RESUMO
Objetivos. Estimar la incidencia de VIH en la población adulta del Perú, 2010, y analizar su distribución según comportamientos de riesgo. Materiales y métodos. Se aplicó el modelo de ONUSIDA según modos de transmisión (MoT). Los datos fueron obtenidos de la revisión detallada de 59 documentos (1984 - 2008). También se analizó bases de datos nacionales para obtener datos específicos. La selección final de los datos fue validada por el grupo técnico y un grupo de expertos. Después de la consulta con expertos, se corrigieron los valores y se realizó un análisis de incertidumbre. El modelo fue ajustado a la prevalencia nacional del 2009 (0,45%). Resultados. La incidencia estimada para el 2010 fue de 0,03%, (4346 nuevas infecciones). El 84% de nuevas infecciones se concentra en grupos de mayor riesgo: hombres que tienen sexo con hombres (55%) y personas que tienen sexo casual heterosexual (6,2%). El 16% restante corresponde a la población heterosexual de bajo riesgo. La transmisión heterosexual es el 43% de nuevos casos, y dentro de estos el 18% corresponde a parejas femeninas de sujetos de alto riesgo. Solo 2,2% de casos está relacionado al trabajo sexual femenino y 1,0% a usuarios de drogas inyectables. Conclusiones. El modelo proporciona una estimación de la incidencia y su distribución entre los grupos de riesgo según el modo de transmisión, consistente con los reportes de casos de VIH. El modelo permite crear escenarios para ayudar a la toma de decisiones y formulación de políticas, así como para vigilancia y planificación de la prevención y control.
Objectives. To estimate HIV incidence in the adult population of Peru, 2010, and analyze its distribution based on risk behavior. Materials and methods. The UNAIDS model was applied based on the modes of transmission (MoT). The information was obtained from the review detailed in 59 documents (1984 - 2008). National databases were also analyzed to obtain specific data. Final selection of data was validated by the technical group and a group of experts. After consultation with experts, values were corrected and an uncertainty analysis was conducted. The model was adjusted to 2009 national prevalence (0.45%). Results. Incidence estimated for 2010 was 0.03%, (4346 new infections). 84% of new infections concentrate on higher risk groups: men who have sex with men (55%) and people who have casual sex with heterosexuals (6.2%). The remaining 16% corresponds to low-risk heterosexual population. Heterosexual transmission accounts for 43% of new cases, 18% of which corresponds to female partners of high risk individuals. Only 2.2% of cases is related to female sexual work and 1.0% to injection drug users. Conclusions. The model provides an estimation of the incidence and its distribution among risk groups according to the mode of transmission, consistent with the HIV case reporting. The model creates scenarios to help decision making and policy formulation, as well as surveillance and planning of prevention and control.
Assuntos
Adulto , Feminino , Humanos , Masculino , Infecções por HIV/epidemiologia , Infecções por HIV/transmissão , Modelos Teóricos , Heterossexualidade , Incidência , Peru/epidemiologia , Comportamento SexualRESUMO
BACKGROUND: The objective of this paper is to review literature in order to calculate regional estimates of the average duration of time individuals maintain a specific high-risk behaviour. METHODS: The review targeted the key populations of female sex workers (FSW), male clients of female sex workers (MCFSW), people who inject drugs (injecting drug users (IDU)) and high-risk men who have sex with men (MSM). To be included in the review the study had to provide information on (1) the time a person spent at risk until death or cessation of the risk behaviour, (2) the percentage of the sample who initiated the risk behaviour in less than a year or (3) the mean or median duration of the behaviour from a representative sample. RESULTS: 49 papers were found for the FSW population describing the period of time FSW stay in sex work to be between 2.9 years (Asia) and 12 years (Latin America). Eight papers were found for MCFSW showing the duration of the risk behaviour in this category varying from 4.6 years in Africa to 32 years in Asia. 86 papers were reviewed for the population of IDU showing that the average time a person injects illegal drugs varies from 5.6 years (Africa) to 21 years (South America). No information was found for duration of high-risk behaviour among MSM; instead, the definitions found in the literature for high- and low-risk behaviour among MSM were described. CONCLUSIONS: There is high variability of estimates of duration of high-risk behaviours at regional level. More research is needed to inform models and prevention programmes on the average duration of time individuals maintain a specific high-risk behaviour.
