RESUMO
Symptoms and laboratory evidence of adrenal suppression developed in 2 children with the human immunodeficiency virus after megestrol acetate (MA) therapy was discontinued; both required transient glucocorticoid replacement therapy. High-dose corticotropin stimulation testing performed on children with the human immunodeficiency virus treated or not treated with MA showed that baseline and post-corticotropin cortisol levels were extremely low in 7 of 10 treated patients and normal in 10 of 10 members of a control group (P <.01). MA may suppress adrenal function, and replacement glucocorticoids may prevent or relieve associated symptoms at times of severe stress or on discontinuation of MA therapy.
Assuntos
Insuficiência Adrenal/etiologia , Estimulantes do Apetite/uso terapêutico , Infecções por HIV/complicações , HIV-1 , Acetato de Megestrol/uso terapêutico , Insuficiência Adrenal/sangue , Insuficiência Adrenal/diagnóstico , Hormônio Adrenocorticotrópico , Estimulantes do Apetite/efeitos adversos , Distribuição de Qui-Quadrado , Criança , Pré-Escolar , Feminino , Infecções por HIV/sangue , Infecções por HIV/tratamento farmacológico , Humanos , Hidrocortisona/sangue , Masculino , Acetato de Megestrol/efeitos adversos , Estatísticas não Paramétricas , Síndrome de Abstinência a Substâncias/sangue , Síndrome de Abstinência a Substâncias/diagnósticoRESUMO
Two infants with congenital syphilis and persistent hypoglycemia were found to have hypopituitarism. Hypopituitarism should be recognized as a potential complication of congenital syphilis; affected infants with persistent hypoglycemia should receive a prompt evaluation of pituitary function.