RESUMO

Background: Choroid plexus tumors are uncommon neoplasms derived from the neuroepithelium that covers the ventricular cavity and the central canal of the spinal cord that are characterized by papillar aspect and intraventricular growth. It occurs more commonly in dogs, but it has been reported in horses, cows, ferrets and is rare in cats. After the meningiomas and gliomas, choroid plexus tumors are the third encephalic tumors in dogs. In veterinary medicine, there are not many actual reports of this type of neoplasia, therefore, the aim of this paper was to report a case of a choroid plexus papilloma in a poodle dog.Case: A six year old dog, female, poodle, was admitted at the Veterinary Hospital of the São Paulo State University Júlio de Mesquita Filho with a complaint of seizures for 15 days, blindness and head tilt to the right side. At the neurological examination, it had depression, head tilt to the right, circling and ataxia, postural reactions defi cits, absent menace response, absent light pupillary reflex with mydriasis and augmented patellar refl ex. The patient was submitted to blood harvest to perform CBC count and biochemical profi le (renal and hepatic), which were normal. The cerebrospinal fluid analysis presented a discrete raise of proteins. The animal was treated with phenobarbital and prednisone, under suspicion of infl ammatory disease or encephalic neopla

Background: Choroid plexus tumors are uncommon neoplasms derived from the neuroepithelium that covers the ventricular cavity and the central canal of the spinal cord that are characterized by papillar aspect and intraventricular growth. It occurs more commonly in dogs, but it has been reported in horses, cows, ferrets and is rare in cats. After the meningiomas and gliomas, choroid plexus tumors are the third encephalic tumors in dogs. In veterinary medicine, there are not many actual reports of this type of neoplasia, therefore, the aim of this paper was to report a case of a choroid plexus papilloma in a poodle dog.Case: A six year old dog, female, poodle, was admitted at the Veterinary Hospital of the São Paulo State University Júlio de Mesquita Filho with a complaint of seizures for 15 days, blindness and head tilt to the right side. At the neurological examination, it had depression, head tilt to the right, circling and ataxia, postural reactions defi cits, absent menace response, absent light pupillary reflex with mydriasis and augmented patellar refl ex. The patient was submitted to blood harvest to perform CBC count and biochemical profi le (renal and hepatic), which were normal. The cerebrospinal fluid analysis presented a discrete raise of proteins. The animal was treated with phenobarbital and prednisone, under suspicion of infl ammatory disease or encephalic neopla

RESUMO

Background: Choroid plexus tumors are uncommon neoplasms derived from the neuroepithelium that covers the ventricular cavity and the central canal of the spinal cord that are characterized by papillar aspect and intraventricular growth. It occurs more commonly in dogs, but it has been reported in horses, cows, ferrets and is rare in cats. After the meningiomas and gliomas, choroid plexus tumors are the third encephalic tumors in dogs. In veterinary medicine, there are not many actual reports of this type of neoplasia, therefore, the aim of this paper was to report a case of a choroid plexus papilloma in a poodle dog.Case: A six year old dog, female, poodle, was admitted at the Veterinary Hospital of the São Paulo State University Júlio de Mesquita Filho with a complaint of seizures for 15 days, blindness and head tilt to the right side. At the neurological examination, it had depression, head tilt to the right, circling and ataxia, postural reactions defi cits, absent menace response, absent light pupillary reflex with mydriasis and augmented patellar refl ex. The patient was submitted to blood harvest to perform CBC count and biochemical profi le (renal and hepatic), which were normal. The cerebrospinal fluid analysis presented a discrete raise of proteins. The animal was treated with phenobarbital and prednisone, under suspicion of infl ammatory disease or encephalic neopla

Background: Choroid plexus tumors are uncommon neoplasms derived from the neuroepithelium that covers the ventricular cavity and the central canal of the spinal cord that are characterized by papillar aspect and intraventricular growth. It occurs more commonly in dogs, but it has been reported in horses, cows, ferrets and is rare in cats. After the meningiomas and gliomas, choroid plexus tumors are the third encephalic tumors in dogs. In veterinary medicine, there are not many actual reports of this type of neoplasia, therefore, the aim of this paper was to report a case of a choroid plexus papilloma in a poodle dog.Case: A six year old dog, female, poodle, was admitted at the Veterinary Hospital of the São Paulo State University Júlio de Mesquita Filho with a complaint of seizures for 15 days, blindness and head tilt to the right side. At the neurological examination, it had depression, head tilt to the right, circling and ataxia, postural reactions defi cits, absent menace response, absent light pupillary reflex with mydriasis and augmented patellar refl ex. The patient was submitted to blood harvest to perform CBC count and biochemical profi le (renal and hepatic), which were normal. The cerebrospinal fluid analysis presented a discrete raise of proteins. The animal was treated with phenobarbital and prednisone, under suspicion of infl ammatory disease or encephalic neopla

