RESUMO
The selenium in the diet of persons in arsenic-endemic areas, high levels of arsenic in the drinking water, was evaluated. The methodology used was that of 24-hr dietary recall. Daily selenium intakes of two rural towns in northern Mexico were found to be similar, approximating 72.9 and 60.6 micrograms. These values were similar to those of a previously arsenic-exposed area from California, Edison community. The Edison participants had a daily selenium intake of 61.8 micrograms. The possible negative effect of selenium to produce differences in reported geographical variation in disease could not be substantiated in this study. Other nutrient intakes, protein and energy were also found similar for communities. Differences were noted in vitamin A intake where one-third the daily requirement was experienced by Mexican participants compared to two-thirds the requirement being satisfied by those participants from Edison.
Assuntos
Arsênio , Dieta , Ingestão de Alimentos , Selênio/análise , Poluição Química da Água , Abastecimento de Água , Adulto , Proteínas Alimentares/análise , Feminino , Humanos , Masculino , México , Pessoa de Meia-Idade , Necessidades Nutricionais , Selênio/administração & dosagem , Vitamina A/administração & dosagem , Vitamina A/análiseRESUMO
Biochemical measurements and 24-h dietary recalls were conducted early (18.9 +/- 5.9 wk) and late (35.1 +/- 2.0 wk) in pregnancy in women attending clinics in Montemorelos, Mexico. Mean weight gain per week (0.4 +/- 0.2 kg) and birth weight (3381 +/- 456 g) were normal. Intakes tended to decline during pregnancy and declined significantly for zinc (p less than 0.05) and vitamin B-6 (p less than 0.03). Mean Zn intake late in pregnancy was low (7.8 +/- 3.3 mg/d). Various supplements were taken but none contained Zn. During pregnancy mean plasma Zn levels fell (p less than 0.001) and late in pregnancy 57% of the women had values suggestive of poor Zn status (less than or equal to 8.1 mumol/L). These data indicate that Zn intakes of approximately 8 mg/d will not maintain plasma Zn levels in late pregnancy. Erythrocyte glutamic-pyruvic transaminase (EGPT) index and the index of diamine oxidase (DAO), a vitamin B-6-requiring enzyme of placental origin, were correlated suggesting that DAO index may be useful in evaluating vitamin B-6 status in pregnancy.
PIP: Biochemical measurements and 24 hour dietary recalls were conducted early (18.9 +0- 5.9 weeks) and late (35.1 +or- 2.0 weeks) in pregnancy in women attending clinics in Montemorelos, Mexico. Mean weight gain per week (0.4 +or- 0.2 kg) and birth weight (3381 +or- 456 grams) were normal. Intakes tended to decline during pregnancy and declined significantly for zinc (p 0.05) and vitamin B-6 (p 0.03). Mean zinc intake late in pregnancy was low (7.8 +or- 3.3 mg/d). Various supplements were taken but none contained zinc. During pregnancy mean plasma zinc levels fell (p 0.001) and late in pregnancy 57% of the women had values suggestive of poor zinc status (or= 8.1 micromoles/liter). These data indicate that zinc intakes of approximately 8 mg/d will not maintain plasma zinc levels in late pregnancy. Erythrocyte glutamic-pyruvic transaminase (EGPT) index and the index of diamine oxidase (DAO), a vitamin B-6-requiring enzyme of placental origin, were correlated suggesting that DAO index may be useful in evaluating vitamin B-6 status in pregnancy.
