RESUMO
Osteosarcoma is the most common bone cancer in dogs. It has a high invasion capacity and commonly metastasizes. This neoplasia ensues mainly in the medullary canal of long bones of the appendicular and axial skeleton, rarely affecting primarily extra-skeletal sites. Primary meningeal osteosarcomas are extremely rare both in human and veterinary medicine. A male, mixed breed dog was admitted at the Veterinary Hospital with a history of over excitement, decreased neurological reflexes, and seizures. The worsening of its clinical condition led to its euthanasia and anatomopathological examination at the Veterinary Pathology Service. This report describes a primary extra-skeletal osteosarcoma of a dogs meninges. Its clinical signs were indicative of a central nervous system disease later diagnosed by histopathological and immunohistochemical analysis.
O osteossarcoma é considerado a neoplasia óssea mais frequente em cães. Tem elevada capacidade invasiva e comumente gera metástase. Essa neoplasia é mais frequentemente observada no canal medular de ossos longos do esqueleto apendicular e axial. É raro que acometa primariamente sítios extraesqueléticos. O osteossarcoma primário meningeal é considerado extremamente raro em medicinas humana e veterinária. Um cão macho e sem raça definida foi atendido no Hospital Veterinário com histórico de excitação, diminuição dos reflexos neurológicos e desenvolvimento de quadro convulsivo. O agravamento do quadro clínico levou à eutanásia do animal e a um exame anatomopatológico pelo Serviço de Patologia Veterinária. O objetivo deste relato é descrever um caso de osteossarcoma extra-esquelético primário de meninge em um cão que apresentou quadro clínico compatível com doença originária do sistema nervoso central e que foi diagnosticado por meio das análises histopatológica e imunohistoquímica.
Assuntos
Masculino , Animais , Cães , Encéfalo/patologia , Meninges/patologia , Osteossarcoma/diagnóstico , Osteossarcoma/veterinária , Imuno-Histoquímica/veterinária , Neoplasias Meníngeas/veterinária , Neoplasias Ósseas/veterináriaRESUMO
Osteosarcoma is the most common bone cancer in dogs. It has a high invasion capacity and commonly metastasizes. This neoplasia ensues mainly in the medullary canal of long bones of the appendicular and axial skeleton, rarely affecting primarily extra-skeletal sites. Primary meningeal osteosarcomas are extremely rare both in human and veterinary medicine. A male, mixed breed dog was admitted at the Veterinary Hospital with a history of over excitement, decreased neurological reflexes, and seizures. The worsening of its clinical condition led to its euthanasia and anatomopathological examination at the Veterinary Pathology Service. This report describes a primary extra-skeletal osteosarcoma of a dogs meninges. Its clinical signs were indicative of a central nervous system disease later diagnosed by histopathological and immunohistochemical analysis.(AU)
O osteossarcoma é considerado a neoplasia óssea mais frequente em cães. Tem elevada capacidade invasiva e comumente gera metástase. Essa neoplasia é mais frequentemente observada no canal medular de ossos longos do esqueleto apendicular e axial. É raro que acometa primariamente sítios extraesqueléticos. O osteossarcoma primário meningeal é considerado extremamente raro em medicinas humana e veterinária. Um cão macho e sem raça definida foi atendido no Hospital Veterinário com histórico de excitação, diminuição dos reflexos neurológicos e desenvolvimento de quadro convulsivo. O agravamento do quadro clínico levou à eutanásia do animal e a um exame anatomopatológico pelo Serviço de Patologia Veterinária. O objetivo deste relato é descrever um caso de osteossarcoma extra-esquelético primário de meninge em um cão que apresentou quadro clínico compatível com doença originária do sistema nervoso central e que foi diagnosticado por meio das análises histopatológica e imunohistoquímica.(AU)
Assuntos
Animais , Masculino , Cães , Osteossarcoma/diagnóstico , Osteossarcoma/veterinária , Meninges/patologia , Encéfalo/patologia , Neoplasias Ósseas/veterinária , Imuno-Histoquímica/veterinária , Neoplasias Meníngeas/veterináriaRESUMO
This study aimed to evaluate the risk factors for tuberculosis (TB) treatment default in a priority city for disease control in Brazil. A cohort of TB cases diagnosed from 2008 to 2009 was followed up from patients' entry into three outpatient sites, in Juiz de Fora, Minas Gerais (Brazil), until the recording of the outcomes. Drug addiction, alcoholism and treatment site appeared to be independently associated with default. Current users of crack as the hardest drug (odds ratio (OR) 12·25, 95% confidence interval (CI) 3·04-49·26) were more likely to default than other hard drug users (OR 5·67, 95% CI 1·34-24·03), former users (OR 4·12, 95% CI 1·11-15·20) and those not known to use drugs (reference group). Consumers at high risk of alcoholism (OR 2·94, 95% CI 1·08-7·99) and those treated in an outpatient hospital unit (OR 8·22, 95% CI 2·79-24·21%) also were more likely to default. Our results establish that substance abuse was independently associated with default. National TB programmes might be more likely to achieve their control targets if they include interventions aimed at improving adherence and cure rates, by diagnosing and treating substance abuse concurrently with standard TB therapy.
