad entre los perfiles de rechazo escolar encontrados en ambos países. Los resultados obtenidos se discuten atendiendo a las características culturales definitorias de cada uno de estos países.

Abstract School refusal behavior is defined as any child or youth's difficulty to attend classes or to remain in the school. This behavior could be based or not on anxiety and prevalence rates from 5 to 28 % if it is considered any type of rejection towards the school. Adolescents demonstrating school refusal behaviors are very likely to demonstrate poorer academic performance, more stress, behavior problems and family conflicts. The psychological, social and educational relevance of the present study is due to the scarce of previous studies that have evaluated the school refusal behavior in Latin America and the high dropout rates that they face in this region. This study is focused on two countries, Ecuador and Chile, in order to identify possible differences regarding school refusal behavior scores between adolescents in both countries. The aim of this investigation was to examine the mean differences scores on school refusal behavior and the formation of school refusal behavior profiles in Ecuadorian and Chilean adolescents to determine whether these results differ from one another based on the geographical origin. In this study participated a total of 4266 students aged between 13 and 17 years old from Ecuador (. = 14.83, SD = 1.86; N = 1588) and Chile (. = 15.23; SD = 1.26; N = 2678). These students were selected by cluster random sampling. The measure used to assess the school refusal behavior was the School Refusal Assessment Scale-Revised (SRAS-R). The SRAS-R is a self-report measure that assesses the relative strength of four proposed functions, or maintaining variables, of school refusal behavior: Factor I. Avoidance of school-based stimuli that provoke Negative Affectivity; Factor II. Escape from aversive Social/Evaluative situations at school; Factor III. Pursuit of Attention from Significant others; and Factor IV. Pursuit of Tangible Reinforcement outside of school. The SRAS-R was administered during the school day (a session of approximately 20 minutes) in groups who completed the scale anonymously in accordance with the ethical standards and also emphasizing the voluntary nature of the test. Regarding the results, mean differences scores on school refusal behavior revealed statistically significant differences of small magnitude with Chilean students reaching higher mean scores in school refusal behavior in order to pursuit the attention from significant others and to obtain tangible reinforces external to the school, in comparison with their equals from Ecuador. Cluster analysis confirmed four school refusal profiles in both countries: Low School Refusal Behavior (characterized by low school refusal behavior scores for the four factors of the SRAS-R), High School Refusal Behavior (characterized by high school refusal behavior scores for the four factors of the SRAS-R), Anxious School Refusal Behavior (profile that combines high scores on the first three factors of the SRAS-R and moderate scores for the fourth) and Absentee School Refusal Behavior (profile that combines moderate levels for the first three factors of the SRAS-R but high in the fourth factor). The results revealed a small variability between the school refusal behavior profiles across the countries. However, Chilean adolescents scored significantly higher than Ecuadorians in school refusal based on the search for tangible external reinforcements. The results of this research supported a low variability of the findings according to the country. The generalization of these results supports the transcultural validity of the SRAS-R and emphasizes that Ecuador and Chile share a similar situation regarding school refusal behavior. Some limitations of this work are considered, and they are proposed as future lines of research. To conclude, the results are discussed taking into account the defining cultural characteristics of each country.

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The aim of the present study was to assess the predictive capacity of several of the most relevant cognitive skills in the academic field that were evaluated using Differential and General Skills Battery(BADyG-E2r). Particular attention was focused on the variables that need to be overcome regarding the curricular objectives related to pass/fail grading as evaluated by the teachers in the instrumental disciplines of Mathematics and Language. The psychometric battery was applied to the 3rd year students in primary education (a total of 512 students) at 4 public schools that were randomly selected in the province of Alicante (Spain). A follow-up of their academic evolution was under taken until the end of primary education. The obtained results show that high scores in Verbal Reasoning, Numerical Reasoning, and Verbal Syllogisms positively and significantly predict academic success at the end of primary education in the subjects of Language and Mathematics.

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BACKGROUND: This study aimed to validate the Spanish version of the Child and Adolescent Perfectionism Scale (CAPS) in Ecuadorian adolescent population. METHODS: The study involved 1,562 students aged 12 to 18 (Mage = 14.83, SD = 1.86) from Quito (Ecuador). Data analysis included Confirmatory Factor Analysis (CFA) with Satorra-Bentler scaled χ², Cronbach's alpha coefficients, Pearson's correlations, and Multigroup CFA to test factorial invariance across sex and age (configural, measurement and structural). Latent means differences were also examined across sex and age groups. RESULTS: Results confirmed the structure of Spanish version of the CAPS with 13 items divided into three factors, Socially Prescribed Perfectionism (SPP), Self-Oriented Perfectionism-Critical (SOP-C) and Self-Oriented-Striving (SOP-S). Additionally, this model remained invariant across sex and age. Significant and positive correlations were obtained between SPP, SOP-C and the three measures of psychological distress (Anxiety, Depression and Stress), whereas SOP-S showed a more adaptive pattern of association. Acceptable reliability values were obtained and latent mean differences across sex and age groups were mainly observed in the SOP-S factor. Concretely, males reported significantly higher latent mean scores than females in SOP-S as well as students aged from 14 to 18 years old in comparison with their younger peers (12- and 13-year olds). CONCLUSIONS: The Spanish version of the CAPS has satisfactory psychometric properties in terms of validity and reliability remaining invariant across sex and age in Ecuadorian adolescents.

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This study aimed to test the 2 × 2 model of dispositional perfectionism in an Ecuadorian sample of 1562 students aged between 12 and 17 years (M = 14.83 years, standard deviation = 1.86 years). The Child and Adolescent Perfectionism Scale and the brief 21-item version of the Depression Anxiety Stress Scales were used. Cluster analysis revealed four profiles: Pure Self-Oriented Perfectionism, Pure Socially Prescribed Perfectionism, Mixed Perfectionism, and Non-perfectionism. Mixed Perfectionism and Non-perfectionism obtained, respectively, the highest and lowest scores in anxiety, depression, and stress. The results are discussed in light of cultural differences in the interpretation and consequences of perfectionism.

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The purpose of this study is to adapt the Trait Meta-Mood Scale-24 (TMMS-24; Fernández-Berrocal, Extremera, & Ramos, 2004, Spanish short version of the TMMS, Salovey, Mayer, Goldman, Turvey, & Palfai, 1995) to the Chilean adolescent population (13-17 years), analyzing the psychometric properties of the instrument through confirmatory factor analyses, factor invariance analysis, and latent mean differences. For this purpose, a sample of 3,255 secondary and high school students, between 12 and 18 years old (M = 15.28, SD = 1.24), were recruited. The results confirm the measurement invariance and structure of TMMS-24 scores by sex and age. The results of the latent mean analysis show the existence of significant differences associated with sex and age in the TMMS-24 attention to feelings factor. The adequate psychometric properties of the TMMS-24 show that it is valid for the Chilean adolescent population, thus covering the existing gap in this context.

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Abstract The aim of the present study was to assess the predictive capacity of several of the most relevant cognitive skills in the academic field that were evaluated using Differential and General Skills Battery(BADyG-E2r). Particular attention was focused on the variables that need to be overcome regarding the curricular objectives related to pass/fail grading as evaluated by the teachers in the instrumental disciplines of Mathematics and Language. The psychometric battery was applied to the 3rd year students in primary education (a total of 512 students) at 4 public schools that were randomly selected in the province of Alicante (Spain). A follow-up of their academic evolution was under taken until the end of primary education. The obtained results show that high scores in Verbal Reasoning, Numerical Reasoning, and Verbal Syllogisms positively and significantly predict academic success at the end of primary education in the subjects of Language and Mathematics.

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Abstract Attention deficit hyperactivity disorder (ADHD) is considered to be one of the most common disorders during children and adolescents' neurodevelopment. Given how much the individuals executive functions are affected, the objective of the present study was to verify the validity of the Neuropsychological Assessment of Executive Functions battery for Children (ENFEN for its acronym in Spanish) as a predictor in the diagnosis of ADHD. The sample consisted of 175 participants from southeast Spain of both sexes aged between 6 and 12 (clinical M=8.39, SD=1.87, and control M=8.78, SD=1.91). The clinical group was composed of 89 (79.50%) males and 23 (20.50%) females, and the control group consisted of 37 (58.70%) males and 26 (41.30%) females. ENFEN is an individual applications battery that allows the executive functions to be globally evaluated using a wide range of elements. We followed a non-experimental research design for this comparative descriptive study. The results indicate that the phonological fluency, colour naming path, and interference scales are closely associated with the diagnosis of ADHD as they provide data on elements including inhibition, mental flexibility, sustained and selective attention, verbal fluency, and working memory. In general, this study supports the usefulness and validity of the ENFEN battery as a tool to clinically diagnose ADHD.

