RESUMO

We did a meta-analysis on all publications (English and other languages) concerned with platelet monoamine oxidase (MAO) in schizophrenia. Essentially, when patients were medicated with a neuroleptic, most studies found that schizophrenics had lower platelet MAO levels than controls. Administration of neuroleptic lowers MAO levels. MAO levels in drug-free schizophrenics were similar to controls. Only a minority of studies found drug-free schizophrenics had decreased platelet MAO levels.

Assuntos

RESUMO

This investigation was conducted with the object of comparing the retention capacity of two visible-light-activated sealants (Concise-3M and Sealite-Kerr) with the more commonly used autopolymerizing sealant (Delton-Johnson & Johnson). The study included sixty-two children, thirty-five boys and twenty-seven girls, between six and eleven years of age. Two hundred twenty-nine first permanent molar occlusal surfaces were treated with sealants (118 maxillary molars and 111 mandibular molars). Sealants were applied according to the manufactures' instructions and cotton rolls were used for partial isolation. After six, twelve, eighteen and twenty-four months, the surfaces treated with the sealants were examined and evaluated. Three categories were used to evaluate each sealant. During each evaluation period the sealants were graded according to complete, partial, or failed retention. No significant difference was noted between Concise and Delton sealants for C when comparing maxillary and mandibular teeth. Significant differences were observed between Concise and Sealite in relation to C on the maxillary and mandibular arches and also between Sealite and Delton on the maxillary arch. There were no significant differences in retention between the maxillary and mandibular teeth, when the same type of sealant was used.

Assuntos

RESUMO

In 1979, the dental health program of the New Mexico Health and Environment Department began a school-based sealant activity. Children in the first, second, third, sixth, and seventh grades in selected New Mexico communities were offered sealants through this sealant activity. During the 1984-85 school year, program staff began seeing several hundred sixth-grade students who had received sealants in either the first, second, or third grade. Tooth- and surface-specific data on the current condition of all the previously sealed occlusal surfaces were collected from all these previous recipients of sealants. During the 1985-86 school year, we found that sixth-grade students who received sealants as first, second, or third graders had 5.6 percent of the occlusal surfaces of their first permanent molars either decayed, missing, or filled. Their classmates who had not previously received sealants had 26.85 percent of the same tooth surfaces either decayed, missing, or filled. During the 1985-86 school year, the complete retention rates for sealants were found to be 67.36 percent after six years, 78.53 percent after five years, and 93.47 percent after one year. The partial retention rates were found to be 10.46 percent after six years, 10.63 percent after five years, and 3.04 percent after one year.

Assuntos

Assuntos

RESUMO

We studied the relationship between the excretion of 3-methoxy-4-hydroxyphenylglycol, the main metabolite of central nervous system norepinephrine, and homovanillic acid, the main metabolite of dopamine, in 16 hyperactive boys and ten controls who were admitted to a clinical research center. We further examined the effect of d-amphetamine (0.5 mg/kg body weight daily for two weeks) on that relationship. The correlation coefficients r between MHPG and HVA excretion were significantly negative in hyperactive boys and significantly positive in controls when the relational effects of age, body surface, and 24-hour urinary creatinine with MHPG and HVA excretion were removed. Furthermore, the correlation coefficient r in hyperactive boys and in responders at baseline differed significantly from the correlation coefficients in post-treatment and in controls. The post-treatment correlation coefficient in hyperactive boys and responders did not differ from that in controls. We suggest an altered relationship between DA and NE activity in hyperactive children. Meaningful interpretation of the data should await the availability of more information on the amount of contribution of central NE and DA metabolism to urinary MHPG and HVA in both hyperactive and normal children.

Assuntos

RESUMO

The 24-hour urinary catecholamine metabolites 3-methoxy-4-hydroxyphenylglycol, normetanephrine, and metanephrine were measured in 23 hyperactive boys and 13 matched healthy controls. The hyperactive children excreted lower MHPG and higher NM (low MHPG/NM ratio) amounts than in controls. The administration of d-amphetamine in the dose of 0.5 mg/kg body weight divided over two doses daily for two weeks decreased MHPG excretion in the hyperactive children. When the hyperactive children group was divided into drug responders and nonresponders according to their pre- and post-treatment scores on the Conners Teacher Questionnaire, d-amphetamine administration decreased MHPG excretion in the responders and did not change it in the nonresponders. Percent decrease in MHPG excretion correlated significantly with percent change in the hyperactivity factor of the questionnaire on the Spearman Rank Order Correlation Coefficient. Pretreatment urinary metabolites did not differentiate the responders from nonresponders. It is suggested that a relationship between CNS norepinephrine metabolism and hyperactivity exists and that d-amphetamine may achieve its therapeutic action in hyperactive children by altering CNS NE metabolism.

Assuntos

Assuntos