Assuntos
Alcoolismo/epidemiologia , Antituberculosos/uso terapêutico , Adesão à Medicação/estatística & dados numéricos , Transtornos Relacionados ao Uso de Substâncias/epidemiologia , Tuberculose/tratamento farmacológico , Adulto , Alcoolismo/complicações , Brasil/epidemiologia , Feminino , Humanos , Masculino , Estudos Prospectivos , Fatores de Risco , Transtornos Relacionados ao Uso de Substâncias/complicações , Tuberculose/complicações , Tuberculose/epidemiologiaRESUMO
STUDY DESIGN: Cross-sectional study. OBJECTIVES: The study aimed (a) to test the cross-validation of current one-repetition maximum (1RM) predictive equations in men with spinal cord injury (SCI); (b) to compare the current 1RM predictive equations to a newly developed equation based on the 4- to 12-repetition maximum test (4-12RM). SETTING: SARAH Rehabilitation Hospital Network, Brasilia, Brazil. METHODS: Forty-five men aged 28.0 years with SCI between C6 and L2 causing complete motor impairment were enrolled in the study. Volunteers were tested, in a random order, in 1RM test or 4-12RM with 2-3 interval days. Multiple regression analysis was used to generate an equation for predicting 1RM. RESULTS: There were no significant differences between 1RM test and the current predictive equations. ICC values were significant and were classified as excellent for all current predictive equations. The predictive equation of Lombardi presented the best Bland-Altman results (0.5 kg and 12.8 kg for mean difference and interval range around the differences, respectively). The two created equation models for 1RM demonstrated the same and a high adjusted R2 (0.971, P<0.01), but different SEE of measured 1RM (2.88 kg or 5.4% and 2.90 kg or 5.5%). CONCLUSION: All 1RM predictive equations are accurate to assess individuals with SCI at the bench press exercise. However, the predictive equation of Lombardi presented the best associated cross-validity results. A specific 1RM prediction equation was also elaborated for individuals with SCI. The created equation should be tested in order to verify whether it presents better accuracy than the current ones.
Assuntos
Modelos Biológicos , Força Muscular , Traumatismos da Medula Espinal/diagnóstico , Traumatismos da Medula Espinal/fisiopatologia , Adulto , Composição Corporal , Estudos Transversais , Humanos , Masculino , Paraplegia/diagnóstico , Paraplegia/fisiopatologia , Paraplegia/reabilitação , Quadriplegia/diagnóstico , Quadriplegia/fisiopatologia , Quadriplegia/reabilitação , Análise de Regressão , Traumatismos da Medula Espinal/reabilitação , Adulto JovemRESUMO
We examined the correspondence in performance between trees selected from a family test and their respective clones from a clonal test of Eucalyptus. Full-sib families were obtained from controlled pollination among individuals of Eucalyptus grandis and between E. grandis and E. urophylla. The hybridizations did not follow a factorial scheme. The family tests were carried out at three locations in Eunápolis and Itabela counties, in Bahia, Brazil, in 2003. Four hundred and ninety-seven high-performance trees were selected, by the individual BLUP procedure, in the family tests at two years of age, based on wood volume. The clones from these trees and 14 checks were evaluated in clonal tests carried out in the same region in 2006. The wood volume of the clones was evaluated at two years of age. Trait correlation between the trees selected from the family and clonal tests was low. The estimate of the coincidence between the best trees and the best clones using an average of the different intensities of selection was only 27%. These results demonstrate that the selection of trees in the family test should not be too drastic; otherwise the chance plus clones may be overlooked.
