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BACKGROUND: Retrospective data suggest an association between bevacizumab efficacy and the incidence of arterial hypertension (AHT). Additionally, epigenetic mechanisms have been related to AHT. METHODS: This prospective observational study conducted by GEICAM Spanish Breast Cancer Research Group included metastatic breast (MBC) or colorectal (mCRC) cancer patients treated with bevacizumab-containing chemotherapy as first-line treatment. Blood pressure (BP) levels were measured (conventional and 24-h Holter monitoring) at baseline and up to cycle 3. Primary endpoint assessed BP levels increase as predictive factor for progression-free survival (PFS). Germline DNA methylation profile was explored in pre-treatment blood samples; principal component analysis was used to define an epigenetic predictive score for increased BP levels. RESULTS: From Oct-2012 to Jul-2016, 143 (78 MBC and 65 mCRC) patients were included. The incidence of AHT according to guidelines was neither predictive of PFS nor of best overall tumor response (BOR). No statistically significant association was observed with systolic BP nor diastolic BP increment for PFS or BOR. Grade 3 and 4 adverse events were observed in 37 and 5% of patients, respectively. We identified 27 sites which baseline methylation status was significantly associated to BP levels increase secondary to bevacizumab-containing chemotherapy. CONCLUSIONS: Neither the frequency of AHT nor the increase of BP levels were predictive of efficacy in MBC and mCRC patients treated with bevacizumab-containing chemotherapy. CLINICAL TRIAL REGISTRY: ClinicalTrials.gov Identifier: NCT01733628.
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Bevacizumab , Neoplasias da Mama , Neoplasias Colorretais , Hipertensão , Humanos , Bevacizumab/uso terapêutico , Bevacizumab/administração & dosagem , Feminino , Neoplasias Colorretais/tratamento farmacológico , Neoplasias Colorretais/patologia , Neoplasias da Mama/tratamento farmacológico , Neoplasias da Mama/patologia , Pessoa de Meia-Idade , Hipertensão/induzido quimicamente , Estudos Prospectivos , Idoso , Masculino , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Idoso de 80 Anos ou mais , Intervalo Livre de Progressão , Metilação de DNARESUMO
Growth hormone (GH) modifies liver gene transcription in a sexually dimorphic manner to meet liver metabolic demands related to sex; thus, GH dysregulation leads to sex-biased hepatic disease. We dissected the steps of the GH regulatory cascade modifying GH-dependent genes involved in metabolism, focusing on the male-predominant genes Lcn13, Asns, and Cyp7b1, and the female-predominant genes Hao2, Pgc1a, Hamp2, Cyp2a4, and Cyp2b9. We explored mRNA expression in 2 settings: (i) intact liver GH receptor (GHR) but altered GH and insulin-like growth factor 1 (IGF1) levels (NeuroDrd2KO, HiGH, aHepIGF1kd, and STAT5bCA mouse lines); and (ii) liver loss of GHR, with or without STAT5b reconstitution (aHepGHRkd, and aHepGHRkd + STAT5bCA). Lcn13 was downregulated in males in most models, while Asns and Cyp7b1 were decreased in males by low GH levels or action, or constant GH levels, but unexpectedly upregulated in both sexes by the loss of liver Igf1 or constitutive Stat5b expression. Hao, Cyp2a4, and Cyp2b9 were generally decreased in female mice with low GH levels or action (NeuroDrd2KO and/or aHepGHRkd mice) and increased in HiGH females, while in contrast, Pgc1a was increased in female NeuroDrd2KO but decreased in STAT5bCA and aHepIGF1kd females. Bioinformatic analysis of RNAseq from aHepGHRkd livers stressed the greater impact of GHR loss on wide gene expression in males and highlighted that GH modifies almost completely different gene signatures in each sex. Concordantly, we show that altering different steps of the GH cascade in the liver modified liver expression of Lcn13, Asns, Cyp7b1, Hao2, Hamp2, Pgc1a, Cyp2a4, and Cyp2b9 in a sex- and gene-specific manner.
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Stenotrophomonas maltophilia is a nonfermenting Gram-negative drug-resistant pathogen that causes healthcare-associated infections. Clinical isolates from Mexico were assessed for biofilm formation using crystal violet staining. Antimicrobial susceptibility was evaluated in planktonic and biofilm cells using the broth microdilution method. The effects of antibiotics on biofilms were visualized using fluorescence microscopy. Fifty isolates were included in this study, of which 14 (28%) were biofilm producers (9 [64%] from blood and 5 [36%] from respiratory samples). In planktonic cells 4/50 (8%) of isolates were resistant to levofloxacin (8.0%) and 22/50 (44%) were resistant to trimethoprim-sulfamethoxazole. All isolates were resistant to levofloxacin and trimethoprim-sulfamethoxazole in biofilm cells. Bacterial biofilms treated with different concentrations of both antibiotics were completely disrupted. In conclusion, S. maltophilia isolated from blood had higher biofilm production than those isolated from respiratory samples. Biofilm production was associated with increased antibiotic resistance. Antibiotic monotherapy might not be the best course of action for the treatment of S. maltophilia infections in Mexico, because it might cause biofilm production and antimicrobial resistance.
