RESUMO
INTRODUCTION: Ovarian cancer is generally diagnosed at advanced stages of the disease; therefore, poor prognoses are typical. The development of tumor markers is thus of utmost importance. Prostasin is a protease that in normal tissues is highly expressed only in the prostate gland and seminal fluid. A previous study showed that prostasin is highly overexpressed in ovarian cancer cell lines. This study sought to evaluate the expression of prostasin in ovarian cancer. METHODS: Fresh tumor samples of ovarian epithelial cancer (n: 12) were analyzed for expression of prostasin mRNA (messenger ribonucleic acid) by conventional and real time quantitative PCR (polymerase chain reaction). As a standard control, a normal prostate sample was analyzed. RESULTS: Using conventional PCR, prostasin was detected in all but one sample. Using quantitative PCR, prostasin was over-expressed in all but one of the samples as compared to the control (prostate). CONCLUSIONS: These findings indicate that prostasin is overexpressed in many epithelial ovarian cancers. Further studies of prostasin as a potential biomarker for this disease are warranted.
Assuntos
Biomarcadores Tumorais/sangue , Regulação Neoplásica da Expressão Gênica , Programas de Rastreamento/métodos , Proteínas de Neoplasias/sangue , Neoplasias Ovarianas/enzimologia , Serina Endopeptidases/sangue , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Pessoa de Meia-Idade , Neoplasias Ovarianas/diagnóstico , Projetos Piloto , Reação em Cadeia da Polimerase Via Transcriptase ReversaRESUMO
INTRODUCTION: Ovarian cancer is generally diagnosed at advanced stages of the disease; therefore, poor prognoses are typical. The development of tumor markers is thus of utmost importance. Prostasin is a protease that in normal tissues is highly expressed only in the prostate gland and seminal fluid. A previous study showed that prostasin is highly overexpressed in ovarian cancer cell lines. This study sought to evaluate the expression of prostasin in ovarian cancer. METHODS: Fresh tumor samples of ovarian epithelial cancer (n: 12) were analyzed for expression of prostasin mRNA (messenger ribonucleic acid) by conventional and real time quantitative PCR (polymerase chain reaction). As a standard control, a normal prostate sample was analyzed. RESULTS: Using conventional PCR, prostasin was detected in all but one sample. Using quantitative PCR, prostasin was over-expressed in all but one of the samples as compared to the control (prostate). CONCLUSIONS: These findings indicate that prostasin is overexpressed in many epithelial ovarian cancers. Further studies of prostasin as a potential biomarker for this disease are warranted.
Assuntos
Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Pessoa de Meia-Idade , Regulação Neoplásica da Expressão Gênica , Programas de Rastreamento/métodos , Proteínas de Neoplasias/sangue , Neoplasias Ovarianas/enzimologia , Serina Endopeptidases/sangue , Biomarcadores Tumorais/sangue , Neoplasias Ovarianas/diagnóstico , Projetos Piloto , Reação em Cadeia da Polimerase Via Transcriptase ReversaAssuntos
Adenocarcinoma/sangue , Anticorpos Antifosfolipídeos/sangue , Neoplasias Pulmonares/sangue , Neoplasias da Próstata/sangue , Trombose Venosa/sangue , Adenocarcinoma/imunologia , Idoso , Humanos , Neoplasias Pulmonares/imunologia , Neoplasias Pulmonares/secundário , Masculino , Pessoa de Meia-Idade , Neoplasias da Próstata/imunologia , Trombose Venosa/imunologiaAssuntos
Humanos , Masculino , Pessoa de Meia-Idade , Adenocarcinoma/sangue , Anticorpos Antifosfolipídeos/sangue , Neoplasias Pulmonares/sangue , Neoplasias da Próstata/sangue , Trombose Venosa/sangue , Adenocarcinoma/imunologia , Neoplasias Pulmonares/imunologia , Neoplasias Pulmonares/secundário , Neoplasias da Próstata/imunologia , Trombose Venosa/imunologiaRESUMO
Os autores apresentaram um caso de angiolipoma epidural pela raridade dessa patologia. De localizaçao epidural torácica a lesao causava maior compressao no nível de T3-T4. Nao havia disrafismos espinhais, nem relato de uso de corticosteróides e simulava enfermidade degenerativa medular pelo tempo de evoluçao.
Assuntos
Humanos , Masculino , Idoso , Angiolipoma , Espaço Epidural , Vértebras Torácicas/cirurgia , Hipertensão , Laminectomia , Equilíbrio Postural , Reflexo de BabinskiRESUMO
Os autores relatam um caso de um paciente de 5 meses de idade, com papiloma de plexo coróide (PPC) associado a hidrocefalia importante por super-produçao liquórica. Como decorrência do tratamento, inúmeras complicaçoes ocorreram, como hematoma subdural agudo, coleçao subdural crônica de início hipertensivo, sendo necessários vários procedimentos cirúrgicos, culminando com derivaçao ventrículo peritoneal e subduro-peritoneal.