Assuntos
Eucalyptus/genética , Especificidade da EspécieRESUMO
AIM: The aim of the present study was to analyze the effects of resistance training in groups (with music) on the lipid profile in obese women. METHODS: The sample was composed of 28 sedentary obese women. Of these, 13 were submitted to the resistance training in group program (GT) and 15 took part in a control group (GC). The training lasted for 9 weeks, with three weekly sessions. The classes emphasized resistance training through the performance of 10 localized exercises. The analysis evaluated the following variables: total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides (TG) and the TC/HDL ratio in the pre and post-training periods in both groups. The data was analyzed using Anova for repeated measures with one factor, adopting P<0.05. RESULTS: The study found significant differences for the training group between the pre- and post-training period in all the analyzed variables, except for the TG. In contrast, for the control group there was no significant difference between the pre and post-training period in any of the variables, except for the TG in which we found a statistically significant increase. The reductions were from 200.62 ± 39.11 mg·dL-1 to 184.92 ± 28.62 mg·dL-1 for TC; from 137.69 ± 32.09 mg·dL-1 to 110.31 ± 21.92 mg·dL-1 for LDL; from 4.48 ± 1.00 to 3.70 ± 0.90 for the TC/HDL ratio and the improvement in the HDL was from 46.23 ± 12.04 mg·dL-1 to 53.15 ± 16.83 mg·dL-1. CONCLUSION: Thus, it was concluded that the resistance training in groups with music was effective since it provided beneficial modifications to the lipid profile, which may result in lower risk of coronary arterial diseases in the obese female population.
Assuntos
Colesterol/sangue , Lipoproteínas HDL/sangue , Lipoproteínas LDL/sangue , Obesidade/sangue , Treinamento Resistido , Triglicerídeos/sangue , Adulto , Composição Corporal , Índice de Massa Corporal , Feminino , Humanos , MúsicaRESUMO
ABSTRACT This study was aimed to evaluate the toxicity of some fungicides applied on cucumber crop (Cucumis sativus L.) in function in the manner of exposure, by contact or ingestion of contaminated preys, for first-instar Chrysoperla externa (Hagen) larvae fed with Aphis gossypii Glover (Hemiptera: Aphididae), and the effects on the subsequent stages of the predator. The experiments were conducted under controlled conditions at 25 ± 2oC; RH: 70 ± 10% and 12h of photophase. The experimental design was completely randomized with 4 treatments and 6 replicates, each plot made up of 4 larvae. The compounds utilized and their respective dosages of application in g a.i.L-1 were sulfur (Kumulus 800PM 1.6), mancozeb (Manzate 800PM 1.6) and copper oxichloride (Recop 840PM 1.49). The control consisted of distilled water. First-instar larvae received the chemicals via spraying and were then individualized into glass tubes, and fed A. gossypii nymphs. In the bioassay, via ingestion, the A. gossypii nymphs treated via spraying with the compounds were given as food to first-stage larvae of C. externa. The total effect of the fungicides from C. externa was established according to the toxicity classes of the IOBC scale, where copper oxichloride proved harmless (class 1) via contact or ingestion. Sulfur and mancozeb by ingestion were harmless, and slightly harmful (class 2) when applied via contact.
RESUMO Objetivou-se avaliar a toxicidade de alguns fungicidas aplicados em cultura de pepino (Cucumis sativus L.), em função das formas de exposição, por contato ou ingestão de presas contaminadas, para larvas de primeiro ínstar de Chrysoperla externa (Hagen) alimentadas com Aphis gossypii Glover (Hemiptera: Aphididae) e os efeitos sobre as fases subseqüentes de desenvolvimento do predador. Os experimentos foram conduzidos em condições controladas a 25 ± 2o C, 70 ± 10% UR e fotofase de 12 horas. O delineamento experimental foi inteiramente ao acaso, com quatro tratamentos e seis repetições, sendo cada parcela composta por quatro larvas. Os compostos utilizados e suas respectivas dosagens de aplicação em g i.a.L-1 foram: enxofre (Kumulus 800PM 1,6), mancozebe (Manzate 800PM 1,6) e oxicloreto de cobre (Recop 840PM 1,49). A testemunha foi composta por água destilada. No bioensaio de contato, larvas de primeiro ínstar de C. externa receberam os produtos via pulverização, por meio de torre de Potter e, em seguida, foram individualizadas em tubos de vidro, as quais foram alimentadas diariamente com ninfas de A. gossypii. No bioensaio via ingestão, as ninfas de A. gossypii tratadas via pulverização com os compostos foram oferecidas como alimento para larvas de primeiro estádio de C. externa. O efeito total dos fungicidas para C. externa foi estabelecido conforme as classes de toxicidade preconizadas pela IOBC, em que oxicloreto de cobre mostrou-se inócuo (classe 1) via contato ou ingestão. Enxofre e mancozebe por ingestão foram inócuos, e quando aplicados via contato foram levemente nocivos (classe 2).
