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BACKGROUND AND OBJECTIVE: Osteoporosis is associated with bone microarchitecture alterations, and the depletion of estrogen during menopause is a major contributing factor to its development. The literature highlights the noteworthy role of gut microbiota in bone metabolism, particularly in the progression of osteoporosis. Periodontal disease leads to alveolar bone loss, which may be influenced by estrogen deficiency, and this mechanism is intricately associated with an imbalance in systemic microbiota. The aim of this study was to evaluate the effects of Bifidobacterium animalis subsp. lactis HN019 (B. lactis HN019) and Lacticaseibacillus casei 01 (L. casei 01) administrations on an osteoporosis animal model. MATERIALS AND METHODS: Thirty-three female rats were randomly divided into three groups: control (C-OVX), C-OVX-HN019 and C-OVX-LC01. All animals were ovariectomized. In groups C-OVX-HN019 and C-OVX-LC01, the probiotics were administered for 4 months. All animals were euthanized after 16 weeks from ovariectomy. Microtomographic, histopathological and immunohistochemical examinations were conducted on periodontal tissues, whereas histomorphometry, histopathological and immunohistochemical analyses were carried out on the intestine. The levels of estradiol were assessed in blood using an immunoenzymatic assay. The data were subjected to statistical analyses (p < .05). RESULTS: The C-OVX-LC01 group exhibited a significant reduction in alveolar bone porosity and an increase in connective tissue density compared to C-OVX (p < .05). The C-OVX-HN019 and C-OVX-LC01 groups presented reduced expression of TRAP and RANKL compared to the C-OVX (p < .05). The C-OVX group presented villi defects, mild neutrophil infiltration, decrease in both villous height and intestinal crypts and reduced expression of intestinal junctional epithelium markers e-cadherin and claudin 01 compared to C-OVX-HN019 and C-OVX-LC01 (p < .05). The C-OVX group had lower estradiol levels than C-OVX-HN019 and C-OVX-LC01 (p < .05). CONCLUSION: The probiotic therapy promoted a reduction in alveolar bone destruction and intestinal permeability as well as an increase in estradiol levels in ovariectomized rats. Specifically, the probiotic strain Lacticaseibacillus casei 01 exhibited greater effectiveness compared to Bifidobacterium animalis subsp. lactis HN019, indicating strain-dependent outcomes.
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Estradiol , Osteoporose , Ovariectomia , Probióticos , Animais , Estradiol/sangue , Probióticos/uso terapêutico , Probióticos/farmacologia , Feminino , Ratos , Osteoporose/patologia , Perda do Osso Alveolar/patologia , Perda do Osso Alveolar/prevenção & controle , Modelos Animais de Doenças , Lacticaseibacillus casei , Bifidobacterium animalis , Microtomografia por Raio-X , Processo Alveolar/patologia , Intestinos/patologia , Intestinos/microbiologia , Microbioma Gastrointestinal , Ratos WistarRESUMO
BACKGROUND: Microbial resistance to antibiotics is a global public health problem, which requires urgent attention. Platonia insignis is a native species from the eastern Brazilian Amazon, used in the treatment of burns and wounds. OBJECTIVES: To evaluate the antimicrobial activity of the hydroalcoholic extract of P. insignis (PIHA), the ethyl acetate fraction (PIAE), and its subfraction containing a mixture of biflavonoids (BF). Moreover, the effect of these natural products on the antibiotic activity against S. aureus strains overexpressing efflux pump genes was also evaluated. METHODS: Minimal inhibitory concentrations were determined against different species of microorganisms. To evaluate the modulatory effect on the Norfloxacin-resistance, the MIC of this antibiotic was determined in the absence and presence of the natural products at subinhibitory concentrations. Inhibition of the EtBr efflux assays were conducted in the absence or presence of natural products. RESULTS: PIHA showed a microbicidal effect against S. aureus and C. albicans, while PIAE was bacteriostatic for S. aureus. PIAE and BF at subinhibitory concentrations were able to reduce the MIC of Norfloxacin acting as modulating agents. BF was able to inhibit the efflux of EtBr efflux in S. aureus strains overexpressing specific efflux pump genes. CONCLUSION: P. inignisis, a source of efflux pump inhibitors, including volkensiflavone and morelloflavone, which were able to potentiate the Norfloxacin activity by NorA inhibition, being also able to inhibit QacA/B, TetK and MsrA. Volkensiflavone and morelloflavone could be used as an adjuvant in the antibiotic therapy of multidrug resistant S. aureus strains overexpressing efflux pumps.
