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BACKGROUND: The COVID-19 pandemic had direct and indirect impacts on public health, also affecting the mental health of the population. OBJECTIVE: To analyze symptoms of generalized anxiety disorder (GAD) and associated factors, in primary health care (PHC) professionals. METHODS: Cross-sectional and analytical study conducted with professionals who work in the Primary Health Care (PHC) of the Northern health macro-region of the state of Minas Gerais, Brazil. Data collection was carried out through an online, self-administered questionnaire, made available from August 27, 2021, to October 30, 2021 using the Google Forms tool. The questionnaire included sociodemographic questions as well as questions related to the history of anxiety and work during the pandemic. To assess anxiety symptoms, the General Anxiety Disorder-7 (GAD-7) instrument was used. Data treatment consisted of descriptive analysis of the variables, bivariate analysis followed by multivariate Poisson Regression with robust variance. RESULTS: 702 health professionals participated in the study and the general prevalence of GAD was 32.2%. Current anxiety symptoms were self-reported by 37.6% of the participants. In the final model, the associated factors identified were: female sex (PR = 1.82; 95% CI = 1.17-2.84; p = 0.007), previous symptoms (PR = 1.58; 95% CI = 1.19-2.10; p = 0.002) and (PR = 2.68; 95% CI = 2.00-3.62; p < 0.001) current self-reported anxiety. CONCLUSION: The results show the need to implement actions in mental health promotion and anxiety prevention, through the dissemination of information about mental health care, health education activities, encouraging the adoption of healthy habits and professional monitoring when necessary.

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OBJECTIVE: to analyze the prevalence of symptoms of common mental disorders (CMDs) in Primary Health Care professionals between August-October/2021. METHODS: this was a cross-sectional study conducted with health professionals in the Northern health macro-region of Minas Gerais state; snowball sampling was used; the dependent variable, CMDs, was evaluated using the Self-Reporting Questionnaire (SRQ-20); Poisson regression was used to perform the statistical analysis. RESULTS: a total of 702 health professionals took part in the study; the prevalence of CDMs was 43.2%. It was higher in those with previous [prevalence ratios (PR) = 2.42; 95%CI 1.43;4.08] and current (PR = 1.54; 95%CI 1.25;1.89) symptoms of mental disorders, overwork during the pandemic (PR = 1.42; 95%CI 1.16;1.73), previous symptoms of anxiety (PR = 1.27; 95%CI 1.01;1.61), depression (PR = 1.27; 95%CI 1.06;1.52) and other mental disorders (PR = 1.20; 95%CI 1.01;1.43). CONCLUSION: there was an association between CDMs and presenting previous and current symptoms of mental disorders and work overload during the covid-19 pandemic.

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Hypertrichosis and dental anomalies may occur alone or in combination in the spectrum of many syndromes. To identify genetic entities characterized by hypertrichosis and dental anomalies, a search was performed in the Mendelian Inheritance in Man database with the terms "hypertrichosis" or "hirsutism" and "tooth" or "dental abnormalities." Nondependent androgen metabolism disturbances were classified as hypertrichosis. Genetic entities with hypertrichosis and dental anomalies were included in the study. Additional searches were performed in the PubMed and Orphanet databases, when necessary, in order to include data from scientific articles. An integrative analysis of the genes associated with the identified syndromes was conducted using STRING to characterize biological processes, pathways, and interactive networks. The p-values were subjected to the false discovery rate for the correction of multiple tests. Thirty-nine syndromes were identified, and dental agenesis was the most frequent dental anomaly present in 41.02% (n = 16) of the syndromes. Causative genes were identified in 33 out of 39 genetic syndromes. Among them, 39 genes were identified, and 38 were analyzed by STRING, which showed 148 biological processes and three pathways that were statistically significant. The most significant biological processes were the disassembly of the nucleosome (GO:0006337, p = 1.09e-06), chromosomal organization (GO:0051276, p = 1.09e-06) and remodeling of the chromatin (GO: 0006338, p = 7.86e-06), and the pathways were hepatocellular carcinoma (hsa05225, p = 5.77e-05), thermogenesis (hsa04714, p = 0.00019), and cell cycle (hsa04110, p = 0.0433). Our results showed that the identification of hypertrichosis and dental anomalies may raise the suspicion of one of the thirty-nine syndromes with both phenotypes.

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Resumo Introdução: O envelhecimento populacional está entre as transformações globais mais importantes. Na população idosa, há prevalência aumentada de condições crônicas que comprometem a autonomia relacionadas ao comprometimento cognitivo. Objetivo: Este estudo buscou estimar a prevalência de comprometimento cognitivo e os fatores associados em uma população de idosos. Método: Trata-se de pesquisa transversal analítica envolvendo idosos com 60 anos ou mais, cadastrados na Estratégia Saúde da Família de Montes Claros, Minas Gerais, Brasil. Para caracterização dos fatores sociodemográficos, hábitos de vida e condições de saúde, utilizou-se o instrumento Brazilian Older Americans Researches and Service Multidimensional Function Assessment Questionnaire; para avaliação cognitiva, o Mini Exame do Estado Mental, e os resultados, ajustados por escolaridade na análise de regressão logística binária, com apresentação de odds ratio (OR) e intervalos de confiança (IC) de 95%. Resultados: Dos 1.746 idosos avaliados, 11,5% apresentaram comprometimento cognitivo. Os fatores de risco associados foram idosos acima de 80 anos (OR=4,463; IC95% 3,160-6,304); analfabetos (OR=3,996; IC95% 2,716-5,791); sem companheiro (OR=1,989; IC95% 1,388-2,850); sedentários (OR=1,777; IC95% 1,208-2,613) e com histórico de Acidente Vascular Cerebral (OR=3,635; IC95% 2,213-5,971). Conclusões: Comprometimento cognitivo foi associado a variáveis passíveis de ações preventivas, como o acesso à escolarização e hábitos de vida saudáveis.

Abstract Background: Population aging is among the most important global transformations. In the elderly population, there is an increased prevalence of chronic conditions that compromise autonomy, related to cognitive impairment. Objective: This study sought to estimate the prevalence of cognitive impairment and associated factors in an elderly population. Method: This is a cross-sectional and analytical survey involving elderly people aged 60 years old or older, registered with the Family Health Strategy of Montes Claros, Minas Gerais, Brazil. To characterize sociodemographic factors, life habits and health conditions, the Brazilian Older Americans Researches and Service Multidimensional Function Assessment Questionnaire was used; for cognitive evaluation, the Mini Mental State Examination, and the results adjusted for education in the binary logistic regression analysis, with the presentation of odds ratios (OR) and 95% confidence intervals (CI). Results: Of the 1,746 aged individuals evaluated, 11.5% presented cognitive impairment. The associated risk factors were elderly over 80 years old (OR=4.463; 95%CI 3.160-6.304); illiterate (OR=3.996; 95%CI 2.716-5.791); without companion (OR=1.989; 95%CI 1.388-2.850); sedentary (OR=1.777; 95%CI 1.208-2.613), and with a history of stroke (OR=3.635; 95%CI 2.213-5.971). Conclusions: Cognitive commitment was associated with variables susceptible to preventive actions, such as access to schooling and healthy living habits.

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ABSTRACT Objective: To analyze specialized dental care through access, demand and the work processes provided by the CEO's, using secondary data from the cycles of the PMAQ-CEO. Material and Methods: Cross-sectional study using public domain data. Variables of interest were selected from the external evaluation instrument data matrices and were grouped in categories. The categories were geographic distribution, structural, human resources, work processes and access and coordination. Results: The total of 932 CEO's were evaluated in 2014 and 1,042 in 2016, most of them type II, present in the Northeast region. In both cycles, the highest average of dentists worked in the endodontic specialty (2.4 professionals per CEO) and the lowest in oral medicine (0.8 professionals per CEO). Of the two cycles, 91.5% of the CEO's had a manager, 79.5% performed action planning activities and 74.5% realized internal self-assessment processes. There was an increase in the mean number of days to be seen at the CEO in all analyzed specialties (p<0.001) and 85.2% of the CEO's managers reported that there is a reference for oral cancer confirmed cases. Conclusion: Between the PMAQCEO cycles the number of CEO has increased, but there are still a big pent-up demand and the presence of care gaps. However, an expansion and improvement of the CEO's actions was evidenced, mainly related to the work processes.

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Objective: to analyze the prevalence of symptoms of common mental disorders (CMDs) in Primary Health Care professionals between August-October/2021. Methods: this was a cross-sectional study conducted with health professionals in the Northern health macro-region of Minas Gerais state; snowball sampling was used; the dependent variable, CMDs, was evaluated using the Self-Reporting Questionnaire (SRQ-20); Poisson regression was used to perform the statistical analysis. Results: a total of 702 health professionals took part in the study; the prevalence of CDMs was 43.2%. It was higher in those with previous [prevalence ratios (PR) = 2.42; 95%CI 1.43;4.08] and current (PR = 1.54; 95%CI 1.25;1.89) symptoms of mental disorders, overwork during the pandemic (PR = 1.42; 95%CI 1.16;1.73), previous symptoms of anxiety (PR = 1.27; 95%CI 1.01;1.61), depression (PR = 1.27; 95%CI 1.06;1.52) and other mental disorders (PR = 1.20; 95%CI 1.01;1.43). Conclusion: there was an association between CDMs and presenting previous and current symptoms of mental disorders and work overload during the covid-19 pandemic.

Objetivo: analizar la prevalencia de síntomas de trastornos mentales comunes (TMC) en profesionales sanitarios de la Atención Primaria de Salud de agosto a octubre de 2021. Métodos: estudio transversal realizado con profesionales de la salud de la macrorregión norte de Minas Gerais. El muestreo fue del tipo bola de nieve. La variable dependiente, TMC, se evaluó mediante el Self-Reporting Questionnaire (SRQ-20). En el análisis estadístico se utilizó la regresión de Poisson. Resultados: participaron 702 profesionales de salud. La prevalencia de TMC fue del 43,2%, mayor en quienes presentaban síntomas de trastornos mentales previos (RP = 2,42; IC95% 1,43;4,08) y actuales (RP = 1,54; IC95% 1,25;1,89); exceso de trabajo durante la pandemia (RP = 1,42; IC95% 1,16;1,73); síntomas previos de ansiedad (RP = 1,27; IC95% 1,01;1,61), depresión (RP = 1,27; IC95% 1,06;1,52) y otros trastornos mentales (RP = 1,20; IC95% 1,01;1,43). Conclusión: hubo una asociación entre los TMC y los síntomas previos y actuales de los trastornos mentales y la sobrecarga de trabajo durante la pandemia de COVID-19.

Objetivo: analisar a prevalência de sintomas de transtornos mentais comuns (TMCs) em profissionais de saúde da Atenção Primária à Saúde, no período agosto-outubro/2021. Métodos: estudo transversal com profissionais de saúde da macrorregião Norte de saúde de Minas Gerais; amostragem de tipo "bola de neve"; a variável dependente, TMCs, foi avaliada pelo Self-Reporting Questionnaire (SRQ-20); utilizou-se regressão de Poisson na análise estatística. Resultados: participaram 702 profissionais de saúde; a prevalência de TMCs foi de 43,2%, maior naqueles que apresentaram sintomas de transtornos mentais prévios [razão de prevalências (RP) = 2,42 ;IC95% 1,43;4,08] e atuais (RP = 1,54; IC95% 1,25;1,89), trabalho a mais durante a pandemia (RP = 1,42; IC95% 1,16;1,73), sintomas prévios de ansiedade (RP = 1,27; IC95% 1,01;1,61), depressão (RP = 1,27; IC95% 1,06;1,52) e outros transtornos mentais (RP = 1,20; IC95% 1,01;1,43). Conclusão: observou-se associação de TMCs com sintomas prévios e atuais de transtornos mentais e sobrecarga de trabalho, durante a pandemia da covid-19.

