RESUMO
Serotonin 2C receptors (5HT2C) are involved in serotonin-driven dynamic equilibrium adjustments responsible for homeostatic stability in brain structures that modulate behavior and emotions. Single nucleotide polymorphisms (SNPs) from the serotonin 2C receptor gene (HTR2C) have been associated with several neurological and mental disorders, including abnormalities in cognitive and emotional processes. The aim of this study was to evaluate the association between the rs6318 SNP of the HTR2C gene and behavioral characteristics exhibited by children and adolescents based on the Child Behavior Checklist (CBCL/6-18) inventory. Eighty-five psychiatric outpatients between 8 and 18 years of age underwent genotyping of the rs6318 SNP. The CBCL/6-18 scale was administered to their caregivers. The chi-squared test was used to assess differences in the frequency of C and G alleles of the rs6318 SNP relative to the grouped CBCL/6-18 scores; significance level was 5%. The presence of the G allele of rs6318 was found to be associated with characteristics of aggressive behavior and social problems, and aggressive behavior was found to be associated with heterozygosis in females. These findings contribute to the identification of mental and behavioral phenotypes associated with gene expression.
Assuntos
Transtornos do Comportamento Infantil/genética , Transtornos Mentais/genética , Receptor 5-HT2C de Serotonina/genética , Adolescente , Alelos , Lista de Checagem , Distribuição de Qui-Quadrado , Criança , Transtornos do Comportamento Infantil/diagnóstico , Estudos Transversais , Feminino , Frequência do Gene/genética , Interação Gene-Ambiente , Genótipo , Humanos , Masculino , Transtornos Mentais/diagnóstico , Polimorfismo de Nucleotídeo Único/genética , Escalas de Graduação Psiquiátrica , Fatores Sexuais , Inquéritos e QuestionáriosRESUMO
Serotonin 2C receptors (5HT2C) are involved in serotonin-driven dynamic equilibrium adjustments responsible for homeostatic stability in brain structures that modulate behavior and emotions. Single nucleotide polymorphisms (SNPs) from the serotonin 2C receptor gene (HTR2C) have been associated with several neurological and mental disorders, including abnormalities in cognitive and emotional processes. The aim of this study was to evaluate the association between the rs6318 SNP of the HTR2C gene and behavioral characteristics exhibited by children and adolescents based on the Child Behavior Checklist (CBCL/6-18) inventory. Eighty-five psychiatric outpatients between 8 and 18 years of age underwent genotyping of the rs6318 SNP. The CBCL/6-18 scale was administered to their caregivers. The chi-squared test was used to assess differences in the frequency of C and G alleles of the rs6318 SNP relative to the grouped CBCL/6-18 scores; significance level was 5%. The presence of the G allele of rs6318 was found to be associated with characteristics of aggressive behavior and social problems, and aggressive behavior was found to be associated with heterozygosis in females. These findings contribute to the identification of mental and behavioral phenotypes associated with gene expression.
Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Transtornos do Comportamento Infantil/genética , Receptor 5-HT2C de Serotonina/genética , Transtornos Mentais/genética , Escalas de Graduação Psiquiátrica , Distribuição de Qui-Quadrado , Transtornos do Comportamento Infantil/diagnóstico , Estudos Transversais , Inquéritos e Questionários , Polimorfismo de Nucleotídeo Único/genética , Alelos , Lista de Checagem , Interação Gene-Ambiente , Frequência do Gene/genética , Genótipo , Transtornos Mentais/diagnósticoRESUMO
No presente trabalho é feita uma revisao histórica e psicopatológica do distúrbio borderline. O autor sugere que a categoria clínica introduzida por Kahlbaum, em 1890, chamada "Heboidophrenie", pode ser considerada como um protoconceito na origem do conceito de transtorno borderline. No final dos anos 70 e anos 80, sob a influência do DSM-III, a esquizofrenia latente ou borderline se transforma em dois subtipos de transtorno de personalidade: esquizotípico e borderline. Alguns aspectos psicopatológicos do distúrbio borderline de personalidade sao revistos, com especial ênfase sobre os sintomas afetivos e as alteraçoes no plano da interaçao social.
Assuntos
Humanos , História do Século XIX , História do Século XX , Transtorno da Personalidade Borderline , Transtorno da Personalidade Borderline/história , Transtorno da Personalidade Borderline/patologia , Transtorno da Personalidade Borderline/psicologiaRESUMO
Religiosity is a complex and fundamental socio-cultural phenomenon. Its possible positive or negative influence on the ethiology and treatment of mental illness remains controversial. Evangelical sects, specially the Pentecostals, have expanded dramatically in the last 40 years, in Latin America. Until now, the socio-cultural implications of this process have not been systematically studied. In the present study a group of patients admitted to a psychiatric unit in a general hospital in Campinas, Brazil, was investigated. Diagnosis distribution and length of hospital stay was related to religion affiliation. More functional psychosis and a shorter length of stay was found in the Pentecostal group. Possible implications of these findings are critically discussed.
Assuntos
Cristianismo , Transtornos Mentais/psicologia , Religião e Psicologia , Adulto , Brasil , Cultura , Feminino , Hospitalização , Hospitais Gerais , Humanos , Tempo de Internação , Masculino , Transtornos Mentais/reabilitação , Pessoa de Meia-IdadeRESUMO
No presente trabalho säo apresentadas algumas das contribuiçöes da filosofia do pensador francês Henri Bergson (1859-1941) para a psicopatologia. Diferentes aspectos da evoluçÒo do pensamento de Bergson säo apresentados, particularmente suas concepçöes do tempo e da intuiçäo. Nesse sentido o dualismo bergsoniano, que contrapöe o tempo cronológico ao tempo vivido e a inteligência à intuiçäo, serve de modelo a uma aproximaçÒo epistemologicamente aceitável entre a psicopatologia médica e objetivista de um lado e a psicopatologia subjetivista (p.ex. a fenomenologia existencial e a psicanálise) do lado oposto.
Assuntos
Humanos , Intuição , Psicopatologia , FilosofiaRESUMO
Religiosity is a complex and fundamental socio-cultural phenomenon. Its possible positive or negative influence on the ethiology and treatment of mental illness remains controversial. Evangelical sects, specially the Pentecostals, have expanded dramatically in the last 40 years, in Latin America. Until now, the socio-cultural implications of this process have not been systematically studied. In the present study a group of patients admitted to a psychiatric unit in a general hospital in Campinas, Brazil, was investigated. Diagnosis distribution and length of hospital stay was related to religion affiliation. More functional psychosis and a shorter length of stay was found in the Pentecostal group. Possible implications of these findings are critically discussed.
RESUMO
Religiosity is a complex and fundamental socio-cultural phenomenon. Its possible positive or negative influence on the ethiology and treatment of mental illness remains controversial. Evangelical sects, specially the Pentecostals, have expanded dramatically in the last 40 years, in Latin America. Until now, the socio-cultural implications of this process have not been systematically studied. In the present study a group of patients admitted to a psychiatric unit in a general hospital in Campinas, Brazil, was investigated. Diagnosis distribution and length of hospital stay was related to religion affiliation. More functional psychosis and a shorter length of stay was found in the Pentecostal group. Possible implications of these findings are critically discussed.
RESUMO
The planning and organization of mental health care in developing countries frequently lacks empirical data. The World Health Organization recommended psychiatric brief inpatient programs in general hospitals for these countries as a cost-effective alternative to the traditional mental hospital. Length of hospital stay is a crucial factor in a cost-effective mental health care organization. In a newly organized psychiatric inpatient unit in a general teaching hospital in Brazil we investigated the influence of 16 socio-demographic and clinical variables on the length of stay. Distance from residence to hospital (P less than 0.10), clinical diagnosis (P less than 0.05) and religious affiliation (P less than 0.05) were significantly related to length of stay. Possible mental health care implications of this short stay program are discussed.
Assuntos
Comparação Transcultural , Países em Desenvolvimento , Tempo de Internação/estatística & dados numéricos , Unidade Hospitalar de Psiquiatria/estatística & dados numéricos , Adolescente , Adulto , Idoso , Brasil , Feminino , Hospitais Gerais/estatística & dados numéricos , Humanos , Masculino , Pessoa de Meia-IdadeAssuntos
Tempo de Internação , Transtornos Mentais/diagnóstico , Religião , Adulto , Brasil , Catolicismo , Feminino , Humanos , Masculino , Cura Mental , Probabilidade , Religião e PsicologiaRESUMO
Existe atualmente grande preocupaçäo em relaçäo ao consumo crescente de drogas. Algumas dessas drogas säo usadas em medicina e apresentam maior potencial para o desenvolvimento de dependência e intoxicaçäo. A partir de aspectos observados em seu serviço, os autores alertam para o perigo do uso näo-médico de propoxifeno. Descrevem alguns pontos da farmacologia, dependência física e intoxicaçäo por esse analgésico. Recomendam seu uso criterioso em casos de pacientes com tendência suicida ou propensos à toxicomania e alcoolismo