RESUMO
BACKGROUND: In recent decades, the prevalence of atopic dermatitis (AD) has risen steadily, and risk factors for AD are currently being investigated worldwide. In Argentina, there are no available data on risk factors of AD. AIM: To determine the prevalence of and any gender predilection for AD, and to identify familial and environmental factors that are associated with increased AD risk. METHODS: In this case-control cross sectional study, 603 children aged 12-60 months old from a poor urban community in Buenos Aires were recruited. AD was defined following UK Working Party Diagnostic Criteria. We evaluated the relationship between AD and the presence of family history of atopy, > 5 family members, wearing synthetic clothes, having a carpeted room, eating > or = 3 eggs/week, tobacco smoking indoors by family members, and living< 300 m from a main road, polluted stream or industry. RESULTS: The prevalence of AD was 41.1% (95% CI 37.2-45.2%). Logistic regression analysis showed that AD was significantly associated only with a family history of atopy (OR = 5.7; 95% CI 3.7-8.8%; P = 0.0000), wearing synthetic clothes (OR = 2.2; 95% CI 1.4-3.5; P = 0.0009), having a carpeted room OR = 1.9; 95% CI 1.2-3.0%; P = 0.009) and living < 300 m from an industry (OR = 1.93; 95% CI 1.2-3.1%; P = 0.0051). CONCLUSION: We found a high prevalence of AD in our study population. Not all the investigated risk factors for AD had a significant association with the disease.
Assuntos
Dermatite Atópica/epidemiologia , Argentina/epidemiologia , Criança , Pré-Escolar , Dermatite Atópica/etiologia , Dermatite Atópica/genética , Métodos Epidemiológicos , Feminino , Predisposição Genética para Doença , Humanos , Lactente , Masculino , Áreas de Pobreza , Características de Residência/estatística & dados numéricos , Fatores Sexuais , Fatores SocioeconômicosRESUMO
Mycosis fungoides (MF) may present with atypical clinical manifestations. Usually it mimics various chronic dermatoses, with the appearance of ulcers during the tumour stage. Infrequently, cutaneous ulcers are the main or initial sign of lymphoma. We report the case of a man who presented multiple skin lesions that clinically appeared to be pyoderma gangrenosum (PG). However, histological and immunohistochemical examination revealed MF. This case illustrates that PG-like ulcers maybe atypical cutaneous manifestations of MF and exceptionally the presenting sign of this disease.
Assuntos
Micose Fungoide/patologia , Pioderma Gangrenoso/patologia , Úlcera Cutânea/patologia , Biópsia por Agulha , Terapia Combinada , Diagnóstico Diferencial , Evolução Fatal , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Micose Fungoide/diagnóstico , Micose Fungoide/terapia , Pioderma Gangrenoso/diagnóstico , Pioderma Gangrenoso/terapia , Índice de Gravidade de Doença , Úlcera Cutânea/diagnóstico , Úlcera Cutânea/terapiaRESUMO
Patients with lymphomas and cutaneous ulcers have a poor prognosis. Commonly the ulcers occur later in the course of lymphomas and may be the source of sepsis. From 59 patients with lymphoma and skin involvement, 12 patients who presented with ulcers were retrospectively analyzed between January 1990 to December 1999. More frequently ulcers were multiple, necrotic, infected and placed on tumors. Sepsis was the main cause of mortality in 10 patients and most cases were secondary to Staphylococcus aureus and Pseudomonas aeruginosa. Factors associated with poor prognosis were febrile neutropenia after chemotherapy and generalized involvement by the lymphoma. Mean survival of deceased patients after onset of ulcers was 6.27 months. We emphasize the importance of an appropriate microbiological study and a prompt therapy.