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Abstract Hypertrichosis and dental anomalies may occur alone or in combination in the spectrum of many syndromes. To identify genetic entities characterized by hypertrichosis and dental anomalies, a search was performed in the Mendelian Inheritance in Man database with the terms "hypertrichosis" or "hirsutism" and "tooth" or "dental abnormalities." Nondependent androgen metabolism disturbances were classified as hypertrichosis. Genetic entities with hypertrichosis and dental anomalies were included in the study. Additional searches were performed in the PubMed and Orphanet databases, when necessary, in order to include data from scientific articles. An integrative analysis of the genes associated with the identified syndromes was conducted using STRING to characterize biological processes, pathways, and interactive networks. The p-values were subjected to the false discovery rate for the correction of multiple tests. Thirty-nine syndromes were identified, and dental agenesis was the most frequent dental anomaly present in 41.02% (n = 16) of the syndromes. Causative genes were identified in 33 out of 39 genetic syndromes. Among them, 39 genes were identified, and 38 were analyzed by STRING, which showed 148 biological processes and three pathways that were statistically significant. The most significant biological processes were the disassembly of the nucleosome (GO:0006337, p = 1.09e-06), chromosomal organization (GO:0051276, p = 1.09e-06) and remodeling of the chromatin (GO: 0006338, p = 7.86e-06), and the pathways were hepatocellular carcinoma (hsa05225, p = 5.77e-05), thermogenesis (hsa04714, p = 0.00019), and cell cycle (hsa04110, p = 0.0433). Our results showed that the identification of hypertrichosis and dental anomalies may raise the suspicion of one of the thirty-nine syndromes with both phenotypes.

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Abstract Objective: To evaluate the surgical rehabilitation of cleft lip and/or palate by the Brazilian public health system. Methods: Retrospective, analytical and comparative ecological study, with information on hospital procedures performed on individuals with cleft lip and/or palate in Centers authorized by the Brazilian public health system, between the years 2008 and 2020. The information was collected in databases Ministry of Health data. Results: Between 2008 and 2020, there was an increase of 8 (36.4%) qualified Centers in Brazil, currently having 30 Centers in 100% of the geographic regions. The surgical procedures performed totaled 68,716; with multiple surgeries being the most frequent. Complete cleft lip and palate was the most frequent type in hospital admissions. The public financial resources invested in the surgical rehabilitation of cleft lip and palate in the qualified Lip and Palate Malformation Treatment Centers were US$ 39,693 million, making an average value per procedure of US$ 577.64. Conclusions: In Brazil, public health system performed and financed, over the years 2008 and 2020, an important volume of surgical procedures for cleft lip and/or palate, which presented a polarization in the Southeast region but with a slight tendency expansion to other regions of the country. The most performed surgical procedures were multiple surgeries and mostly for individuals with cleft lip and palate. The amounts paid showed a heretogeneous distribution in the national territory. Level of evidence: Level 5: Report containing program evaluation data.

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OBJECTIVE: To evaluate the surgical rehabilitation of cleft lip and/or palate by the Brazilian public health system. METHODS: Retrospective, analytical and comparative ecological study, with information on hospital procedures performed on individuals with cleft lip and/or palate in Centers authorized by the Brazilian public health system, between the years 2008 and 2020. The information was collected in databases Ministry of Health data. RESULTS: Between 2008 and 2020, there was an increase of 8 (36.4%) qualified Centers in Brazil, currently having 30 Centers in 100% of the geographic regions. The surgical procedures performed totaled 68,716; with multiple surgeries being the most frequent. Complete cleft lip and palate was the most frequent type in hospital admissions. The public financial resources invested in the surgical rehabilitation of cleft lip and palate in the qualified Lip and Palate Malformation Treatment Centers were US$ 39,693 million, making an average value per procedure of US$ 577.64. CONCLUSIONS: In Brazil, public health system performed and financed, over the years 2008 and 2020, an important volume of surgical procedures for cleft lip and/or palate, which presented a polarization in the Southeast region but with a slight tendency expansion to other regions of the country. The most performed surgical procedures were multiple surgeries and mostly for individuals with cleft lip and palate. The amounts paid showed a heretogeneous distribution in the national territory. LEVEL OF EVIDENCE: Level 5: Report containing program evaluation data.

