1.
Genes Chromosomes Cancer
; 31(1): 48-53, 2001 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-11284035
RESUMO
To obtain more information on chromosomal changes in the up-to-now poorly studied tumor class of penile squamous cell carcinoma (SCC), we performed a comparative genomic hybridization study of 26 cases of this rare tumor. DNA sequence copy number alterations (CNAs) very similar to those detected in other SCC types, such as oral and esophageal SCC, were noted. The most common copy number gains were found in 8q24, 16p11-12, 20q11-13, 22q, 19q13, and 5p15, and the most common deletions were detected in 13q21-22, 4q21-32, and along the X chromosome. Classifying the patients according to the number of CNAs showed a possible correlation with clinical outcome.
Assuntos
Carcinoma de Células Escamosas/genética , Deleção Cromossômica , Amplificação de Genes/genética , Neoplasias Penianas/genética , Adulto , Idoso , Idoso de 80 Anos ou mais , Dosagem de Genes , Humanos , Masculino , Pessoa de Meia-Idade , Hibridização de Ácido Nucleico
2.
J Pediatr
; 102(6): 938-40, 1983 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6406655