Resumen El trastorno por déficit de atención en hiperactividad (TDAH) es uno de los trastornos más frecuentes en el neurodesarrollo de niños y adolescentes. Las personas que lo padecen se caracterizan por presentar dificultades en los procesos de atención sostenida, ser muy activos y tener un deficiente control de sus impulsos. Pese a su elevada prevalencia y la existencia de diversas pruebas utilizadas para su diagnóstico, se conocen pocos datos sobre la utilidad y validez diagnóstica de estas herramientas. Dada la gran afectación que estos sujetos presentan en las funciones ejecutivas, el objetivo de este estudio es comprobar la utilidad y validez de la batería de Evaluación Neuropsicológica de las Funciones Ejecutivas en Niños (ENFEN), como predictora herramienta de apoyo al diagnóstico de TDAH. La muestra de estudio estuvo compuesta por 175 participantes de ambos sexos, con edades comprendidas entre los 6 y 12 años (grupo clínico M=8.39, SD=1.87 y grupo control M=8.78, SD=1.91). El grupo clínico estaba compuesto por 89 (79.50%) hombres y 23 (20,50%) mujeres, y el grupo de control por 37 (58,70%) hombres y 26 (41,30%) mujeres. ENFEN es una batería de aplicación individual, compuesta por varias subpruebas que requieren el empleo de funciones ejecutivas para resolver los elementos que las componen. Se siguió un diseño no-experimental para llevar a cabo un estudio descriptivo comparativo. Los resultados señalaron que las escalas Fluidez Fonológica, Sendero Color e Interferencia que requieren en mayor medida inhibición, flexibilidad mental, atención sostenida y selectiva, fluidez verbal y memoria de trabajo, entre otras aptitudes cognitivas, son las que mejor se asocian al diagnóstico de TDAH. En general, este estudio apoya la utilidad y validez de la prueba ENFEN como herramienta para el diagnóstico clínico del TDAH.

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RESUMEN Fundamento: el oligohidramnios con frecuencia impide una gestación exitosa y es necesario buscar alternativas terapéuticas que minimicen los daños que causa al feto. Objetivo: caracterizar el uso de la hidroterapia materna endovenosa en el manejo del oligohidramnios. Métodos: se realizó un estudio observacional descriptivo de corte transversal. El universo quedó constituido por 1 272 gestantes con un tiempo de gestación ≥ 34 semanas que presentaban oligohidramnios divididas en dos grupos según el uso o no de la hidroterapia materna endovenosa. Se utilizó estadística descriptiva con distribución de frecuencias absolutas y relativas. Resultados: la media de índice de líquido amniótico al ingreso en el grupo uno fue de 3,9 cm y en el grupo dos de 4,1 cm, la cual ascendió en este último a 6,2 cm después del uso de la hidroterapia materna endovenosa. El 49,58 % de gestantes del grupo uno fueron cesáreas y 63,29 % del grupo dos tuvieron un parto eutócico. La indicación de cesárea por estado fetal intranquilizante se presentó en 182 grávidas del grupo uno y 139 gestantes del grupo dos. El bajo peso al nacer se presentó en 29 y 26 neonatos de las gestantes del grupo uno y dos respectivamente. Conclusiones: el uso de la hidroterapia materna endovenosa incrementó el promedio del índice de líquido amniótico. La mayoría de las pacientes hidratadas tuvieron un parto eutócico y fue menor la cantidad de gestantes con estado fetal intranquilizante y con complicaciones neonatales en ese grupo.

ABSTRACT Background: oligohydramnio frequently blocks a successful pregnancy and it is necessary to found therapeutics options that reduce its damages over the fetus. Objective: to characterize the use of maternal intravenous hydration on the management of oligohydramnio. Methods: an observational descriptive cross-sectional study was carried out. The universe was constituted by 1 272 pregnant women with gestational age ≥ 34 weeks who suffered from oligohydramnio. They were divided into 2 groups depending on the use or not of maternal intravenous hydration. A descriptive statistic with absolute and relative frequencies was used. Results: the average of amniotic liquid index at the admission was 3.9 cm in group 1 and 4.1 cm in group 2, in which it increased until 6.2 cm after maternal intravenous hydration. 49.58 % of women in group 1 were cesarean and 63.29 % of women in group 2 have a eutocic labor. Fetal distress was the indication of cesarean in 182 and 139 pregnant women of group 1 and 2 respectively. 29 and 26 newborn of group 1 and 2 respectively have low birth weight. Conclusions: maternal intravenous hydration increases the average of amniotic liquid index. The majority of hydrated maternal women have a eutocic labor, newborn complications were less in that group too.