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Antibacterianos/farmacologia , Proteínas de Bactérias , Biflavonoides/farmacologia , Clusiaceae , Resistência a Medicamentos , Staphylococcus aureus , Proteínas de Bactérias/antagonistas & inibidores , Proteínas de Bactérias/metabolismo , Resistência a Medicamentos/efeitos dos fármacos , Resistência a Medicamentos/fisiologia , Flores , Testes de Sensibilidade Microbiana , Extratos Vegetais/farmacologia , Staphylococcus aureus/efeitos dos fármacos , Staphylococcus aureus/metabolismoRESUMO
OBJECTIVE: Juvenile-onset systemic lupus erythematosus (JoSLE) is associated with low bone mass for age and fractures; nevertheless, risk factors for bone impairment are poorly understood. The aim of this study was to evaluate risk factors for bone mass loss in JoSLE patients. METHODS: Forty-nine female JoSLE patients were evaluated at baseline and after a 3.5-year follow-up regarding clinical, laboratory (including bone turnover markers), areal bone mineral density (aBMD) and bone microarchitecture parameters using high-resolution peripheral quantitative computed tomography (HR-pQCT). Based on the difference between final and baseline aBMD value, the patients were divided into three groups: aBMD gain (BG), aBMD loss (BL) and aBMD no change (NC). RESULTS: The mean patient age was 18.7 ± 3.3 years. Sixty-one percent of patients presented with aBMD gain, 18.4% aBMD loss, and 20.4% remained stable during this follow-up period. Comparing the BL with the BG group, there was a higher frequency of alcohol consumption (p = 0.009), a higher frequency of inadequate calcium intake (p = 0.047) and lower levels of baseline procollagen type 1 amino-terminal propeptide (P1NP) (p = 0.036) in the BL group. Moreover, worsening of HR-pQCT parameters trabecular volumetric density (p = 0.003) and cortical thickness (p = 0.009) was observed in the BL group. In addition, a higher frequency of renal activity was observed comparing the BL + NC with the BG group (p = 0.036). CONCLUSIONS: This is the first longitudinal study that has analyzed the risk factors of bone loss in JoSLE patients. The authors emphasize the importance of evaluating lifestyle habits and renal disease activity in these young women. Furthermore, this study suggests that trabecular and cortical compartments deteriorated, and low levels of P1NP may be a predictor of bone impairment in JoSLE.
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Densidade Óssea/fisiologia , Osso e Ossos/patologia , Lúpus Eritematoso Sistêmico/complicações , Adolescente , Consumo de Bebidas Alcoólicas/epidemiologia , Osso e Ossos/metabolismo , Cálcio/administração & dosagem , Feminino , Seguimentos , Humanos , Nefropatias/etiologia , Nefropatias/fisiopatologia , Estilo de Vida , Estudos Longitudinais , Lúpus Eritematoso Sistêmico/fisiopatologia , Estudos Prospectivos , Fatores de Risco , Tomografia Computadorizada por Raios X , Adulto JovemRESUMO
The aim of this systematic review was to describe the anatomical and surgical factors related to cranial nerve injuries in Le Fort I osteotomy. The protocol of this systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO). Two independent reviewers performed an unrestricted electronic database search in the MEDLINE/PubMed, LILACS, Scopus, Web of Science, and Cochrane databases up to and including August 2018. Thirty-two articles were selected for data extraction and synthesis: 30 studies were identified in the main search and two by a manual search. The level of agreement between the reviewers was considered excellent (κ=0.779 for study selection and κ=0.767 for study eligibility). This study revealed that the main nerve affected was the trigeminal nerve, followed by the oculomotor, abducens, optic, facial, and vagus and accessory nerves. Cleft lip and palate patients presented the highest incidence of cranial nerve damage. Cranial nerve damage after Le Fort I osteotomy is not rare. Anatomical and structural knowledge of the patient are necessary in order to minimize the risks of cranial nerve injury in Le Fort I osteotomy.
