RESUMO
A patient with chronic inflammatory demyelinating polyradiculoneuropathy and systemic lupus erythematosus arising after rubella vaccination was initially treated with plasmapheresis, corticosteroids and intravenous immunoglobulins, with partial response. After shift to rituximab, most clinical symptoms improved markedly, emphasizing the possible role of this monoclonal antibody in conventional therapy-resistant cases.
Assuntos
Anticorpos Monoclonais Murinos/uso terapêutico , Antirreumáticos/uso terapêutico , Lúpus Eritematoso Sistêmico/tratamento farmacológico , Polirradiculoneuropatia Desmielinizante Inflamatória Crônica/tratamento farmacológico , Corticosteroides/uso terapêutico , Adulto , Feminino , Humanos , Imunoglobulinas Intravenosas/uso terapêutico , Lúpus Eritematoso Sistêmico/complicações , Polirradiculoneuropatia Desmielinizante Inflamatória Crônica/complicações , Retratamento , Rituximab , Resultado do TratamentoRESUMO
OBJECTIVE: To assess the oral health status and treatment needs of older adults, living in the Valparaiso Region of Chile. BASIC RESEARCH DESIGN: A random sample of 354 older adults, aged 60 years or older, living independently in the community were examined orally by calibrated examiners and underwent a structured oral health interview. Data collection extended from October 2006 to June 2007. RESULTS: This was a largely dentate population (80%) with a mean DMFT score of 21.6 (s.d. 5.7). While about 28% of the dentate sample had all their restorative needs unmet, 30.8% had all of their restorative needs met. Regarding periodontal health, 3.3% had sound periodontum; complex periodontal therapy (CPI 3-4) was needed by 43.1% of the sample. CONCLUSION: This study represents one of the largest data collections in oral health among older adults living in Chile. Participants seemed to have better oral health status than previously reported. Of particular relevance is the reduction of the decayed component and the increased number of sound teeth in the present sample. Participants also presented lower need for advance periodontal treatment. Yet, inequalities were apparent in the proportion of unmet restorative needs. Strategies to develop oral health care programmes focused on improving access to and use of preventive services for older adults are critical. Further research is indicated to get a more complete picture of the factors that shape the oral health of Chilean older adults.
Assuntos
Nível de Saúde , Disparidades em Assistência à Saúde , Vida Independente , Saúde Bucal , Idoso , Chile , Estudos Transversais , Índice CPO , Assistência Odontológica para Idosos/estatística & dados numéricos , Prótese Dentária/estatística & dados numéricos , Restauração Dentária Permanente/estatística & dados numéricos , Escolaridade , Feminino , Humanos , Renda , Seguro Saúde , Masculino , Estado Civil , Pessoa de Meia-Idade , Avaliação das Necessidades , Doenças Periodontais/terapia , Índice Periodontal , Pobreza , Saúde da População Rural/estatística & dados numéricos , Fatores Sexuais , Perda de Dente/terapia , Saúde da População Urbana/estatística & dados numéricosRESUMO
OBJECTIVE: To describe the prevalence of overweight, obesity and being thin in adolescents of La Paz City, Bolivia. DESIGN: Cross-sectional study, clustered sampling. SETTING: La Paz, Bolivia, August-September 2003. SUBJECTS: Height and weight of 525 adolescents (mean age 16 y; s.d.+/-1.3) attending public and private schools were measured; sociodemographic characteristics were assessed with a short questionnaire. RESULTS: The present study reveals that 9.3% (+/-2.5) of the sample are thin adolescents; 19.8% (+/-3.4) is the overall prevalence of overweight and 2.3% (+/-1.3) the overall prevalence of obesity. The odds of being thin were higher among those working (P=0.03) and among those of higher age (P<0.001). The odds of being overweight were higher among female subjects (P<0.001). The odds of being obese were higher among younger adolescents (P=0.046) and among the more wealthy ones (P=0.044). CONCLUSIONS: A large prevalence of 22% overweight/obesity in adolescents from La Paz City was observed. The findings support the need of enhanced nutritional surveillance and interventions particularly in female adolescents.
Assuntos
Obesidade/epidemiologia , Classe Social , Adolescente , Fatores Etários , Bolívia/epidemiologia , Análise por Conglomerados , Estudos Transversais , Feminino , Humanos , Masculino , Vigilância da População , Prevalência , Fatores SexuaisRESUMO
The expression of 9-O-acetylated gangliosides recognized by the Jones monoclonal antibody (mAb) correlates with cell migration and axonal outgrowth in the developing rat nervous system. We studied the expression of these gangliosides during the development and maturation of the rat olfactory system. Beginning on embryonic day 13 (E13) the olfactory epithelium and the migratory mass were intensely stained with Jones mAb. However, though this immunoreactivity disappeared from the olfactory epithelium at E19, it remained in a few fascicles and some glomeruli of the newborn and adult olfactory bulbs. We concluded that the expression of 9-O-acetylated gangliosides by olfactory axons and/or migrating cells may facilitate axonal outgrowth during development and might be involved in the formation of new glomeruli in the mature olfactory bulb.
