RESUMO
Hepatitis E virus (HEV) infection involving zoonotic genotypes is a public health problem in high-income and non-endemic developing countries. Herein we report the detection of a human genotype 1 (HEV-1) strain infecting a domestic pig, which is not considered a natural reservoir of this genotype. Viral load was quantified in stool by Real-Time qPCR and sequence analyses were performed. Infectivity of the HEV-1 strain was assesed by in vitro isolation in A549 cell line. Results suggest that certain epidemiological settings might favour accidental spillover infection and thus influence the host range restriction of HEV.
Assuntos
Vírus da Hepatite E/isolamento & purificação , Hepatite E/veterinária , Hepatite E/virologia , Doenças dos Suínos/virologia , Animais , Fezes/virologia , Anticorpos Anti-Hepatite , Hepatite E/imunologia , Vírus da Hepatite E/classificação , Vírus da Hepatite E/genética , Vírus da Hepatite E/imunologia , Humanos , Filogenia , Sus scrofa/imunologia , Sus scrofa/virologia , Suínos , Doenças dos Suínos/imunologiaRESUMO
Resumen: La infección por el Virus de la Hepatitis E (VHE) en individuos inmunocompetentes generalmente se presenta como hepatitis aguda autolimitada. En determinados escenarios clínicos (embarazadas y pacientes con enfermedad hepática crónica) puede manifestarse como falla hepática aguda. Se han descripto casos de hepatitis crónica en inmunocomprometidos. En Uruguay se han reportado 14 casos de hepatitis aguda autolimitada por VHE. En el presente artículo se describe el primer caso de falla hepática aguda por VHE en Uruguay.
Abstract: Hepatitis E Virus (HEV) typically causes an acute and self-limiting infection in immune-competent individuals, though acute liver failure is described in some settings (pregnancy, chronic liver disease). Chronic hepatitis has been described in immunosuppressed patients. Fourteen autochthonous cases of self-limiting acute hepatitis for HEV were reported in Uruguay. The first case of acute liver failure for HEV is described in the present article.