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Background: COVID-19 progression is associated with an increased risk of arterial and venous thrombosis. Randomised trials have demonstrated that anticoagulants reduce the risk of thromboembolism in hospitalised patients with COVID-19, but a benefit of routine anticoagulation has not been demonstrated in the outpatient setting. Methods: We conducted a randomised, open-label, controlled, multicentre study, evaluating the use of rivaroxaban in mild or moderate COVID-19 patients. Adults ≥18 years old, with probable or confirmed SARS-CoV-2 infection, presenting within ≤7 days from symptom onset with no clear indication for hospitalization, plus at least 2 risk factors for complication, were randomised 1:1 either to rivaroxaban 10 mg OD for 14 days or to routine care. The primary efficacy endpoint was the composite of venous thromboembolic events, need of mechanical ventilation, acute myocardial infarction, stroke, acute limb ischemia, or death due to COVID-19 during the first 30 days. ClinicalTrials.gov: NCT04757857. Findings: Enrollment was prematurely stopped due to sustained reduction in new COVID-19 cases. From September 29th, 2020, through May 23rd, 2022, 660 patients were randomised (median age 61 [Q1-Q3 47-69], 55.7% women). There was no significant difference between rivaroxaban and control in the primary efficacy endpoint (4.3% [14/327] vs 5.8% [19/330], RR 0.74; 95% CI: 0.38-1.46). There was no major bleeding in the control group and 1 in the rivaroxaban group. Interpretation: On light of these findings no decision can be made about the utility of rivaroxaban to improve outcomes in outpatients with COVID-19. Metanalyses data provide no evidence of a benefit of anticoagulant prophylaxis in outpatients with COVID-19. These findings were the result of an underpowered study, therefore should be interpreted with caution. Funding: COALITION COVID-19 Brazil and Bayer S.A.

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Common bean is a highly important food in tropical regions, where most production occurs on small farms with limited use of technology and, consequently, greater vulnerability to abiotic stresses such as nutritional stress. Usually phosphorus (P) is the most limiting nutrient for crop growth in these regions. The aim of this study was to characterize the gene expression profiles of the genotypes of common bean IAC Imperador (P-responsive) and DOR 364 (P-unresponsive) under different P concentrations using RNA-seq transcriptome sequencing technology. Plants were grown hydroponically, with application of two P concentrations (4.00 mg L-1 restrictive level and 8.00 mg L-1 control level). Differential expression analyses, annotation, and functional classification were performed comparing genotypes within each P rate administered and comparing each genotype response to the different P levels. Considering differential expression analyses within genotypes, IAC Imperador exhibited 1538 up-regulated genes under P restriction and 1679 up-regulated genes in the control, while DOR 364 exhibited 13 up-regulated genes in the control and only 2 up-regulated genes under P restriction, strongly corroborating P-unresponsiveness of this genotype. Genes related to phosphorus restriction were identified among the differentially expressed genes, including transcription factors such as WRKY, ERF, and MYB families, phosphatase related genes such as pyrophosphatase, acid phosphatase, and purple acid phosphatase, and phosphate transporters. The enrichment test for the P restriction treatment showed 123 enriched gene ontologies (GO) for IAC Imperador, while DOR 364 enriched only 24. Also, the enriched GO correlated with P metabolism, compound metabolic processes containing phosphate, nucleoside phosphate binding, phosphorylation, and also response to stresses. Thus, this study proved to be informative to phosphorus limitation in common bean showing global changes at transcript level.

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Butyltins (BTs), polyaromatic hydrocarbons (PAHs), organochlorine pesticides (OCPs), and polychlorinated biphenyls (PCBs) were assessed in a mid-latitude environment of the Patagonian coast, distant from significant pollutant sources. Bioaccumulation processes through bottom sediment resuspension were suggested by BTs level (expressed as ng of tin [Sn] g(-1) dry wt) found in surface sediment (

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The Patagonian coast is characterized by the existence of pristine ecosystems which may be particularly sensitive to oil contamination. In this study, a simulated oil spill at acute and chronic input levels was carried out to assess the effects of contamination on the macrobenthic community structure and the bioturbation activity of sediments sampled in Caleta Valdés creek. Superficial sediments were either noncontaminated or contaminated by Escalante crude oil and incubated in the laboratory for 30 days. Oil contamination induced adverse effects on macrobenthic community at both concentrations with, for the highest concentration, a marked decrease of approximately 40 and 55 % of density and specific richness, respectively. Besides the disappearance of sensitive species, some other species like Oligochaeta sp. 1, Paranebalia sp., and Ostracoda sp. 2 species have a higher resistance to oil contamination. Sediment reworking activity was also affected by oil addition. At the highest level of contamination, nearly no activity was observed due to the high mortality of macroorganisms. The results strongly suggest that an oil spill in this protected marine area with no previous history of contamination would have a deep impact on the non-adapted macrobenthic community.