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Fenda Labial , Traumatismos dos Nervos Cranianos , Humanos , Maxila , Osteotomia Maxilar , Osteotomia de Le Fort , Estudos ProspectivosRESUMO
Soybean (Glycine max L.)-breeding programs aim to develop cultivars with high grain yields and high tolerance to Asian soybean rust (Phakopsora pachyrhizi). Considering that the traits targeted for breeding are mainly quantitative in nature, knowledge of associations between traits allows the breeder to formulate indirect selection strategies. In this study, we investigated phenotypic, genotypic, and environmental correlations between the agronomic traits of soybean plants naturally infected with P. pachyrhizi, and identified agronomic traits that would be useful in indirectly selecting soybean genotypes for high yields. The study was conducted on the Capim Branco Farm, Uberlândia, Brazil, with 15 soybean genotypes, which were cultivated in a completely randomized block design with four replications. Fourteen phenotypic traits were evaluated using the GENES software. The phenotypic and genotypic correlations were positive and of a high magnitude between the total number of pods and the number of pods with two or three grains, indicating that the total number of pods is a useful trait for the indirect selection of soybean genotypes for high grain yields. Strong environmental correlations were found between plant height at blooming and maturity and grain yield and yield components.
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Glycine max/genética , Phakopsora pachyrhizi/genética , Doenças das Plantas/genética , Locos de Características Quantitativas/genética , Brasil , Cruzamento , Regulação da Expressão Gênica de Plantas , Genótipo , Phakopsora pachyrhizi/patogenicidade , Fenótipo , Glycine max/crescimento & desenvolvimento , Glycine max/microbiologiaRESUMO
This study aimed to comparatively analyse the electromyographic activity of the masseter and temporal muscles at rest and during mandible postural clinical conditions (right and left laterality, protrusion and maximum voluntary contraction), right and left maximum molar bite forces and the masticatory efficiency of individuals with schizophrenia or mood disorders - all medicated (medicated groups) compared with control group (healthy volunteers) via electromyography. Individuals were distributed into three groups: Group I (Schizophrenia - 20 individuals), Group II (mood disorders - 20 individuals) and Group III (Control - 40 individuals). Basically, the results were only statistically significant for the clinical mandible conditions and bite force. The most unsatisfactory results were observed in the medicated groups in relation to the control group. The group with mood disorders obtained the most unsatisfactory results compared with the group with schizophrenia. It was suggested by these observations that the association of mood disorders and schizophrenia with medication has negatively affected the stomatognathic system in relation to controls when the electromyography and bite force were used for the analysis.
