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Neurotoxicology ; 31(6): 747-51, 2010 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-20600290

RESUMO

This study investigated the effect of the pre- and perinatal exposure to di-(2-ethylhexyl) phthalate (DEHP) on the neuroendocrine parameters that regulate reproduction in peripubertal male rats. DEHP at dose of 3 and 30mg/kg bw/day was administered orally to female rat since pregnancy onset until weaning. The male litters were sacrificed at 30 days of age to determine gonadotropin serum level and the hypothalamic contents of the amino acids aspartate and gamma-aminobutyric acid. No changes in gonadotropin, aspartate and gamma-aminobutyric acid levels were detected at the low dose. DEHP 30mg/kg bw/day reduced testis weight and serum FSH, in correlation with a significant increase in the inhibitory GABAergic tone and a reduction in the stimulatory effect of aspartate on gonadotropin level. This study provides unknown data regarding changes in the hypothalamic contents of the amino acid neurotransmitters, which are involved in the neuroendocrine regulation of reproductive axis, in peripubertal male rat offspring from dams exposed to DEHP during gestational and lactational periods. This could be related with the gonadotropin modifications also here described.


Assuntos
Dietilexilftalato/toxicidade , Hormônio Foliculoestimulante/metabolismo , Hipotálamo/metabolismo , Neurotransmissores/metabolismo , Efeitos Tardios da Exposição Pré-Natal/induzido quimicamente , Maturidade Sexual/fisiologia , Aminoácidos/antagonistas & inibidores , Aminoácidos/metabolismo , Animais , Ácido Aspártico/antagonistas & inibidores , Ácido Aspártico/metabolismo , Feminino , Hipotálamo/efeitos dos fármacos , Lactação/efeitos dos fármacos , Lactação/metabolismo , Masculino , Gravidez , Efeitos Tardios da Exposição Pré-Natal/metabolismo , Ratos , Ratos Wistar , Maturidade Sexual/efeitos dos fármacos , Ácido gama-Aminobutírico/metabolismo
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