RESUMO
In elastic stable intramedullary nailing (ESIN), there are different opinions among surgeons on whether to leave the nail buried in the same arm or to leave it exposed. OBJECTIVE: To determine the risk of re-fracture in patients with a nail buried directly into the amr or left exposed as a treatment for forearm fractures, and to investigate postoperative complications. PATIENTS AND METHOD: The study included 113 pediatric patients with a forearm fracture of both diaphyses. Two groups were formed according to whether the nail was buried (Group B, n: 53) in the same arm or left exposed (Group E, n: 60). Data on the number of open reductions, the time to nail removal, the anesthesia type used for its removal, the number of re-fractures, skin infection, and nail entry site irritation were analyzed. RESULTS: The mean union times between the groups were not significantly different (P = 0.371). The mean time of nail removal in group B (16.02 ± 1.29 weeks) was significantly longer than that of group E (6.65 ± 0.95 weeks) (P < 0.001). Open reduction rates were similar between groups (P = 0.401). The general anesthesia rate for nail removal in group B (77.4%) was significantly higher than group E (11.7%) (P < 0.001). The re-fracture rate was higher in patients who underwent open reduction in both groups (P < 0.001). CONCLUSION: The results of this study demonstrated that, despite the increased infection rate, leaving the nail exposed did not increase the re-fracture rate, which was associated with open reduction.
Assuntos
Pinos Ortopédicos , Fixação Intramedular de Fraturas , Fraturas do Rádio , Fraturas da Ulna , Humanos , Criança , Feminino , Masculino , Fixação Intramedular de Fraturas/instrumentação , Fixação Intramedular de Fraturas/efeitos adversos , Fixação Intramedular de Fraturas/métodos , Fraturas da Ulna/cirurgia , Fraturas do Rádio/cirurgia , Complicações Pós-Operatórias/etiologia , Remoção de Dispositivo , Pré-Escolar , Recidiva , Adolescente , Estudos Retrospectivos , Fatores de Tempo , Traumatismos do Antebraço/cirurgiaRESUMO
OBJECTIVE: The objective of this study was to assess the effectiveness and safety of levosimendan as an alternative treatment for pediatric patients with decompensated heart failure unresponsive to conventional inotropes and to emphasize its role in enhancing cardiovascular stability. METHODS: A total of 15 pediatric patients with decompensated heart failure, stemming from acute fulminant myocarditis (53.3%) and post-congenital heart disease surgery complications (46.7%), received levosimendan. The evaluation focused on adverse effects, respiratory support requirements, and concurrent inotropic medication use during levosimendan treatment. Key cardiovascular parameters were assessed at 0, 6, 12, and 24 h post-levosimendan infusion. RESULTS: Levosimendan administration significantly improved key cardiovascular metrics. Left ventricular ejection fraction increased notably from 45±14.8% to 58±15.6% at 24 h (p<0.001). Systolic and diastolic blood pressures rose significantly, with systolic increasing from 79 (68-90) to 98 (89-109) mmHg and diastolic from 47 (40-57) to 66 (54-76) mmHg by 24 h (p<0.001). Heart rate decreased from 162 (111-175) to 132 (99-148) bpm (p=0.02), and lactate levels significantly decreased from 4.15 (2.3-6.5) to 1.85 (0.8-2.6) mmol/L within 6 h (p<0.001). CONCLUSION: Levosimendan demonstrates its significance in managing pediatric heart failure, indicating its safety and potential to enhance cardiac outcomes by reducing reliance on traditional inotropes.
Assuntos
Cardiotônicos , Insuficiência Cardíaca , Hidrazonas , Piridazinas , Simendana , Humanos , Simendana/uso terapêutico , Insuficiência Cardíaca/tratamento farmacológico , Cardiotônicos/uso terapêutico , Piridazinas/uso terapêutico , Piridazinas/efeitos adversos , Masculino , Feminino , Hidrazonas/uso terapêutico , Pré-Escolar , Criança , Resultado do Tratamento , Lactente , Adolescente , Pressão Sanguínea/efeitos dos fármacos , Miocardite/tratamento farmacológico , Fatores de Tempo , Frequência Cardíaca/efeitos dos fármacos , Volume Sistólico/efeitos dos fármacosRESUMO
SUMMARY OBJECTIVE: The objective of this study was to assess the effectiveness and safety of levosimendan as an alternative treatment for pediatric patients with decompensated heart failure unresponsive to conventional inotropes and to emphasize its role in enhancing cardiovascular stability. METHODS: A total of 15 pediatric patients with decompensated heart failure, stemming from acute fulminant myocarditis (53.3%) and post-congenital heart disease surgery complications (46.7%), received levosimendan. The evaluation focused on adverse effects, respiratory support requirements, and concurrent inotropic medication use during levosimendan treatment. Key cardiovascular parameters were assessed at 0, 6, 12, and 24 h post-levosimendan infusion. RESULTS: Levosimendan administration significantly improved key cardiovascular metrics. Left ventricular ejection fraction increased notably from 45±14.8% to 58±15.6% at 24 h (p<0.001). Systolic and diastolic blood pressures rose significantly, with systolic increasing from 79 (68-90) to 98 (89-109) mmHg and diastolic from 47 (40-57) to 66 (54-76) mmHg by 24 h (p<0.001). Heart rate decreased from 162 (111-175) to 132 (99-148) bpm (p=0.02), and lactate levels significantly decreased from 4.15 (2.3-6.5) to 1.85 (0.8-2.6) mmol/L within 6 h (p<0.001). CONCLUSION: Levosimendan demonstrates its significance in managing pediatric heart failure, indicating its safety and potential to enhance cardiac outcomes by reducing reliance on traditional inotropes.