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The aim of this study was to describe the oral health services offered by the Unified Health System in the northern macro-region of Minas Gerais, Brazil, during the COVID-19 pandemic. This was an observational, cross-sectional and descriptive study. Data collection took place between August and September 2020 through the completion of online questionnaires by oral health managers in the northern municipalities of Minas Gerais and by consultation of information available in the Special Epidemiological Bulletin Coronavirus North Macro-region n° 14. After collection, data were transferred to SPSS® (Statistical Package for the Social Sciences for Windows, version 24.0). Analyses were performed using frequency, mean, standard deviation and percentages. It was found that all included municipalities suspended elective treatments and maintained emergency dental care at all levels of care. In 62.5% of municipalities there were oral health professionals contaminated by COVID-19. Oral health teams implemented specific interventions to address the pandemic,with the most frequent being tele-orientation (74.7%), use of sanitary barriers (72%), and telemonitoring (68%). At the beginning of the pandemic, 62.5% of municipalities lacked personal protective equipment. Comsidering these results, it was found that the COVID-19 pandemic impacted the supply of dental services in northern Minas Gerais due to the suspension of elective care, contamination of professionals, lack of personal protective equipment, and development of new interventions. Thus, oral health teams had to adapt to new contexts of health interventionsto face COVID-19 and maintain dental care services.

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RESUMO Objetivo: Realizar uma revisão sistemática da literatura avaliando a prevalência de transtornos mentais em profissionais da saúde durante a pandemia da COVID-19. Métodos: Trata-se de revisão sistemática conduzida com base no checklist Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). As bases de dados usadas foram a Biblioteca Virtual de Saúde (BVS) e os serviços da United States National Library of Medicine (NLM) via PubMed, com as estratégias de busca: "COVID-19" AND "Saúde mental"; "COVID-19" AND "Saúde mental" AND "pessoal de saúde", em português e inglês, selecionando artigos observacionais e/ou de prevalência publicados a partir de 2020. Resultados: A busca resultou na identificação de 18.643 artigos, e a amostra final foi composta por 9 artigos. Os sintomas mais frequentes foram os de depressão, ansiedade e insônia em profissionais que atuaram no período da pandemia da COVID-19, predominantemente do sexo feminino e idade média de 34,5 anos. A média da prevalência de ansiedade, depressão e insônia foi, respectivamente, de 40,3%, 39,9% e 36,1%, aferidas em 8.866 profissionais da saúde. Os profissionais atuantes na linha de frente no combate à COVID-19 apresentaram maiores prevalências de transtornos mentais comuns em relação a outros profissionais de saúde. Conclusões: Mostraram-se associadas a maiores prevalências de sintomas de TMC: sexo feminino, atuação na linha de frente, maior jornada de trabalho, histórico de uso de medicamentos psicotrópicos, condições inadequadas de trabalho, uso de álcool e tabaco e atuação na área de enfermagem. Observa-se a importância de estratégias de atenção à saúde mental dos profissionais de saúde.

ABSTRACT Objective: To conduct a systematic review of the literature evaluating the prevalence of mental disorders in health professionals during the COVID-19 pandemic. Methods: This is a systematic review conducted based on the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist. The databases used were the Biblioteca Virtual de Saúde (BVS) and the services of the United States National Library of Medicine (NLM) via PubMed, with the search strategies: "COVID-19" AND "Mental health"; "COVID-19" AND "Mental health" AND "health personnel", in Portuguese and English, selecting observational and/or prevalence articles published from 2020 onwards. Results: The search resulted in the identification of 18,643 articles, and the final sample consisted of 9 articles. The most frequently evaluated symptoms were symptoms of depression, anxiety and insomnia in professionals who worked during the COVID-19 pandemic period, predominantly female and mean age of 34.5 years. The average prevalence of anxiety, depression and insomnia was respectively 40.3%, 39.9% and 36.1%, measured in 8,866 health professionals. Health professionals working on the front line in the fight against Covid-19 had higher prevalence of common mental disorders in relation to other health professionals. Conclusions: The following were associated with a higher prevalence of CMD symptoms: female sex, frontline work, longer working hours, history of psychotropic medication use, inadequate working conditions, use of alcohol and tobacco, and work in the nursing field. The importance of mental health care strategies for health professionals is observed.

