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1.
Int J Immunogenet ; 35(2): 107-9, 2008 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-18321306

RESUMO

We have analysed the linkage disequilibrium pattern between the promoter TA microsatellite and Single Nucleotide Polymorphism (SNP) haplotypes for the CYBB gene. None of the CYBB SNPs serve as good surrogates for the microsatellite alleles, previously associated with mild malaria. Thus, the candidate (TA)(n) microsatellite should be directly tested in genetic epidemiology studies.


Assuntos
Repetições de Dinucleotídeos/genética , Desequilíbrio de Ligação/genética , Malária/genética , Glicoproteínas de Membrana/genética , NADPH Oxidases/genética , Polimorfismo de Nucleotídeo Único , Locos de Características Quantitativas/genética , Feminino , Humanos , Malária/epidemiologia , Masculino , Epidemiologia Molecular , NADPH Oxidase 2
2.
Genes Immun ; 9(3): 224-30, 2008 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-18340359

RESUMO

G-protein-coupled receptor for asthma susceptibility (GPRA or GPR154) was identified as an asthma and atopy candidate gene by positional cloning. Some subsequent studies suggest associations of GPRA single nucleotide polymorphisms (SNPs) and haplotypes with asthma or atopy susceptibility. However, the associated SNPs or haplotypes vary among studies. The role of GPRA genetic variation in asthma and atopy remains unsolved. Published data on GRPA variants and asthma come exclusively from Caucasian and Asian populations. We examined whether GPRA SNPs and haplotypes are associated with asthma and atopy in a Mexican population. We genotyped and analyzed 27 GPRA SNPs in 589 nuclear families consisting of asthmatic children aged 4-17 years of age and their parents in Mexico City. Atopy was determined by skin prick tests to 25 aeroallergens. The 27 SNPs examined provided excellent coverage of the GPRA gene. GPRA SNPs and haplotypes were not associated with childhood asthma and the degree of atopy to aeroallergens in a Mexican population. Our review of studies of GPRA variants in relation to asthma phenotypes shows considerable heterogeneity. Accordingly, our results suggest that GPRA variants are not an important contributor to childhood asthma and atopy susceptibility in a Mexican population.


Assuntos
Asma/genética , Predisposição Genética para Doença/genética , Variação Genética , Hipersensibilidade Imediata/genética , Receptores Acoplados a Proteínas G/genética , Adolescente , Criança , Pré-Escolar , Clonagem Molecular , Genótipo , Haplótipos/genética , Humanos , México , Polimorfismo de Nucleotídeo Único/genética
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