RESUMO
Objective: The aim of this study was to evaluate the clinical and radiologic results and complications of patients who underwent ankle arthrodesis performed by the transfibular approach and anterior approach in end-stage ankle osteoarthritis. Methods: Between 2016 and 2022, 41 patients who satisfied the inclusion criteria for this retrospective comparative analysis were included. Of them, 19 patients are included in the anterior approach group and 22 patients are included in the transfibular approach group. The mean age of the participants is 58.9 years. Collected data included the BMI, American Orthopedic Foot and Ankle Society (AOFAS) hindfoot scale, visual analogue scale (VAS) score, diabetes, smoking, time to fusion, nonunion, union rate, preoperative and postoperative coronal tibiotalar angle and complications. Result: The mean time to bone union was 14.3 weeks (range 11-17 weeks) in the anterior approach group, and 11.3 weeks in the transfibular approach group. Statistically significant difference was found between the two groups. Nonunion occurred in one case in the transfibular approach group and three cases in the anterior approach group. There was no significant difference in the nonunion rate between the both groups (p = 0.321). VAS score, and AOFAS score of the two groups were similar and no significant differences were found (p = 0.491, p = 0.448, p = 0.146, p = 0.073, p = 0.173, p = 0.506, respectively). Conclusions: A stable and firm ankle arthrodesis and plantigrade foot can be achieved with both transfibular approach and anterior approach technique. Level of Evidence III, Retrospective Comparative Study.
Objetivo: Avaliar os resultados clínicos e radiológicos e as complicações de pacientes submetidos à artrodese de tornozelo realizada por abordagem transfibular e abordagem anterior em fase terminal de osteoartrite de tornozelo. Métodos: Foram incluídos 41 pacientes atendidos entre 2016 e 2022 que satisfizeram os critérios de inclusão para esta análise comparativa retrospectiva. Destes, 19 incluídos no grupo de abordagem anterior e 22 no grupo de abordagem transfibular. A média de idade foi de 58,9 anos. Os dados coletados incluíram o índice de massa corporal (IMC), a escala de retropé da American Orthopedic Foot and Ankle Society (AOFAS), o escore da escala visual analógica (EVA), assim como a presença de diabetes, tabagismo, tempo de fusão, não união, taxa de união, ângulo tibiotalar coronal pré e pós-operatório e complicações. Resultado: O tempo médio de consolidação óssea foi de 14,3 semanas (variação de 11 a 17 semanas) no grupo de abordagem anterior e 11,3 semanas no grupo de abordagem transfibular. Foi encontrada diferença estatisticamente significante entre os dois grupos. A consolidação não ocorreu em um caso no grupo de abordagem transfibular e em três casos no grupo de abordagem anterior. Não houve diferença significativa na taxa de não consolidação entre os dois grupos (p = 0,321). Os escores nas escalas EVA e AOFAS dos dois grupos foram semelhantes, não sendo encontradas diferenças significativas (p = 0,491, p = 0,448, p = 0,146, p = 0,073, p = 0,173, p = 0,506, respectivamente). Conclusões: Uma artrodese estável e firme do tornozelo e um pé plantígrado podem ser obtidos tanto com a abordagem transfibular quanto com a técnica de abordagem anterior. Nível de Evidência III, Estudo Comparativo Retrospectivo.
RESUMO
ABSTRACT Objective: The aim of this study was to evaluate the clinical and radiologic results and complications of patients who underwent ankle arthrodesis performed by the transfibular approach and anterior approach in end-stage ankle osteoarthritis. Methods: Between 2016 and 2022, 41 patients who satisfied the inclusion criteria for this retrospective comparative analysis were included. Of them, 19 patients are included in the anterior approach group and 22 patients are included in the transfibular approach group. The mean age of the participants is 58.9 years. Collected data included the BMI, American Orthopedic Foot and Ankle Society (AOFAS) hindfoot scale, visual analogue scale (VAS) score, diabetes, smoking, time to fusion, nonunion, union rate, preoperative and postoperative coronal tibiotalar angle and complications. Result: The mean time to bone union was 14.3 weeks (range 11-17 weeks) in the anterior approach group, and 11.3 weeks in the transfibular approach group. Statistically significant difference was found between the two groups. Nonunion occurred in one case in the transfibular approach group and three cases in the anterior approach group. There was no significant difference in the nonunion rate between the both groups (p = 0.321). VAS score, and AOFAS score of the two groups were similar and no significant differences were found (p = 0.491, p = 0.448, p = 0.146, p = 0.073, p = 0.173, p = 0.506, respectively). Conclusions: A stable and firm ankle arthrodesis and plantigrade foot can be achieved with both transfibular approach and anterior approach technique. Level of Evidence III, Retrospective Comparative Study.
RESUMO Objetivo: Avaliar os resultados clínicos e radiológicos e as complicações de pacientes submetidos à artrodese de tornozelo realizada por abordagem transfibular e abordagem anterior em fase terminal de osteoartrite de tornozelo. Métodos: Foram incluídos 41 pacientes atendidos entre 2016 e 2022 que satisfizeram os critérios de inclusão para esta análise comparativa retrospectiva. Destes, 19 incluídos no grupo de abordagem anterior e 22 no grupo de abordagem transfibular. A média de idade foi de 58,9 anos. Os dados coletados incluíram o índice de massa corporal (IMC), a escala de retropé da American Orthopedic Foot and Ankle Society (AOFAS), o escore da escala visual analógica (EVA), assim como a presença de diabetes, tabagismo, tempo de fusão, não união, taxa de união, ângulo tibiotalar coronal pré e pós-operatório e complicações. Resultado: O tempo médio de consolidação óssea foi de 14,3 semanas (variação de 11 a 17 semanas) no grupo de abordagem anterior e 11,3 semanas no grupo de abordagem transfibular. Foi encontrada diferença estatisticamente significante entre os dois grupos. A consolidação não ocorreu em um caso no grupo de abordagem transfibular e em três casos no grupo de abordagem anterior. Não houve diferença significativa na taxa de não consolidação entre os dois grupos (p = 0,321). Os escores nas escalas EVA e AOFAS dos dois grupos foram semelhantes, não sendo encontradas diferenças significativas (p = 0,491, p = 0,448, p = 0,146, p = 0,073, p = 0,173, p = 0,506, respectivamente). Conclusões: Uma artrodese estável e firme do tornozelo e um pé plantígrado podem ser obtidos tanto com a abordagem transfibular quanto com a técnica de abordagem anterior. Nível de Evidência III, Estudo Comparativo Retrospectivo.
