RESUMO

The synthesis, in vitro evaluation, and structure-activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties.

Assuntos

Alilamina/síntese química , Alilamina/farmacologia , Antifúngicos/química , Antifúngicos/farmacologia , Alilamina/análogos & derivados , Antifúngicos/síntese química , Arthrodermataceae/efeitos dos fármacos , Células Cultivadas , Simulação por Computador , Testes de Sensibilidade Microbiana , Modelos Químicos , Estrutura Molecular , Relação Estrutura-Atividade