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Força de Mordida , Músculo Masseter/fisiopatologia , Mastigação/fisiologia , Transtornos do Humor/fisiopatologia , Esquizofrenia/fisiopatologia , Músculo Temporal/fisiopatologia , Adulto , Estudos de Casos e Controles , Eletromiografia/métodos , Feminino , Humanos , Masculino , Músculo Masseter/efeitos dos fármacos , Pessoa de Meia-Idade , Transtornos do Humor/tratamento farmacológico , Esquizofrenia/tratamento farmacológico , Músculo Temporal/efeitos dos fármacos , Adulto JovemRESUMO
BACKGROUND: Presence of tumor markers in serum might be connected to the number of secreting cells and with the stage of the neoplasm. However, there are few studies regarding these markers in veterinary clinical oncology. OBJECTIVES: To determine the serum concentrations of cancer antigen 15.3 (CA 15.3), carcinoembryonic antigen (CEA), and lactate dehydrogenase (LDH) in female dogs with different stages of mammary cancer. ANIMALS: Ninety female dogs, including 30 that were healthy, 40 that had nonmetastatic cancer, 12 with regional metastasis, and 8 with distant lymph node metastasis. METHODS: Prospective case-controlled observational study. Serum samples were collected to measure CA15.3, CEA, and LDH from 60 female dogs with mammary cancer during mastectomy and 30 healthy female dogs during routine check-up. CA15.3 and CEA were determined by chemiluminescent immunoassay and LDH by ultraviolet kinetic method. Western blotting analysis was performed to confirm the specificity and possible cross-reactivity of human CA15.3 and CEA antibodies with canine serum. Group data were compared by ANOVA followed by Student-Newman-Keuls and Tukey's tests. Correlations were investigated by Pearson and Spearman tests. RESULTS: CEA, CA15.3, and LDH were measurable in all groups. Higher serum concentration of CA15.3 and LDH was associated with regional and distant metastases. There was a significantly higher serum CA15.3 concentration in animals with lymph node metastasis when compared with animals without metastasis. There were no significant differences in CEA among groups. Expression of CA15.3 and CEA in canine serum was confirmed by Western blotting. CONCLUSIONS AND CLINICAL IMPORTANCE: Serum CA15.3 can be used to distinguish nonmetastatic from metastatic carcinomas.
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Antígeno Carcinoembrionário/sangue , Doenças do Cão/sangue , Regulação Neoplásica da Expressão Gênica/fisiologia , L-Lactato Desidrogenase/sangue , Neoplasias Mamárias Animais/sangue , Adenocarcinoma/sangue , Adenocarcinoma/metabolismo , Adenocarcinoma/veterinária , Animais , Biomarcadores Tumorais , Antígeno Carcinoembrionário/genética , Antígeno Carcinoembrionário/metabolismo , Carcinoma/sangue , Carcinoma/metabolismo , Carcinoma/veterinária , Estudos de Casos e Controles , Doenças do Cão/metabolismo , Cães , Feminino , L-Lactato Desidrogenase/genética , L-Lactato Desidrogenase/metabolismo , Neoplasias Mamárias Animais/classificação , Neoplasias Mamárias Animais/metabolismoRESUMO
It has been proposed that the subgenus Archaeotityus comprises the most ancient species group within the medically important scorpion genus Tityus. cDNA encoding sodium-channel active toxins from the type species of this subgenus, Tityus clathratus (central Venezuela), have been isolated and sequenced. Two cDNAs were retrieved that encoded 61 amino acid-long putative neurotoxins named Tcl1 and Tcl2. Sequence identity was highest (87%) when both were compared with -toxin Ts1 from the Brazilian scorpion Tityus serrulatus and its homologs from T. bahiensis, T. stigmurus, and T. costatus. A Bayesian analysis indicated statistical support for the grouping of T. clathratus Tcl1 and Tcl2 with Brazilian gamma-like -toxins, reinforcing previous phylogenetic studies which suggested an evolutionary relationship between the subgenus Archaeotityus and scorpion species inhabiting southeast South America belonging to the subgenus Tityus.
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It has been proposed that the subgenus Archaeotityus comprises the most ancient species group within the medically important scorpion genus Tityus. cDNA encoding sodium-channel active toxins from the type species of this subgenus, Tityus clathratus (central Venezuela), have been isolated and sequenced. Two cDNAs were retrieved that encoded 61 amino acid-long putative neurotoxins named Tcl1 and Tcl2. Sequence identity was highest (87%) when both were compared with -toxin Ts1 from the Brazilian scorpion Tityus serrulatus and its homologs from T. bahiensis, T. stigmurus, and T. costatus. A Bayesian analysis indicated statistical support for the grouping of T. clathratus Tcl1 and Tcl2 with Brazilian gamma-like -toxins, reinforcing previous phylogenetic studies which suggested an evolutionary relationship between the subgenus Archaeotityus and scorpion species inhabiting southeast South America belonging to the subgenus Tityus.