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Abstract: The aim of this study was to describe the oral health services offered by the Unified Health System in the northern macro-region of Minas Gerais, Brazil, during the COVID-19 pandemic. This was an observational, cross-sectional and descriptive study. Data collection took place between August and September 2020 through the completion of online questionnaires by oral health managers in the northern municipalities of Minas Gerais and by consultation of information available in the Special Epidemiological Bulletin Coronavirus North Macro-region n° 14. After collection, data were transferred to SPSS® (Statistical Package for the Social Sciences for Windows, version 24.0). Analyses were performed using frequency, mean, standard deviation and percentages. It was found that all included municipalities suspended elective treatments and maintained emergency dental care at all levels of care. In 62.5% of municipalities there were oral health professionals contaminated by COVID-19. Oral health teams implemented specific interventions to address the pandemic,with the most frequent being tele-orientation (74.7%), use of sanitary barriers (72%), and telemonitoring (68%). At the beginning of the pandemic, 62.5% of municipalities lacked personal protective equipment. Comsidering these results, it was found that the COVID-19 pandemic impacted the supply of dental services in northern Minas Gerais due to the suspension of elective care, contamination of professionals, lack of personal protective equipment, and development of new interventions. Thus, oral health teams had to adapt to new contexts of health interventionsto face COVID-19 and maintain dental care services.

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The enamel renal syndrome (ERS) is a rare autosomal recessive disease that is associated with mutations in the FAM20A gene. The syndrome is characterized by impaired amelogenesis of the hypoplastic type and nephrocalcinosis, presenting with presence of thin or absence of enamel, late dental eruption, intrapulpal calcifications, bilateral nephrocalcinosis, and normal plasma calcium level. The objective is to characterize ERS by systematically literature reviewing, highlighting the main findings of the syndrome to increase knowledge about this condition in the health professionals. The study is a systematic review of the scientific literature, whose research was developed in the PubMed database in March 2018. A total of 69 articles were found. Two authors analyzed their abstracts and selected, according to the language and main subject, 30 articles to write this study. A total of 69 patients were cited in the studies and their data were analysed. There was gender equivalence and the ages ranged from 1 to 64 years old. There is a clear hereditary relation of the syndrome, since there was consanguinity in 18 cases, indicating a percentage of 26.08% and family history in 30 cases (43.47%). Laboratory changes vary greatly from patient to patient and may even remain unchanged. The relationship between the syndrome and the mutation in the FAM20A gene can be proven from the data, since all patients with ERS screened by the mutation were positive. With the advancement of the ERS studies, some associations with the syndrome are suspected, such as the presence of gingival fibromatosis, hearing loss, and hypertrichosis. Thus, it is noticed that the syndrome does not show a predilection for gender or age and there is a strong hereditary character, marked by the consanguinity and family history of the patients. The association with the FAM20A gene is reinforced, since the mutation was identified in all patients analyzed.

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Early life is a critical period for the development of the central nervous system (CNS) when the brain undergoes functional organization, neuronal proliferation and migration. This study aimed to evaluate influences and possible interactions of the neonatal handling (NH) on morphologic, biochemical and molecular markers in the hippocampus, as well as on Mu opioid receptors (MOR) immunoreactivity when adolescent rats were exposed to morphine. On postnatal day (PND) 1, male pups were assigned to two experimental groups: unhandled (UH) or neonatal handling (NH), whose procedure was applied from PND2 to PND9. On PND 50, animals were submitted to memory behavioral test, anesthesia and euthanasia for blood collection and hippocampus removal. Animals exposed to NH showed: i) increased levels of proBDNF and brain-derived neurotrophic factor (BDNF); ii) increased memory performance; iii) decreased lipid peroxidation (LP) in plasma and hippocampus; iv) increased antioxidant defenses; v) increased glucocorticoids receptor (GR) levels. Interestingly, our data showed a positive correlation between BDNF and working memory after NH procedure (r2 = 0.73; P = 0.006). Animals submitted to NH showed an increased per se of MOR immunoreactivity regardless of morphine exposure, while this increasing was also observed in the UH group after morphine exposure, even in a small extent. NH beneficial influence during early stage of life can be reflected during the development of the puppies, enhancing memory performance, preventing oxidative events and improving molecular targets in hippocampus. Further experimental studies in addition to clinical ones are needed to validate NH protocol as a therapeutic tool.