Assuntos
Gravidez/sangue , Piridoxina/sangue , Zinco/sangue , Adulto , Estatura , Peso Corporal , Dieta , Feminino , Humanos , México , Cuidado Pré-NatalRESUMO
As a follow-up of our study of pregnant women, we report effects of zinc supplementation during pregnancy in another population of 138 Hispanic teenagers in Los Angeles. Teenagers were randomized (double-blind) to a control or zinc-supplemented group and received similar daily vitamin and mineral supplements except for 20 mg zinc added to the zinc-supplemented group's capsules. Initially, mean dietary zinc intakes of both groups were about 50% of the Recommended Dietary Allowance and their mean serum zinc levels did not differ significantly (69.8 +/- 11.2 micrograms/dl in control and 69.0 +/- 11.4 micrograms/dl in zinc-supplemented group). Zinc supplementation did not maintain mean serum zinc levels during pregnancy but, as in our earlier study, it reduced (p = 0.018) the number of low serum zinc values (less than or equal to 53 micrograms/dl) in late pregnancy. Zinc supplementation did not affect outcome of pregnancy but serum zinc levels were lower (p = 0.038) in teenagers with pregnancy-induced hypertension than in normotensives.
Assuntos
Hispânico ou Latino , Gravidez na Adolescência , Zinco/sangue , Adolescente , Antropometria , Peso ao Nascer , California , Dieta , Método Duplo-Cego , Feminino , Humanos , Recém-Nascido , Rememoração Mental , México/etnologia , Necessidades Nutricionais , Pobreza , Gravidez , Distribuição Aleatória , Albumina Sérica , Zinco/administração & dosagemRESUMO
The effects of zinc supplementation on levels of various blood constituents and the outcome of pregnancy in 213 Hispanic women attending a prenatal clinic in Los Angeles was assessed in this double-blind study. The women were randomized into either a control (C) or a zinc-supplemented (Z) group and received similar vitamin and mineral supplements except that 20 mg zinc was added to the Z group's capsules. At the final interview, women (C + Z) with low serum Zn levels (less than or equal to 53 micrograms/dl) had higher (p less than 0.01) mean ribonuclease activity and lower (p less than 0.01) mean delta-aminolevulinic acid dehydratase activity than women with acceptable serum zinc levels. The incidence of pregnancy-induced hypertension was higher (p less than 0.003) in the C than in the Z group, but pregnancy-induced hypertension was not associated with low serum zinc levels at either the initial or final interview. The expected increase in serum copper levels was greater (less than 0.001) in women with pregnancy-induced hypertension (C + Z) than in normotensives. Except for pregnancy-induced hypertension, there was a higher incidence of abnormal outcomes of pregnancy in the noncompliers than in the compliers (C + Z).
Assuntos
Gravidez , Cuidado Pré-Natal , Zinco/uso terapêutico , California , Cobre/sangue , Método Duplo-Cego , Feminino , Hispânico ou Latino , Humanos , Hipertensão/sangue , México/etnologia , Cooperação do Paciente , Sintase do Porfobilinogênio/sangue , Pobreza , Complicações Cardiovasculares na Gravidez/sangue , Distribuição Aleatória , Ribonucleases/sangue , Vitaminas/uso terapêutico , Zinco/sangueRESUMO
The effect of zinc supplementation on concentrations of zinc in hair and serum of 213 pregnant Hispanic women attending a clinic in Los Angeles was assessed using a random, double-blind experiment. Both the treatment (T) and control (C) groups received similar vitamin and mineral supplements except that 20 mg zinc was added to the supplements for the treatment group. Nutrient intakes were calculated from 24-h recalls. The initial mean dietary zinc intake of both groups was about 50% of the Recommended Dietary Allowance (9 +/- 5 mg). Initially there were no significant differences between the two groups in mean zinc levels in serum (66 +/- 11 micrograms/dl, C, and 65 +/- 12 micrograms/dl, T) or in hair (184 +/- 41 micrograms/g, C, and 175 +/- 38 micrograms/g, T). Zinc supplementation did not alter mean zinc levels in serum or hair but significantly (p less than 0.05) reduced the number of low serum zinc values (less than or equal to 53.3 micrograms/dl) toward the end of pregnancy. Although serum zinc levels do decline in pregnancy, our results suggest that severely depressed levels (less than or equal to 50 to 55 micrograms/dl) indicate inadequate zinc status.