RESUMO
Female androgenetic alopecia is one cause of alopecia in women, although the ideal treatment for this condition remains far from defined. The objective of this study was to evaluate the efficacy and safety of intradermal injections with 0.5% minoxidil for the management of female androgenetic alopecia in a randomized, placebo-controlled trial. A total of 54 women diagnosed with female androgenetic alopecia were divided into two groups: one group received intradermal injections of 0.5% minoxidil, and the other received 0.9% saline. Biopsy, trichogram, Trichoscan (Tricholog GmbH, Freiburg, Germany), and self-assessment findings were used to evaluate the outcomes of treatment with minoxidil. In the treated group, there was a significant increase in the terminal-to-vellus hair ratio (P < .001) and in the percentage of anagen hairs (P = .048) and an improvement in hair loss and volume (P = .021 and P = .028, respectively). These results show that intradermal injections with minoxidil were more effective than placebo (P < .001) in the treatment of female androgenetic alopecia with a good safety profile.
Assuntos
Alopecia , Minoxidil , Administração Tópica , Alopecia/diagnóstico , Alopecia/tratamento farmacológico , Método Duplo-Cego , Feminino , Cabelo , Humanos , Injeções Intradérmicas , Minoxidil/efeitos adversos , Resultado do TratamentoRESUMO
Hidroacanthoma simplex is a rare intraepidermal neoplasia that arises from the acrosyringial portion of the eccrine duct. Malignant transformation of hidroacanthoma simplex is reported in the literature and the treatment is performed with wide excision or Mohs micrographic surgery. We report the first case successfully treated with cryosurgery with a long-term follow up.
Assuntos
Criocirurgia , Porocarcinoma Écrino/cirurgia , Poroma/cirurgia , Neoplasias das Glândulas Sudoríparas/cirurgia , Idoso , Dermoscopia , Porocarcinoma Écrino/patologia , Humanos , Masculino , Poroma/patologia , Neoplasias das Glândulas Sudoríparas/patologiaRESUMO
Abstract: Hidroacanthoma simplex is a rare intraepidermal neoplasia that arises from the acrosyringial portion of the eccrine duct. Malignant transformation of hidroacanthoma simplex is reported in the literature and the treatment is performed with wide excision or Mohs micrographic surgery. We report the first case successfully treated with cryosurgery with a long-term follow up.
Assuntos
Humanos , Masculino , Idoso , Neoplasias das Glândulas Sudoríparas/cirurgia , Criocirurgia , Poroma/cirurgia , Porocarcinoma Écrino/cirurgia , Neoplasias das Glândulas Sudoríparas/patologia , Dermoscopia , Poroma/patologia , Porocarcinoma Écrino/patologiaAssuntos
Foliculite/microbiologia , Tinha/microbiologia , Trichophyton/isolamento & purificação , Idoso , Antifúngicos/uso terapêutico , Biópsia , Face/microbiologia , Face/patologia , Dermatoses Faciais/tratamento farmacológico , Dermatoses Faciais/patologia , Foliculite/tratamento farmacológico , Humanos , Itraconazol/uso terapêutico , Masculino , Tinha/tratamento farmacológicoAssuntos
Humanos , Masculino , Idoso , Tinha/microbiologia , Trichophyton/isolamento & purificação , Foliculite/microbiologia , Tinha/tratamento farmacológico , Biópsia , Itraconazol/uso terapêutico , Face/microbiologia , Face/patologia , Dermatoses Faciais/patologia , Dermatoses Faciais/tratamento farmacológico , Foliculite/tratamento farmacológico , Antifúngicos/uso terapêuticoRESUMO
Abstract Frontal fibrosing alopecia is a distinctive form of scarring alopecia considered to be a clinical variant of lichen planopilaris. It predominantly occurs in postmenopausal women and has a slowly progressive course. It was first described by Kossard in 1994. Since then the number of reported cases has increased significantly. Coexistence of frontal fibrosing alopecia and autoimmune disorders - such as discoid erythematosus lupus and Sjögren's syndrome - may suggest a common pathogenic background among the diseases.
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Síndrome de Sjogren/complicações , Alopecia/complicações , Fibrose , Lúpus Eritematoso Discoide/complicações , Lúpus Eritematoso Discoide/patologia , Folículo Piloso/patologia , Derme/patologia , Alopecia/imunologia , Alopecia/patologia , Líquen Plano/imunologia , Líquen Plano/patologiaRESUMO
We describe the case of a 9-year-old boy with idiopathic bone marrow aplasia and severe neutropenia, who developed skin ulcers under cardiac monitoring electrodes. The diagnosis of primary cutaneous aspergillosis was made after the second biopsy and culture. Imaging investigation did not reveal internal fungal infection. The child was treated, but did not improve and died 3 months after admission. The report highlights and discusses the preventable risk of aspergillus skin infection in immunocompromised patients.
Assuntos
Anemia Aplástica/imunologia , Aspergilose/microbiologia , Aspergillus niger/isolamento & purificação , Dermatomicoses/microbiologia , Úlcera Cutânea/microbiologia , Anemia Aplástica/complicações , Aspergilose/complicações , Aspergilose/patologia , Criança , Dermatomicoses/complicações , Dermatomicoses/patologia , Eletrodos/efeitos adversos , Evolução Fatal , Humanos , Hifas/isolamento & purificação , Masculino , Necrose , Neutropenia/complicações , Úlcera Cutânea/patologiaRESUMO
Abstract: We describe the case of a 9-year-old boy with idiopathic bone marrow aplasia and severe neutropenia, who developed skin ulcers under cardiac monitoring electrodes. The diagnosis of primary cutaneous aspergillosis was made after the second biopsy and culture. Imaging investigation did not reveal internal fungal infection. The child was treated, but did not improve and died 3 months after admission. The report highlights and discusses the preventable risk of aspergillus skin infection in immunocompromised patients.
Assuntos
Humanos , Masculino , Criança , Aspergilose/microbiologia , Aspergillus niger/isolamento & purificação , Úlcera Cutânea/microbiologia , Dermatomicoses/microbiologia , Anemia Aplástica/imunologia , Aspergilose/complicações , Aspergilose/patologia , Úlcera Cutânea/patologia , Evolução Fatal , Hifas/isolamento & purificação , Dermatomicoses/complicações , Dermatomicoses/patologia , Eletrodos/efeitos adversos , Anemia Aplástica/complicações , Necrose , Neutropenia/complicaçõesRESUMO
Frontal fibrosing alopecia is a distinctive form of scarring alopecia considered to be a clinical variant of lichen planopilaris. It predominantly occurs in postmenopausal women and has a slowly progressive course. It was first described by Kossard in 1994. Since then the number of reported cases has increased significantly. Coexistence of frontal fibrosing alopecia and autoimmune disorders - such as discoid erythematosus lupus and Sjögren's syndrome - may suggest a common pathogenic background among the diseases.