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Antibacterianos , Biofilmes , Infecções por Bactérias Gram-Negativas , Levofloxacino , Testes de Sensibilidade Microbiana , Stenotrophomonas maltophilia , Combinação Trimetoprima e Sulfametoxazol , Stenotrophomonas maltophilia/efeitos dos fármacos , Biofilmes/efeitos dos fármacos , Biofilmes/crescimento & desenvolvimento , Combinação Trimetoprima e Sulfametoxazol/farmacologia , Levofloxacino/farmacologia , Humanos , Antibacterianos/farmacologia , Infecções por Bactérias Gram-Negativas/tratamento farmacológico , Infecções por Bactérias Gram-Negativas/microbiologia , México , Microscopia de FluorescênciaRESUMO
BACKGROUND: Sarcopenia is a condition associated with aging and multiple medical conditions such as CKD and hypovitaminosis D. METHODS: An observational cross-sectional study was carried out, based on patients registered in a database of specialized nephrology consultation in the city of Manizales, Colombia. 101 patients over 18 years of age who had stage 3 or 4 CKD were included. RESULTS: The frequency of sarcopenia was 10.9%. No relationship was found between sarcopenia alone and serum vitamin D levels. However, when sarcopenia was categorized as severe there was a direct relationship with hypovitaminosis D. There was also a direct relationship between dynapenia and hypovitaminosis D. In addition, patients who had serum vitamin D levels above 40 ng/ml had better muscle performance, and, consequently, probably a lower risk of frailty. CONCLUSION: When patients, within their treatment, received vitamin D supplementation, no effect on muscle performance was observed.
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Insuficiência Renal Crônica , Sarcopenia , Deficiência de Vitamina D , Humanos , Adolescente , Adulto , Colômbia/epidemiologia , Sarcopenia/epidemiologia , Estudos Transversais , Deficiência de Vitamina D/complicações , Deficiência de Vitamina D/epidemiologia , Vitamina D , Insuficiência Renal Crônica/complicaçõesRESUMO
Introducción: La lesión renal aguda asociada con el uso de medios de contrastes yodados (LRA-MCI) es un trastorno iatrogénico con potenciales implicaciones en morbilidad y mortalidad, motivo de preocupación en los servicios de imágenes. Los últimos años han marcado cambios importantes en la concepción que se tiene sobre esta entidad, desde una definición más precisa y su verdadera incidencia hasta el impacto real de algunas estrategias para su prevención.Objetivo: Generar recomendaciones basadas en la evidencia para el uso de medios de contraste yodados e n pacientes sometidos a procedimientos radiológicos terapéuticos y de diagnóstico, mediante un consenso de expertos. Metodología: A partir de la formulación de preguntas de investigación relacionadas con la LRA-MCI se realizó la búsqueda de evidencia en PubMed, Embase y Scopus, entre enero de 2013 y agosto de 2022. Los artículos se seleccionaron por medio de una revisión sistemática y con la metodología de consenso Delphi modificado. La calidad de los documentos se valoró aplicando instrumentos de evaluación de calidad de la evidencia de los documentos. Resultados:Se formularon 22 recomendaciones para el manejo de pacientes que requieren administración de medio de contraste yodado. Un panel de 11 expertos, entre los que se contó con 4 nefrólogos, 4 radiólogos y 1 nefrólogo pediatra, participaron en la elaboración del consenso en 5 sesiones virtuales y 15 horas de trabajo.Conclusiones: El término lesión renal aguda asociada al uso de medios de contraste yodados (LRA-MCI) debe usarse idealmente y abandonar otras definiciones que infieren una causalidad manifiesta. Su incidencia: los datos recientes demuestran que se ubica muy por debajo de lo tradicionalmente considerado. Solo una baja tasa de filtración glomerular estimada (TFGe) se considera factor de riesgo independiente. Respecto a su prevención, únicamente la hidratación ha mostrado un potencial beneficio como medida nefroprotectora.
