RESUMO
Diffuse large B-cell lymphoma (DLBCL) associated with chronic inflammation is a recently adopted category of DLBCL, which describes an aggressive B-cell lymphoma raised in the setting of non-immune chronic inflammation. Primary presentation of this subtype of DLBCL in bone is extremely rare. Here, we present the case of a 27 year old woman with DLBCL of the right distal femur, identified after a three-year history of chronic osteomyelitis. In this report, we describe the clinical and histopathologic features of this unusual presentation of DLBCL and discuss aspects relevant to diagnosis and treatment of this entity.
Assuntos
Neoplasias Femorais/patologia , Articulação do Joelho/patologia , Linfoma Difuso de Grandes Células B/patologia , Osteomielite/patologia , Adulto , Antibacterianos/uso terapêutico , Anticorpos Monoclonais Murinos/uso terapêutico , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Doença Crônica , Ciclofosfamida/uso terapêutico , Dicloxacilina/uso terapêutico , Doxorrubicina/uso terapêutico , Feminino , Neoplasias Femorais/tratamento farmacológico , Herpesvirus Humano 4/patogenicidade , Humanos , Articulação do Joelho/diagnóstico por imagem , Linfoma Difuso de Grandes Células B/tratamento farmacológico , Osteomielite/diagnóstico por imagem , Osteomielite/tratamento farmacológico , Prednisona/uso terapêutico , Radiografia , Rituximab , Vincristina/uso terapêuticoRESUMO
The human eye can be compromised by a variated spectrum of neoplasms and reactive processes. Here we present a rare case of a primary intraocular inflammatory myofibroblastic tumor (IMT) dependent on the sclera and choroid in a 31-year-old female. The knowledge surrounding IMTs, previously included in the category of inflammatory pseudotumors, has undergone dynamic changes in the past two decades. Here we review the characteristics of these tumors in the human eye and in the surrounding structures, and we describe the recent advances that allow molecular characterization of the neoplastic nature of this entity.
Assuntos
Neoplasias Oculares/metabolismo , Miofibroma/metabolismo , Proteínas de Neoplasias/metabolismo , Receptores Proteína Tirosina Quinases/metabolismo , Adulto , Quinase do Linfoma Anaplásico , Feminino , Humanos , Doenças da Esclera/metabolismoRESUMO
BACKGROUND: The anaplastic ganglioglioma (AG) is the high-grade counterpart of ganglioglioma, a rare mixed tumor composed of neuronal/ganglion and glial cells. MATERIALS AND METHODS: We describe the histopathology and immunohistochemistry in 7 cases of AG and correlate them with the clinical and radiological features. RESULTS: Our AG patients correspond to 2.5% of the central nervous system tumor patients evaluated in our institution. The mean age at presentation was 25.7 years, with a male predominance. The most common clinical presentation was generalized tonic-clonic seizures (3/7 cases), in correlation with frequent cortical/subcortical location (6/7 cases). Histopathologically, all our cases showed high-grade features in glial (glial fibrillary acid protein-positive) and neuron-ganglion cells (synaptophysin, PGP-9.5, neurofilament, NSE and CD56-positive), as well as moderate cellularity, frequent mitotic figures and a Ki-67 labeling index >5%. All our patients had poor survival. CONCLUSION: We found that a typical histopathological and immunohistochemical profile is constant and can be useful in early diagnosis of these aggressive neoplasms.
Assuntos
Neoplasias Encefálicas/patologia , Ganglioglioma/patologia , Adulto , Criança , Feminino , Humanos , Imuno-Histoquímica , Masculino , Adulto JovemRESUMO
Thyroid follicular neoplasms with signet ring cell morphology represent a challenging cytological and histopathologic diagnosis. The low frequency of these neoplasms and their broad differential diagnosis contribute to this difficult scenario. Here, we present an exceptionally rare case of thyroid follicular carcinoma with signet ring cell morphology in a 62-year-old female. We analyze the characteristics in fine-needle aspiration cytology, histopathology, and immunohistochemistry and compare our results in a discussion with previous literature reports.