RESUMO
BACKGROUND: Idiopathic intracranial hypertension (IIH) is characterized by increased cerebrospinal fluid (CSF) pressure of unknown cause. It has been suggested that the inflammatory process plays a role in the pathophysiology of the disease. Sortilin-1, lipocalin-2, autotaxin, decorin, and interleukin-33 (IL-33) are among the factors involved in inflammatory processes. OBJECTIVE: To investigate the CSF levels of sortilin-1, lipocalin-2, autotaxin, decorin, and IL-33 in patients with IIH. METHODS: A total of 24 IIH patients and 21 healthy controls were included in the study. Demographic characteristics of the patients and of the control group as well as CSF pressures were evaluated. Sortilin-1, lipocalin-2, autotaxin, decorin and IL-33 levels in the CSF were measured. RESULTS: The CSF levels lipocalin-2, sortilin-1, autotaxin, IL-33 and CSF pressure were significantly higher in the patients group compared with the control group (p < 0.001). Decorin levels were reduced in patients (p < 0.05). There was no correlation between the autotaxin and IL-33 levels and age, gender, CSF pressure, and body mass index. The results of our study showed that inflammatory activation plays an important role in the development of the pathophysiology of IIH. In addition, the fact that the markers used in our study have never been studied in the etiopathogenesis of IIH is important in explaining the molecular mechanism of this disease. CONCLUSION: Studies are needed to evaluate the role of these cytokines in the pathophysiology of the disease. It is necessary to evaluate the effects of these molecules on this process.
ANTECEDENTES: A hipertensão intracraniana idiopática (HII) é caracterizada pelo aumento da pressão do líquido cefalorraquidiano (LCR) de causa desconhecida. Tem sido sugerido que o processo inflamatório desempenha um papel na fisiopatologia da doença. Sortilina-1, lipocalina-2, autotaxina, decorina e interleucina-33 (IL-33) estão entre os fatores envolvidos nos processos inflamatórios. OBJETIVO: Investigar os níveis de sortilina-1, lipocalina-2, autotaxina, decorina e IL-33 no LCR de pacientes com HII. MéTODOS: Um total de 24 pacientes com HII e 21 controles saudáveis foram incluídos no estudo. Foram avaliadas as características demográficas dos pacientes e do grupo controle, bem como as pressões liquóricas. Os níveis de sortilina-1, lipocalina-2, autotaxina, decorina e IL-33 no LCR foram medidos. RESULTADOS: Os níveis no líquido cefalorraquidiano lipocalina-2, sortilina-1, autotaxina, IL-33 e pressão liquórica foram significativamente maiores no grupo de pacientes em comparação com o grupo controle (p < 0,001). Os níveis de decorina foram reduzidos nos pacientes (p < 0,05). Não houve correlação entre os níveis de autotaxina e IL-33 e idade, sexo, pressão liquórica e índice de massa corporal. Os resultados do nosso estudo mostraram que a ativação inflamatória desempenha um papel importante no desenvolvimento da fisiopatologia da HII. Além disso, o fato de os marcadores utilizados em nosso estudo nunca terem sido estudados na etiopatogenia da HII é importante para explicar o mecanismo molecular dessa doença. CONCLUSãO: Estudos são necessários para avaliar o papel dessas citocinas na fisiopatologia da doença. É necessário avaliar os efeitos dessas moléculas nesse processo.
Assuntos
Biomarcadores , Pseudotumor Cerebral , Humanos , Decorina/líquido cefalorraquidiano , Interleucina-33/líquido cefalorraquidiano , Lipocalina-2/líquido cefalorraquidiano , Pseudotumor Cerebral/líquido cefalorraquidiano , Pseudotumor Cerebral/diagnóstico , Biomarcadores/líquido cefalorraquidianoRESUMO
Abstract The purpose of this study was to compare the effect of different disinfection protocols of dentin on bond strength of an MDP-containing universal adhesive. Twelve extracted mandibular third molars were separated horizontally at the mid-coronal of crown to get smooth and sound dentin surfaces using low-speed diamond saw. The teeth were randomly fallen into four groups: chlorhexidine (CHX), ozone, Er,Cr:YSGG laser irradiation (LASER) and no treatment (control). After cavity disinfection application, a universal adhesive (G-Premio Bond) was applied to the surface of dentin according to self-etch mode as instructed by the manufacturer. After incremental built-up of composite resin (Charisma Smart), the specimens were immersed in distilled water at 37°C for 24h. Dentin/composite beams with 1 mm² cross sectional area were produced and micro-tensile bond strength (µTBS) was applied on these beams (n=20). Failure mods were determined under a stereomicroscope at ×40. The resin penetration of samples stained with Rhodamine B fluorochrome dye was examined with a confocal laser scanning microscope. Statistical analysis was performed with SPSS-22. Test results were analyzed using One-way Anova and Tukey HSD Post-Hoc tests (p0.5). All applications of cavity disinfection procedures decreased the µTBS of the resin-dentin interface.
