RESUMO
Chagas disease (CD) has been changing from an endemic Latino-American disease to a condition found outside endemic regions, due to migratory movements. Although often subclinical, its acute phase can be lethal. This study aimed to assess survival during the acute phase of CD and its relationship with ventricular function in an experimental model. To this end, 30 Syrian hamsters were inoculated with Trypanosoma cruzi (IG) and other 15 animals received saline solution (CG). Groups were monitored daily and submitted to echocardiography in two moments: before the challenge and 15 days post-infection. Left ventricular ejection fraction (LVEF) and global longitudinal myocardial strain (GLS) of the LV were measured. The IG was divided into groups of animals with and without clinical signs of disease. ANOVA for mixed models was used to compare ventricular function parameters. Survival analysis was studied using Kaplan-Meier curves and the log-rank test. The follow-up lasted 60 days. LVEF in IG was reduced through time (53.80 to 43.55%) compared to CG (57.86 to 59.73%) (p=0.002). There was also a reduction of GLS (-18.97% to -12.44%) in the IG compared to CG (p=0.012). Twelve animals from IG died compared to one animal from CG. Eleven out of the 12 animals from the IG group died before presenting with clinical signs of infection. Survival was reduced in the IG compared to CG over time (p=0.02). The reduced survival during the acute phase of this experimental model of Chagas disease was related to the significant reduction of LV function. The mortality rate in the IG was higher in the group presenting with clinical signs of infection.
Assuntos
Doença de Chagas , Disfunção Ventricular Esquerda , Animais , Cricetinae , Modelos Animais , Estudos Prospectivos , Volume Sistólico , Função Ventricular EsquerdaRESUMO
Dentre as doenças cardiovasculares, a insuficiência cardíaca (IC) por ser via final comum de muitas doenças que acometem o coração, tem seu destaque por apresentar alta prevalência na população, responsável também por altas taxas de mortalidade e morbidade. A avaliação da capacidade funcional dos pacientes com IC é realizada através de testes de esforço que impõe sobrecargas ao sistema cardiorrespiratório do indivíduo. Além do teste de caminhada de 6 minutos, o teste cardiopulmonar (TCP) é outro teste de esforço capaz de proporcionar múltiplas variáveis que, submetidas à adequada análise, podem orientar quanto ao prognóstico dos indivíduos. A junção de algumas dessas variáveis tem sido proposta para uma análise mais rápida e eficaz em relação ao prognóstico dos pacientes com IC. Desse modo, o objetivo deste estudo foi aplicar a tabela de multivariáveis do TCP nos...