Assuntos

Humanos , Recém-Nascido , Retinopatia da Prematuridade/classificação , Retinopatia da Prematuridade/epidemiologia , Retinopatia da Prematuridade/história , Retinopatia da Prematuridade/terapia

RESUMO

INTRODUCTION: Retinopathy of prematurity (ROP) is the first cause of childhood blindness in Argentina and is reaching epidemic proportions. To gain greater insight into the issues involved in this epidemic, we analyzed the characteristics of the infants referred for treatment of very severe ROP to the Dr. Juan P. Garrahan Pediatric Hospital, located in the city of Buenos Aires. METHODS: We performed a retrospective study of patients referred for ROP from 01/01/96 to 12/31/03. Very severe ROP was defined as threshold disease or worse in both eyes, plus disease in zones 1 or 2, or Rush disease. Unusual patients were defined as those with very severe ROP with a gestational age (GA) of > 31 weeks or birth weight (BW) > 1500 g. Patients were divided into two groups according to the distance between the referring center and our hospital: group A consisted of those from nearby areas ( 70 km from the hospital. RESULTS: During the study period, the number of cases progressively increased while the proportion of "unusual" patients slightly decreased. The total number of infants referred was 809 and 14 % were unusual patients; 55 % had very severe ROP, 89 % were treated, and 7 % were referred too late and lost the opportunity for treatment. Group B comprised 61 % of the infants referred. Very severe ROP was present in 53 % of patients in group A and in 56 % of those in group B. The mean GA was 29.5 +/- 3.1 weeks in group A and 30.8 +/- 2.6 in group B (p < 0.001); 90.5 % of the patients in group A and 64 % of those in group B required mechanical ventilation (p < 0.001). No predictors for very severe ROP were found in multifactorial analysis. CONCLUSIONS: We report a childhood epidemic of blindness in which the prevalence of very severe ROP increased during the study period and the disease occurred in large, fairly mature newborns. The differences found in relation to the referring center and the lack of correlation between very severe ROP and prematurity or the use of mechanical ventilation suggests substantial disparity in healthcare, which should be taken into account when planning prevention strategies.

Assuntos

Países em Desenvolvimento , Retinopatia da Prematuridade , Argentina/epidemiologia , Feminino , Humanos , Recém-Nascido , Recém-Nascido Prematuro , Masculino , Retinopatia da Prematuridade/epidemiologia , Retinopatia da Prematuridade/terapia , Estudos Retrospectivos

Assuntos

Doenças do Ducto Colédoco , Cistos , Adolescente , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Masculino

RESUMO

Es importante que el patologo realice un estudio completo y que el clinico sepa interpretar el informe entregado para establecer un prognostico y un tratamiento correcto. Anatomopatologicamente se estudian las caracteristicas del tumor en cuanto a tamano, margen tumoral, infiltracion de piel y/o planos profundos, tipo histologico, grado de diferenciacion, invasion de vasos sanguineos o linfaticos e infiltracion linfocitica peritumoral. El analisis de los ganglios debe considerar el numero total de comprometidos en relacion al numero total de estudiados, el tamano macro o microscopico de la metastasis la localizacion y la existencia de invasion mas alta de la capsula.El estudio del resto de la mama y la presencia de otros focos tumorales o la patologia benigna asociada completan el examen.Se describe la clasificacion histopatologica de los canceres de mama y una relacion entre el tipo histologico y el pronostico

Assuntos

Humanos , Feminino , Neoplasias da Mama