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Common bean (Phaseolus vulgaris L.) is frequently grown in weathered soils with low phosphorus (P) availability, and this is one of the main limitations on its production. This study aimed to assess 20 common bean genotypes in a hydroponic system to select the best P concentration for inducing nutritional deficiency and to classify the genotypes in terms of nutrient utilization efficiency. The concentrations of P applied were 8.00, 4.00, 2.00 and 0.05 mg L¹. At 21 days, in the plot subjected to an application of the most severe stress, the 0.05 mg L¹ dose of P, had smaller plant size and early leaf abscission was observed. The 4.00 mg L¹ dose of P was the most efficient in inducing stress for discrimination of cultivars in terms of efficiency of use of P. The following genotypes: IAPAR 81, Carioca Comum, IAC Carioca Tybatã, IAC Imperador and G 2333 stood out as being efficient and responsive to P, while the two cultivars DOR 364 and Jalo Precoce were the most inefficient and unresponsive.(AU)

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Common bean (Phaseolus vulgaris L.) is frequently grown in weathered soils with low phosphorus (P) availability, and this is one of the main limitations on its production. This study aimed to assess 20 common bean genotypes in a hydroponic system to select the best P concentration for inducing nutritional deficiency and to classify the genotypes in terms of nutrient utilization efficiency. The concentrations of P applied were 8.00, 4.00, 2.00 and 0.05 mg L¹. At 21 days, in the plot subjected to an application of the most severe stress, the 0.05 mg L¹ dose of P, had smaller plant size and early leaf abscission was observed. The 4.00 mg L¹ dose of P was the most efficient in inducing stress for discrimination of cultivars in terms of efficiency of use of P. The following genotypes: IAPAR 81, Carioca Comum, IAC Carioca Tybatã, IAC Imperador and G 2333 stood out as being efficient and responsive to P, while the two cultivars DOR 364 and Jalo Precoce were the most inefficient and unresponsive.

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The Northern San Jorge Gulf (NSJG) was designated Interjurisdictional Coastal Marine Park "Patagonia Austral" in 2008 with the objective of conserving biodiversity and natural resources. Metals released to the environment can be accumulated by organisms and can be toxic in some cases, making it necessary to evaluate their presence and biological risk. This study examined concentrations of Fe, Mn, Zn, Cu, Cr, Ni, Cd and Pb in intertidal sediments of the NSJG, and was the first study of its kind to be conducted in this area. Concentrations of all metals fell below biological risk levels. Anthropogenic enrichment was only found for Ni around the Aristizábal lighthouse and was attributed to the frequent oil spills that impact this particular area.

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Feathers are useful to determine mercury (Hg) contamination. We evaluated the mercury concentration in feathers of Magellanic penguins (Spheniscus magellanicus) age 1.5 years to 25 years at Punta Tombo, Argentina before and during their molt. Mercury ranged between <1.4 and 367 ng/g dry weight, with three extreme high values (8996 ng/g, 3011 ng/g and 1340 ng/g) all in young adults. The median concentration was lowest for juveniles and significantly higher for adults but with high variation among older adults. Males and females had similar mercury loads. Compared with other penguin species, concentrations in Magellanic penguins were low. Mercury levels for Magellanic penguins in the Southwest Atlantic for older adults averaged 206±98 ng/g, and serve as a baseline for biomonitoring and/or ecotoxicological studies.

