Assuntos
Antibióticos Antineoplásicos/análise , Streptomyces/análise , Troleandomicina/análise , Antibióticos Antineoplásicos/uso terapêutico , Espectroscopia de Ressonância Magnética , Naftacenos/análise , Naftacenos/uso terapêutico , Neoplasias Experimentais/tratamento farmacológico , Troleandomicina/uso terapêuticoRESUMO
The authors present the first observations on the isolation of two quinonoid compounds from Hyptis fructicosa Salzm ex Benth; Labiatae. The referred naturally compounds present antimicrobial and antineoplastic activity against Gram-positive microrganisms and mouse Erlich carcionama, respectivelly.
Assuntos
Antineoplásicos Fitogênicos/isolamento & purificação , Extratos Vegetais/isolamento & purificação , Plantas Medicinais , Quinonas/isolamento & purificação , Animais , Antineoplásicos Fitogênicos/uso terapêutico , Bactérias/efeitos dos fármacos , Carcinoma de Ehrlich/tratamento farmacológico , Avaliação de Medicamentos , Resistência Microbiana a Medicamentos , Métodos , Camundongos , Testes de Sensibilidade Microbiana , Transplante de Neoplasias , Neoplasias Experimentais/tratamento farmacológico , Fitoterapia , Extratos Vegetais/uso terapêutico , Quinonas/uso terapêutico , Sarcoma 180/tratamento farmacológicoRESUMO
This paper deals with the stimulatory effect of the compound 2-methyl-1,4-naphthoquinone, Menadione (vit. K3), in young chicken, during the growing period. That's the case of other products like Bacitracin, Actinomycin D and Terramycin, whose hormetic activity is supplanted by the referred Menadione. Authors present the experimental data with analytical discussion of the results.
Assuntos
Crescimento/efeitos dos fármacos , Vitamina K/farmacologia , Análise de Variância , Animais , Bacitracina/farmacologia , Peso Corporal/efeitos dos fármacos , Galinhas , Dactinomicina/farmacologia , Feminino , Masculino , Oxitetraciclina/farmacologia , Estimulação Química , Fatores de TempoRESUMO
In the course of our program on the antimicrobial and antineoplastic substances from higher plants we have studied many flavonoid compounds isolated from root back of Lonchocarpus neuroscapha Benth. In the present paper a slight effect on sarcoma 180 and Ehrlich carcinoma of cordoin, 4-hydroxy-cordoin and 4-hydroxy-derricin, as well as the only observed effect of derricin on sarcoma 180 were observed. The antimicrobial action of four prenylated chalcones, i.e. 4-hydroxy-derricin, 4-hydroxy-lonchocarpin, 4-hydroxy-cordoin and 4-hydroxy-isocordoin is reported.
Assuntos
Antineoplásicos Fitogênicos/isolamento & purificação , Chalcona/isolamento & purificação , Propiofenonas/isolamento & purificação , Animais , Antineoplásicos Fitogênicos/farmacologia , Bactérias/efeitos dos fármacos , Carcinoma de Ehrlich/tratamento farmacológico , Chalcona/análogos & derivados , Chalcona/farmacologia , Resistência Microbiana a Medicamentos , Dose Letal Mediana , Camundongos , Testes de Sensibilidade Microbiana , Extratos Vegetais , Sarcoma 180/tratamento farmacológicoRESUMO
In this paper the authors present the first report concerning the biological effects of a diterpene isolated from Croton aff. argyrophylloides Muell. Arg (Euphorbiaceae). Some biological and physiochemical properties of the antibiotic, named argyrophillic acid, were appreciated in comparison with those presented by cunabic acid, an antibiotic isolated from Icthyothere cunabi. The authors still show the microbial action of the abietic acid and confront it with that of the argyrophilic acid, the new antibiotic here reported.