Assuntos
Adenocarcinoma Folicular/patologia , Neoplasias da Glândula Tireoide/patologia , Adenocarcinoma Folicular/metabolismo , Biomarcadores Tumorais/metabolismo , Biópsia por Agulha Fina , Feminino , Humanos , Imuno-Histoquímica , Pessoa de Meia-Idade , Neoplasias da Glândula Tireoide/metabolismoRESUMO
The epithelioid hemangioendothelioma (EHE) is a rare type of endothelial neoplasm found mainly in soft tissues and visceral organs and in extraordinary cases in large veins like the iliac veins. Currently, there is an active discussion in which EHE behavior, classification, new diagnostic tools, and treatment procedures are proposed. Here, we present 2 cases of EHE and discuss our experience in diagnosis and treatment of this neoplasm.
Assuntos
Hemangioendotelioma Epitelioide/patologia , Veia Ilíaca/patologia , Neoplasias Vasculares/patologia , Adulto , Anticoagulantes/uso terapêutico , Biomarcadores Tumorais/análise , Biópsia , Feminino , Hemangioendotelioma Epitelioide/química , Hemangioendotelioma Epitelioide/terapia , Humanos , Veia Ilíaca/química , Veia Ilíaca/cirurgia , Imuno-Histoquímica , Masculino , Flebografia , Radioterapia Adjuvante , Veia Safena/transplante , Resultado do Tratamento , Neoplasias Vasculares/química , Neoplasias Vasculares/terapia , Adulto JovemRESUMO
Glioblastoma (GBM) is one of the most highly aggressive neoplasms of the central nervous system. Extra-cranial metastases in GBM are rare. Here we present the case of a 26-year-old man with extra-cranial metastasis of a frontal lobe GBM to the parotid gland, cervical lymph nodes, and bones, with initial diagnosis made by fine needle aspiration cytology (FNAC) of the parotid gland. FNAC is a reliable technique in the study of primary and secondary parotid gland neoplasms, allowing a presumptive diagnosis in difficult cases. We correlate the cytologic, histopathologic, and immunohistochemical findings in this case and discuss previous literature reports.
Assuntos
Neoplasias Encefálicas/patologia , Glioblastoma/secundário , Neoplasias Parotídeas/secundário , Adulto , Biópsia por Agulha Fina , Neoplasias Ósseas/secundário , Citodiagnóstico , Humanos , Metástase Linfática/patologia , Masculino , Neoplasias Parotídeas/cirurgiaRESUMO
We have described a primary esophageal meningioma (MG) clinical case diagnosed in a 62-year-old woman; also, we review the literature about extracranial MGs. To our knowledge, this is the first case report of an extracranial MG occurring primarily in the esophagus. These are benign neoplasms reported classically in the central nervous system (CNS). The extrancranial MGs have histopathologic and inmunohistochemical features identical to those observed in CNS MGs; thus, the main diagnostic hurdle is to keep it in the differential for lesions occurring outside the CNS.
Assuntos
Neoplasias Esofágicas/diagnóstico , Esofagoscopia , Meningioma/diagnóstico , Biópsia , Diagnóstico Diferencial , Neoplasias Esofágicas/patologia , Feminino , Humanos , Meningioma/patologia , Pessoa de Meia-IdadeRESUMO
The vein of Galen aneurysmal malformation (VGAM) is an extremely rare arterio-venous malformation. The VGAM clinical manifestations vary depending on the magnitude of vascular compromise and the age at initial presentation. Neonates typically present with severe congestive heart failure. Here we present a case in which a systolic heart murmur was the first manifestation of high output heart failure due to a VGAM.
Assuntos
Insuficiência Cardíaca/diagnóstico , Insuficiência Cardíaca/etiologia , Humanos , Recém-Nascido , Masculino , Sopros Sistólicos/etiologia , Malformações da Veia de Galeno/complicaçõesRESUMO
The vein of Galen aneurysmal malformation (VGAM) is an extremely rare arteriovenous malformation. The VGAM clinical manifestations vary depending on the magnitude of vascular compromise and the age at initial presentation. Neonates typically present with severe congestive heart failure. Here we present a case in which a systolic heart murmur was the first manifestation of high output heart failure due to a VGAM.
Las malformaciones de la vena cerebral de Galeno (MVG) son extremadamente raras. Sus manifestaciones clínicas varían dependiendo de la magnitud del compromiso vascular y la edad inicial de presentación. En neonatos, típicamente se presenta con una insuficiencia cardiaca congestiva grave. Se presenta un caso en el cual un soplo sistólico cardiaco fue la primera manifestación de una insuficiencia cardíaca de gasto alto secundaria a una malformación aneurismática de la vena de Galeno.