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AIM: The mandibular division of the trigeminal nerve is the largest of the three major divisions of the trigeminal nerve (fifth cranial nerve). In this way, many health professionals belonged to different fields are commonly evaluating patients suffering with orofacial pain and stomatognatic dysfunction associated to this structure. But, in the most cases, it is difficult to establish a correct diagnosis due to the anatomical complexity of the head and neck surfaces, especially when the focus is the trigeminal nerve. Thus, the objective of this research was to present the anatomical variations of the mandibular nerve and its branches correlated to more common clinical situations. METHODS: For this purpose, 20 human heads were anatomically dissected, so to study their structures, an external, medial and endocranial view. RESULTS: No significant variations related to ophthalmic and maxillary nerves were observed. Anatomical variations were observed in 20% of the total human heads dissected, all related to mandibular nerve and its branches: masseter, temporal, auriculotemporal and lingual. Variations in three to seven, on the number of the following nerves ramus, masseter and temporal were described. CONCLUSIONS: According to the present data using the described methodology, it was possible to conclude that anatomical variations are present in many subjects and they can explain many clinical situations that involve the stomatognathic structures.
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Variação Genética , Nervo Mandibular/anatomia & histologia , Adulto , Nervo da Corda do Tímpano/anatomia & histologia , Dor Facial/etiologia , Humanos , Complicações Intraoperatórias/prevenção & controle , Nervo Lingual/anatomia & histologia , Traumatismos do Nervo Lingual , Masculino , Mandíbula/anatomia & histologia , Pessoa de Meia-Idade , Traumatismos do Nervo TrigêmeoRESUMO
UNLABELLED: The masseter and temporal muscles of patients with maxillary and mandibular osteoporosis were submitted to electromyographic analysis and compared with a control group. In conclusion, individuals with osteoporosis did not show significantly lower masticatory cycle performance and efficiency compared to the control group during the proposal mastications. INTRODUCTION: This study aimed to examine electromyographically the masseter and temporal muscles of patients with maxillary and mandibular osteoporosis and compare these patients with control patients. METHODS: Sixty individuals of both genders with an average age of 53.0 +/- 5 years took part in the study, distributed in two groups with 30 individuals each: (1) individuals with osteoporosis; (2) control patients during the habitual and non-habitual mastication. The electromyographic apparel used was a Myosystem-BR1-DataHomins Technology Ltda., with five channels of acquisition and electrodes active differentials. Statistical analysis of the results was performed using SPSS version 15.0 (Chicago, IL, USA). RESULTS: The result of the Student's t test indicated no significant differences (p > 0.05) between the normalized values of the ensemble average obtained in masticatory cycles in both groups. CONCLUSION: Based on the results of this study, it was concluded that individuals with osteoporosis did not show significantly lower masticatory cycle performance and efficiency compared to control subjects during the habitual and non-habitual mastications. This result is very important because it demonstrates the functionality of the complex physiological process of mastication in individuals with osteoporosis at the bones that compose the face.
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Mandíbula/fisiopatologia , Mastigação/fisiologia , Maxila/fisiopatologia , Osteoporose/fisiopatologia , Idoso , Estudos de Casos e Controles , Eletromiografia , Feminino , Humanos , Masculino , Músculo Masseter/fisiopatologia , Pessoa de Meia-Idade , Músculo Temporal/fisiopatologiaRESUMO
INTRODUCTION: The physical activity and adequate food plays a key role in improving health and the control of diseases. OBJECTIVE: This paper aims at determining the nutritional state through anthropometric measures, socioeconomic level, the most common illnesses and type of physical activity, beyond food consumption and the place where meals are taken, of under-graduate students of the Nutrition course in UFPE. METHODS: The sample is constituted of 68 female students, of different periods and at ages between 18 and 27 years old. The process of selection of the sample was for convenience. The students voluntarily participated and answered three questionnaires, respectively, on their socioeconomic level (income of the family) and possible illnesses they had, measures of the cutaneous folds and type of practiced physical activity; register of consumed foods and local where the meals were carried. Statistical analysis was performed by absolute frequency, percentage, average and standard deviation. The margin of error used in the testing employees was 5%. RESULTS: In relation to the incomes, they had predominated above three minimum wages (86%), the parents have a predominant role in the expenditure of their