RESUMO
In 64 maternal-infant pairs, we tested the hypotheses that serum calcitonin, serum gastrin, and plasma glucagon concentrations are elevated in infants at risk for early neonatal hypocalcemia, and that elevated serum gastrin and plasma glucagon result in elevated serum calcitonin and low serum calcium values in neonates. Serum Ca declined significantly in neonates at 24 hours of age, and was inversely correlated with serum calcitonin. Cord serum calcitonin, gastrin, and plasma glucagon concentrations rose significantly at 24 hours of age. Cord calcitonin was significantly higher in preterm compared with term infants, and there was no significant difference between asphyxiated and nonasphyxiated preterm neonates; in term neonates cord calcitonin concentration was inversely correlated with Apgar scores at 1 and 5 minutes. Cord calcitonin was not correlated with cord gastrin or glucagon. Cord and 24-hour gastrin and glucagon values were not related to prematurity; cord glucagon, but not gastrin, was related to birth asphyxia. We conclude that (1) serum calcitonin, gastrin, and plasma glucagon values rise postnatally; cord calcitonin is elevated in preterm and in asphyxiated term infants; serum calcitonin concentration does not correlate with the elevated serum gastrin and plasma glucagon values; and at 24 hours of age, decreased serum Ca is correlated with serum calcitonin, and hence calcitonin might play a role in the pathogenesis of early neonatal hypocalcemia.
Assuntos
Calcitonina/sangue , Gastrinas/sangue , Glucagon/sangue , Hipocalcemia/etiologia , Índice de Apgar , Asfixia Neonatal/sangue , Sangue Fetal , Idade Gestacional , Humanos , Hipocalcemia/sangue , Recém-Nascido , Minerais/sangue , Estudos ProspectivosRESUMO
In 25 newborn infants, 30 "exchange" transfusions were performed. Pre-exchange serum calcitonin concentrations of newborn infants were higher than those of normal adults and of donor blood used for exchange transfusion. A gradual decline of serum calcitonin concentrations was observed with increasing postnatal age. Serum calcium and magnesium concentrations were inversely related to serum calcitonin concentrations. Newborn infants had significant elevations of serum calcitonin values within a few minutes after the administration of calcium. Gestationally younger infants (less than or equal to 33 weeks) had significantly more pronounced and swifter elevations of serum calcitonin concentrations after calcium administration than gestationally more mature infants (less than 33 weeks). We speculate that calcitonin may be an important "fetal hormone" and that increased calcitonin concentrations may relate to the pathogenesis of neonatal hypocalcemia.
Assuntos
Calcitonina/sangue , Cálcio/administração & dosagem , Transfusão Total , Recém-Nascido , Cálcio/sangue , Feminino , Idade Gestacional , Humanos , Hipocalcemia/etiologia , Doenças do Recém-Nascido/etiologia , Magnésio/sangue , MasculinoRESUMO
One hundred and eight "exchange" blood transfusions were done on 61 newborn infants. Baseline serum PTH concentrations and the PTH rise in response to citrate-induced hypocalcemia were studied. Baseline PTH values increased with postnatal age, particularly after the first three days of life. The acute response of PTH to citrate-induced hypocalcemia appears within ten minutes following the initiation of exchange transfusion and was shortlived in spite of further decline of serum ionized calcium. The dominant effect of postnatal age over gestational age was demonstrated: postnatally older but gestationally less mature infants exhibited greater responsiveness than postnatally younger, but gestationally more mature, infants. The PTH response during exchange transfusion was blunted in hypomagnesemic infants. Since lower serum magnesium concentrations were also present during the first three days of life, a separate effect of serum magnesium concentrations on parathyroid responsiveness cannot be ruled out in this study.
Assuntos
Transfusão Total/métodos , Magnésio/sangue , Hormônio Paratireóideo/sangue , Cuidado Pós-Natal/métodos , Fatores Etários , Cálcio/sangue , Citratos/efeitos adversos , Feminino , Idade Gestacional , Humanos , Hiperbilirrubinemia/terapia , Hipocalcemia/induzido quimicamente , Recém-Nascido , Magnésio/administração & dosagem , Masculino , Fatores SexuaisRESUMO
Twenty pre-eclamptic mothers treated with MgSO4 and their newborn infants were studied prospectively to determine the clinical and biochemical effects of hypermagnesemia. Maternal serum magnesium concentration rose to 4.4 mg/dl at delivery and was accompanied by a fall in maternal serum calcium concentration during labor. Neonatal serum Mg concentration remained elevated for the first 72 hours of life (mean at 72 hours = 3.0 mg/dl). Serum Mg concentration was higher in premature infants and in babies with birth asphyxia and/or hypotonia. Serum Ca concentration was higher and serum PTH was lower in hypermagnesemic study infants when compared to a retrospectively selected, matched froup of control infants. We speculate that elevated serum Mg values in these infants result in a shift of Ca from bone to plasma, and that elevated Mg and Ca concentrations further suppress neonatal parathyroid function.