RESUMO
A case report of a HIV seropositive 8-year-old child with vulvar and anal border neoplasia, both grade 3, and the adopted therapeutic management are presented. The mother reported the history of a progressively growing verrucous lesion in the vulva since the age of three and a half years. On physical examination a pigmented and elevated lesion was observed in the whole vulvar region extending to the anal region and intergluteal sulcus. After biopsies and anatomic pathological examination, antiretroviral therapy, adequate for age, and topical application of podophyllotoxin associated with Thuya officinalis extract was started. Three months afterwards vaporization and CO2 laser excision were performed in five sequential sessions, thereafter associated with topical imiquimod application. After the first two sessions of laser therapy early relapses occurred. After four weeks of imiquimod use, already a significant improvement of the lesions was observed, making the following laser therapy sessions easier. We conclude that antiretroviral therapy associated with podophyllotoxin and Thuya was not effective regarding regression of the lesions. Laser therapy alone led to early relapses. The local use of imiquimod associated with laser was effective in decreasing and controling the lesions.
Assuntos
Neoplasias do Ânus/terapia , Carcinoma/terapia , Infecções por HIV/diagnóstico , Infecções por HIV/tratamento farmacológico , Neoplasias Vulvares/terapia , Administração Tópica , Aminoquinolinas/administração & dosagem , Fármacos Anti-HIV/uso terapêutico , Neoplasias do Ânus/patologia , Carcinoma/patologia , Criança , Terapia Combinada , Feminino , Seguimentos , Infecções por HIV/imunologia , Soropositividade para HIV , Humanos , Imiquimode , Hospedeiro Imunocomprometido , Terapia com Luz de Baixa Intensidade/métodos , Infecções por Papillomavirus/patologia , Infecções por Papillomavirus/terapia , Medição de Risco , Resultado do Tratamento , Neoplasias Vulvares/patologiaRESUMO
Sentinel node mapping reduces surgical morbidity and allows the use of more accurate tumour staging techniques. Radionuclide studies are preferentially performed using small colloids, which have limited availability in our country. The possibility of using phytate for sentinel node mapping was raised because of the similarity between its biodistribution and that of nanocolloids in the reticulo-endothelial system. In this paper we evaluated the use of 99mTc-phytate for sentinel node mapping, correlating the histopathological results with the status of the rest of the lymph node chain in different malignant tumours. A total of 100 patients were studied. group 1 consisted of 62 patients with breast cancer, group 2 of 20 patients with melanoma and group 3 of 18 patients with vulvar carcinoma. Lymph node scintigraphy was carried out after injecting 99mTc-phytate subdermally, and the sentinel node projection was marked on the skin. After 18-24 h, intraoperative sentinel node localisation was performed using a gamma probe (combined with visual localisation using patent blue dye) in 75 patients, and lymph node dissection was then carried out. Radionuclide scintigraphy identified the sentinel node in 98% of all studies. Intraoperative detection using the gamma probe was equally efficient: group 1=93% (38/41), group 2=95% (18/19) and group 3=100% (15/15). The sentinel node was involved in 41%, 31% and 20% of cases in groups 1, 2 and 3, respectively. Among the patients with positive nodes, the sentinel node was the only one affected in 53% of group 1, 50% of group 2 and 67% of group 3 cases. The method's negative predictive value was 91% in group 1 and 100% in the other groups. One false-negative study occurred in a patient who had a multifocal tumour and an intraparenchymatous lymph node; another occurred in a patient with a macroscopically affected node found during surgery. There were no side-effects related to the 99mTc-phytate. It is concluded that scintigraphic and intraoperative sentinel node identification was satisfactorily performed using 99mTc-phytate. The results were comparable to those previously described in the literature using other radiopharmaceuticals. Easy availability and low cost justify the use of phytate in our practice.