Assuntos
Assunção de Riscos , África , América , Ásia , Usuários de Drogas , Feminino , Humanos , Masculino , Profissionais do Sexo , Fatores de TempoRESUMO
BACKGROUND: A retrospective analysis of deaths registered in the Brazilian Mortality System was conducted to quantify the under-reporting of HIV/AIDS deaths and those misclassified to AIDS-related conditions in the 15-49 years old population in Brazil. METHODS: Death rates for AIDS-related diseases were calculated by age and sex for 1985-2009. Changes in the age-sex-specific death rates over time were used to identify conditions likely to be misclassified AIDS deaths and to quantify the corresponding number of misclassified deaths. Deaths due to ill-defined causes were redistributed across all other natural causes of death. The resulting total number of AIDS deaths was further adjusted for incompleteness of the mortality reporting system. RESULTS: Out of the 28 potential causes of death investigated, five increased in the same distinct age pattern as AIDS: pneumonia, Kaposi's sarcoma, other immunodeficiencies, other septicaemia and toxoplasmosis. 18 490 deaths due to these five causes were recoded to HIV/AIDS from 1985 to 2009. 38 145 deaths due to ill-defined causes were redistributed to AIDS and 15 485 were added to the number of AIDS deaths to correct for completeness of the mortality system in Brazil. Altogether, 72 120 deaths were recoded to AIDS between 1985 and 2009 and added to the reported 194 445 AIDS related deaths in the country, representing 27% misclassification of AIDS deaths in Brazil. CONCLUSIONS: This study demonstrated that AIDS mortality is underestimated by the official mortality information system in Brazil. Efforts need to be made to reduce misclassification of causes of death in the future and identify ways in which the confidentiality of information regarding cause of death can be maintained.
Assuntos
Síndrome da Imunodeficiência Adquirida/epidemiologia , Síndrome da Imunodeficiência Adquirida/mortalidade , Métodos Epidemiológicos , Adolescente , Adulto , Brasil/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Análise de Sobrevida , Adulto JovemRESUMO
OBJECTIVES: To estimate HIV incidence in the adult population of Peru, 2010, and analyze its distribution based on risk behavior. MATERIALS AND METHODS: The UNAIDS model was applied based on the modes of transmission (MoT). The information was obtained from the review detailed in 59 documents (1984 - 2008). National databases were also analyzed to obtain specific data. Final selection of data was validated by the technical group and a group of experts. After consultation with experts, values were corrected and an uncertainty analysis was conducted. The model was adjusted to 2009 national prevalence (0.45%). RESULTS: Incidence estimated for 2010 was 0.03%, (4346 new infections). 84% of new infections concentrate on higher risk groups: men who have sex with men (55%) and people who have casual sex with heterosexuals (6.2%). The remaining 16% corresponds to low-risk heterosexual population. Heterosexual transmission accounts for 43% of new cases, 18% of which corresponds to female partners of high risk individuals. Only 2.2% of cases is related to female sexual work and 1.0% to injection drug users. CONCLUSIONS: The model provides an estimation of the incidence and its distribution among risk groups according to the mode of transmission, consistent with the HIV case reporting. The model creates scenarios to help decision making and policy formulation, as well as surveillance and planning of prevention and control.
Assuntos
Infecções por HIV/epidemiologia , Infecções por HIV/transmissão , Modelos Teóricos , Adulto , Feminino , Heterossexualidade , Humanos , Incidência , Masculino , Peru/epidemiologia , Comportamento SexualRESUMO
AIM: To investigate the factors associated with hepatitis C virus (HCV) infection among non-injecting cocaine users (NICUs) and to compare practices associated with HCV and HIV infection. DESIGN: An intercountry cross-sectional study. Setting Buenos Aires and Montevideo metropolitan areas. PARTICIPANTS: A total of 871 NICUs. MEASUREMENTS: NICUs were interviewed and their blood was drawn and used for HCV, HIV, HBV surface antigen (HbsAg), HB-anticore and Venereal Disease Research Laboratory (VRDL) antibody assays. Bivariate and multivariate logistic regression analyses included comparisons of HCV and HIV mono-infected participants with HCV-HIV seronegatives. FINDINGS: Prevalence rates were 8.8 [95% confidence interval (CI): 6.9-10.8) for HCV and 7.9 (95% CI: 6.1-9.7) for HIV. HCV-infected NICUs were twice as likely as HCV-HIV seronegatives to have shared straws for cocaine snorting or sniffing, even when adjusted for other variables. HCV prevalence rates ranged from 3.6% among NICUs who denied sharing straws and having had an injection drug user (IDU) or an HIV-positive sexual partner to 12.6% among participants who reported ever having shared straws or having had either an IDU- or HIV-positive sexual partner (χ(2) (trend) = 6.56, P = 0.01). CONCLUSIONS: Non-injecting cocaine users from South America are vulnerable to multiple infections and HCV infection appears to occur through the sharing of straws. HCV infection is associated with intimate relationships with IDUs or HIV-seropositive partners, supporting the hypothesis that HCV risk may be due primarily to risk-taking behaviour associated with drugs in this population.
