RESUMO
INTRODUCTION: Breast cancer is the most common type among women and brings to them significant organic changes. A new intracranial pressure monitorization method consists of an external system of sensors that detects micrometric deformations on the cranial bones and transmits, in real-time, electrical signals that are visualized on a monitor. OBJECTIVE: To identify changes in intracranial pressure due to chemotherapy connections through non-invasive methodology. METHODS: The present study was conducted at Hospital Santa Casa de Misericordia in the city of Ponta Grossa, PR, Brazil in 2017. The variables P2/P1 ratio (ICP morphological evaluation), laboratory parameters, comorbidities, and clinical aspects of the volunteers were evaluated. The vascular toxicity of chemotherapy often causes endothelial dysfunction, resulting in a loss of vasodilation effects and suppresses anti-inflammatory and vascular repair functions. RESULTS: The values of the P2/P1 ratio before and after chemotherapy were also compared between groups. A statistically significant difference was observed in the pre chemotherapy P2/P1 values compared to the post-chemotherapy values. CONCLUSION: Variations in ICP may occur in cancer patients. Further studies are necessary to evaluate if this change may contribute to the chemotherapy side effects occurrence.
INTRODUÇÃO: O câncer de mama é o tipo mais comum entre as mulheres e traz para elas significativas alterações orgânicas. Um novo método de monitoramento da pressão intracraniana consiste em um sistema externo de sensores que detecta deformações micrométricas nos ossos cranianos e transmite, em tempo real, sinais elétricos que são visualizados em um monitor. OBJETIVO: Identificar alterações na pressão intracraniana devido às conexões de quimioterapia por meio de metodologia não invasiva. MÉTODOS: O presente estudo foi realizado no Hospital Santa Casa de Misericórdia da cidade de Ponta Grossa, PR, Brasil, em 2017. Foram avaliadas as variáveis relação P2/P1 (avaliação morfológica da PIC), parâmetros laboratoriais, comorbidades e aspectos clínicos dos voluntários. A toxicidade vascular da quimioterapia frequentemente causa disfunção endotelial, resultando na perda dos efeitos vasodilatadores e suprime as funções anti-inflamatórias e de reparo vascular. RESULTADOS: Os valores da relação P2/P1 antes e após a quimioterapia também foram comparados entre os grupos. Uma diferença estatisticamente significativa foi observada nos valores de P2/P1 pré-quimioterapia em comparação com os valores pós-quimioterapia. CONCLUSÃO: Variações na PIC podem ocorrer em pacientes com câncer. Mais estudos são necessários para avaliar se essa alteração pode contribuir para a ocorrência dos efeitos colaterais da quimioterapia.
Assuntos
Humanos , Neoplasias da Mama/tratamento farmacológico , Pressão Intracraniana , Capacitância Vascular , Estudos de Casos e ControlesRESUMO
End-stage renal disease (ESRD) is treated mainly by hemodialysis, however, hemodialysis is associated with frequent complications, some of them involve the increased intracranial pressure. In this context, monitoring the intracranial pressure of these patients may lead to a better understanding of how intracranial pressure morphology varies with hemodialysis. This study aimed to follow-up patients with ESRD by monitoring intracranial pressure before and after hemodialysis sessions using a noninvasive method. We followed-up 42 patients with ESRD in hemodialysis, for six months. Noninvasive intracranial pressure monitoring data were obtained through analysis of intracranial pressure waveform morphology, this information was uploaded to Brain4care® cloud algorithm for analysis. The cloud automatically sends a report containing intracranial pressure parameters. In total, 4881 data points were collected during the six months of follow-up. The intracranial pressure parameters (time to peak and P2/P1 ratio) were significantly higher in predialysis when compared to postdialysis for the three weekly sessions and throughout the follow-up period (p<0.01) data showed general improvement in brain compliance after the hemodialysis session. Furthermore, intracranial pressure parameters were significantly higher in the first weekly hemodialysis session (p<0.05). In conclusion, there were significant differences between pre and postdialysis intracranial pressure in patients with ESRD on hemodialysis. Additionally, the pattern of the intracranial pressure alterations was consistent over time suggesting that hemodialysis can improve time to peak and P2/P1 ratio which may reflect in brain compliance.