RESUMO

Metronidazole is a nitronidazolic antibiotic used in veterinary medicine to the treatment of a variety of diseases. The cause of metronidazole neurotoxicity has not been determined. We report the case of a dog, female, Teckel, five-year-old, with a history of dorsiflexion of the tail, ataxia, muscle stiffness, recumbency, vertical nystagmus, apathy and anorexia, which was being medicated for seven days with metronidazole in a dose higher than the maximum recommended, and the neurological signs began after this period. Neurological signs were consistent with central vestibular dysfunction caused by metronidazole, such as ataxia and vertical nystagmus. In addition to the neurological changes, the clinical signs of anorexia and apathy are consistent with the administration of excessive doses of the medicine. The diagnosis of metronidazole-induced toxicosis is based on the history of normal to increased doses, clinical signs and resolution after discontinuation of the drug. In general, the prognosis is good after drug withdrawal and early diagnosis. Some dogs may die and others may recover completely. The neurotoxicosis has disappeared after the suspension of the medicine and supportive treatment. Veterinarians must be aware of potential complications associated with the use of this medicine, as well as limit their chronic use or high doses for the most severe cases, and diagnose t

O metronidazol é um antibiótico nitronidazólico usado na medicina veterinária para o tratamento de uma variedade de doenças. A causa da neurotoxicidade pelo metronidazol ainda não foi determinada. Relata-se o caso de um cão, fêmea, da raça Teckel, de cinco anos de idade, com histórico de dorsoflexão da cauda, ataxia, rigidez de musculatura, decúbito, nistagmo vertical, apatia e anorexia, que estava sendo medicada há sete dias com metronidazol em dose maior que a máxima recomendada, sendo que os sinais neurológicos iniciaram-se após esse período. As alterações neurológicas foram compatíveis com disfunção vestibular central causada pelo metronidazol, tais como ataxia e nistagmo vertical. Além das alterações neurológicas, o quadro de anorexia e apatia é condizente com a administração de doses excessivas do fármaco. O diagnóstico da intoxicação por metronidazol é baseado na história de administração de doses normais a aumentadas, nos sinais clínicos e na resolução destes após a suspensão da droga. Geralmente, o prognóstico é favorável após a suspensão do medicamento e com o diagnóstico precoce. Alguns cães podem morrer e outros podem se recuperar completamente. O cão apresentou resolução completa do quadro de neurotoxicose após a suspensão da terapia e o tratamento de suporte. Os médicos veterinários devem estar alertas sobre as complicações potenciais associadas ao uso deste medic

RESUMO

Metronidazole is a nitronidazolic antibiotic used in veterinary medicine to the treatment of a variety of diseases. The cause of metronidazole neurotoxicity has not been determined. We report the case of a dog, female, Teckel, five-year-old, with a history of dorsiflexion of the tail, ataxia, muscle stiffness, recumbency, vertical nystagmus, apathy and anorexia, which was being medicated for seven days with metronidazole in a dose higher than the maximum recommended, and the neurological signs began after this period. Neurological signs were consistent with central vestibular dysfunction caused by metronidazole, such as ataxia and vertical nystagmus. In addition to the neurological changes, the clinical signs of anorexia and apathy are consistent with the administration of excessive doses of the medicine. The diagnosis of metronidazole-induced toxicosis is based on the history of normal to increased doses, clinical signs and resolution after discontinuation of the drug. In general, the prognosis is good after drug withdrawal and early diagnosis. Some dogs may die and others may recover completely. The neurotoxicosis has disappeared after the suspension of the medicine and supportive treatment. Veterinarians must be aware of potential complications associated with the use of this medicine, as well as limit their chronic use or high doses for the most severe cases, and diagnose t

