RESUMO
Leukoplakia, a common lesion in the oral cavity, is considered a premalignant lesion that can develop into carcinoma. In 1986, a group of pathologists described a variant of epithelial dysplasia and named it "koilocytic dysplasia" (KD). This article presents a case of KD that was identified for 12 years as "carcinoma in situ". Even after removal of the lesion, it recurred with no signs of malignancy. The histopathological findings revealed all of the signs of KD (koilocytosis, acanthosis, multinucleated keratinocytes and atypical mitoses). Liquid-based cytology and hybrid capture were performed to confirm the diagnosis. Despite a professional recommendation to have the lesion removed surgically, the patient chose periodic clinical control. The mechanism of HPV transmission in the oral cavity still remains partially unknown. Additional studies on this subject are required to better understand the role of HPV in cell transformation in the oral cavity.
Assuntos
Leucoplasia Oral , Humanos , Leucoplasia Oral/patologia , Leucoplasia Oral/cirurgia , Masculino , Pessoa de Meia-Idade , Recidiva , Fatores de TempoRESUMO
In this study, 14 mild-to-moderate essential hypertensive patients of both sexes were studied with regard to the effects of two different treatments, urapidil (60 to 180 mg/day) and diuretics (chlorthalidone and hydrochlorothiazide-25 to 50 mg/day) on glucose metabolism, insulin sensitivity and plasma lipid profile. Blood pressure was equally reduced by both treatments. However, urapidil treatment was accompanied by significant lower plasma levels of cholesterol, HDL-cholesterol and triglycerides as compared with diuretic treatment. Also, a significantly higher insulin sensitivity index, determined by the euglycemic insulin clamp technique, was observed during urapidil therapy. Our results demonstrated that urapidil is as effective as diuretics in reducing blood pressure of essential hypertensive patients, with the potential advantage of a favorable profile in regard to the glucose and lipid metabolisms.