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The use of prognostic markers for breast cancer is important for routine diagnosis and research. Interleukin-8 is a chemotactic cytokine produced by several cell types in response to inflammation, however, its expression, regulation and function are poorly understood. Recent studies have associated angiogenesis and inflammatory processes with tumor malignancy. The present study investigated the correlation between interleukin-8 expression and breast cancer prognosis. Interleukin-8 expression was assessed in 72 women with mammary neoplasia by immunohistochemistry and the results were statistically correlated with clinical-pathological findings. There was an inverse correlation between interleukin-8 expression and metastasis (p=0.03) and/or local recurrence (p=0.02). In the patient group that received post-surgery chemotherapy and radiotherapy, a lower interleukin-8 expression was found in those women that showed local recurrence (p=0.01). Multivariate logistic regression showed estrogen receptor negativity, progesterone positivity and metastasis with increased risk of death (p<0.05). The data reflect the complexity of the role of interleukin-8 in tumor microenvironment and support its classification as a possible prognostic marker, although more studies are necessary for its inclusion in clinical practice.

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The environmental quality of Ushuaia Bay, located at the southernmost tip of South America, is affected by the anthropogenic pressure of Ushuaia city. In this study, levels and sources of hydrocarbons in coastal sediments were assessed. Aliphatic hydrocarbon fractions ranged between 5.5 and 1185.3 µg/g dry weight and PAHs from not detected to 360 ng/g. Aliphatic diagnostic indices, the nalkanes homologous series occurrence, Aliphatic Unresolved Complex Mixtures (AliUCMs), and pristane and phytane isoprenoids indicated a petrogenic input. Some sites showed biogenic features masked by the anthropogenic signature. Particularly in port areas biodegradation processes were evident. PAH ratios showed a mixture of petrogenic and pyrogenic sources. Aliphatic and aromatic UCMs were strongly correlated, reflecting chronic pollution. Three areas were distinguished inside the bay: (1) east, with low hydrocarbons impact; (2) central, where hydrocarbons accumulation was related to source proximity and sediment characteristics; (3) south-west, where sediment characteristics and current circulation favour hydrocarbons accumulation.

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FUNDAMENTO: Embora o Escore de Risco TIMI seja o mais utilizado em síndromes coronarianas agudas sem supradesnível do segmento ST (SCA), o Escore GRACE tem potencial superioridade prognóstica, pois foi criado a partir de um registro observacional, parte das variáveis são tratadas de forma semiquantitativa e a função renal é computada em seu cálculo. OBJETIVO: Testar a hipótese de que o Escore de Risco GRACE tem superior valor prognóstico hospitalar, comparado ao Escore TIMI em pacientes admitidos com SCA. MÉTODOS: Foram incluídos indivíduos com angina instável ou infarto do miocárdio sem supradesnível do segmento ST, consecutivamente internados em unidade coronariana entre agosto de 2007 e janeiro de 2009. RESULTADOS: Foram estudados 154 pacientes, idade 71 ± 13 anos, 56 por cento do gênero feminino, mediana do GRACE de 117 e mediana do TIMI de 3. Durante o período de internamento, a incidência de eventos foi 8,4 por cento (12 óbitos e 1 infarto não fatal). O teste de Hosmer-Lemeshow aplicado ao Escore GRACE apresentou χ2 de 5,3 (P = 0,72), enquanto Escore TIMI apresentou χ2 de 1,85 (P = 0,60). Desta forma, ambos os escores apresentaram boa calibração. Quanto à análise de discriminação, o Escore GRACE apresentou estatística-C de 0,91 (95 por cento IC = 0,86 - 0,97), significativamente superior à estatística-C de 0,69 do Escore TIMI (95 por cento IC = 0,55 - 0,84) - P = 0,02 para diferença entre os escores. CONCLUSÃO: Em relação à predição de eventos hospitalares em pacientes com SCA, o Escore GRACE tem superior capacidade prognóstica quando comparado ao Escore TIMI.