Assuntos
Transtornos Relacionados ao Uso de Cocaína/epidemiologia , Cocaína/administração & dosagem , Hepatite C/epidemiologia , Abuso de Substâncias por Via Intravenosa/epidemiologia , Adolescente , Adulto , Argentina/epidemiologia , Transtornos Relacionados ao Uso de Cocaína/complicações , Comorbidade , Métodos Epidemiológicos , Feminino , Infecções por HIV/epidemiologia , Hepatite B/epidemiologia , Hepatite C/transmissão , Humanos , Masculino , Assunção de Riscos , Comportamento Sexual , Parceiros Sexuais , Abuso de Substâncias por Via Intravenosa/complicações , População Urbana/estatística & dados numéricos , Uruguai/epidemiologiaRESUMO
INTRODUCCIÓN: la pasta base de cocaína (PBC) es una forma fumable de cocaína de creciente utilización entre los jóvenes. OBJETIVO: describir el patrón de consumo de drogas, las seroprevalencias de VIH, hepatitis B (VHB), hepatitis C (VHC), sífilis y otrosproblemas de salud en usuarios de PBC en un centro asistencial de Argentina. MÉTODO: se incluyeron voluntarios mayores de 18 años, asistidos en el Centro Nacional de Reeducación Social (CENARESO)en el período 2006-2007, que consumieron PBC en los 6 meses anteriores a la entrevista y que nunca utilizaron drogas inyectables. Se aplicó un cuestionario estructurado, se tomó una muestra de sangre para serología de VIH, VHB, VHC y sífilis, y se analizó una sub-muestra de radiografías de tórax. RESULTADOS: más de la mitad de los 146 voluntarios manifestó haber fumado PBC varias veces por semana. Los participantes eran también consumidores frecuentes de cocaína en polvo (64%), cannabis (80,8%) y tranquilizantes (44,5%). Los principales problemas de salud auto-percibidos como consecuencia del consumo de PBC fueron las lesiones orales y la pérdida de peso. El 4,3% de los voluntarios resultó VIH-positivo. Las prevalencias de infección por sífilis, VHB y VHC fueron 2,7%, 5,5%, y 5,5%, respectivamente. El 16% estaba coinfectado con uno o más de los agentes estudiados. DISCUSIÓN: la prevalencia de infecciones, unida a otros problemas de salud de los usuarios de PBC, indica la necesidad de nuevas investigaciones a fin de diseñar intervenciones preventivas y terapéuticas apropiadas
INTRODUCTION: cocaine paste is a smokable form of cocaine increasingly used among young people. OBJECTIVE:to describe patterns of drugs, seroprevalences of HIV, hepatitis B (HBV), hepatitis C (HCV), syphilis and other health problems among coca paste users assisted at a drug treatment center in Argentina. METHOD: volunteers, eighteen-year-old and olderassisted at the National Center for Social Re-education (CENARESO)during 2006-2007, who had consumed coca paste over the past 6 months previous to the interview and had never injected drugs, were selected. A structured questionnaire wasused and blood was drawn to test HIV, HBV, HCV and syphilis. A sub-sample of thorax X-rays was analyzed. RESULTS: morethan half of the 146 volunteers had smoked coca paste severaltimes a week. The use of other drugs was frequently associated: sniffed cocaine 64%, cannabis 80,8%, and tranquilizers 44,5. Oral lesions and lost of weight were referred as health problems stemming from coca paste use. Out of the 146 volunteers, 4.3%resulted HIV-positive. Prevalences of infection for syphilis, HBV, and HCV were 2,7%, 5,5% and 5,5%, respectively. 16% wasco-infected with one or more infectious agents. DISCUSSION: the prevalence of infections detected, along with other clinical problems found among this coca paste users, show the need for further research, in order to design proper preventive and therapeutic interventions
Assuntos
Humanos , Capacitação de Recursos Humanos em Saúde , Cocaína , Demografia , Epidemiologia Descritiva , Hepacivirus , Infecções por HIV/prevenção & controle , Recursos para a Pesquisa , Sífilis/prevenção & controle , Transtornos Relacionados ao Uso de Cocaína , Vírus da Hepatite B , Ensaio de Imunoadsorção EnzimáticaRESUMO
The aim is to estimate HBV prevalence and the associated risks among noninjecting cocaine users (NICUs). In 2002-2003, a total of 824 NICUs from Buenos Aires (Argentina) and Montevideo (Uruguay) were interviewed using a structured questionnaire. Serologic tests were carried out for Human Immunodeficiency Virus (HIV), hepatitis B (HBV), syphilis, and others. The population was divided into two serologic groups: HBV-infected and seronegative group. Univariate and binary logistic model were developed. The results seem to indicate that, among NICUs, HBV is transmitted through sexual contact. Prevention measures, including vaccine, are needed in order to control and minimize risks. The study's limitations are noted.
