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1.
Cureus ; 12(12): e12355, 2020 Dec 29.
Artigo em Inglês | MEDLINE | ID: mdl-33527044

RESUMO

Background Meningiomas are the single most common brain tumor. The incidence of these tumors increases with age; different studies have shown that meningiomas usually appear after the age of 50. These tumors are more common in women than in men, and women are twice as likely to suffer from the condition. Surgery is the primary form of treatment, which can be curative with complete resection. If the tumor is unresectable or other treatments such as surgery and radiotherapy have failed, hormonal therapy or chemotherapy may be considered. There is limited information about the clinical, demographic, and histopathological characteristics of these tumors in the population of Bogotá, Colombia. Objective To evaluate the expression of progesterone receptors in patients over 18 years old who have been diagnosed with meningiomas in a high-complexity hospital in Bogota, Colombia, and to describe the demographic and histopathological characteristics of these patients. Methods This is a descriptive and retrospective case series. Patients with meningioma who underwent surgical resection at a high-complexity hospital in Bogota, Colombia, from 2016 to 2019 were retrospectively identified and studied. Demographic variables, such as age and gender, were extracted from the clinical chart. Indirect immunoperoxidase staining was carried out for the progesterone receptor (PR) and Ki67. PR is analyzed as positive and negative, and the Ki67 proliferation index was determined. Results Thirty-two meningiomas from patients who underwent surgery were available for analysis. Twenty-five (78.1%) were positive for PR, 71.8% were females, and 93% were World Health Organization (WHO) grade I. Meningothelial (28%), fibrous (25%), and transitional (25%) meningiomas were the most frequent subtypes, correspondingly. The Ki67 mean value was 1.14 (0.11-10.71). Conclusion Our case series showed a greater frequency of meningiomas in women, with a high PR expression and a low Ki67 proliferation rate. These data correlate with literature worldwide.

2.
Int J Rheumatol ; 2009: 368032, 2009.
Artigo em Inglês | MEDLINE | ID: mdl-20204175

RESUMO

Background. The systemic vasculitides are syndromes characterized by inflammation and injury (necrosis or thrombosis) of blood vessels, resulting in clinical manifestations according to the affected vascular bed, but not classically in stocking-glove neuropathy. Objective. To describe a form of primary vasculitis affecting strictly peripheral nerves manifesting as stocking-glove neuropathy. Methods. Case series of 110 patients seen in three centers in Bogotá who presented with symptoms and signs of polyneuropathy and/or were identified with vasculitis affecting only the peripheral nerves, and who underwent sural nerve biopsy. Results. Six patients had a vasculitis affecting only the peripheral nerves diagnosed on sural nerve biopsy which demonstrated a mixed infiltrate of monocytes/macrophages and lymphocytes especially in the small epineurial blood vessels. Over time, all had worsening of symptoms, with grip weakness and motor deficits in the hand and feet. Serologies and acute phase reactants were normal in all patients. Treatment response to immunosuppression was satisfactory in 5 patients; 1 patient had progressive neurologic damage. Conclusions. There is a distinct form of primary vasculitis of the peripheral nervous system characterized by distal sensory polyneuropathy with stocking-glove distribution with good prognosis, few and minor relapses and good response to treatment even after delayed diagnosis.

3.
Acta neurol. colomb ; 21(3): 209-215, sept. 2005. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-424675

RESUMO

Se presenta un caso de encefalomielitis aguda diseminada multifásica atendido en el hospital Simón Bolívar-Bogotá Colombia. La paciente acudió al servicio de urgencias en varias oportunidades por signos y síntomas de compromiso neurológico multifocal; su tratamiento inicialmente tuvo una orientación neuroinfecciosa. El curso clínico demandó una cuidadosa revisión de los estudios patológicos y de imagen llegando al diagnóstico la encefalomielitis, por lo que se instauró tratamiento con esteroides. Se discuten la etiopatogenia de la enfermedad, su presentación clínica y posible tratamiento


Assuntos
Encefalomielite Aguda Disseminada
4.
Acta neurol. colomb ; 16(4): 385-390, dez. 2000.
Artigo em Espanhol | LILACS | ID: lil-307281

RESUMO

Se presenta un niño con un episodio de debilidad muscular progresiva que comprometió las cuatro extremidades y cursó con insuficiencia respiratoria y disautonomía. Sus antecedentes incluían tres episodios de síndrome de Guillain-Barre. Se discute el diagnóstico diferencial en la clínica y en el laboratorio de neurofisilogía, en especial con la polineuropatía desmielinizante crónica y se analizan las diversas opciones de tratamiento para estos casos


Assuntos
Neuropatias Hereditárias Sensoriais e Autônomas , Debilidade Muscular , Polirradiculoneuropatia
5.
Rev. colomb. gastroenterol ; 15(2): 95-102, jun. 2000. ilus, tab
Artigo em Espanhol | LILACS | ID: lil-300395

RESUMO

El interés por la metaplasia intestinal especializada (MIE), de localización cardial, crece conforme se incrementa la prevalencia de adenocarcinoma de la union esofagogastrica. Se plantean diversas hipotesis que la asocian con la presencia de reflujo gastroesofagico y sus complicaciones, la actividad gastrica, la presencia de carditis y Helicobacter pylori, sin que hasta el momento se tenga confirmacion irrefutable de cada una de ellas. Si bien su prevalencia en paises como Estados Unidos y los de Europa es alta, 15 a 50 por ciento, no se conoce en nuestro medio. Objetivo: conocer la prevalencia de la MIE de localización cardial en una poblacion colombiana y establecer sus asociaciones con la presencia de reflujo gastroesofagico esofago de Barrett, carditis, histologia gastrica e infeccion por H. pylori. Materiales y metodos: el estudio se llevo a cabo en un municipio de 373.335 habitantes; para una prevalencia esperada de MIE de 20 por ciento; para una prevalencia esperada de MIE de 20 por ciento, se calculó una muestra de 265 pacientes, que fueron captados en forma consecutiva de aquellos remitidos por síntomas dispepticos a la unidad de endoscopia del hospital local. Antes del procedimiento endoscopico, se aplico un formulario donde se consignaban los datos de identificacion, los sintomas de reflujo gastroesofagico, su duracion en semanas y la frecuencia de presentacion en dias por semana...


Assuntos
Esôfago de Barrett/patologia , Helicobacter pylori , Metaplasia , Prevalência , Refluxo Gastroesofágico/patologia , Junção Esofagogástrica/patologia
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