BACKGROUND: Although the TIMI score is the one most frequently used in acute coronary syndromes (ACS) without ST-segment elevation, the GRACE score has potential prognostic superiority, as it was created based on an observational registry, part of the variables is treated in a semi-quantitative form and renal function is taken into account in its calculation. OBJECTIVE: To test the hypothesis that the GRACE risk score has superior in-hospital prognostic value, when compared to the TIMI score in patients admitted with ACS. METHODS: Individuals with unstable angina or myocardial infarction without ST-segment elevation, consecutively admitted at the Coronary Unit between August 2007 and January 2009, were included in the study. RESULTS: A total of 154 patients aged 71 ± 13 years, of which 56 percent were females, with a GRACE median of 117 and a TIMI median of 3 were studied. During the hospitalization period, the incidence of events was 8.4 percent (12 deaths and 1 non-fatal infarction). The Hosmer-Lemeshow test applied to the GRACE score presented an χ2 of 5.3 (P = 0.72), whereas the TIMI score presented an χ2 of 1.85 (P = 0.60). Therefore, both scores presented good calibration. As for the analysis of discrimination, the GRACE score presented a C-statistics of 0.91 (95 percentCI= 0.86 - 0.97), significantly superior to the C-statistics of 0.69 of the TIMI score (95 percentCI = 0.55 - 0.84) - P = 0.02 for the difference between the scores. CONCLUSION: Regarding the prediction of hospital events in patients with ACS, the GRACE score has superior prognostic capacity when compared to the TIMI score.

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BACKGROUND: Although the TIMI score is the one most frequently used in acute coronary syndromes (ACS) without ST-segment elevation, the GRACE score has potential prognostic superiority, as it was created based on an observational registry, part of the variables is treated in a semi-quantitative form and renal function is taken into account in its calculation. OBJECTIVE: To test the hypothesis that the GRACE risk score has superior in-hospital prognostic value, when compared to the TIMI score in patients admitted with ACS. METHODS: Individuals with unstable angina or myocardial infarction without ST-segment elevation, consecutively admitted at the Coronary Unit between August 2007 and January 2009, were included in the study. RESULTS: A total of 154 patients aged 71 +/- 13 years, of which 56% were females, with a GRACE median of 117 and a TIMI median of 3 were studied. During the hospitalization period, the incidence of events was 8.4% (12 deaths and 1 non-fatal infarction). The Hosmer-Lemeshow test applied to the GRACE score presented an chi2 of 5.3 (P = 0.72), whereas the TIMI score presented an chi2 of 1.85 (P = 0.60). Therefore, both scores presented good calibration. As for the analysis of discrimination, the GRACE score presented a C-statistics of 0.91 (95%CI= 0.86 - 0.97), significantly superior to the C-statistics of 0.69 of the TIMI score (95%CI = 0.55 - 0.84) - P = 0.02 for the difference between the scores. CONCLUSION: Regarding the prediction of hospital events in patients with ACS, the GRACE score has superior prognostic capacity when compared to the TIMI score.

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BACKGROUND: Pulmonary embolism is associated with high mortality in patients with hypotension or circulatory shock. However, the association between some clinical variables and mortality is still unclear in hemodynamically stable patients. OBJECTIVES: To derive an in-hospital mortality risk stratification model in hemodynamically stable patients with pulmonary embolism. METHODS: This is a prospective multicenter cohort study of 582 consecutive patients admitted in emergency units or intensive care units with clinically suspected pulmonary embolism and whose diagnosis was confirmed by one or more of the following tests: pulmonary arteriography, spiral CT angiography, magnetic resonance angiography, Doppler echocardiography, pulmonary scintigraphy, or venous duplex scan. Data on demographics, comorbidities and clinical manifestations were collected and included in a logistic regression analysis so as to build the prediction model. RESULTS: Overall mortality was 14.1%. The following parameters were identified as independent death risk variables: age > 65 years, bed rest > 72h, chronic cor pulmonale, sinus tachycardia, and tachypnea. After risk stratification, mortalities of 5.4%, 17.8%, and 31.3% were found in the low, moderate and high-risk subgroups, respectively. The model showed 65.5% sensitivity and 80% specificity, with a 0.77 area under the curve. CONCLUSION: In hemodynamically stable patients with pulmonary embolism, age > 65 years, bed rest > 72h, chronic cor pulmonale, sinus tachycardia and tachypnea were independent predictors of in-hospital mortality. However, further validation of the prediction model in other populations is required so that it can be incorporated into the clinical practice.