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Multiple studies have demonstrated an association between cancer and nonsyndromic oral clefts in different populations. In this study, we assessed the occurrence of nonsyndromic oral clefts in families of patients with acute lymphoblastic leukemia (ALL, n = 50) and controls (n = 125). The parents of the patients answered a questionnaire with basic demographic information and family history of nonsyndromic oral clefts in first-degree relatives. Statistical analysis was carried out using Fisher's exact test. In the ALL group, 22 (44%) were male and 28 (56%) were female, and the average age was 13.2 ± 12.2 years. In the control group, 64 (51.2%) were male and 65 were female and the average age was 11.3 ± 10.3 years. Two out of 50 patients (4%) with acute lymphoblastic leukemia had a positive history of nonsyndromic oral clefts, whereas there were no reported occurrences of nonsyndromic oral clefts in the control group (OR: 12.94, 95% CI: 0.61-274.6, p = 0.08). Despite the limited population, the frequency of nonsyndromic oral clefts was increased in the first-degree relatives of patients with acute lymphoblastic leukemia. Studies with larger samples and molecular analyses are needed to better understand the possible etiological relationship between cancer and nonsyndromic oral clefts.

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BACKGROUND.: This study aimed to evaluate the scientific production of researchers in the field of Medicine who receive a productivity grant from the CNPq. METHODS: The curriculum Lattes of 542 researchers with active grants from 2012 to 2014 were included in the analysis. Grants categories/levels were stratified into three groups according to the CNPq database (1A-B, 1C-D, and 2). RESULTS.: There was a predominance of grants in category 2. During their academic career, Medicine researchers published 76512 articles, with a median of 119 articles per researcher (IQ, interquartile range, 77 to 174). Among the 76512 articles, 36584 (47.8%) were indexed in the Web of Science (WoS database). Researchers in Medicine were cited 643159 times in the WoS database, with a median of 754 citations (IQ, 356 to 1447). There were significant differences among the categories of grants concerning the number of citations in WoS (P <0.001). There was a significant difference in the number of times researchers were cited according to the specialty included in Medicine area. (P < 0.001). CONCLUSION.: Strategies to improve the scientific output qualitatively possibly can be enhanced by the knowledge of the profile of researchers in the field of Medicine.

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SUMMARY BACKGROUND. This study aimed to evaluate the scientific production of researchers in the field of Medicine who receive a productivity grant from the CNPq. METHODS: The curriculum Lattes of 542 researchers with active grants from 2012 to 2014 were included in the analysis. Grants categories/levels were stratified into three groups according to the CNPq database (1A-B, 1C-D, and 2). RESULTS. There was a predominance of grants in category 2. During their academic career, Medicine researchers published 76512 articles, with a median of 119 articles per researcher (IQ, interquartile range, 77 to 174). Among the 76512 articles, 36584 (47.8%) were indexed in the Web of Science (WoS database). Researchers in Medicine were cited 643159 times in the WoS database, with a median of 754 citations (IQ, 356 to 1447). There were significant differences among the categories of grants concerning the number of citations in WoS (P <0.001). There was a significant difference in the number of times researchers were cited according to the specialty included in Medicine area. (P < 0.001). CONCLUSION. Strategies to improve the scientific output qualitatively possibly can be enhanced by the knowledge of the profile of researchers in the field of Medicine.

RESUMO OBJETIVO: O objetivo deste estudo foi avaliar a produção científica de pesquisadores da área de Medicina que recebem bolsa de produtividade do CNPq. MÉTODOS: Os currículos Lattes de 542 pesquisadores com bolsas ativas de 2012 a 2014 foram incluídos na análise. As categorias/níveis das bolsas de produtividade foram estratificadas em três grupos de acordo com a classificação do CNPq (1A-B, 1C-D e 2). RESULTADOS: Houve predomínio de bolsas na categoria 2. Durante a carreira acadêmica, pesquisadores da Medicina publicaram 76.512 artigos, com mediana de 119 artigos por pesquisador (Intervalo Interquartil, IQ, 77 a 174). Entre os 76.512 artigos, 36.584 (47,8%) foram indexados no banco de dados da Web of Science (WoS). Pesquisadores em Medicina receberam 643.159 citações no banco de dados de WoS, com uma mediana de 754 citações (IQ, 356 a 1.447). Houve diferenças significativas entre as categorias de bolsas em relação ao número de citações em WoS (P < 0,001). Houve uma diferença significativa no número de citações recebidas pelos pesquisadores de acordo com a especialidade incluída na área de Medicina (P < 0,001). CONCLUSÃO: Estratégias para melhorar qualitativamente a produção científica possivelmente podem ser aprimoradas pelo conhecimento do perfil dos pesquisadores no campo da Medicina.

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