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Resumen La literatura informa que la prevalencia de la ansiedad en edad infantil ha aumentado exponencialmente durante las últimas décadas, lo que ha generado la necesidad de monitorear de forma permanente los estados emocionales, principalmente en niños, y así evitar las dificultades de esta problemática. El objetivo fue establecer diferencias en ansiedad escolar en función del sexo y el curso académico en estudiantes chilenos de educación básica. Para esto se contó con 3212 alumnos de 30 colegios de Ñuble, en Chile, 1639 niñas y 1573 niños, en edades entre los ocho y los 15 años (M = 10,05, DT = 1,01). La ansiedad escolar se evaluó con el Inventario de ansiedad escolar para educación primaria, el cual evalúa tres sistemas de respuesta (cognitiva, conductual y psicofisiológica), y cuatro factores situacionales (ansiedad ante el castigo escolar, ansiedad ante la victimización, ansiedad ante la evaluación social y ansiedad ante la evaluación y el fracaso escolar). Los resultados indican que las niñas presentan niveles de ansiedad significativamente mayores que los niños, aunque de pequeña magnitud. Con respecto al curso académico, se observan diferencias estadísticamente significativas entre 4° y 5°, entre 4° y 6° y entre 5° y 6° año. Estos resultados corroboran los obtenidos en investigaciones previas y alertan sobre su permanencia en el tiempo.

Abstract The literature reports that the prevalence of anxiety in childhood has increased exponentially during the last decades, generating with it the need to permanently monitor emotional states mainly in children and thus avoid the difficulties of this problem. The objective was to establish differences in school anxiety according to gender and academic course in Chilean students of basic education. The sample consisted of 3212 students from 30 schools in Ñuble, in Chile, 1639 girls and 1573 children and ages between 8 and 15 years (M = 10,05, DT = 1,01), school anxiety was evaluated with the School Anxiety Inventory for children of Elementary Education, which evaluates three response systems (cognitive, behavioral and psychophysiological), and four situational factors (anxiety about social assessment, anxiety about evaluation and school failure, school punishment and anxiety about victimization). The results indicate that girls have significantly higher anxiety levels than boys, although of small magnitude. Regarding the academic year, there are statistically significant differences between 4th and 5th, between 4th and 6th and between 5th and 6th year. These results corroborate those obtained in previous research and alert about the permanence of them over time.

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Se realizó un estudio descriptivo y transversal de 9 932 pacientes, quienes presentaron urgencias bucofaciales, atendidos en el Cuerpo de Guardia de Cirugía Maxilofacial del Hospital Provincial Docente Clinicoquirúrgico Saturnino Lora Torres de Santiago de Cuba, desde enero del 2006 hasta diciembre del 2010, a fin de caracterizarles desde los puntos de vista clínico y terapéutico. Se halló una elevada incidencia de afectados con procesos patológicos agudos que constituyeron urgencias en el Servicio de Cirugía Maxilofacial, aunque solo 3,3 por ciento de ellos fueron hospitalizados. Hubo un predominio de pacientes con traumatismos de partes blandas, procesos inflamatorios sépticos agudos y procesos dolorosos de cabeza y cuello. La mayoría de los procederes quirúrgicos y ortopédicos se efectuaron en el cuerpo de guardia antes citado, lo cual pertenece a la categoría de cirugía menor y bajo régimen de atención ambulatoria

A descriptive and cross-sectional study of 9 932 patients who presented oral and facial emergencies, assisted in the Maxillofacial Surgery emergency room of Saturnino Lora Torres Teaching Clinical Surgical Provincial Hospital in Santiago de Cuba, was carried out from January, 2006 to December, 2010, in order to characterize them from the clinical and therapeutical points of view. It was found a high incidence of affected patients with acute pathological processes that constituted emergencies in the Maxillofacial Surgery Service, although just 3.3 percent of them were hospitalized. There was a prevalence of patients with soft parts trauma, acute septic inflammatory processes and painful processes of head and neck. Most of the surgical and orthopedic procedures were carried out in the emergency room above mentioned, which belong to the category of minor surgery and under ambulatory care

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Se presenta el caso clínico de una anciana de 80 años de edad con antecedentes de demencia senil, quien acudió acompañada de sus hijos a la consulta de Emergencia del Hospital Provincial Docente Clinicoquirúrgico Saturnino Lora Torres por presentar mordedura de un perro en la región labial. A la paciente se le realizó lavado de la herida, desbridamiento y profilaxis, seguidos de la confección de colgajos locales combinados y sutura inmediata. Los resultados cosméticos y funcionales fueron catalogados como favorables.

