Assuntos
Androgênios/uso terapêutico , Anemia Aplástica/terapia , Transplante de Medula Óssea , Corticosteroides/uso terapêutico , Anemia Aplástica/tratamento farmacológico , Anemia Aplástica/epidemiologia , Anemia Aplástica/etiologia , Anemia Aplástica/cirurgia , Soro Antilinfocitário/uso terapêutico , Transplante de Medula Óssea/efeitos adversos , Transplante de Medula Óssea/mortalidade , Ciclosporinas/uso terapêutico , Doença Enxerto-Hospedeiro/etiologia , Humanos , Terapia de Imunossupressão , Infecções/etiologiaAssuntos
Pancitopenia/induzido quimicamente , Transtornos Relacionados ao Uso de Substâncias/complicações , Criança , Família , Terapia Familiar , Humanos , Inseticidas/intoxicação , Masculino , Transtornos Mentais/complicações , Transtornos Mentais/terapia , Solventes/intoxicação , Transtornos Relacionados ao Uso de Substâncias/psicologia , Transtornos Relacionados ao Uso de Substâncias/terapiaAssuntos
Afibrinogenemia/congênito , Afibrinogenemia/genética , Criança , Feminino , Humanos , LinhagemRESUMO
From a group of 115 children with hereditary haemorrhagic disease, nine suffered avoidable accidents or incidents during their treatment, these nine patients represent 8.6% of the cases. The observed complications included a giant cervical hematoma and hemomediastinum after a puncture of the internal jugular vein; an encephalic lesion associated with descompressive craneotomy; a hemophilic pseudo cyst associated with inappropriate treatment of a tibial fracture; acute bleeding and shock after surgery for tonsillectomy and circumcision; subdural hygroma after a subdural puncture; giant hematoma and acute anemia secondary to a venous dissection; permanent dyslexia after inappropriate puncture; giant hematoma and acute anemia secondary to a venous dissection; permanent dyslexia after inappropriate management of intracranial bleeding; bleeding and acute anemia after surgical drainage of a prepucial hematoma and a joint hematoma of the left knee after synovectomy and application of a prosthesis.
Assuntos
Hemofilia A/complicações , Hemofilia B/complicações , Doença Iatrogênica , Doenças de von Willebrand/complicações , Adulto , Anemia/etiologia , Pré-Escolar , Craniotomia/efeitos adversos , Hemofilia A/diagnóstico , Hemorragia/etiologia , Humanos , Doença Iatrogênica/prevenção & controle , Lactente , Masculino , Complicações Pós-Operatórias , Punções/efeitos adversosRESUMO
Between 1964 and 1971, 113 children with the syndrome of disseminated intravascular coagulation were studied at the Hospital Infantil de México, including 17 cases with the diagnosis of fulminant purpura. Comparison was established with reports from foreign institutions. The following conclusions are offered: Fulminant purpura appears after a period of latency following the causal disease. It is not caused by septicemia; shows a clear picture in infants, preschool and school children, with letality index of 17.7%. In Mexico, DIC was caused by infection in 88% of the cases and in 68% of them, the infection started in the digestive tract. The diagnosis of fulminant purpura is based on the clinical picture, while in DIC, the diagnosis must also be based on laboratory tests unless one half of the diagnoses be missed.
Assuntos
Coagulação Intravascular Disseminada/epidemiologia , Púrpura/epidemiologia , Adolescente , Criança , Pré-Escolar , Coagulação Intravascular Disseminada/etiologia , Feminino , Humanos , Lactente , Recém-Nascido , Masculino , México , Púrpura/etiologiaRESUMO
The effect of humidification of the environment was studied on the frequency and severeness of spistaxes in a group of 16 children. A control group was composed of 18 children with the idea that they were similar, but the hematologic conditions of the latter group were more unfavorable. A decrease of epistaxis was not found; there was a minimal prolongation of the days between one and the next nosebleeding picture. A definite decrease in the severeness of bleeding was found in the second group as judged by a lesser necessity of transfusions.
Assuntos
Epistaxe/etiologia , Umidade , Trombocitopenia/complicações , Doença Aguda , Corticosteroides , Contagem de Células Sanguíneas , Plaquetas , Criança , Pré-Escolar , Epistaxe/sangue , Epistaxe/terapia , Feminino , Humanos , Masculino , Trombocitopenia/sangue , Trombocitopenia/terapiaRESUMO
Thirty-two patients with hereditary hemorrhagic diseases and a platelet functional abnormality were set apart from our group of patients with hereditary hemorrhagic diseases, and their symptoms, signs and hematological examinations were collected; the initial events and the age of the patients when they were obsserved, the main hemorrhagic manifestations during their clinical course, the clinical severity of the disorders, the survival of the patients and the laboratory test for hemostasis useful to make the diagnosis, were evaluated. In reference to bleeding time, thirty patients had abnormal bleeding time, but the other two had normal bleeding time.
Assuntos
Transtornos da Coagulação Sanguínea/genética , Adolescente , Adulto , Transtornos da Coagulação Sanguínea/sangue , Transtornos da Coagulação Sanguínea/diagnóstico , Transtornos da Coagulação Sanguínea/terapia , Transtornos Plaquetários/diagnóstico , Criança , Pré-Escolar , Consanguinidade , Diagnóstico Diferencial , Fator VIII/análise , Feminino , Hemostasia , Humanos , Masculino , Prognóstico , Púrpura Trombocitopênica/diagnóstico , Doenças de von Willebrand/diagnósticoRESUMO
Studies of a Mexican kindred present evidence for a unique phenotype of erythrocyte glucosephosphate isomerase, GPI Valle Hermoso. The proband was apparently the homozygous recipient of a mutant autosomal allele governing production of an isozyme characterized by decreased activity, marked thermal instability, normal kinetics and pH optimum, and normal starch gel electrophoretic patterns. Unlike previously known cases, leukocyte and plasma GPI activities were unimpaired. This suggested that the structural alteration primarily induced enzyme instability without drastically curtailing catalytic effectiveness, thereby allowing compensation by cells capable of continued protein synthesis. Age-related losses of GPI, however, were not evident by density-gradient fractionation of affected erythrocytes.