RESUMO
ABSTRACT Encrusted cystitis (EC) was first described as chronic cystitis with mucosal calcification in 1914 (1). It is a very rare chronic inflammatory disease presenting with dysuria, pelvic pain and gross hematuria. Voided urine contains mucus or calcified mucopurulent stone like particles. Urinalysis always reveals alkaline pH. It may be present in healthy individuals with no predisposing etiological factors (2-4). Etiologically, previous urological diseases, immunosuppression, urinary infection with urea splitting bacteria, or urological interventions resulting in bladder mucosa trauma may also be present (5, 6). In the present case report, we describe a novel treatment for EC with intravesical dimethyl sulfoxide.
Assuntos
Humanos , Masculino , Adulto , Dimetil Sulfóxido/uso terapêutico , Corynebacterium/classificação , Infecções por Corynebacterium/tratamento farmacológico , Cistite/tratamento farmacológico , Administração Intravesical , Doença Crônica , Resultado do Tratamento , Corynebacterium/isolamento & purificação , Infecções por Corynebacterium/diagnóstico , Infecções por Corynebacterium/microbiologia , Cistite/diagnóstico , Cistite/microbiologiaRESUMO
Encrusted cystitis (EC) was first described as chronic cystitis with mucosal calcification in 1914 (1). It is a very rare chronic inflammatory disease presenting with dysuria, pelvic pain and gross hematuria. Voided urine contains mucus or calcified mucopurulent stone like particles. Urinalysis always reveals alkaline pH. It may be present in healthy individuals with no predisposing etiological factors (2-4). Etiologically, previous urological diseases, immunosuppression, urinary infection with urea splitting bacteria, or urological interventions resulting in bladder mucosa trauma may also be present (5, 6). In the present case report, we describe a novel treatment for EC with intravesical dimethyl sulfoxide.
Assuntos
Infecções por Corynebacterium/tratamento farmacológico , Corynebacterium/classificação , Cistite/tratamento farmacológico , Dimetil Sulfóxido/uso terapêutico , Administração Intravesical , Adulto , Doença Crônica , Corynebacterium/isolamento & purificação , Infecções por Corynebacterium/diagnóstico , Infecções por Corynebacterium/microbiologia , Cistite/diagnóstico , Cistite/microbiologia , Humanos , Masculino , Resultado do TratamentoRESUMO
INTRODUCTION: We aimed to assess the relationship between prostate volume (PV) and high grade prostate carcinoma (HGPCa) in patients with benign and suspicious digital rectal examination (DRE) in our prostate biopsy cohort. MATERIALS AND METHODS: Between 2009-2012, 759 consecutive initial transrectal systematic 12 cores prostate biopsies were included. PVs were calculated with transrectal ultrasound. Only prostate adenocarcinomas (PCa) were included into the study. For standardization, patients with missing data, and who have been exposed to any form of hormonal or radiation therapy were excluded. Patients were categorized with DRE (negative or positive) and Gleason sum [<7: low grade PCa(LGPCa), ≥7: HGPCa]. RESULTS: Median PV was significantly lower in patients with HGPCa. There was a significantly increased risk of HGPCa with PV according to all groups in univariate logistic regression (LR). The significant relationship continued in multivariate LR with PSA and age. From the ROC curve analyses, again a significantly statistical concordance was found between the detection of HGPCa and PV (AUC:0.63, p<0.001), as well as between HGPCa and tPSA (AUC:0.73, p<0.001). tPSA and PV were also significantly concordant with HGPCa both in DRE negative and positive patients. CONCLUSIONS: There is a significant relationship between HGPCa and decreasing PV. The continued significant relationship both in DRE negative and positive patients reinforces this relation.
Assuntos
Carcinoma/patologia , Exame Retal Digital/métodos , Próstata/patologia , Neoplasias da Próstata/patologia , Idoso , Biópsia , Carcinoma/diagnóstico por imagem , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Gradação de Tumores , Próstata/diagnóstico por imagem , Antígeno Prostático Específico/sangue , Neoplasias da Próstata/diagnóstico por imagem , Curva ROC , Padrões de Referência , Estudos Retrospectivos , Fatores de Risco , Carga Tumoral , UltrassonografiaRESUMO
Introduction We aimed to assess the relationship between prostate volume (PV) and high grade prostate carcinoma (HGPCa) in patients with benign and suspicious digital rectal examination (DRE) in our prostate biopsy cohort. Materials and methods Between 2009-2012, 759 consecutive initial transrectal systematic 12 cores prostate biopsies were included. PVs were calculated with transrectal ultrasound. Only prostate adenocarcinomas (PCa) were included into the study. For standardization, patients with missing data, and who have been exposed to any form of hormonal or radiation therapy were excluded. Patients were categorized with DRE (negative or positive) and Gleason sum [<7: low grade PCa(LGPCa), ≥7: HGPCa]. Results Median PV was significantly lower in patients with HGPCa. There was a significantly increased risk of HGPCa with PV according to all groups in univariate logistic regression (LR). The significant relationship continued in multivariate LR with PSA and age. We found a PV cut-off value of 47.9cc for HGPCa. HGPCa was significantly higher in <47.9 volume, both in DRE positive and negative patients and in the whole cohort, although LGPCa did not differ significantly. Conclusions There is a significant relationship between HGPCa and decreasing PV. The continued significant relationship both in DRE negative and positive patients reinforces this relation. .