O metronidazol é um antibiótico nitronidazólico usado na medicina veterinária para o tratamento de uma variedade de doenças. A causa da neurotoxicidade pelo metronidazol ainda não foi determinada. Relata-se o caso de um cão, fêmea, da raça Teckel, de cinco anos de idade, com histórico de dorsoflexão da cauda, ataxia, rigidez de musculatura, decúbito, nistagmo vertical, apatia e anorexia, que estava sendo medicada há sete dias com metronidazol em dose maior que a máxima recomendada, sendo que os sinais neurológicos iniciaram-se após esse período. As alterações neurológicas foram compatíveis com disfunção vestibular central causada pelo metronidazol, tais como ataxia e nistagmo vertical. Além das alterações neurológicas, o quadro de anorexia e apatia é condizente com a administração de doses excessivas do fármaco. O diagnóstico da intoxicação por metronidazol é baseado na história de administração de doses normais a aumentadas, nos sinais clínicos e na resolução destes após a suspensão da droga. Geralmente, o prognóstico é favorável após a suspensão do medicamento e com o diagnóstico precoce. Alguns cães podem morrer e outros podem se recuperar completamente. O cão apresentou resolução completa do quadro de neurotoxicose após a suspensão da terapia e o tratamento de suporte. Os médicos veterinários devem estar alertas sobre as complicações potenciais associadas ao uso deste medic

RESUMO

São descritos os achados anatomopatológicos de um caso de mixossarcoma cutâneo em um Hamster Sírio de 2 anos de idade. Macroscopicamente, foi evidenciada um grande massa cutânea na região cervical lateral direita. A microscopia revelou a presença de um caso de mixossarcoma caracterizado por células fusiformes pleomórficas, frouxamente arranjadas, distribuídas aleatoriamente e, apresentando quantidade moderada de substância basofílica amorfa no estroma e áreas hemorrágicas. O estroma basofílico amorfo foi positivo na coloração Alcian blue, confirmando a presença de matriz mucopolissacarídea. Na imunoistoquímica, as células neoplásicas expressaram vimentina e foram negativas para a marcação de citoqueratina e proteína ácida fibrilar (GFAP).

The pathological findings in a 2-years-old Syrian hamster (Mesocricetus auratus) with a cutaneous myxosarcoma are described. Grossly, there was a large cutaneous mass in the right cervical region. Microscopical evaluation revealed a myxosarcoma characterized by pleomorphic, fusiform cells loosely arranged, randomly distributed, and presenting a moderate amount of basophilic amorphous stroma. There were hemorrhagic areas within the tumor. The basophilic amorphous stroma was positive to Alcian blue confirming the presence of a mucopolysaccharide matrix. Immunohistochemically, the neoplastic cells expressed vimentin, and were negative for cytokeratin or glial fibrillary acidic protein (GFAP).

RESUMO

RESUMO A encefalite do cão Pug é uma doença inflamatória idiopática rara do sistema nervoso central, que acomete cães de raças de pequeno porte. Acredita-se que tenha relação com infecções virais e com a presença de anticorpos contra uma substância presente no cérebro, além da predisposição genética e racial. Os sinais clínicos decorrentes desta enfermidade incluem: letargia, ataxia, andar em círculos, déficits proprioceptivos, cegueira e convulsões, dentre outros. O diagnóstico é difícil, sendo geralmente necroscópico, não exististindo tratamento específico para a doença, o que torna o prognóstico ruim. O presente relato descreve o caso de um cão da raça Pug, de um ano de idade, atendido no Hospital Veterinário da UNESP/Botucatu, apresentando apatia, desorientação, sialorréia, dispnéia e um episódio convulsivo. Após parada cardiorrespiratória, o animal veio a óbito, sendo encaminhado à necrópsia, onde pelos achados anatomopatológicos estabeleceu-se o diagnóstico de encefalite do Pug. Palavras-chave: sistema nervoso central, inflamação, histopatologia. PUG DOG ENCEPHALITIS: CASE REPORT ABSTRACT The Pug dog encephalitis is a rare idiopathic inflammatory disease of the central nervous system, which affects dogs from small breeds. It is believed to have relation with viral infections and the presence of antibodies against a substance in the brain, in addition to genetic and

RESUMO

RESUMO A encefalite do cão Pug é uma doença inflamatória idiopática rara do sistema nervoso central, que acomete cães de raças de pequeno porte. Acredita-se que tenha relação com infecções virais e com a presença de anticorpos contra uma substância presente no cérebro, além da predisposição genética e racial. Os sinais clínicos decorrentes desta enfermidade incluem: letargia, ataxia, andar em círculos, déficits proprioceptivos, cegueira e convulsões, dentre outros. O diagnóstico é difícil, sendo geralmente necroscópico, não exististindo tratamento específico para a doença, o que torna o prognóstico ruim. O presente relato descreve o caso de um cão da raça Pug, de um ano de idade, atendido no Hospital Veterinário da UNESP/Botucatu, apresentando apatia, desorientação, sialorréia, dispnéia e um episódio convulsivo. Após parada cardiorrespiratória, o animal veio a óbito, sendo encaminhado à necrópsia, onde pelos achados anatomopatológicos estabeleceu-se o diagnóstico de encefalite do Pug. Palavras-chave: sistema nervoso central, inflamação, histopatologia. PUG DOG ENCEPHALITIS: CASE REPORT ABSTRACT The Pug dog encephalitis is a rare idiopathic inflammatory disease of the central nervous system, which affects dogs from small breeds. It is believed to have relation with viral infections and the presence of antibodies against a substance in the brain, in addition to genetic and