Assuntos
Transtornos Relacionados ao Uso de Cocaína/epidemiologia , Hepatite B/epidemiologia , Comportamento Sexual/psicologia , Adulto , Argentina/epidemiologia , Transtornos Relacionados ao Uso de Cocaína/psicologia , Transtornos Relacionados ao Uso de Cocaína/virologia , Estudos Transversais , Feminino , Infecções por HIV/epidemiologia , Infecções por HIV/psicologia , Infecções por HIV/virologia , Hepatite B/psicologia , Hepatite B/virologia , Humanos , Entrevistas como Assunto , Masculino , Razão de Chances , Seleção de Pacientes , Prevalência , Fatores de Risco , Inquéritos e Questionários , Uruguai/epidemiologiaRESUMO
HIV cross-sectional studies were conducted among high-risk populations in 9 countries of South America. Enzyme-linked immunosorbent assay screening and Western blot confirmatory testing were performed, and env heteroduplex mobility assay genotyping and DNA sequencing were performed on a subset of HIV-positive subjects. HIV prevalences were highest among men who have sex with men (MSM; 2.0%-27.8%) and were found to be associated with multiple partners, noninjection drug use (non-IDU), and sexually transmitted infections (STIs). By comparison, much lower prevalences were noted among female commercial sex workers (FCSWs; 0%-6.3%) and were associated mainly with a prior IDU and STI history. Env subtype B predominated among MSM throughout the region (more than 90% of strains), whereas env subtype F predominated among FCSWs in Argentina and male commercial sex workers in Uruguay (more than 50% of strains). A renewed effort in controlling STIs, especially among MSM groups, could significantly lessen the impact of the HIV epidemic in South America.
Assuntos
Infecções por HIV/epidemiologia , Infecções por HIV/transmissão , HIV/genética , Adulto , Estudos Transversais , Transmissão de Doença Infecciosa , Feminino , Produtos do Gene env/genética , Análise Heteroduplex , Homossexualidade Masculina , Humanos , Entrevistas como Assunto , Modelos Logísticos , Masculino , Epidemiologia Molecular , Prevalência , Fatores de Risco , Trabalho Sexual , Comportamento Sexual , América do Sul/epidemiologia , Abuso de Substâncias por Via IntravenosaRESUMO
Injection drug use is the main mechanism of human immunodeficiency virus (HIV) transmission in Argentina (40% of reported AIDS cases in Argentina). This study was conducted among street-recruited injection drug users (IDUs) from Buenos Aires, with the aim of estimating seroprevalence and coinfection of HIV, hepatitis B virus (HBV), hepatitis C virus (HCV), and human T-lymphotropic viruses (HTLVs). A total of 174 volunteers participated in this study; 137 were men (78.7% of volunteers). The average age of the participants was 30 years. Only 64 of participants (37%) had no viral infection, whereas 110 (63%) were infected with > or =1 viruses. Seroprevalences were 44.3% for HIV, 54.6% for HCV, 42.5% for HBV, 2.3% for HTLV-I, and 14.5% for HTLV-II. Among the 77 HIV-infected persons, only 6.5% (5 persons) were not coinfected with other viruses; 88.3% (68) were coinfected with HCV and 68.8% (53) were coinfected with HBV. We demonstrated the existence of multiple viral infections with a high rate of prevalence in IDUs in Buenos Aires, Argentina.