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FUNDAMENTO: A embolia pulmonar apresenta alta mortalidade em pacientes com hipotensão arterial ou choque circulatório. Entretanto, em pacientes hemodinamicamente estáveis, a associação de algumas variáveis clínicas com a mortalidade ainda não está claramente estabelecida. OBJETIVOS: Derivar um modelo de estratificação do risco de mortalidade intra-hospitalar em pacientes com embolia pulmonar hemodinamicamente estáveis. MÉTODOS: Estudo de coorte multicêntrico prospectivo de 582 pacientes consecutivos que foram admitidos em unidades de emergência ou de terapia intensiva, com suspeita clínica de embolia pulmonar, e que tiveram o diagnóstico confirmado por meio de um ou mais dos seguintes exames: arteriografia pulmonar, angiotomografia computadorizada helicoidal, angioressonância magnética, ecodopplercardiograma, cintilografia pulmonar ou duplex-scan venoso. Os dados sobre características demográficas, comorbidades e manifestações clínicas foram coletados e incluídos em uma análise de regressão logística para compor o modelo de predição. RESULTADOS: A mortalidade global foi de 14,1 por cento. Foram identificadas como variáveis independentes de risco de óbito: idade > 65 anos; repouso no leito > 72h; cor pulmonale crônico; taquicardia sinusal e taquipnéia. Após a estratificação por faixas de risco, observaram-se mortalidades de 5,4 por cento, 17,8 por cento e 31,3 por cento, respectivamente nos subgrupos de baixo, moderado e alto riscos. O modelo mostrou sensibilidade de 65,5 por cento e especificidade de 80 por cento, com uma área sob a curva de 0,77. CONCLUSÃO: Em pacientes hemodinamicamente estáveis com embolia pulmonar, a idade > 65 anos, o repouso no leito > 72h, o cor pulmonale crônico, a taquicardia sinusal e a taquipnéia foram preditores independentes da mortalidade intra-hospitalar. Entretanto o modelo de predição necessita ser validado em outras populações para sua incorporação à prática clínica.

BACKGROUND: Pulmonary embolism is associated with high mortality in patients with hypotension or circulatory shock. However, the association between some clinical variables and mortality is still unclear in hemodynamically stable patients. OBJECTIVES: To derive an in-hospital mortality risk stratification model in hemodynamically stable patients with pulmonary embolism. METHODS: This is a prospective multicenter cohort study of 582 consecutive patients admitted in emergency units or intensive care units with clinically suspected pulmonary embolism and whose diagnosis was confirmed by one or more of the following tests: pulmonary arteriography, spiral CT angiography, magnetic resonance angiography, Doppler echocardiography, pulmonary scintigraphy, or venous duplex scan. Data on demographics, comorbidities and clinical manifestations were collected and included in a logistic regression analysis so as to build the prediction model. RESULTS: Overall mortality was 14.1 percent. The following parameters were identified as independent death risk variables: age > 65 years, bed rest > 72h, chronic cor pulmonale, sinus tachycardia, and tachypnea. After risk stratification, mortalities of 5.4 percent, 17.8 percent, and 31.3 percent were found in the low, moderate and high-risk subgroups, respectively. The model showed 65.5 percent sensitivity and 80 percent specificity, with a 0.77 area under the curve. CONCLUSION: In hemodynamically stable patients with pulmonary embolism, age > 65 years, bed rest > 72h, chronic cor pulmonale, sinus tachycardia and tachypnea were independent predictors of in-hospital mortality. However, further validation of the prediction model in other populations is required so that it can be incorporated into the clinical practice.

FUNDAMENTO: La embolia pulmonar presenta alta mortalidad en pacientes con hipotensisn arterial o shock circulatorio. Sin embargo, en pacientes hemodinamicamente estables, la asociacisn de algunas variables clmnicas con la mortalidad todavma no esta claramente establecida. OBJETIVO: Derivar un modelo de estratificacisn del riesgo de mortalidad intrahospitalaria en pacientes con embolia pulmonar hemodinamicamente estables. MITODOS: Estudio de cohorte multicintrico prospectivo de 582 pacientes consecutivos que ingresaron en unidades de emergencia o de terapia intensiva, con sospecha clmnica de embolia pulmonar, y que tuvieron el diagnsstico confirmado por medio de uno o mas de los examenes: arteriografma pulmonar, angiotomografma computadorizada helicoidal, angiorresonancia magnitica, ecocardiografma doppler, centellografma pulmonar o duplex scan venoso. Los datos sobre caractermsticas demograficas, comorbilidades y manifestaciones clmnicas se recolectaron e se incluyeron en un analisis de regresisn logmstica para componer el modelo de prediccisn. RESULTADOS: La mortalidad global fue del 14,1 por ciento. Se identificaron como variables independientes de riesgo de sbito: edad > 65 aqos; reposo en la cama > 72h; cor pulmonale crsnico; taquicardia sinusal y taquipnea. Tras la estratificacisn por franjas de riesgo, se observaron mortalidades del 5,4 por ciento, el 17,8 por ciento y el 31,3 por ciento, respectivamente en los subgrupos de bajo, moderado y alto riesgos. El modelo revels sensibilidad del 65,5 por ciento y especificidad del 80 por ciento, con un area bajo la curva de 0,77. CONCLUSISN: En pacientes hemodinamicamente estables con embolia pulmonar, la edad > 65 aqos, el reposo en la cama > 72h, el cor pulmonale crsnico, la taquicardia sinusal y la taquipnea fueron predictores independientes de la mortalidad intrahospitalaria. Sin embargo, el modelo de prediccisn necesita validarse en otras poblaciones para su incorporacisn a la practica ...

