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Mol Biol Rep ; 49(8): 7601-7609, 2022 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-35657453

RESUMO

BACKGROUND: STR allele frequency databases from populations are necessary to take full advantage of the increased power of discrimination offered by massively parallel sequencing (MPS) platforms. MATERIAL AND METHODS: For this reason, we sequenced 58 STRs (aSTRs, X-STRs, and Y-STRs) and 94 identity informative SNPs (iiSNPs) on 105 Mestizo (admixed) individuals from Monterrey City (Northeast, Mexico), with the Primer Set-A of the ForenSeq™ DNA Signature Prep Kit. RESULTS: Most of the STR markers were in Hardy Weinberg equilibrium, with a few exceptions. We found 346 different length-based alleles for these 58 STRs; nevertheless, they became 528 alleles when the sequence was assessed. The combined power of discrimination from autosomal STRs (aSTRs) was -virtually- 100% in both length and sequence-based alleles, while the power of exclusion was 99.9999999976065 and 99.9999999999494%, respectively. Haplotypes based on X-STRs and Y-STRs showed 100% of discriminatory capacity. CONCLUSIONS: These results provide -for the first time- forensic genomic population data from Mexico necessary for interpretation in kinship and criminal analyses.


Assuntos
Impressões Digitais de DNA , Polimorfismo de Nucleotídeo Único , DNA , Frequência do Gene/genética , Sequenciamento de Nucleotídeos em Larga Escala , Humanos , México , Repetições de Microssatélites/genética , Polimorfismo de Nucleotídeo Único/genética , Análise de Sequência de DNA
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