RESUMO
Background: Ameloblastic fibro-odontoma is a benign tumor derived from odontogenic epithelium and mesenchymaltissue, which forms enamel and dentin. It is a rare neoplasm in all species. One of the most common sites for their occurrence is the anterior mandibules. The prevalence of this odontogenic tumor is higher in young animals and only few casesare described in cattle. The purpose of this article is describe the clinical, surgical and the histopathological characteristicof a fibro-odontoma case in a Jersey Cow.Case: A 3-year-old Jersey cow was presented with a progressively growing mass in the anterior mandible displacing theincisor teeth. The mass measured approximately 12 cm diameter and there was a focal area of myiasis. The owner reportedweight loss and eating difficulties. The animal was treated with antibiotics for a few weeks but the conservative treatment failed, and the heifer underwent surgical removal of the lesion. The tumor was sent for histopathological evaluationat UFPR-Palotina Pathology laboratory. Microscopically, the excised mass was poorly delimited, and was composed oftumor cells of mesenchymal and epithelial origin which infiltrated and compressed surrounding tissues. Neoplastic cellswere arranged in bundles which multifocally formed dental sacs (dental follicles) of various sizes. These dental sacswere formed by neoplastic ameloblasts, and were surrounded by abundant fibrous connective tissue. The central zone ofthe tumor consisted of a loose, vacuolated neoplastic stellate reticulum. Mitotic figures were rare, and there was moderate anisokaryosis. In some areas, neoplastic ameloblasts surrounded the stellate reticulum. The presence of a sparse,well-organized basophilic extracellular matrix produced presumably by the tumor cells and interpreted as dentin. Thesemicroscopic characteristics led to the diagnosis of an...(AU)
Assuntos
Animais , Feminino , Bovinos , Odontoma/patologia , Odontoma/cirurgia , Odontoma/veterinária , Neoplasias Bucais/veterináriaRESUMO
Background: Ameloblastic fibro-odontoma is a benign tumor derived from odontogenic epithelium and mesenchymaltissue, which forms enamel and dentin. It is a rare neoplasm in all species. One of the most common sites for their occurrence is the anterior mandibules. The prevalence of this odontogenic tumor is higher in young animals and only few casesare described in cattle. The purpose of this article is describe the clinical, surgical and the histopathological characteristicof a fibro-odontoma case in a Jersey Cow.Case: A 3-year-old Jersey cow was presented with a progressively growing mass in the anterior mandible displacing theincisor teeth. The mass measured approximately 12 cm diameter and there was a focal area of myiasis. The owner reportedweight loss and eating difficulties. The animal was treated with antibiotics for a few weeks but the conservative treatment failed, and the heifer underwent surgical removal of the lesion. The tumor was sent for histopathological evaluationat UFPR-Palotina Pathology laboratory. Microscopically, the excised mass was poorly delimited, and was composed oftumor cells of mesenchymal and epithelial origin which infiltrated and compressed surrounding tissues. Neoplastic cellswere arranged in bundles which multifocally formed dental sacs (dental follicles) of various sizes. These dental sacswere formed by neoplastic ameloblasts, and were surrounded by abundant fibrous connective tissue. The central zone ofthe tumor consisted of a loose, vacuolated neoplastic stellate reticulum. Mitotic figures were rare, and there was moderate anisokaryosis. In some areas, neoplastic ameloblasts surrounded the stellate reticulum. The presence of a sparse,well-organized basophilic extracellular matrix produced presumably by the tumor cells and interpreted as dentin. Thesemicroscopic characteristics led to the diagnosis of an...
Assuntos
Feminino , Animais , Bovinos , Neoplasias Bucais/veterinária , Odontoma/cirurgia , Odontoma/patologia , Odontoma/veterináriaRESUMO
Objetivos: Nos últimos anos foram desenvolvidos diversos trabalhos visando entender o comportamento biológico e definir a melhor forma de abordagem para os Tumores de Estroma Gastrointestinal. Nessa revisão, são organizadas informações atualizadas sobre o assunto. Métodos: Foi realizado levantamento bibliográfico, sem restrição de período, nas bases de dados PubMed e LILACS. Foi utilizada a palavra- -chave "Tumores de Estroma Gastrointestinal", que deveria aparecer no título dos artigos. Foram encontrados 1619 artigos e, depois da leitura dos resumos, foram selecionados 20 artigos publicados entre 1998 e 2018. Resultados: Foram levantados dados relevantes e atualizados sobre a epidemiologia, histopatologia, apresentação clínica, diagnóstico, prognóstico e tratamento dos Tumores de Estroma Gastrointestinal. Conclusões: Apesar de ser considerada uma neoplasia rara, é um assunto que deve ser estudado e discutido pela definição recente do diagnóstico e da abordagem terapêutica.
Objectives: In recent years, several studies have been developed to understand the biological behavior and to define the best therapeutic approach for Gastrointestinal Stromal Tumor. In this review, we have organized up-to-date information on the subject. Methods: A bibliographic survey was carried out, without period restriction, in PubMed and LILACS databases. The key word "Gastrointestinal Stromal Tumors" was used, which should appear in the title of the articles. A total of 1619 articles were found and, after reading the abstracts, 20 papers published between 1998 and 2018 were selected. Results: We collected relevant and updated data on the epidemiology, histopathology, clinical presentation, diagnosis, prognosis and treatment of Gastrointestinal Stromal Tumors. Conclusions: Despite being considered a rare neoplasm, it is a subject that must be studied and discussed because of the recent definition of diagnosis and the therapeutic approach.