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The Patagonian coast is considered a relatively pristine environment. However, studies conducted along coastal Patagonia have showed hydrocarbon pollution mostly concentrated at ports that have fishing, oil loading, general merchant, and/or tourist activities. A high value of total aliphatic hydrocarbons (TAH) was found at the Rawson fishing port (741 microg/g dw). In other ports with and without petroleum-related activities, hydrocarbon values were approximately 100 microg/g dw. The highest values for TAH and total aromatic hydrocarbons (TArH) were found in Faro Aristizábal, north of San Jorge gulf (1304 and 737 microg/g dw, respectively). This is very likely the result of petroleum-related activities at the Comodoro Rivadavia, Caleta Cordova, and Caleta Olivia ports located within this gulf. In other coastal areas away from potential anthropogenic sources, hydrocarbon values were less than 2 and 3 microg/g dw for TAH and TArH, respectively. This review of published and unpublished information suggests that ports are important oil pollution sources in the Patagonian coast. More detailed studies are needed to evaluate the area affected by port activities, to understand the mechanisms of hydrocarbon distribution in surrounding environments, and to assess bioaccumulation in marine organisms. Despite that some regulations exist to control oil pollution derived from port and docked vessel activities, new and stricter management guidelines should be implemented.

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OBJECTIVE: To evaluate the association between troponin I concentrations (TnI) in patients submitted to elective percutaneous coronary interventions (PCI) and adverse coronary events (ACE) during a six month follow-up period. METHODS: One hundred and eleven patients who had been submitted to an elective PCI were consecutively selected during a one year timeframe. The patients had stable angina (SA), unstable angina (UA) or silent ischemia (SI) and were asymptomatic for at least 72 hours before the procedure. TnI concentrations were measured between 8 and 24 hours after the PCI. Each patient was contacted by telephone six months later and interviewed regarding ACE which were defined as death, myocardial infarction, new revascularization and recurrent ischemia. RESULTS: Twenty-four patients showed elevated concentrations of TnI (21.6%) after the PCI regardless of clinical characteristics or procedure complications. Those who presented elevated TnI concentrations had higher event rates: 66.7 vs. 42.5% (RR=1.57; CI 95%=1.08-2.28). This risk seems to be higher in the subgroups of females and patients with a previous diagnosis of unstable angina. Multivariate analysis confirmed that gender was the only effect modifying co-variable associated with ACE risk, which is higher for females with elevated TnI concentrations (OR=7.22; CI 95%=1.4 -36.9) and unaltered for males (OR=1.26; CI 95%=0.35-4.55). CONCLUSION: Elevated TnI concentrations were a common occurrence after PCI and is a factor related to the development of ACE in the mid term. However, when adjusted for other variables, this effect is only maintained in female patients.

