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Int J Immunogenet ; 51(4): 235-241, 2024 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-38679820

RESUMO

Vitamin D status has been involved with coronavirus disease 19 (COVID-19) severity. This may be mediated by vitamin D metabolism regulatory genes. Of interest is the vitamin D receptor (VDR) gene, which has been previously associated with other inflammatory and respiratory diseases. In order to investigate the role of VDR gene polymorphisms in COVID-19 severity and outcome, a total of 292 COVID-19 patients were classified according to severity in moderate (n = 56), severe (n = 89) and critical (n = 147) and, according to outcome in survivor (n = 163) and deceased (n = 129), and analysed for FokI and TaqI VDR gene polymorphisms by polymerase chain reaction-based restriction enzyme digestion. The FokI and TaqI single nucleotide polymorphisms (SNPs) were not associated with COVID-19 severity or mortality individually but when analysed by haplotype, TC was associated with an increased risk of presenting critical COVID-19. Additionally, FokI CT genotype was more frequent in COVID-19 patients with hypertension, and T allele carriers presented higher aspartate aminotransferase levels. Our results suggest a relationship between VDR FokI and TaqI SNPs and COVID-19 severity in Mexican population. Although there are some previous reports of VDR polymorphisms in COVID-19, this represents the first report in Latin American population. Further studies on other populations are encouraged.


Assuntos
COVID-19 , Predisposição Genética para Doença , Polimorfismo de Nucleotídeo Único , Receptores de Calcitriol , SARS-CoV-2 , Índice de Gravidade de Doença , Humanos , Receptores de Calcitriol/genética , COVID-19/genética , Feminino , México , Masculino , Pessoa de Meia-Idade , Idoso , Haplótipos , Adulto , Alelos , Genótipo , Estudos de Coortes , Frequência do Gene
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