study (46%), followed by the father (24%), mother (9%), husband (4%), other responsible ones (10%); 7% did not give information. The most common illnesses were: allergic rhinitis, tonsillitis, sleeplessness and intestinal constipation. The weight, the height, the index of body mass and the relation waist hip of the students were within normal standards. The abdominal circumference varied only in 2.57 cm between the studied age range. In relation to the practice of physical activities, 67% were sedentary, 20% practiced light activity and 13% moderate. In relation to where the meals are had, breakfast, in its majority (76%), was carried at home, followed by supper (56%), while lunch (41%) and snack 1 (34%), at University. Among the pupils who did not inform the place where they had their meals there was a high percentage for the big meals and a small one for the minor ones. The main kinds of consumed meals were breakfast, lunch and supper (98%). For the small meals, the values were: snack 1 (54%), snack 2 (61%), snack 3 (45%). The analysis of food consumption for three days disclosed ingestion of energy with deficit of 21% in relation to the recommended one (p < 0.001); the macro-nutrients showed percentages within the standards; the intake of fiber (11.8 g/day) was less than recommended (p < 0.001). Meat, eggs and cereals were ingested daily (for about 80%); vegetables (40%), legumes, fruits and candies (25% 30%), around four or six days a week. Roots and tubercles, salty, embedded and non alcoholic drinks were consumed from one to three days weekly (70%). Animal guts were not consumed by 50% of the studied population. CONCLUSIONS: Having analyzed all this, the studied students need to modify their food habits, acquiring knowledge on the importance of a balanced diet, as well as the practice of physical activity systematically, to prevent illnesses and attain a better quality of life.
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Antropometria , Atividade Motora , Estado Nutricional , Estudantes , Adolescente , Adulto , Brasil , Feminino , Humanos , Fatores Socioeconômicos , UniversidadesRESUMO
This work reports the second record of the scorpion Tityus bahiensis Perty from Venezuela. The specimen was found alive in a wardrobe at a hotel resort in Margarita Island, northeastern Venezuela. Morphological characterization allowed its assignment to the Tityus bahiensis population inhabiting the southernmost area of the species' geographic range, e.g. the state of São Paulo in Brazil, northern Argentina and Paraguay. The fact that the only available Venezuelan antiscorpion (anti-Tityus discrepans) serum does not neutralize the effects of alpha- and beta-toxin from Tityus serrulatus venom (which resembles in composition that of T. bahiensis) constitutes a warning to local clinicians confronted with envenomations by noxious species transported to Venezuela from Brazil by human agency.
RESUMO
This work reports the second record of the scorpion Tityus bahiensis Perty from Venezuela. The specimen was found alive in a wardrobe at a hotel resort in Margarita Island, northeastern Venezuela. Morphological characterization allowed its assignment to the Tityus bahiensis population inhabiting the southernmost area of the species' geographic range, e.g. the state of São Paulo in Brazil, northern Argentina and Paraguay. The fact that the only available Venezuelan antiscorpion (anti-Tityus discrepans) serum does not neutralize the effects of alpha- and beta-toxin from Tityus serrulatus venom (which resembles in composition that of T. bahiensis) constitutes a warning to local clinicians confronted with envenomations by noxious species transported to Venezuela from Brazil by human agency.
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Animais , Escorpiões/anatomia & histologia , Venenos de Escorpião/toxicidade , Antivenenos , Venezuela/epidemiologiaRESUMO
ABSTRACT Sporotrichosis is a mycosis caused by the geophilic fungus Sporothrixschenckii that can infect different species of animals, including humans. The mycosis has a worldwide distribution, mainly in the tropical and subtropical regions. The infection is usually associated with the traumatic inoculation of soil, vegetables or organic materials contaminated by the fungus, being, therefore, considered an occupational mycosis, affecting mainly rural workers. The zoonotic potential of the domestic feline has been recognized since the 1980s, due to the presence of a great number of microorganisms present in this animal species. Concerning the important epidemiological role of the domestic feline, this study describes a case of cutaneous sporotrichosis with ascendant lymphangitis in a rural worker contaminated by an asymptomatic feline. One 40-year-old human male presented nodular injuries 15 days after being scratched by a cat. Samples of lesion exudates were collected for mycological analysis, which resulted in the isolation of the S. schenckii. After the diagnostic confirmation of sporotrichosis, treatment with cetoconazol was started, which resulted in the regression of the lesions. This study emphasizes the importance of the domestic feline as an important carrier of the sporotrichosis agent for humans.
