Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros











Base de dados
Intervalo de ano de publicação
2.
Stem Cell Res Ther ; 13(1): 309, 2022 07 15.
Artigo em Inglês | MEDLINE | ID: mdl-35840987

RESUMO

Type 1 diabetes mellitus (T1D) is a chronic disease characterized by an autoimmune destruction of insulin-producing ß-pancreatic cells. Although many advances have been achieved in T1D treatment, current therapy strategies are often unable to maintain perfect control of glycemic levels. Several studies are searching for new and improved methodologies for expansion of ß-cell cultures in vitro to increase the supply of these cells for pancreatic islets replacement therapy. A promising approach consists of differentiation of stem cells into insulin-producing cells (IPCs) in sufficient number and functional status to be transplanted. Differentiation protocols have been designed using consecutive cytokines or signaling modulator treatments, at specific dosages, to activate or inhibit the main signaling pathways that control the differentiation of induced pluripotent stem cells (iPSCs) into pancreatic ß-cells. Here, we provide an overview of the current approaches and achievements in obtaining stem cell-derived ß-cells and the numerous challenges, which still need to be overcome to achieve this goal. Clinical translation of stem cells-derived ß-cells for efficient maintenance of long-term euglycemia remains a major issue. Therefore, research efforts have been directed to the final steps of in vitro differentiation, aiming at production of functional and mature ß-cells and integration of interdisciplinary fields to generate efficient cell therapy strategies capable of reversing the clinical outcome of T1D.


Assuntos
Diabetes Mellitus Tipo 1 , Células-Tronco Pluripotentes Induzidas , Células Secretoras de Insulina , Diferenciação Celular , Diabetes Mellitus Tipo 1/terapia , Humanos , Células-Tronco Pluripotentes Induzidas/metabolismo , Insulina/metabolismo
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA