RESUMO

A single dose of calcitonin (150 mIU/100 g body weight, sc) produced a significant decrease in liver antipyrine hydroxylase and aminopyrine demethylase activities. By contrast, pentobarbital sleeping time was not altered by calcitonin treatment. The present results indicate that acute calcitonin administration depresses the metabolism of substrates of the mixed function oxidase system of rat liver.

Assuntos

Aminopirina N-Desmetilase/metabolismo , Calcitonina/farmacologia , Fígado/enzimologia , Oxigenases de Função Mista/metabolismo , Animais , Antipirina/metabolismo , Masculino , Pentobarbital/metabolismo , Ratos , Ratos Endogâmicos , Sono/efeitos dos fármacos

RESUMO

A single dose of calcitonin (150 mIU/100g body weight, sc) produced a significant decrease in liver antipyrine hydroxylase and aminopyrine demethylase activities. By contrast, pentobarbital sleeping time was not altered by calcitonin treatment. The present results indicate that acute calcitonin administration depresses the metabolism of substrates of the mixed function oxidase system of rat liver

Assuntos

Ratos , Animais , Masculino , Calcitonina/farmacologia , Fígado/enzimologia , Oxigenases de Função Mista/metabolismo , Sono/efeitos dos fármacos , Sistema Enzimático do Citocromo P-450 , Microssomos Hepáticos