Assuntos
Infecções por HIV/epidemiologia , Infecções por HTLV-II/epidemiologia , Hepatite B/epidemiologia , Hepatite C/epidemiologia , Abuso de Substâncias por Via Intravenosa , Adolescente , Adulto , Argentina/epidemiologia , Feminino , HIV , Infecções por HIV/complicações , Soroprevalência de HIV , Infecções por HTLV-II/complicações , Hepacivirus , Hepatite B/complicações , Vírus da Hepatite B , Hepatite C/complicações , Humanos , Masculino , Pessoa de Meia-Idade , Uso Comum de Agulhas e Seringas , Estudos SoroepidemiológicosRESUMO
Se presenta una comparación de las tasas de participación y de las razones de la falta de respuesta en encuestas realizadas en cinco países de América Latina y el Caribe con el objetivo de medir la prevalencia de comportamientos de riesgo que determinan la transmisión del virus de la inmunodeficiencia humana. Dichas encuestas se basaron en muestras probabilísticas de la población de ambos sexos comprendida entre 15 y 49 años de edad, excepto en México, donde se estudió solo a los hombres. Se estimaron tres componentes de la participación: las proporciones de viviendas entrevistadas, de viviendas entrevistadas con personas elegibles y de personas elegibles que cumplimentaron la entrevista. Además, se calculó un índice global que combinaba los tres componentes. La tasa global de respuesta osciló entre 35,6 por ciento en México y 81,4 por ciento en Chile, y el componente de esta tasa con mayor variabilidad fue la participación de personas elegibles, que varió entre 50 por ciento en México y 95 por ciento en Cuba. Estos valores fueron más bajos de lo esperado, sobre todo en los hombres, y servirán de orientación para futuras encuestas, ya que se deberán considerar tasas de rechazo mayores de las previstas en el protocolo. Los resultados permiten inferir la validez de las estimaciones de la prevalencia de los diversos comportamientos de riesgo observados y establecen una referencia para calcular el tamaño muestral de futuras encuestas y mejorar la metodología de la investigación
This study compares participation rates and reasons for nonresponse in surveys conducted in five countries of Latin America and the Caribbean. The objective of the surveys was to measure the prevalence of risk behaviors affecting the transmission of human immunodeficiency virus. The surveys were based on probability samples of the population of both sexes between 15 and 49 years old, except in Mexico, where only men were included. Proportions of three components of participation were estimated: residences interviewed, interviewed residences with eligible persons, and eligible persons who completed the interview. In addition, an overall index that combined the three components was calculated. The overall response rate ranged from 35.6% in Mexico to 81.4% in Chile. The component with the greatest variability was the participation of eligible persons, which ranged from 50% in Mexico to 95% in Cuba. These values were lower than what had been expected, especially among men, and will serve to guide future surveys, since rejection rates higher than the ones expected in the protocol should be considered. The results make it possible to infer the validity of the prevalence estimates for the various observed risk behaviors. The results also establish a benchmark to calculate the sample size in future surveys and to improve research methodology
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Assunção de Riscos , Infecções Sexualmente Transmissíveis , HIV , Pesquisa , Coleta de Dados , Saúde Pública , América LatinaAssuntos
Pesquisa , Coleta de Dados , HIV , América Latina , Saúde Pública , Assunção de Riscos , Infecções Sexualmente TransmissíveisRESUMO
Las enfermedades de transmisión sexual (ETS) constituyen un problema de salud pública con importantes consecuencias y secuelas que incluyen la enfermedad inflamatoria pélvica, la infertilidad, el carcinoma cervical y los desenlaces adversos del embarazo. En la última década, la estrecha asociación entre la presencia de ETS y el aumento del riesgo de transmisión sexual del virus de la inmunodeficiencia humana ha renovado el interés por la prevención y control de las ETS. Sin embargo, en América Latina y el Caribe, la información epidemiológica sobre la magnitud del problema de las ETS es escasa y, en general, está limitada a un pequeño número de estudios y a datos oficiales incompletos de los países de la zona. Tras una cuidadosa revisión de la literatura y un análisis de los datos que posee la Organización Mundial de la Salud sobre cada país, hemos estimado la prevalencia e incidencia en América Latina y el Caribe de cuatro ETS curables (sífilis, gonorrea, infección por clamídias y tricomoniasis) en hombres y mujeres de 15 a 49 años de edad. Para ello se utilizaron parámetros tales como la duración de la infección, la estimación de los pacientes tratados frente a los no tratados y los datos de población. En 1996, el número estimado de casos en América Latina y el Caribe fue de 1,3 millones para la sífilis, de 7,1 millones para la gonorrea, de 10,0 millones para las infecciones clamidiales y de 17,7 millones para la tricomoniasis. Con una cifra estimada total que, en el mejor de los casos, es superior a 36 millones de casos anuales, las ETS tratables parecen constituir un importante problema de salud pública en la zona
Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Vaginite por Trichomonas , Gonorreia , Infecções Sexualmente Transmissíveis , Sífilis , América Latina , Região do CaribeRESUMO
Sexually transmitted diseases (STDs) have long been known for their great impact on health. In 1995, there were an estimated 333 million new cases of curable STDs among adults around the world (1). The prevalence of STDs in many developing countries, including those of Latin America and the Caribbean (LAC), is extremely high. In the AIDS era there is an urgent need to adequately control and manage these diseases. A delay in diagnosing and treating STDs can lead to chronic complications and irreversible sequelae. Women and children suffer the main consequences. In women, the most serious consequences are acute and chronic pelvic inflammatory diseases, infertility, ectopic pregnancy, and cervical cancer. Infection during pregnancy may cause spontaneous abortion, stillbirth, prematurity, low birthweight, congenital syphilis, and opthalmia neonatorum. There is an urgent need to improve STD surveillance and prevention in the LAC nations. This paper intends to help in that effort by reviewing relevant STD prevalence and incidence of gonorrhea, syphilis, chlamydia, and trichomoniasis in Latin America and the Caribbean (AU)
RESUMO
At present, human immunodeficiency virus (HIV) is thought to have infected over 17 million people worldwide, over 1 million in North America and roughly 2 million in Latin America and the Caribbean. By comparison, infection with the tuberculosis (TB) agent mycobacterium tuberculosis is far more common, current estimates that roughly one-third of the world's population is infected. These two infections tend to aggravate each other. That is, HIV leads to a progressive immune system depression that favors reactivation of TB in people with latent tuberculous infections; it promotes progression of TB primary infections or reinfections to full-blown tuberculous disease; and it fosters TB transmission, because those simultaneously infected with HIV and M. tuberculosis tend to develop a bacilliferous and contagious TB that can be transmitted to other susceptible individuals, even though the latter are HIV-negative. In addition, this coinfection tends to promote circulation of drug-resistant M. tuberculosis and to produce peculiar manifestations that complicate TB diagnosis, treatment, and control. Overall, it seems clear that the growing threat posed by the these associated agents demands effective action in the form of well-coordinated measures involving thoroughgoing participation by all countries
Edited and updated version of a contribution previously published in Spanish in the BOSP. 116(3):250-262, 1994
Assuntos
Síndrome da Imunodeficiência Adquirida , Tuberculose , Infecções por HIV , Surtos de Doenças , América Latina , Região do CaribeRESUMO
En el presente artículo se describen la pandemia del SIDA y su evolución desde que comenzó, así como la distribución geográfica de la enfermedad en América Latina y el Caribe. Posteriormente se examina el problema de la tuberculosis desde el punto de vista de su patogenia y repercusión en la salud pública de los países y se explica la interacción entre el virus de la inmunodeficiencia humana y Mycobacterium tuberculosis en América Latina y el Caribe, prestando atención a las características de la asociación que la convierten en un problema de salud pública de gravedad. Por último se señala la necesidad prioritaria de conocer el estado actual de esta asociación en los diversos países y de diseminar la información que en ellos se genera (AU)
Assuntos
Síndrome da Imunodeficiência Adquirida , América Latina , Tuberculose , Surtos de Doenças , Região do CaribeRESUMO
At present, human immunodeficiency virus (HIV) is thought to have infected over 17 million people worldwide, over 1 million in North America and the Caribbean. By comparison, infection with the tuberculosis (TB) agent Mycobacterium tuberculosis is far more common, current estimates indicating that roughly one-third of the world's population is infected. These two infections tend to aggravate each other. That is, HIV leads to a progressive immune system depression that favors reactivation of TB in people with latent tuberculosis infections; it promotes progression of TB primary infections or reinfections to full-blown tuberculosis disease; and it fosters TB transmission, because those simultaneously infected with HIV and M. tuberculosis tend to develop a baciliferous and contagious TB that can be transmitted to other susceptible individuals, even though the latter are HIV-negative. In addition, this coinfection tends tok promote circulation of drug-resistant M. tuberculosis and to produce peculiar manifestations that complicate TB diagnosis, treatment, and control. Overall, it seems clear that the growing threat posed by these associated agents demands effective action in the form of well-coordinated measures involving thoroughgoing participation by all countries (AU)