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OBJETIVO: Avaliar a associação entre níveis de troponina I (TnI) em pacientes submetidos, eletivamente, a intervenções coronárias percutâneas (ICP) com ocorrência de eventos cardíacos adversos (ECA) no seguimento de 6 meses. MÉTODOS: No período de um ano, foram selecionados consecutivamente 111 pacientes submetidos a ICP eletiva, com angina estável (AE), instável (AI) ou isquemia silenciosa (IS), assintomáticos por mais de 72 horas antes do procedimento. As dosagens de TnI foram realizadas entre 8 e 24 horas após a ICP. Cada paciente foi contatado por telefone, após seis meses, e questionado quanto à ocorrência de ECA, definidos como morte, infarto do miocárdio, nova revascularização e recorrência de isquemia. RESULTADOS: Ocorreu elevação de TnI em 24 (21,6 por cento) pacientes após a ICP, independente de características clínicas e complicações do procedimento. O surgimento de eventos foi mais freqüente em quem apresentou elevação de TnI: 66,7 vs. 42,5 por cento (RR=1,57; IC95 por cento=1,08-2,28). Este risco parece ser maior nos subgrupos de gênero feminino e naqueles com diagnóstico prévio de AI. Após análise multivariada, apenas gênero se confirmou como co-variável modificadora de efeito com risco de ECA maior em mulheres com elevação de TnI (OR=7,22. IC95 por cento=1,4 -36,9) e similar em homens (OR=1,26. IC95 por cento=0,35-4,55). CONCLUSÃO: Elevação de TnI foi freqüentemente encontrada após ICP e é um fator associado ao surgimento de ECA a médio prazo. Entretanto, quando ajustada para outras variáveis, este efeito só se manteve em pacientes do gênero feminino.

OBJECTIVE: To evaluate the association between troponin I concentrations (TnI) in patients submitted to elective percutaneous coronary interventions (PCI) and adverse coronary events (ACE) during a six month follow-up period. METHODS: One hundred and eleven patients who had been submitted to an elective PCI were consecutively selected during a one year timeframe. The patients had stable angina (SA), unstable angina (UA) or silent ischemia (SI) and were asymptomatic for at least 72 hours before the procedure. TnI concentrations were measured between 8 and 24 hours after the PCI. Each patient was contacted by telephone six months later and interviewed regarding ACE which were defined as death, myocardial infarction, new revascularization and recurrent ischemia. RESULTS: Twenty-four patients showed elevated concentrations of TnI (21.6 percent) after the PCI regardless of clinical characteristics or procedure complications. Those who presented elevated TnI concentrations had higher event rates: 66.7 vs. 42.5 percent (RR=1.57; CI 95 percent=1.08-2.28). This risk seems to be higher in the subgroups of females and patients with a previous diagnosis of unstable angina. Multivariate analysis confirmed that gender was the only effect modifying co-variable associated with ACE risk, which is higher for females with elevated TnI concentrations (OR=7.22; CI 95 percent=1.4 -36.9) and unaltered for males (OR=1.26; CI 95 percent=0.35-4.55). CONCLUSION: Elevated TnI concentrations were a common occurrence after PCI and is a factor related to the development of ACE in the mid term. However, when adjusted for other variables, this effect is only maintained in female patients.

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No reports are registered on responses to boron fertilization nutrient deficiency and toxicity in triticale crops. The aim of this study was to evaluate triticale response to different rates of boron in comparison to wheat in an hapludox with initial boron level at 0.08 mg dm-3 4 FONT FACE=Symbol>´ /FONT> 4 factorial design trial completely randomized blocks design (n = 4). Boron rates were 0; 0.62; 1.24 and 1.86 mg dm-3; triticale cultivars were IAC 3, BR 4 and BR 53 and IAPAR 38 wheat crop was used for comparison. The wheat (IAPAR 38) crop presented the highest boron absorption level of all. Among triticale cultivars, the most responsive was IAC 53, presenting similar characteristics to wheat, followed by BR 4; these two crops are considered tolerant to higher boron rates in soil. Regarding to BR 53, no absorption effect was observed, and the cultivars was sensitive to boron toxicity. Absorption responses differed for each genotype. That makes it possible to choose and use the best-adapted plants to soils with different boron rates.

No Brasil não existem registros de respostas de adubação com boro para a cultura do triticale, sendo a ação deste nutriente uma incógnita, tanto em relação a deficiência quanto a toxidez, causas que levam a redução de produtividade. O objetivo deste trabalho foi avaliar a resposta do triticale a diferentes níveis de boro em comparação com o trigo (Triticum aestivum). Utilizou-se um Latossolo Vermelho distrófico com teor inicial de boro de 0,08 mg dm-3. O delineamento foi um fatorial 4 FONT FACE=Symbol>´ /FONT> 4, distribuído em blocos casualizados, com quatro repetições, quatro níveis de boro: 0; 0,62; 1,24 e 1,86 mg dm-3 de B e três cultivares de triticale, IAC 3, BR 4 e BR 53, mais um cultivar de trigo, IAPAR 38, para comparação. Cada cultivar respondeu de forma diferente com relação às variáveis estudadas em função da aplicação de diferentes níveis de boro. O trigo (IAPAR 38) apresenta maior eficiência na absorção de boro. A cultivar de triticale mais responsiva quanto à absorção foi a IAC 3, que apresentou característica semelhante ao trigo, seguida da cultivar BR 4, demonstrando serem cultivares tolerantes a maiores níveis de boro no solo. Para a BR 53, não ocorreu efeito para absorção, com a cultivar apresentando sensibilidade à toxidez de boro. A eficiência de absorção é diferenciada para cada genótipo possibilitando a escolha e utilização de plantas que possuam maior adaptação ao meio.