RESUMO

This study was aimed at evaluating the use of a homologous bone implant preserved sugar in natura (Ga) (8) or in 300% sugar solution (Gb) (8) for reconstitution of the thoracic wall in 16 cats, involving three ribs. A costal defect was made on the right side of the thoracic wall and the preserved ribs were used as homologous bone implants for the correction of this defect. These ribs were fixed to the receptor by means of a catheter needle. The animals were clinically evaluated by X-rays and histology. The percentual of implant incorporation at 60 days was 91.7% in the Ga and 73.9% in the Gb. A mild resorption was observed at different times, 29.2% in the in natura sugar group, and 37.8% in the 300% sugar group. No case of infection or rejection was observed in the evaluated period. The homologous rib bone implant preserved in sugar in natura or in 300% solution is efficient for the reconstitution of costal wall in cats.

O objetivo deste estudo foi avaliar a eficiência do açúcar em diferentes formas de conservação para ossos, verificar a eficiência do implante de costela conservada na reconstituição de defeito torácico, avaliar a fixação da costela com agulha de cateter, e monitorar a estabilidade e a dinâmica do tórax após o implante. Além disso, buscou-se avaliar clinicamente, macroscopicamente, histologicamente e radiograficamente o material implantando. Os 16 implantes utilizados foram costelas homólogas conservadas em açúcar in natura (Ga) ou a 300% (Gb), na reconstituição de costelas de gatos. Os animais foram separados em dois grupos: Ga (8), utilizando açúcar "in natura" e o Gb (8), solução a 300%. Foi realizado defeito no terço médio do lado direito do tórax de 16 gatos adultos, os quais foram fixados no leito receptor por meio de agulha de cateter. A porcentagem de incorporação dos implantes foi de 91,7% aos 60 dias no Ga e 73,9% no Gb. Foram verificadas, em diferentes etapas, leve reabsorção do implante em 29,2% no Ga e de 37,8% no Gb. Não foi observado qualquer caso de eliminação ou de infecção. É possível concluir que o implante ósseo homólogo de costela conservado em açúcar "in natura" ou a 300% é uma opção viável para a reconstituição da parede torácica de gatos.

RESUMO

This study was aimed at evaluating the use of a homologous bone implant preserved sugar in natura (Ga) (8) or in 300% sugar solution (Gb) (8) for reconstitution of the thoracic wall in 16 cats, involving three ribs. A costal defect was made on the right side of the thoracic wall and the preserved ribs were used as homologous bone implants for the correction of this defect. These ribs were fixed to the receptor by means of a catheter needle. The animals were clinically evaluated by X-rays and histology. The percentual of implant incorporation at 60 days was 91.7% in the Ga and 73.9% in the Gb. A mild resorption was observed at different times, 29.2% in the in natura sugar group, and 37.8% in the 300% sugar group. No case of infection or rejection was observed in the evaluated period. The homologous rib bone implant preserved in sugar in natura or in 300% solution is efficient for the reconstitution of costal wall in cats.

O objetivo deste estudo foi avaliar a eficiência do açúcar em diferentes formas de conservação para ossos, verificar a eficiência do implante de costela conservada na reconstituição de defeito torácico, avaliar a fixação da costela com agulha de cateter, e monitorar a estabilidade e a dinâmica do tórax após o implante. Além disso, buscou-se avaliar clinicamente, macroscopicamente, histologicamente e radiograficamente o material implantando. Os 16 implantes utilizados foram costelas homólogas conservadas em açúcar in natura (Ga) ou a 300% (Gb), na reconstituição de costelas de gatos. Os animais foram separados em dois grupos: Ga (8), utilizando açúcar "in natura" e o Gb (8), solução a 300%. Foi realizado defeito no terço médio do lado direito do tórax de 16 gatos adultos, os quais foram fixados no leito receptor por meio de agulha de cateter. A porcentagem de incorporação dos implantes foi de 91,7% aos 60 dias no Ga e 73,9% no Gb. Foram verificadas, em diferentes etapas, leve reabsorção do implante em 29,2% no Ga e de 37,8% no Gb. Não foi observado qualquer caso de eliminação ou de infecção. É possível concluir que o implante ósseo homólogo de costela conservado em açúcar "in natura" ou a 300% é uma opção viável para a reconstituição da parede torácica de gatos.