Assuntos
Gangliosídeos/biossíntese , Olfato/fisiologia , Animais , Anticorpos Monoclonais/imunologia , Axônios/fisiologia , Feminino , Imuno-Histoquímica , Fibras Nervosas/fisiologia , Bulbo Olfatório/embriologia , Bulbo Olfatório/metabolismo , Mucosa Olfatória/embriologia , Mucosa Olfatória/metabolismo , Condutos Olfatórios/embriologia , Condutos Olfatórios/metabolismo , Gravidez , RatosRESUMO
Variable angle strabismus can be inward (esotropy) or outward (exotropy) or vary from esotropy to exotropy. Mental retardation has been found to be related to strabismus in 50% or more of the cases and 35% of these had variable angle strabismus. A total of 61 patients with variable angle strabismus were studied finding 55.7% with esotropy, 36% exotropy and 8.2% varying from esotropy to exotropy. Of those under study, 64% were females and 77% under five years old. No accommodative factors were found in any of the patients. The best results were obtained through surgery (recession plus Faden) previous rehabilitation.
Assuntos
Transtornos Psicomotores/complicações , Estrabismo/complicações , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Lactente , MasculinoRESUMO
Se efectua la revision clinica, metodos diagnosticos y tratamiento en 87 pacientes con cancer gastrico avanzado en el Hospital Central de Aeronautica; 54 fueron varones (65,5%) y 30 mujeres (34,5%)con edad promedio de 64,5 anos y con lesion localizada en el tercio medio (51,3%), siendo histologicamente predominante el adenocarcinoma diferenciado (72,4%). La efectividad diagnostica combinando la endoscopia y la radiologia fue del 98,8% y para el metodo endoscopico el 97,4%. Se evalua la sobrevida obtenida desde el momento en que se efectuo el diagnostico histologico en ll,6 meses, habiendo recibido tratamiento medico 23 pacientes (26,4%) y quirurgico 64 (73,6%). En todos los casos la presentacion clinica fue tardia y no caracteristica
Assuntos
Adulto , Pessoa de Meia-Idade , Humanos , Masculino , Feminino , Neoplasias Gástricas , PeruRESUMO
Veinte y dos pacientes con atrofia muscular peronea fueron sometidos a estudio electrofisiologico. El numero de unidades motoras funcionantes fue estimado en los musculos de las eminencias tenar e hipotenar, en el extensor corto de los dedos y en el soleo. La velocidad de conduccion nerviosa de miembros superiores e inferiores. En base a los valores de velocidad de conduccion motora hallados en nervio mediano dos grupos de pacientes fueron individualizados: uno de ellos con marcada reduccion de esos valores y el restante con cifras normales o muy discretamente disminuidas. Una significativa perdida de unidades motoras fue hallada en ambos grupos y no estuvo correlacionada con la edad de los pacientes, asi como tampoco con la velocidad de conduccion motora hallada. La capacidad de colateralizacion de los axones sobrevivientes se mantuvo en miembros superiores, pero no en inferiores. Estos hallazgos sugieren que la atrofia muscular peronea es una enfermedad heterogenea en terminos del grado de denervacion que puede afectar a distintos individuos que padecen la misma entidad patologica
Assuntos
Atrofia Muscular , Nervo FibularRESUMO
Veinte y dos pacientes con atrofia muscular peronea fueron sometidos a estudio electrofisiologico. El numero de unidades motoras funcionantes fue estimado en los musculos de las eminencias tenar e hipotenar, en el extensor corto de los dedos y en el soleo. La velocidad de conduccion nerviosa de miembros superiores e inferiores. En base a los valores de velocidad de conduccion motora hallados en nervio mediano dos grupos de pacientes fueron individualizados: uno de ellos con marcada reduccion de esos valores y el restante con cifras normales o muy discretamente disminuidas. Una significativa perdida de unidades motoras fue hallada en ambos grupos y no estuvo correlacionada con la edad de los pacientes, asi como tampoco con la velocidad de conduccion motora hallada. La capacidad de colateralizacion de los axones sobrevivientes se mantuvo en miembros superiores, pero no en inferiores. Estos hallazgos sugieren que la atrofia muscular peronea es una enfermedad heterogenea en terminos del grado de denervacion que puede afectar a distintos individuos que padecen la misma entidad patologica