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J Pharm Pharm Sci ; 14(1): 17-35, 2011.
Artigo em Inglês | MEDLINE | ID: mdl-21501550

RESUMO

PURPOSE: This work describes the preparation of new nanocomposites based on lamellar silicates (AAM-alkyl ammonium montmorillonite) obtained by the intercalation of PVP K30 and glyceril monostearate. METHODS: By XRD, TGA and DSC analysis the AAM was characterized and its compactation characteristics, functionality and toxicity were also tested. The AAM/PVP K-30 and AAM/GME nanocomposite obtained were evaluated to identify the interlamellar spacing values by XRD diffratograms. Tablets were prepared using methyldopa and theophylline as model drugs and the dissolution tests were carried out in simulated gastric fluid and simulated enteric fluid. RESULTS: AAM showed a good compactability and compressibility characteristics for tablets preparation. The intercalation yields (approximately 25%) of the nanocomposites were efficient. The AAM/PVP K-30 nanocomposites were successfully tested as dissolution enhancers and sustained release matrixes. CONCLUSIONS: The results also suggested the promising use of AAM (viscogel B8) and the new nanocomposite prepared by clay/PVP K-30 intercalation as a new matrix for sustained release and the feasibility of using these new nanocomposites as dissolution enhancer.


Assuntos
Sistemas de Liberação de Medicamentos , Excipientes/química , Povidona/química , Silicatos/química , Animais , Bentonita/química , Bentonita/toxicidade , Varredura Diferencial de Calorimetria , Excipientes/toxicidade , Metildopa/administração & dosagem , Metildopa/química , Camundongos , Nanocompostos , Solubilidade , Comprimidos , Teofilina/administração & dosagem , Teofilina/química , Termogravimetria , Testes de Toxicidade , Difração de Raios X
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