Resumen El propósito de este estudio fue comparar el efecto de diferentes protocolos de desinfección de la dentina sobre la fuerza de unión de un adhesivo universal que contiene MDP. Doce terceros molares mandibulares extraídos se quebraron horizontalmente en la mitad de la corona para obtener superficies de dentina lisas y sólidas utilizando una sierra de diamante de baja velocidad. Los dientes se dividieron aleatoriamente en cuatro grupos: clorhexidina (CHX), ozono, irradiación con láser Er,Cr:YSGG (LASER) y ningún tratamiento (control). Después de la aplicación de la desinfección de la cavidad, se aplicó un adhesivo universal (G-Premio Bond) a la superficie de la dentina según el modo de autograbado indicado por el fabricante. Después de la obturación con resina compuesta (Charisma Smart), las muestras se sumergieron en agua destilada a 37°C durante 24h. Se produjeron porciones de dentina/resina con un área de sección transversal de 1 mm² y se aplicó una fuerza de adhesión microtensile (µTBS) (n=20). Los modos de falla se determinaron bajo un microscopio estereoscópico a ×40. La penetración de la resina de las muestras teñidas con colorante fluorocromo rodamina B se examinó con un microscopio de barrido láser confocal. El análisis estadístico se realizó con SPSS-22. Los resultados de las pruebas se analizaron utilizando las pruebas post-hoc Anova unidireccional y Tukey HSD (p0.5). Todas las aplicaciones de procedimientos de desinfección de cavidades redujeron el µTBS de la interfaz resina-dentina.
Assuntos
Humanos , Desinfecção , Desinfetantes/uso terapêutico , Boca , TurquiaRESUMO
Abstract Background Idiopathic intracranial hypertension (IIH) is characterized by increased cerebrospinal fluid (CSF) pressure of unknown cause. It has been suggested that the inflammatory process plays a role in the pathophysiology of the disease. Sortilin-1, lipocalin-2, autotaxin, decorin, and interleukin-33 (IL-33) are among the factors involved in inflammatory processes. Objective To investigate the CSF levels of sortilin-1, lipocalin-2, autotaxin, decorin, and IL-33 in patients with IIH. Methods A total of 24 IIH patients and 21 healthy controls were included in the study. Demographic characteristics of the patients and of the control group as well as CSF pressures were evaluated. Sortilin-1, lipocalin-2, autotaxin, decorin and IL-33 levels in the CSF were measured. Results The CSF levels lipocalin-2, sortilin-1, autotaxin, IL-33 and CSF pressure were significantly higher in the patients group compared with the control group (p < 0.001). Decorin levels were reduced in patients (p < 0.05). There was no correlation between the autotaxin and IL-33 levels and age, gender, CSF pressure, and body mass index. The results of our study showed that inflammatory activation plays an important role in the development of the pathophysiology of IIH. In addition, the fact that the markers used in our study have never been studied in the etiopathogenesis of IIH is important in explaining the molecular mechanism of this disease. Conclusion Studies are needed to evaluate the role of these cytokines in the pathophysiology of the disease. It is necessary to evaluate the effects of these molecules on this process.
Resumo Antecedentes A hipertensão intracraniana idiopática (HII) é caracterizada pelo aumento da pressão do líquido cefalorraquidiano (LCR) de causa desconhecida. Tem sido sugerido que o processo inflamatório desempenha um papel na fisiopatologia da doença. Sortilina-1, lipocalina-2, autotaxina, decorina e interleucina-33 (IL-33) estão entre os fatores envolvidos nos processos inflamatórios. Objetivo Investigar os níveis de sortilina-1, lipocalina-2, autotaxina, decorina e IL-33 no LCR de pacientes com HII. Métodos Um total de 24 pacientes com HII e 21 controles saudáveis foram incluídos no estudo. Foram avaliadas as características demográficas dos pacientes e do grupo controle, bem como as pressões liquóricas. Os níveis de sortilina-1, lipocalina-2, autotaxina, decorina e IL-33 no LCR foram medidos. Resultados Os níveis no líquido cefalorraquidiano lipocalina-2, sortilina-1, autotaxina, IL-33 e pressão liquórica foram significativamente maiores no grupo de pacientes em comparação com o grupo controle (p < 0,001). Os níveis de decorina foram reduzidos nos pacientes (p < 0,05). Não houve correlação entre os níveis de autotaxina e IL-33 e idade, sexo, pressão liquórica e índice de massa corporal. Os resultados do nosso estudo mostraram que a ativação inflamatória desempenha um papel importante no desenvolvimento da fisiopatologia da HII. Além disso, o fato de os marcadores utilizados em nosso estudo nunca terem sido estudados na etiopatogenia da HII é importante para explicar o mecanismo molecular dessa doença. Conclusão Estudos são necessários para avaliar o papel dessas citocinas na fisiopatologia da doença. É necessário avaliar os efeitos dessas moléculas nesse processo
RESUMO
In this study, nickel tolerance (NiSO4.7H2O) of some Turkish national barley (Hordeum vulgare L.) genotypes (Bülbül-89, Kalayci-97, Karatay-94, Larende, Tarm-92, Tokak-157/37, Yesevi-93 and Zeynel Aga) was investigated. Barley genotypes were exposed to different nickel concentrations [0 mM (control), 250, 500, 1000, 1500, and 2000 ppm]. Nickel toxicity significantly inhibited root and coleoptile growth in all barley genotypes in a concentration-dependent manner. However, root growth was much more inhibited by nickel applications in comparison with coleoptile growth, probably due to a higher level of sensitivity of root meristems against nickel toxicity or direct contact of roots with nickel ions in the growth medium. Root growth in the genotype Karatay-94 and coleoptile growth in the genotype Yesevi-93 was more remarkably reduced by nickel toxicity. Root and coleoptile growth in the genotypes Larende and Kalayci-97 were less affected under nickel toxicity, respectively. In addition, nickel toxicity disturbed water relations in barley genotypes dependent on the organ type, as demonstrated by more severe inhibition in root fresh weight as compared to coleoptile fresh weight. These results could show that nickel toxicity reduced water uptake from growth medium in barley genotypes used in this study. Changes in dry weight of roots and coleoptiles indicated that nickel toxicity more severely decreased biomass accumulation in roots of barley genotypes. The calculated tolerance indices demonstrated that the genotype Kalayci-97 is the most tolerant to nickel toxicity, while the genotype Karatay-94 is the most susceptible one.(AU)
Assuntos
Hordeum/genética , Níquel/toxicidade , Níquel/química , Raízes de Plantas/química , Estudo de Prova de ConceitoRESUMO
Several treatment options for replacement of anterior missing teeth exist, varying from no-prep (no preparation) adhesive restorations to implants. Patients' biological, psychological, economic conditions or age have an effect on the treatment choice. It is important to perform the most conservative and beneficial treatment option considering the patient based factors. The aim of this case report was to demonstrate a single session, minimally invasive, cantilevered 2-unit all-ceramic restorations replacing anterior missing teeth combined with the advantages of CAD/CAM technology and materials. (AU)
Existem várias opções de tratamento para reabilitação de dentes anteriores ausentes, variando de restaurações adesivas sem preparo (sem preparação) até implantes. As condições biológicas, psicológicas, econômicas ou a idade dos pacientes têm um efeito na escolha do tratamento. É importante realizar a opção de tratamento mais conservadora e benéfica, considerando os fatores baseados no paciente. O objetivo deste relato de caso foi demonstrar em sessão única, minimamente invasiva, um cantiléver de restaurações de cerâmica pura de 2 unidades, reabilitando a região de dentes anteriores ausentes combinadas com as vantagens da tecnologia CAD/CAM.(AU)
Assuntos
Humanos , Masculino , Adulto , Prótese Adesiva , Prótese Dentária , Desenho Assistido por ComputadorRESUMO
ABSTRACT We conducted retinal neovascularization under subfoveal fibrotic nodule for Coats disease by using optic coherence tomography-angiography before and after ranibizumab treatment. Our patient was an 8-year-old boy who was referred with suspicious left retinal mass. His visual acuity was 20/400 in the left eye and 20/20 in the right eye at the time of admission. Posterior segment evaluation of the left eye revealed telengiectatic vessels at the inferotemporal region of the peripheral retina with hard exudates around the optic disc and macula typical for Coats disease. His optic coherence tomography revealed a subfoveal fibrotic nodule after ranibizumab injections and laser photocoagulation treatment. The optic coherence tomography-angiography results revealed neovascularization under the subfoveal nodule at the superficial vascular complex layer. After 3 intravitreal ranibizumab injections, his neovascularization regressed on optic coherence tomography-angiography and his visual acuity improved. To the best of our knowledge, this is the first report demonstrating neovascularization under the subfoveal fibrotic nodule in Coats disease on the basis of comparative with the help of optic coherence tomography-angiography before and after the treatment.
RESUMO Demonstramos uma neovascularização da retina sob o nódulo fibrótico subfoveal na doença de Coats com a ajuda da Angiotomografia de Coerência Óptica (OCT-A) antes e após o tratamento com ranibizumabe. Paciente do sexo masculino de 8 anos foi encaminhado com suspeita de massa retiniana no olho esquerdo. A acuidade visual foi de 20/400 no olho esquerdo e de 20/20 no olho direito. A avaliação do segmento posterior do olho esquerdo revelou vasos telengiectáticos na região inferotemporal da retina periférica e exsudados duros em torno do disco óptico e mácula típica da doença de Coats. A angiotomografia de coerência óptica apresentou nódulo fibrótico subfoveal após injeções de ranibizumabe e tratamento com fotocoagulação a laser. A angiotomografia de coerência óptica mostrou neovascularização sob o nódulo subfoveal na camada superficial do complexo vascular. Após três injeções de ranibizumabe intravítreo, a neovascularização regrediu na angiografia por tomografia de coerência óptica e a acuidade visual melhorou. onde sabemos, este é o primeiro relato a mostrar neovascularização sob nódulo fibrótico subfoveal na Doença de Coats com a ajuda da angiografia por tomografia de coerência óptica antes e após o tratamento.
RESUMO
We conducted retinal neovascularization under subfoveal fibrotic nodule for Coats disease by using optic coherence tomography-angiography before and after ranibizumab treatment. Our patient was an 8-year-old boy who was referred with suspicious left retinal mass. His visual acuity was 20/400 in the left eye and 20/20 in the right eye at the time of admission. Posterior segment evaluation of the left eye revealed telengiectatic vessels at the inferotemporal region of the peripheral retina with hard exudates around the optic disc and macula typical for Coats disease. His optic coherence tomography revealed a subfoveal fibrotic nodule after ranibizumab injections and laser photocoagulation treatment. The optic coherence tomography-angiography results revealed neovascularization under the subfoveal nodule at the superficial vascular complex layer. After 3 intravitreal ranibizumab injections, his neovascularization regressed on optic coherence tomography-angiography and his visual acuity improved. To the best of our knowledge, this is the first report demonstrating neovascularization under the subfoveal fibrotic nodule in Coats disease on the basis of comparative with the help of optic coherence tomography-angiography before and after the treatment.