The case report of an 80 years elderly woman with history of Alzheimer´s is presented, who went along with her children to the Emergency Service of Saturnino Lora Torres Teaching Clinical Surgical Provincial Hospital due to a dog bite in the labial region. The wound cleaning, debridement and prophylaxis was carried out to the patient, followed by making combined local flaps and immediate suture. The cosmetic and functional results were classified as favorable.

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Se realizó un estudio descriptivo, transversal y aleatorizado de 102 pacientes con fracturas del complejo cigomático, tratados con osteosíntesis semirrígida en el Servicio de Cirugía Maxilofacial del Hospital Provincial Docente Clinicoquirúrgico Saturnino Lora Torres de Santiago de Cuba, desde enero de 2005 hasta diciembre de 2011, con vistas a caracterizarles según variables demográficas y terapéuticas en las fases preoperatoria, intraoperatoria y posoperatoria. En la casuística predominaron los accidentes del tránsito como mecanismos causales de las lesiones (55,8 por ciento), la depresión de la eminencia cigomática y la presencia de escalones óseos palpables en el marco orbitario inferior y/o lateral como síntomas principales (92,1 por ciento, respectivamente), y la exposición escleral como complicación posoperatoria (55,2 por ciento), entre otros; asimismo, el valor del tiempo preoperatorio incrementó el riesgo de secuelas y la vía de acceso subciliar se asoció con un mayor riesgo de exposición escleral para el acceso al marco inferior y/o suelo orbitario. Por otra parte, tanto el enoftalmos como el hipoftalmos son de difícil solución y tienen una tendencia significativa de convertirse en secuelas posoperatorias

A descriptive, cross-sectional and randomized study of 102 patients with fractures of the zygomatic complex, treated with semirigid osteosynthesis in the Maxillofacial Surgery Service of Saturnino Lora Torres Teaching Clinical Surgical Provincial Hospital was carried out in Santiago de Cuba, from January, 2005 to December, 2011, aimed at characterizing them according to demographic and therapeutic variables in the presurgical, intrasurgical and postsurgical phases. In the case material there was a prevalence of traffic accidents as causal mechanisms of the lesions (55.8 percent), depression of the zygomatic eminence and presence of palpable bony steps in the lower and/or lateral orbitary edge as main symptoms (92.1 percent, respectively), and the scleral exhibition as postsurgical complication (55.2 percent), among others; also, the value of the presurgical time increased the risk of sequelae and the subciliary approach was associated with a higher risk of scleral exhibition for approaching to the lower edge and/or orbitary floor. On the other hand, either enophthalmos or hypophthalmos are of difficult solution and have a significant tendency of becoming postsurgical sequelae

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Antimony is a metalloid that affects biological functions in humans due to a mechanism still not understood. There is no doubt that the toxicity and physicochemical properties of Sb are strongly related with its chemical state. In this paper, the interaction between Sb(III) and Sb(V) with bovine serum albumin (BSA) was investigated in vitro by fluorescence spectroscopy, and circular dichroism (CD) under simulated physiological conditions. Moreover, the coupling of the separation technique, asymmetric flow field-flow fractionation, with elemental mass spectrometry to understand the interaction of Sb(V) and Sb(III) with the BSA was also used. Our results showed a different behaviour of Sb(III) vs. Sb(V) regarding their effects on the interaction with the BSA. The effects in terms of protein aggregates and conformational changes were higher in the presence of Sb(III) compared to Sb(V) which may explain the differences in toxicity between both Sb species in vivo. Obtained results demonstrated the protective effect of GSH that modifies the degree of interaction between the Sb species with BSA. Interestingly, in our experiments it was possible to detect an interaction between BSA and Sb species, which may be related with the presence of labile complex between the Sb and a protein for the first time.

