RESUMO
Autosomal recessive Robinow syndrome is a form of mesomelic dwarfism with multiple rib and vertebral anomalies. Using autozygosity mapping we have identified a genetic locus (RBNW1) for this syndrome at chromosome 9q22 in seven consanguineous families from Oman. Our results indicate that the gene lies within a 4 cM region between markers D9S1836 and D9S1803 (maximum multipoint LOD score 12.3). In addition, we have analysed two non-Omani families with autosomal recessive Robinow and found no genetic heterogeneity.
Assuntos
Cromossomos Humanos Par 9/genética , Nanismo/genética , Osso e Ossos/anormalidades , Brasil , Mapeamento Cromossômico , Consanguinidade , Genes Recessivos , Ligação Genética , Haplótipos , Humanos , Escore Lod , Repetições de Microssatélites , Omã , Reino UnidoRESUMO
A high-grade steel model with different preparation angles of 3 degrees, 7 degrees and 11 degrees in one- and two-step impression techniques were made for the determination of the influence of the preparation angle on the dimension loyalty of the resulting master casts. Using a 3-D-measuring instrument, analysis of the data showed that with the correction technique the model abutments led to a reduction in dependency on the preparation angle. The general reduction in stump height of the abutments was independent of the preparation angle. The double-mix technique showed decent increased abutments and is thus recommended for impressions of supragingival preparations.
Assuntos
Técnica de Moldagem Odontológica , Modelos Dentários , Análise de Variância , Sulfato de Cálcio , Dente Suporte , Materiais para Moldagem Odontológica/química , Humanos , Imageamento Tridimensional , Teste de Materiais , Polivinil/química , Pressão , Resinas Sintéticas/química , Siloxanas/química , Aço Inoxidável , Propriedades de Superfície , Fatores de TempoRESUMO
Estradiol benzoate (10 microg EB) given to ovariectomized-adrenalectomized rats induced sexual receptivity in half the animals and increased alpha-MSH in the preoptic area, ventromedial nucleus (VMN) and arcuate nucleus (ARC), in all the animals, although levels were significantly higher in the VMN and ARC of the receptive (R) subgroup. EB also raised levels of beta-endorphin in the VMN and ARC in the R rats only. POMC expression was not altered. EB did not affect alphaMSH in extra-hypothalamic areas, but addition of progesterone, raised levels in the septum, amygdala, hippocampus and caudate putamen. Only in the VMN, ARC and septum were the steroid-induced increases correlated with onset of sexual behavior.