RESUMO A esporotricose é uma micose causada pelo fungo geofílico Sporothrix schenckii que pode infectar diferentes espécies de animais, inclusive o homem. A micose tem distribuição mundial, principalmente nas regiões tropicais e subtropicais. A infecção está, normalmente, associada com a inoculação traumática de solo, vegetais ou materiais orgânicos contaminados pelo fungo, sendo, portanto, considerada uma micose ocupacional, afetando, principalmente trabalhadores rurais. O potencial zoonótico do felino doméstico tem sido reconhecido desde a década de 80, possivelmente devido ao grande número do organismo presente nessa espécie animal. Em vista do importante papel epidemiológico do felino doméstico, este estudo descreve um caso de esporotricose cutânea com linfangite ascedente em um trabalhador rural contaminado por um felino assintomático. Um humano, com 40 anos, do sexo masculino, apresentou lesões nodulares 15 dias após ter sido arranhado por um gato hígido. Foram coletadas amostras de exsudato das lesões para análise micológica, a qual resultou no isolamento do S. schenckii. Após a confirmação do diagnóstico de esporotricose, foi iniciado o tratamento com o cetoconazol que resultou na regressão das lesões. O estudo ressalta a importância do felino doméstico como importante carreador do agente da esporotricose para o homem.
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AIM: This study had the goal of analyzing masseter and temporalis muscles of individuals with Eagle's Syndrome, establishing comparisons with healthy control individuals by means of electromyography, due to the importance of the masticatory musculature upon the various functions of the stomatognathic system and the effects of Eagle's syndrome on this system's functioning. METHOD: Ten women with Eagle's syndrome and ten healthy controls volunteered to participate in the study. A Myosystem I system, Prosecon Ltda (Uberlândia/MG, Brazil) with 12 channels was used Active differential electrodes were placed on the belly of both masseters and on the anterior temporalis. Firstly, rest position was registered and then the patients were instructed to clench their teeth with maximum strength for four seconds to register the Clenching at Usual Maximum Intercuspation. Next, the clinical conditions of chewing, mandible laterality, and water swallowing were performed. RESULTS: The normalized data of muscle activity during the different clinical conditions and at rest position were compared by Student's t test, considering two groups: controls and syndrome bearers. The masticatory muscles of every syndrome bearers showed hyperactivity during the analyzed clinical conditions; except for chewing, in which the right masseter did not show greater electromyographic activity. CONCLUSION: It is concluded that individuals with the syndrome showed muscular hyperactivity when compared to healthy individuals, due to the interference of the elongated styloid process, which leads to dysfunctions of the stomatognathic system in the syndrome bearers, with signs and symptoms related to craniofacial pain, dysphagia, otalgy, temporomandibular dysfunctions, and headache.