Assuntos
Linfoma Cutâneo de Células T/patologia , Neoplasias Cutâneas/patologia , Úlcera Varicosa/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Linfoma não Hodgkin/complicações , Linfoma não Hodgkin/patologia , Linfoma Cutâneo de Células T/complicações , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Neoplasias Cutâneas/complicações , Úlcera Varicosa/microbiologiaRESUMO
Patients with lymphomas and cutaneous ulcers have a poor prognosis. Commonly the ulcers occur later in the course of lymphomas and may be the source of sepsis. From 59 patients with lymphoma and skin involvement, 12 patients who presented with ulcers were retrospectively analyzed between January 1990 to December 1999. More frequently ulcers were multiple, necrotic, infected and placed on tumors. Sepsis was the main cause of mortality in 10 patients and most cases were secondary to Staphylococcus aureus and Pseudomonas aeruginosa. Factors associated with poor prognosis were febrile neutropenia after chemotherapy and generalized involvement by the lymphoma. Mean survival of deceased patients after onset of ulcers was 6.27 months. We emphasize the importance of an appropriate microbiological study and a prompt therapy.
RESUMO
Introducción: Trabajos efectuados en la edad adulta indican que el consumo de sodio (CS) se relaciona con la presión arterial (PA). Sin embargo en niños y adolescentes no existen datos concluyentes al respecto. El propósito del presente estudio consiste en investigar el CS, estimar correlación entre CS y PA, establecer asociación entre consumo de dietas hipersódicas (CDHS) y presión arterial elevada (PAE) y determinar si existe sensibilidad al sodio dependiente de la obesidad y de los antecedentes familiares de hipertensión arterial (AFHTA). Población: Se estudiaron adolescentes de 15 años, de ambos sexos, sin antecedentes patológicos, que concurrían a establecimientos secundarios del partido de Avellaneda. Material y métodos: Las mediciones de PA se efectuaron aplicando la metodología aconsejada por la "Task Force". Se consideró hipertensión arterial (HTA) a aquellos valores que alcanzaran o superaran en 3 oportunidades el percentilo 95 de PA para el percentilo 50 de talla según la "Revaloración de la Second Task Force". El consumo de sodio y los antecedentes familiares de HTA fueron recabados mediante un cuestionario entregado a los alumnos, respondido en forma conjunta con sus padres. Resultados: Estudiamos 363 adolescentes de 15 años. El consumo medio de sodio fue de 3,8 g/día. Presentaron correlación negativa estadísticamente significativa con el CS sólo la PA sistólica y la PAE en los varones. No encontramos asociación entre CDHS y PAE, ni sensibilidad al sodio en nuestra muestra. Conclusión: El CS de los adolescentes de la muestra supera ampliamente los requerimientos diarios. Consideramos necesario ampliar la casuística y rever la metodología para corroborar nuestros hallazgos
Assuntos
Adolescente , Sódio na Dieta , Pressão SanguíneaRESUMO
Introducción: Trabajos efectuados en la edad adulta indican que el consumo de sodio (CS) se relaciona con la presión arterial (PA). Sin embargo en niños y adolescentes no existen datos concluyentes al respecto. El propósito del presente estudio consiste en investigar el CS, estimar correlación entre CS y PA, establecer asociación entre consumo de dietas hipersódicas (CDHS) y presión arterial elevada (PAE) y determinar si existe sensibilidad al sodio dependiente de la obesidad y de los antecedentes familiares de hipertensión arterial (AFHTA). Población: Se estudiaron adolescentes de 15 años, de ambos sexos, sin antecedentes patológicos, que concurrían a establecimientos secundarios del partido de Avellaneda. Material y métodos: Las mediciones de PA se efectuaron aplicando la metodología aconsejada por la "Task Force". Se consideró hipertensión arterial (HTA) a aquellos valores que alcanzaran o superaran en 3 oportunidades el percentilo 95 de PA para el percentilo 50 de talla según la "Revaloración de la Second Task Force". El consumo de sodio y los antecedentes familiares de HTA fueron recabados mediante un cuestionario entregado a los alumnos, respondido en forma conjunta con sus padres. Resultados: Estudiamos 363 adolescentes de 15 años. El consumo medio de sodio fue de 3,8 g/día. Presentaron correlación negativa estadísticamente significativa con el CS sólo la PA sistólica y la PAE en los varones. No encontramos asociación entre CDHS y PAE, ni sensibilidad al sodio en nuestra muestra. Conclusión: El CS de los adolescentes de la muestra supera ampliamente los requerimientos diarios. Consideramos necesario ampliar la casuística y rever la metodología para corroborar nuestros hallazgos