Assuntos
Neovascularização de Coroide , Neovascularização Retiniana , Telangiectasia Retiniana , Inibidores da Angiogênese/uso terapêutico , Criança , Neovascularização de Coroide/tratamento farmacológico , Angiofluoresceinografia , Humanos , Injeções Intravítreas , Masculino , Ranibizumab/uso terapêutico , Neovascularização Retiniana/diagnóstico por imagem , Neovascularização Retiniana/tratamento farmacológico , Telangiectasia Retiniana/complicações , Telangiectasia Retiniana/diagnóstico por imagem , Telangiectasia Retiniana/tratamento farmacológico , Tomografia de Coerência ÓpticaRESUMO
ABSTRACT Objectives: To define the normal ranges of the thicknesses of the skin and subcutaneous tissues via ultrasonography, and determine whether the current syringe needle-lengths used for the subcutaneous injections were appropriate. Methods: The thicknesses of the skin and subcutaneous tissues of 2244 students were measured at the left arm using ultrasonography. The patients were divided into three groups based on their age: 6-8, 9-12 and 13-17 years. Results: The thicknesses of the skin, subcutaneous tissue and skin-subcutaneous tissue were found to be positively correlated with their age, body mass index (BMI) and body surface area. All these were observed to be gender related. There was the possibility to make intramuscular injections for 50%, 25% and 25% of boys within the age groups of 6-8, 9-12 and 13-17 years, respectively. For girls, the risk of intramuscular injection was 25% for all the age groups. Conclusion: The study showed that the skin and skin-subcutaneous tissue thicknesses varied as a function of the patients' age, gender, BMIs and body surface areas.
RESUMO
This study aimed to investigate the effects of chronic restraint stress (RS) and a high-fat diet (HFD) on the osseointegration of titanium implants in a rat model. After the surgical insertion of titanium implants into the metaphysis of the tibial bone, the rats were randomly divided into four equal groups (n = 8 each): control (CNT), restraint stress (RS), high-fat diet (HFD), and restraint stress plus high fat diet (RS-HFD). CNT: Rats received no further treatment during the 92-day experimental period. RS: Stress was applied to the rats beginning from two days after the implant surgery for one hour per day for the first 30 days, two hours per day for the next 30 days, and three hours per day for the last 30 days. HFD: Rats were fed a HFD for the following 90 days starting two days after surgery. RS-HFD: Rats were fed a HFD and RS was applied to rats for the following 90 days, starting two days after surgery. At the end of the experimental period, the rats were euthanized, and the implants and surrounding bone tissues were removed for histological analysis. Statistical analysis was performed by one way ANOVA and Bonferrroni tests. There were no significant differences in the bone-implant connection levels between the groups (p > 0.05), but in the HFD and RS-HFD groups, the bone filling ratios were found to be lower compared with the controls (p < 0.05) The data analyzed in this study suggest that an HFD with or without chronic RS adversely affected bone tissue in the rats during the 90-day osseointegration period.
Assuntos
Prótese Ancorada no Osso , Dieta Hiperlipídica/psicologia , Osseointegração/fisiologia , Estresse Psicológico/fisiopatologia , Tíbia/fisiopatologia , Titânio , Alanina Transaminase/sangue , Animais , Aspartato Aminotransferases/sangue , Glicemia/análise , Colesterol/sangue , Implantação Dentária Endóssea/métodos , Feminino , Distribuição Aleatória , Ratos Sprague-Dawley , Valores de Referência , Reprodutibilidade dos Testes , Tíbia/patologia , Tíbia/cirurgia , Fatores de Tempo , Triglicerídeos/sangueRESUMO
Abstract This study aimed to investigate the effects of chronic restraint stress (RS) and a high-fat diet (HFD) on the osseointegration of titanium implants in a rat model. After the surgical insertion of titanium implants into the metaphysis of the tibial bone, the rats were randomly divided into four equal groups (n = 8 each): control (CNT), restraint stress (RS), high-fat diet (HFD), and restraint stress plus high fat diet (RS-HFD). CNT: Rats received no further treatment during the 92-day experimental period. RS: Stress was applied to the rats beginning from two days after the implant surgery for one hour per day for the first 30 days, two hours per day for the next 30 days, and three hours per day for the last 30 days. HFD: Rats were fed a HFD for the following 90 days starting two days after surgery. RS-HFD: Rats were fed a HFD and RS was applied to rats for the following 90 days, starting two days after surgery. At the end of the experimental period, the rats were euthanized, and the implants and surrounding bone tissues were removed for histological analysis. Statistical analysis was performed by one way ANOVA and Bonferrroni tests. There were no significant differences in the bone-implant connection levels between the groups (p > 0.05), but in the HFD and RS-HFD groups, the bone filling ratios were found to be lower compared with the controls (p < 0.05) The data analyzed in this study suggest that an HFD with or without chronic RS adversely affected bone tissue in the rats during the 90-day osseointegration period.
Assuntos
Animais , Feminino , Estresse Psicológico/fisiopatologia , Tíbia/fisiopatologia , Titânio , Osseointegração/fisiologia , Dieta Hiperlipídica/psicologia , Prótese Ancorada no Osso , Aspartato Aminotransferases/sangue , Valores de Referência , Tíbia/cirurgia , Tíbia/patologia , Fatores de Tempo , Triglicerídeos/sangue , Glicemia/análise , Distribuição Aleatória , Colesterol/sangue , Reprodutibilidade dos Testes , Ratos Sprague-Dawley , Implantação Dentária Endóssea/métodos , Alanina Transaminase/sangueRESUMO
Abstract This study aimed to investigate the effects of chronic restraint stress (RS) and a high-fat diet (HFD) on the osseointegration of titanium implants in a rat model. After the surgical insertion of titanium implants into the metaphysis of the tibial bone, the rats were randomly divided into four equal groups (n = 8 each): control (CNT), restraint stress (RS), high-fat diet (HFD), and restraint stress plus high fat diet (RS-HFD). CNT: Rats received no further treatment during the 92-day experimental period. RS: Stress was applied to the rats beginning from two days after the implant surgery for one hour per day for the first 30 days, two hours per day for the next 30 days, and three hours per day for the last 30 days. HFD: Rats were fed a HFD for the following 90 days starting two days after surgery. RS-HFD: Rats were fed a HFD and RS was applied to rats for the following 90 days, starting two days after surgery. At the end of the experimental period, the rats were euthanized, and the implants and surrounding bone tissues were removed for histological analysis. Statistical analysis was performed by one way ANOVA and Bonferrroni tests. There were no significant differences in the bone-implant connection levels between the groups (p > 0.05), but in the HFD and RS-HFD groups, the bone filling ratios were found to be lower compared with the controls (p < 0.05) The data analyzed in this study suggest that an HFD with or without chronic RS adversely affected bone tissue in the rats during the 90-day osseointegration period.