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Fundamento: la diabetes mellitus es una prioridad de la salud pública en el mundo, que asociada al embarazo, representa un gran desafío para el obstetra por la posibilidad de complicaciones maternas, fetales y perinatales. Objetivo: caracterizar los resultados maternos-perinatales en las gestantes diabéticas. Métodos: se realizó un estudio observacional, descriptivo, transversal en el Hospital Universitario Gineco-Obstétrico Provincial Ana Betancourt de Mora de Camagüey desde el año 2007 hasta-2015. El universo de estudio quedó constituido por 1 972 gestantes divididas en dos grupos. Los datos fueron obtenidos de las historias clínicas y procesados mediante estadística descriptiva. Resultados: se distribuyó a las gestantes de acuerdo al tipo de trastorno metabólico durante el embarazo; que padecieron diabetes gestacional y en la diabetes pregestacional la variedad de diabetes mellitus tipo 1 prevaleció en cada año. Según las alteraciones presentes al término hubo neonatos macrosómicos seguidos del bajo peso al nacer y las malformaciones congénitas, con mayor incidencia en los neonatos hijos de madres con diabetes pregestacional. En cuanto a la morbimortalidad perinatal hubo muertes fetales tardías y neonatales. Conclusiones: es más habitual encontrar en un grupo de gestantes con alteraciones metabólicas, una cifra superior de diabetes gestacional que de diabetes pregestacional. La macrosomía fetal es la alteración más frecuente al término del embarazo, seguidas del bajo peso al nacer, las malformaciones y las muertes fetales y neonatales. Una sensible dispensarización por el médico de familia, por ser una enfermedad crónica, el valorar los antecedentes reproductivos y la justa caracterización personal de cada embarazada, proveerá de calidad la atención prenatal y garantizará una correcta vigilancia perinatal hospitalaria.

Background: the care of diabetic patients is an important objective of health systems around the world. When this condition is associated to the pregnancy it requires a special care because it may causes different complications in pregnant women, fetus and new born. Objective: to describe the results related to the labor of diabetic pregnant in Provincial University Obstetrics and Gynecology Hospital at Camagüey during 2007-2015. Methods: an observational descriptive cross-sectional study was carried out. The universe was sample by 1972 pregnant women that were divided in two groups. The data were obtained from medical records and they were processed by descriptive statistics. Results: 87, 37 % pregnant women suffered from gestational diabetes. 165 new born were macrocosmic and 85 had intrauterine growth retardation. In this study 38 new born died and 17 had some congenital malformation. Conclusions: gestational diabetes is more frequent than pre-gestational diabetes in a group of pregnant women. The most common alteration at the end of pregnancy in these women was macrocosmic. An important objective of medical services in diabetic’s pregnant women is to reduce fetal mortality and mortality around the labor.

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Se efectuó un estudio descriptivo y transversal de 25 pacientes con cáncer infectados por el virus del herpes simple bucal, quienes tenían el sistema inmunológico deteriorado debido al tratamiento oncoespecífico, atendidos en la consulta estomatológica del Policlínico de Especialidades del Hospital Provincial Docente Clinicoquirúrgico Saturnino Lora Torres de Santiago de Cuba, desde enero de 2014 hasta igual mes de 2016, a fin de evaluar los resultados del diagnóstico clínico y citopatológico de esta afección. En la casuística prevalecieron el sexo masculino, el dolor como sintomatología clínica, el bermellón del labio inferior como el sitio de mayor incidencia y la quimioterapia como la modalidad terapéutica de mayor reactivación de este agente viral. La citología exfoliativa confirmó la presencia de células epiteliales gigantes multinucleadas con cuerpos de inclusiones intranucleares y necrosis de células infectadas, respectivamente, siendo estos los hallazgos microscópicos más significativos

A descriptive and cross-sectional study of 25 patients with cancer infected by the oral herpes simplex virus was carried out. They had the immunologic system damaged due to oncospecific treatment, assisted in the stomatological service of the Specialties Polyclinic of Saturnino Lora Torres Teaching Clinical Surgical Provincial Hospital in Santiago de Cuba, from January, 2014 to the same month in 2016, in order to evaluate the results of the clinical and cytopathologic diagnosis of this disorder. In the case material the male sex and pain as clinical symptomatology, the vermilion of the lower lip as the place of more incidence and chemotherapy as the therapeutic modality of this viral agent higher reactivation prevailed. The exfoliative cytology confirmed the presence of multinucleous giant epithelial cells with bodies of intranuclear inclusions and infected cells necrosis, respectively, being these the most significant microscopic findings

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