Assuntos
Cálcio/sangue , Doenças do Recém-Nascido/sangue , Magnésio/sangue , Hormônio Paratireóideo/sangue , Feminino , Idade Gestacional , Humanos , Recém-Nascido , Recém-Nascido Prematuro , Sulfato de Magnésio/uso terapêutico , Troca Materno-Fetal , Pré-Eclâmpsia/tratamento farmacológico , Gravidez , Estudos ProspectivosRESUMO
Osteodystrophy frequently accompanies severe childhood hepatobiliary disease. Proposed causes include malabsorption of vitamin D and calcium, and diminished 25-hydroxylation of vitamin D. Two children, ages 23 and 35 months, with radiographic and biochemical evidence of rickets with extrahepatic biliary atresia, were treated with 1,25-dihydroxyvitamin D3. The minimal effective therapeutic dose and efficacy of 1,25-(OH)2D3 in the treatment of rickets associated with severe childhood hepatic disease were determined. Oral 1,25-(OH)2D3 was ineffective at doses of 0.10 microgram/kg/day. Parenteral doses of 0.20 microgram/kg/day effectively produced radiographic, bone mineral (photon absorptiometric), and biochemical evidence of healing. The need for four times the physiologic dose of 1,25-(OH)2D3 by the parenteral route suggested enhanced catabolism of, or end-organ resistance to, 1,25-(OH)2D3 in our patients with severe cholestatic liver disease treated with phenobarbital.
Assuntos
Di-Hidroxicolecalciferóis/uso terapêutico , Hidroxicolecalciferóis/uso terapêutico , Hepatopatias/complicações , Raquitismo/tratamento farmacológico , Ductos Biliares/anormalidades , Feminino , Humanos , Lactente , Masculino , Raquitismo/etiologiaRESUMO
Sixteen neonates, ranging in gestational age from 27 to 41 weeks and in postnatal age from birth to 8 days, were evaluated for their renal response to an endogenous PTH stimulus in 22 separate experiments. The PTH stimulus was generated by the decreased serum ionized Ca that accompanies exchange transfusion with citrated blood. The neonates increased their serum PTH from 95.8 +/- 13.1 to 133.9 +/- 15.4 microliterEq/ml (mean +/- SEM) during the transfusion, while increasing their urinary cAMP from 0.77 +/- 0.11 to 1.45 +/- 0.22 nmol/ml, and their urinary P from 12.9 +/- 2.6 to 30.6 +/- 6.1 mg/dl in the four hours following the exchange transfusion. This response was not related to postnatal or gestational age. We speculate that lack of renal responsiveness to PTH does not play a major role in the pathogenesis of early neonatal hypocalcemia.
Assuntos
Citratos/farmacologia , AMP Cíclico/urina , Hipocalcemia/fisiopatologia , Doenças do Recém-Nascido/fisiopatologia , Glândulas Paratireoides/efeitos dos fármacos , Fosfatos/urina , Transfusão Total , Feminino , Humanos , Recém-Nascido , Íons , Masculino , Hormônio Paratireóideo/sangue , Hormônio Paratireóideo/fisiologia , Estimulação QuímicaAssuntos
Di-Hidroxicolecalciferóis/uso terapêutico , Hidroxicolecalciferóis/uso terapêutico , Hipocalcemia/prevenção & controle , Doenças do Prematuro/prevenção & controle , Cálcio/metabolismo , Di-Hidroxicolecalciferóis/farmacologia , Humanos , Hidroxicolecalciferóis/sangue , Recém-Nascido , Absorção Intestinal/efeitos dos fármacos , Magnésio/sangue , Hormônio Paratireóideo/sangue , Fósforo/sangue , Estudos ProspectivosRESUMO
Fifty-six diabetic mothers and their infants were studied prospectively from birth. Twenty-one of 56 IDM had serum Mg less than or equal to 1.5 mg/dl, on at least one occasion during the first 3 days. Serum Mg in these hypomagnesemic infants did not demonstrate the normal increase with postnatal age that was present in normomagnesemic infants. Decreased neonatal serum Mg was related to increased severity of maternal diabetes, young mothers, mothers for lower gravidity, and prematurity. Decreased serum Mg, alone or with decreased ionized or total Ca, did not correlate with neuromuscular irritability in the infants. Decreased serum Mg in IDM was associated with decreased maternal serum Mg, decreased neonatal ionized and total Ca, increased serum P, and decreased parathyroid function. Serum Mg was not related to dietary P intake, or urinary Ca or P excretion. Thus, transitory neonatal hypomagnesemia occurs in IDM; it is speculated that factors causing HM might include maternal HM or neonatal hyperphosphatemia, and that the HM is related to the hypocalcemia and functional hypoparathyroidism of IDM.
Assuntos
Doenças Fetais/metabolismo , Doenças do Recém-Nascido/etiologia , Magnésio/sangue , Gravidez em Diabéticas , Sangue , Glicemia/metabolismo , Cálcio/metabolismo , Diabetes Mellitus/classificação , Feminino , Humanos , Concentração de Íons de Hidrogênio , Recém-Nascido , Magnésio/urina , Glândulas Paratireoides/fisiopatologia , Fósforo/urina , Gravidez , Gravidez em Diabéticas/metabolismo , Estudos ProspectivosRESUMO
To determine the functional capabilities of the parathyroid glands, 17 EDTA infusions were given to 11 children (ages 1 month to 12 years) and to two mothers of four of the children. Serum ionized Ca fell from 4.1 mg/dl to 3.4 mg/dl. Excessive parathyroid hormone responses were elicited during seven of nine EDTA infusions in five children and in one adult with hypophosphatemic rickets, during the active phase of rickets. In four of five subjects with problems related to hypercalcemia, borderline low or undetectable PTH responses were elicited. Three relatively normal PTH responses were obtained, two in an infant after phosphate-induced hypocalcemic tetany was corrected, and one in a child with a malabsorption syndrome. The renal tubular reabsorption of phosphate was inversely related and the urinary cyclic AMP excretion was positively related to the PTH response. Thus EDTA infusions in infants and children might be useful in the identification of hyper-, normo-, or hypoparathyroid states and would be of value in defining the functional condition of the parathyroid glands in children with deranged Ca or P metabolism.