Assuntos
Humanos , Animais , Estresse Psicológico/fisiopatologia , Tíbia/fisiopatologia , Titânio , Osseointegração/fisiologia , Dieta Hiperlipídica/psicologia , Prótese Ancorada no Osso , Aspartato Aminotransferases/sangue , Valores de Referência , Tíbia/cirurgia , Tíbia/patologia , Fatores de Tempo , Triglicerídeos/sangue , Glicemia/análise , Distribuição Aleatória , Colesterol/sangue , Reprodutibilidade dos Testes , Ratos Sprague-Dawley , Implantação Dentária Endóssea/métodos , Alanina Transaminase/sangueRESUMO
Purpose: De-bonding strength of ceramic veneers by laser use needs to be evaluated in detail. The aim of this study, is to determine the contribution of ceramic thickness and cementing agents to the de-bonding strength of ceramic veneers using Er,Cr:YSGG laser. Methods: A total of 120 maxillary central incisors specimens were randomly divided into twelve groups on the basis of disc thickness, cementing agent, and Er,Cr:YSGG laser use. Under laboratory conditions, 120 IPS Empress II system discs 0.5mm, 1mm, and 2mm in thickness were applied to the tooth surfaces, for laser use. An Er,Cr:YSGG laser system was applied to the central surface of the IPS Empress II discs on specimens in all laser groups (Groups 1,3,5,7,9,11). Then the shear bond strength (SBS) for all specimens were tested with a testing machine at a speed of 0.5mm/min. The SBS values were considered as the de-bonding strength. Results: The mean de-bonding strength values for Groups 9 and 11 (0,5 mm disc thickness + laser application) have the lowest median load (0.000 N), while Group 4 (2mm disc thickness + no laser) has the highest median load (573.885 N). The de-bonding strengths of all the groups without laser application were higher than those of all groups with laser use. When laser is applied, the mean de-bonding strength decreases with decreasing disc thickness, and it reaches zero at 0.5mm thickness of discs cemented by self- or total-etch adhesives. Conclusions: The de-bonding strength decreases with laser use, and decreasing disc thickness. In the absence of laser, the mean de-bonding values of discs cemented by a total etch adhesive system are always higher than those of discs cemented with a self-etch adhesive system. Without any extra load, all 0.5mm thick discs were dislodged from teeth while applying or testing the laser.
Propósito: La resistencia de desunión de las carillas de cerámica mediante el uso del láser debe evaluarse en detalle. El objetivo de este estudio es determinar la contribución del espesor de la cerámica y los agentes de cementación a la resistencia de desunión de las carillas de cerámica utilizando el láser Er, Cr: YSGG. Métodos: Un total de 120 incisivos centrales maxilares se dividieron al azar en doce grupos según el grosor del disco, el agente de cementación y el uso del láser Er, Cr: YSGG. En condiciones de laboratorio, se aplicaron en las superficies de los dientes 120 discos del sistema IPS Empress II de 0,5mm, 1mm y 2mm de grosor, para uso con láser. Se aplicó un sistema láser Er, Cr: YSGG a la superficie central de los discos IPS Empress II en muestras de todos los grupos de láser (Grupos 1,3,5,7,9,11). Luego, la resistencia de la unión al cizallamiento (SBS) para todas las muestras se probó con una máquina de prueba a una velocidad de 0.5mm/min. Los valores de SBS se consideraron como la fuerza de desunión. Resultados: Los valores medios de resistencia de desunión para los Grupos 9 y 11 (espesor de disco de 0,5mm + aplicación de láser) demostró la carga media más baja (0,000 N), mientras que el Grupo 4 (espesor de disco de 2 mm + sin láser) tuvo la carga media más alta (573.885 N). Las fuerzas de desunión de todos los grupos sin aplicación de láser fueron superiores a las de todos los grupos con uso de láser. Cuando se aplica el láser, la fuerza media de desunión disminuye al disminuir el grosor del disco, y llega a cero con el grosor de 0,5mm de los discos cementados, para ambos adhesivos de grabado. Conclusiones: la fuerza de desunión disminuye con el uso del láser y disminuye con el grosor del disco. En ausencia de láser, los valores medios de desunión de los discos cementados con un sistema de adhesivo de grabado total son siempre más altos que los de los discos cementados con un sistema de adhesivo de autograbado. Sin ninguna carga adicional, todos los discos de 0,5mm de grosor se desprendieron de los dientes al aplicar el láser.
