RESUMO

Analogs of curcuphenol/elvirol, naturally occurring bisabolane sesquiterpenes, were prepared in six steps from alkyl-α-tetralones employing an aromatization reaction of cyclic dienone precursors and olefination of the key aldehyde intermediates. The in vitro antifungal activities of 6a, 6b, 6d, and 6g are also reported.

Assuntos

Aldeídos/química , Antifúngicos/química , Sesquiterpenos/química , Antifúngicos/síntese química , Antifúngicos/farmacologia , Ciclização , Testes de Sensibilidade Microbiana , Sesquiterpenos/síntese química , Sesquiterpenos/farmacologia

RESUMO

Enantiomerically pure compounds as precursors for the synthesis of hydroxylated derivatives of artemisinin/arteether have been prepared from (+)-(S)-carvone and (+)-car-2-ene.

Assuntos

Artemisininas/síntese química , Sesquiterpenos/síntese química , Estereoisomerismo