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Doenças Ósseas/fisiopatologia , Eletromiografia , Músculo Masseter/fisiopatologia , Contração Muscular , Osso Temporal/anormalidades , Osso Temporal/fisiopatologia , Músculo Temporal/fisiopatologia , Adulto , Dor Facial/fisiopatologia , Feminino , Humanos , Mastigação , SíndromeRESUMO
Tityus gonzalespongai n. sp. is a species endemic to the high mountains of Anzoátegui State, Venezuela. It is found between 1,600 and 2,200 m in ''La Laguna'' mountain. Its habitat includes the area of ''Bosque Húmedo Montano Bajo'' with the type of vegetation of ''Bosque Ombrófilo Montano Siempreverde'' (''Bosques Nublados Costeros'' that includes the ''Subpáramos Arbustivos''). It is distinguished from other Tityus species (T. caripitensis, T. monaguensis, and T. nororientalis) by the following characteristics: 1- the disposition of the trichobothria in the pedipalps; 2- ventral keels of the caudal segments of the metasoma (segment II, double and parallel in the proximal two thirds, then convergent and finally divergent in the base; segments III and IV, double and parallel in the basal third, then convergent in a single keel that divides in the base); 3- the number of lines of denticles of the movable finger of the right pedipalp (male = 14; female = 14); 4- pectineous teeth (right/left: male = 15/15: female = 16/15); 5- color: movable and fixed fingers dark brown; prosoma and metasoma, ochre; caudal segment IV, slightly darker than the previous ones; V and the telson, dark brown. T. gonzalespongai belongs to the ''androcottoides'' group and presents a marked sexual dimorphism. It is the first species of the Tityus genus described and reported in Anzoátegui State, expanding this taxa distribution in Venezuela.
RESUMO
Tityus gonzalespongai n. sp. is a species endemic to the high mountains of Anzoátegui State, Venezuela. It is found between 1,600 and 2,200 m in "La Laguna" mountain. Its habitat includes the area of "Bosque Húmedo Montano Bajo" with the type of vegetation of "Bosque Ombrófilo Montano Siempreverde" ("Bosques Nublados Costeros" that includes the "Subpáramos Arbustivos"). It is distinguished from other Tityus species (T. caripitensis, T. monaguensis, and T. nororientalis) by the following characteristics: 1- the disposition of the trichobothria in the pedipalps; 2- ventral keels of the caudal segments of the metasoma (segment II, double and parallel in the proximal two thirds, then convergent and finally divergent in the base; segments III and IV, double and parallel in the basal third, then convergent in a single keel that divides in the base); 3- the number of lines of denticles of the movable finger of the right pedipalp (male=14; female=14); 4- pectineous teeth (right/left: male=15/15: female=16/15); 5- color: movable and fixed fingers dark brown; prosoma and metasoma, ochre; caudal segment IV, slightly darker than the previous ones; V and the telson, dark brown. T. gonzalespongai belongs to the "androcottoides" group and presents a marked sexual dimorphism. It is the first species of the Tityus genus described and reported in Anzoátegui State, expanding this taxa distribution in Venezuela.
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Animais , Escorpiões/anatomia & histologia , Escorpiões/classificação , Venezuela , Especificidade da EspécieRESUMO
A census of the sandfly fauna was undertaken in 1993-98 in 5 endemic leishmaniasis foci situated at different altitudes in Anzoátegui State, Venezuela. From the 17 species of Lutzomyia identified, we believe that Lu. ovallesi, Lu. panamensis and Lu. gomezi are the probable vectors of cutaneous leishmaniasis, while Lu. evansi might transmit visceral leishmaniasis.
Assuntos
Leishmaniose Cutânea/parasitologia , Leishmaniose Visceral/parasitologia , Psychodidae/classificação , Animais , Doenças Endêmicas , Feminino , Humanos , Insetos Vetores , Leishmaniose Cutânea/epidemiologia , Leishmaniose Visceral/epidemiologia , Masculino , Psychodidae/parasitologia , Venezuela/epidemiologiaRESUMO
We report new percutaneous techniques for perforating the pulmonary valve in pulmonary atresia with intact ventricular septum, in 3 newborns who had this birth defect. There was mild to moderate hypoplastic right ventricle, a patent infundibulum, and no coronary-cavitary communications. We succeeded in all cases, and no complications related to the procedure occurred. The new coaxial radiofrequency system was easy to handle, which simplified the procedure. Two patients required an additional source of pulmonary flow (Blalock-Taussig shunt) in the first week after catheterization. All patients had a satisfactory short-term clinical evolution and will undergo recatheterization within 1 year to define the next therapeutic strategy. We conclude that this technique may be safely and efficiently performed, especially when the new coaxial radiofrequency system is used, and it may become the initial treatment of choice in select neonates with pulmonary atresia and intact ventricular septum.