Assuntos
Humanos , Cerâmica/uso terapêutico , Colagem Dentária , Resistência ao Cisalhamento , Lasers de Estado Sólido/uso terapêutico , Esmalte Dentário/efeitos da radiação , Materiais Dentários/química , Facetas DentáriasRESUMO
OBJECTIVE: This study aims to evaluate the clinical and biochemical (oxidative stress and pro-inflammatory mediators) effects of the gaseous ozone use accompanied by scaling and root planning (SRP) in periodontal treatment. MATERIAL AND METHODS: The study population consisted of 40 patients with chronic periodontitis (CP) randomly sorted into two groups of 20. The experimental group received SRP plus 3 watts gaseous ozone in two separate applications five days apart, whereas the control group received SRP plus placebo. Clinical periodontal parameters were assayed and saliva samples were taken before the initial and one month after the second treatment. Periodontal examination assessed plaque index (PI), gingival index (GI), probing depth, and clinical attachment level (CAL). Total antioxidant status (TAS), total oxidant status (TOS), nitric oxide (NO), 8-hydroxy-2'-deoxyguanosine (8-OHdG), myeloperoxidase (MPO), glutathione (GSH), malondialdehyde (MDA), and transforming growth factor-beta (TGF-ß) levels were evaluated from saliva samples. RESULTS: Changes following treatment in PI, GI, probing depth, and CAL scores were similar for both groups (p>0.05). Of note, TGF-ß levels were observed to be higher in the treatment group than in controls (p<0.05). Changes in 8-OHdG, TAS, TOS, NO, MPO, GSH and MDA levels, however, were not significantly different between groups (p>0.05). CONCLUSION: The findings of this study indicate that SRP plus gaseous ozone versus SRP alone does not correlate to a significant improvement in periodontal recovery.
Assuntos
Periodontite Crônica/terapia , Oxidantes Fotoquímicos/uso terapêutico , Ozônio/uso terapêutico , Aplainamento Radicular/métodos , 8-Hidroxi-2'-Desoxiguanosina , Adulto , Antioxidantes/análise , Periodontite Crônica/patologia , Índice de Placa Dentária , Desoxiguanosina/análogos & derivados , Desoxiguanosina/análise , Ensaio de Imunoadsorção Enzimática , Feminino , Glutationa/análise , Humanos , Masculino , Malondialdeído/análise , Pessoa de Meia-Idade , Óxido Nítrico/análise , Oxidantes/antagonistas & inibidores , Índice Periodontal , Peroxidase/análise , Reprodutibilidade dos Testes , Saliva/química , Estatísticas não Paramétricas , Fatores de Tempo , Fator de Crescimento Transformador beta/análise , Resultado do TratamentoRESUMO
Abstract Objective: This study aims to evaluate the clinical and biochemical (oxidative stress and pro-inflammatory mediators) effects of the gaseous ozone use accompanied by scaling and root planning (SRP) in periodontal treatment. Material and Methods: The study population consisted of 40 patients with chronic periodontitis (CP) randomly sorted into two groups of 20. The experimental group received SRP plus 3 watts gaseous ozone in two separate applications five days apart, whereas the control group received SRP plus placebo. Clinical periodontal parameters were assayed and saliva samples were taken before the initial and one month after the second treatment. Periodontal examination assessed plaque index (PI), gingival index (GI), probing depth, and clinical attachment level (CAL). Total antioxidant status (TAS), total oxidant status (TOS), nitric oxide (NO), 8-hydroxy-2'-deoxyguanosine (8-OHdG), myeloperoxidase (MPO), glutathione (GSH), malondialdehyde (MDA), and transforming growth factor-beta (TGF-β) levels were evaluated from saliva samples. Results: Changes following treatment in PI, GI, probing depth, and CAL scores were similar for both groups (p>0.05). Of note, TGF-β levels were observed to be higher in the treatment group than in controls (p<0.05). Changes in 8-OHdG, TAS, TOS, NO, MPO, GSH and MDA levels, however, were not significantly different between groups (p>0.05). Conclusion: The findings of this study indicate that SRP plus gaseous ozone versus SRP alone does not correlate to a significant improvement in periodontal recovery.
Assuntos
Humanos , Masculino , Feminino , Adulto , Oxidantes Fotoquímicos/uso terapêutico , Ozônio/uso terapêutico , Aplainamento Radicular/métodos , Periodontite Crônica/terapia , Saliva/química , Fatores de Tempo , Ensaio de Imunoadsorção Enzimática , Índice Periodontal , Índice de Placa Dentária , Reprodutibilidade dos Testes , Fator de Crescimento Transformador beta/análise , Resultado do Tratamento , Oxidantes/antagonistas & inibidores , Peroxidase/análise , Estatísticas não Paramétricas , Desoxiguanosina/análise , Desoxiguanosina/análogos & derivados , Periodontite Crônica/patologia , Glutationa/análise , Malondialdeído/análise , Pessoa de Meia-Idade , Óxido Nítrico/análise , Antioxidantes/análiseRESUMO
This study aimed to investigate the effects of different doses of systemic melatonin application on new bone formation during mandibular distraction osteogenesis (DO) in rats. Mandibular DO was performed on 30 adult female Sprague-Dawley rats, which were randomly divided into three groups: control group (CNT), melatonin dose 1 (MLT-D1), and melatonin dose 2 (MLT-D2). A five-day latent waiting period and a ten-day distraction phase followed the surgery. After the surgery, rats from the MLT-D1 and MLT-D2 groups received 25 and 50 mg/kg melatonin, respectively, at 7, 14, 21, 28, and 35 days. The animals were euthanised 28 days after distraction, i.e. at 43 days after surgery. Histological and histomorphometric analyses revealed that the distracted bone area was completely filled with new bone formation in all three groups. The MLT-D2 group exhibited the most new bone formation, followed by MLT-D1 and CNT. The melatonin groups had more osteoclasts than the CNT (p < 0.05). The number of osteoblasts was higher in the melatonin groups than in the CNT group, and the MLT-D2 had more osteoclasts than the MLT-D1 group (p < 0.05). Finally, the osteopontin (OPN) and vascular endothelial growth factor (VEGF) levels were higher in the melatonin groups than in the CNT group, and the MLT-D2 had higher OPN and VEGF levels than the MLT-D1 (p < 0.05). This study suggests that systemic melatonin application could increase new bone formation in DO.