RESUMO

No reports are registered on responses to boron fertilization nutrient deficiency and toxicity in triticale crops. The aim of this study was to evaluate triticale response to different rates of boron in comparison to wheat in an hapludox with initial boron level at 0.08 mg dm-3 4 FONT FACE=Symbol>´ /FONT> 4 factorial design trial completely randomized blocks design (n = 4). Boron rates were 0; 0.62; 1.24 and 1.86 mg dm-3; triticale cultivars were IAC 3, BR 4 and BR 53 and IAPAR 38 wheat crop was used for comparison. The wheat (IAPAR 38) crop presented the highest boron absorption level of all. Among triticale cultivars, the most responsive was IAC 53, presenting similar characteristics to wheat, followed by BR 4; these two crops are considered tolerant to higher boron rates in soil. Regarding to BR 53, no absorption effect was observed, and the cultivars was sensitive to boron toxicity. Absorption responses differed for each genotype. That makes it possible to choose and use the best-adapted plants to soils with different boron rates.

No Brasil não existem registros de respostas de adubação com boro para a cultura do triticale, sendo a ação deste nutriente uma incógnita, tanto em relação a deficiência quanto a toxidez, causas que levam a redução de produtividade. O objetivo deste trabalho foi avaliar a resposta do triticale a diferentes níveis de boro em comparação com o trigo (Triticum aestivum). Utilizou-se um Latossolo Vermelho distrófico com teor inicial de boro de 0,08 mg dm-3. O delineamento foi um fatorial 4 FONT FACE=Symbol>´ /FONT> 4, distribuído em blocos casualizados, com quatro repetições, quatro níveis de boro: 0; 0,62; 1,24 e 1,86 mg dm-3 de B e três cultivares de triticale, IAC 3, BR 4 e BR 53, mais um cultivar de trigo, IAPAR 38, para comparação. Cada cultivar respondeu de forma diferente com relação às variáveis estudadas em função da aplicação de diferentes níveis de boro. O trigo (IAPAR 38) apresenta maior eficiência na absorção de boro. A cultivar de triticale mais responsiva quanto à absorção foi a IAC 3, que apresentou característica semelhante ao trigo, seguida da cultivar BR 4, demonstrando serem cultivares tolerantes a maiores níveis de boro no solo. Para a BR 53, não ocorreu efeito para absorção, com a cultivar apresentando sensibilidade à toxidez de boro. A eficiência de absorção é diferenciada para cada genótipo possibilitando a escolha e utilização de plantas que possuam maior adaptação ao meio.

RESUMO

OBJECTIVE: To evaluate the performance of the turbidimetric method of C-reactive protein (CRP) as a measure of low-grade inflammation in patients admitted with non-ST elevation acute coronary syndromes (ACS). METHODS: Serum samples obtained at hospital arrival from 68 patients (66 11 years, 40 men), admitted with unstable angina or non-ST elevation acute myocardial infarction were used to measure CRP by the methods of nephelometry and turbidimetry. RESULTS: The medians of C-reactive protein by the turbidimetric and nephelometric methods were 0.5 mg/dL and 0.47 mg/dL, respectively. A strong linear association existed between the 2 methods, according to the regression coefficient (b=0.75; 95% C.I.=0.70-0.80) and correlation coefficient (r=0.96; P<0.001). The mean difference between the nephelometric and turbidimetric CRP was 0.02 0.91 mg/dL, and 100% agreement between the methods in the detection of high CRP was observed. CONCLUSION: In patients with non-ST elevation ACS, CRP values obtained by turbidimetry show a strong linear association with the method of nephelometry and perfect agreement in the detection of high CRP.

Assuntos