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1.
West Indian Med J ; 52(2): 124-6, 2003 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-12974062

RESUMO

It has been shown that an excess of pregnancy and birth complications (PBCs) does not contribute to the excess rates of schizophrenia reported for the population of Caribbean origin in Britain compared with the native Caucasian British population. We therefore attempted to compare the rate of PBCs between a sample of schizophrenics in Britain with that of a sample from Trinidad where some of the Caribbean migrants to Britain originated. First contact patients with schizophrenia according to the CATEGO system diagnosis were identified in Trinidad and London. Their mothers, where available, were interviewed using the Lewis-Murray scale for pregnancy and birth complications. Data from Trinidad and Tobago concerning 56 patients were compared with those of the Caucasian (n = 61) and African-Caribbean (n = 50) patients in London. The rate of PBCs was similar for the Caucasian British patients (24.6%) and the patients in Trinidad and Tobago (21.7%). The rates were lowest in the African-Caribbean patients in London (14.0%), though this difference was not statistically significant. These findings suggest that pregnancy and birth complications are a risk factor for a substantial minority of patients with schizophrenia in Trinidad and London. It also confirms that the excess rates of schizophrenia reported for the Caribbean population in Britain are not due to these complications.


Assuntos
População Negra , Complicações do Trabalho de Parto/epidemiologia , Complicações na Gravidez/epidemiologia , Resultado da Gravidez , Esquizofrenia/epidemiologia , População Branca , Adolescente , Adulto , Distribuição por Idade , Idade de Início , Traumatismos do Nascimento/epidemiologia , Peso ao Nascer , Distribuição de Qui-Quadrado , Estudos de Coortes , Emigração e Imigração , Feminino , Humanos , Incidência , Recém-Nascido , Recém-Nascido Prematuro , Londres/epidemiologia , Masculino , Pessoa de Meia-Idade , Razão de Chances , Gravidez , Fatores de Risco , Estudos de Amostragem , Esquizofrenia/diagnóstico , Distribuição por Sexo , Trinidad e Tobago/epidemiologia , População Urbana
2.
Br J Psychiatry ; 171: 145-7, 1997 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-9337950

RESUMO

BACKGROUND: It has been suggested that the increased rate of psychotic illness among African-Caribbeans living in Britain is due to an excess of pregnancy and birth complications (PBCs). METHOD: We therefore compared the frequency of PBCs in a group of White psychotic patients (n = 103) and a comparable group of patients of African-Caribbean origin (n = 61); the latter consisted of 30 first-generation (born in the Caribbean) and 31 second-generation (born in Britain) individuals. RESULTS: White psychotic patients were more than twice as likely to have a history of PBCs as their African-Caribbean counterparts (odds ratio = 2.34, 95% confidence interval (CI) 0.88-6.47, P = 0.062). The same trend was observed among patients with a DSM-III diagnosis of schizophrenia (odds ratio = 1.65, 95% CI 0.56-4.97, P = 0.32). The rate of PBCs was similar among the first- and second-generation Caribbean psychotic patients. CONCLUSIONS: The increased rate of psychotic illness that has been reported among the African-Caribbean population in Britain is not due to an increased prevalence of PBCs.


Assuntos
Traumatismos do Nascimento/etnologia , Complicações na Gravidez/etnologia , Transtornos Psicóticos/etnologia , Adulto , África/etnologia , Feminino , Humanos , Londres/epidemiologia , Masculino , Gravidez , Complicações na Gravidez/epidemiologia , Complicações na Gravidez/psicologia , Prevalência , Transtornos Psicóticos/epidemiologia , Esquizofrenia/epidemiologia , Esquizofrenia/etnologia , Índias Ocidentais/etnologia , População Branca/estatística & dados numéricos
3.
Br J Psychiatry ; 169(6): 776-80, 1996 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-8968638

RESUMO

BACKGROUND: The high rate of schizophrenia among the second-generation African-Caribbean population in Britain has prompted much concern and speculation. Sugarman and Craufurd have reported that the morbid risk in the siblings of second-generation African-Caribbean schizophrenic patients was unusually high compared with that of the siblings of White patients. METHOD: We sought to replicate these findings by comparing the morbid risk for schizophrenia in the first-degree relatives of 111 White and 73 African-Caribbean psychotic probands. The latter comprised 35 first-generation (born in the Caribbean) and 38 second-generation (born in Britain) probands. RESULTS: The morbid risk for schizophrenia was similar for the parents and siblings of White and first-generation African-Caribbean patients, and for the parents of the second-generation African-Caribbean probands. However, the siblings of second-generation African-Caribbean psychotic probands had a morbid risk for schizophrenia that was seven times that of their White counterparts (P = 0.007); similarly, the siblings of second-generation African-Caribbean schizophrenic probands had a morbid risk for schizophrenia that was four times that of their White counterparts (P = 0.05). CONCLUSIONS: These findings replicate those of the earlier report of Sugarman and Craufurd, and suggest either that the second-generation African-Caribbean population in Britain is particularly vulnerable to some environmental risk factors for schizophrenia, or that some environmental factors act selectively on this population in Britain.


Assuntos
População Negra/genética , Negro ou Afro-Americano/psicologia , Transtornos Psicóticos/genética , Esquizofrenia/genética , População Branca/genética , População Branca/psicologia , Adulto , África/etnologia , Filho de Pais com Deficiência/psicologia , Comparação Transcultural , Feminino , Humanos , Masculino , Fenótipo , Transtornos Psicóticos/diagnóstico , Transtornos Psicóticos/etnologia , Risco , Esquizofrenia/diagnóstico , Esquizofrenia/etnologia , Meio Social , Reino Unido/epidemiologia , Índias Ocidentais/etnologia
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