Introduction: Acute kidney injury associated with the use of iodinated contrast media (AKI-ICM) is an iatrogenic disorder with potential implications in morbidity and mortality, a cause for concern in imaging services. The last few years have marked important changes in the conception of this entity, from a more precise definition and its true incidence to the real impact of some strategies for its prevention. Objective: To generate evidence-based recommendations for the use of iodinated contrast media in patients undergoing diagnostic and therapeutic radiological procedures, by means of an expert consensus. Methodology: Based on the formulation of research questions related to AKI-ICM, a search for evidence was carried out in PubMed, Embase and Scopus, between January 2013 and August 2022. The articles were selected by means of a systematic review and with the modified Delphi consensus methodology. The quality of the papers was assessed by applying paper evidence quality assessment instruments. Results: Twenty-two recommendations were formulated for the management of patients requiring administration of iodinated contrast medium. A panel of 11 experts, including 4 nephrologists, 4 radiologists and 1 pediatric nephrologist, participated in the development of the consensus in 5 virtual sessions and 15 hours of work. Conclusions: The term acute kidney injury associated with the use of iodinated contrast media (AKI-ICM) should ideally be used and other definitions that infer overt causality abandoned. Its incidence: recent data show that it is well below that traditionally considered. Only a low estimated glomerular filtration rate (eGFR) is considered an independent risk factor. Regarding its prevention, only hydration has shown a potential benefit as a nephroprotective measure
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Injúria Renal Aguda , Meios de Contraste , Taxa de Filtração GlomerularRESUMO
This paper presents new approaches to fit regression models for symbolic internal-valued variables, which are shown to improve and extend the center method suggested by Billard and Diday and the center and range method proposed by Lima-Neto, E.A.and De Carvalho, F.A.T. Like the previously mentioned methods, the proposed regression models consider the midpoints and half of the length of the intervals as additional variables. We considered various methods to fit the regression models, including tree-based models, K-nearest neighbors, support vector machines, and neural networks. The approaches proposed in this paper were applied to a real dataset and to synthetic datasets generated with linear and nonlinear relations. For an evaluation of the methods, the root-mean-squared error and the correlation coefficient were used. The methods presented herein are available in the the RSDA package written in the R language, which can be installed from CRAN.
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Objetivo: determinar la presencia de cambios en los diagnósticos electroencefalográficos pre y post operatorios de niños de cero a 17 años llevados a cirugía de corazón en una institución de referencia en Colombia entre los meses de agosto a noviembre del año 2017. Materiales y métodos: se tomó electroencefalograma una hora previa al procedimiento quirúrgico cardíaco y otros siete días después procedimiento; se recolectaron datos clínicos asociados a presencia de anormalidades en el electroencefalograma. Los datos fueron sometidos a análisis descriptivo, bivariado y multivariado. Resultados: se encontraron cambios en los trazados electroencefalográficos del preoperatorio al post operatorio de dos maneras. una con deterioro de los trazados de normales a anormales y la otra con empeoramiento del trazado anormal. Conclusiones: los pacientes son intervenido presentan trazados electroencefalográfico alterados. La población llevada a cirugía cardiaca en el centro del estudio es muy diversa lo que ocasiona resultados neurológicos variados e influyen en los cambios en los trazados post operatorios..(Au)
Objective: to determine the presence of changes in the pre and postoperative electroencephalographic diagnoses of children from zero to 18 years of age who underwent heart surgery in a reference institution in Colombia between the months of August to November of 2017. Materials and methods: electroencephalogram was taken one hour prior to the cardiac surgical procedure and another seven days after the procedure, clinical data were collected associated with the presence of abnormalities in the electroencephalogram. The data were subjected to descriptive, bivariate, and multivariate analysis. Results: changes in electroencephalographic traces were found from preoperative to postoperative in two ways, one with deterioration of normal to abnormal traces and the other with worsening of the abnormal tracing. Conclusions: patients are taken to surgery despite having altered paths. The population taken to cardiac surgery at the center of the study is very diverse, which causes varied neurological results and influences changes in post-operative traces..(Au)
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La respuesta a la infección viral produce un estado de trombosis o hipercoagulabilidad que, unido a la inflamación de las células endoteliales, puede generar disfunción plaquetaria y predisposición a la formación de trombos que, aunque con frecuencia son más venosos, también pueden aparecer en el sistema arterial y producir infartos a cualquier nivel así como tromboembolia e hipertensión pulmonar. Estas manifestaciones han sido captadas hospitalariamente y al egreso de los pacientes detectados por SARS-CoV-2 habiendo ya cumplido el tiempo establecido de virulencia. Los criterios diagnósticos de respuesta inmunológica trombótica asociada a COVID-19 (RITAC) ayudan a seleccionar al paciente que está predispuesto a esta condición; a esto se añade que el paciente ya tiene un diagnóstico de infección por SARS-CoV-2 (AU)
The response to viral infection produces a prothrombotic state of hypercoagulability , united with an inflammation of endothelial cells, It can generate platelet dysfunction and predisposition to the formation of thrombus, that, although, are more frequently venous, Also, it can appear in the arterial system and cause heart attacks at any level; thromboembolism and pulmonary hypertension, as well. These manifestations have been captured hospitably and with the egress of patients detected by SARS-CoV-2. The diagnostic criteria of RITAC (abbreviation in Spanish of Thrombotic Immune Response Associated to COVID-19), help to select the patient who is predisposed to this condition; adding that the patient already has a diagnosis of SARS-CoV-2 infection (AU)
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Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Pneumonia Viral , Trombose , Infecções por Coronavirus , Betacoronavirus , Panamá , Embolia Pulmonar , Unidade Hospitalar de Odontologia/estatística & dados numéricosRESUMO
RESUMEN: Este trabajo implica una revisión del trabajo de investigación sobre el aprendizaje mediado por tecnología en estudiantes de alta capacidad. El estudio fue realizado por medio de un análisis bibliométrico de la producción científica en la renombrada base de datos Scopus. Fueron evaluados, sin filtro temporal, 35 artículos publicados entre 1993 y 2018, de los cuales se analizó una selección de indicadores de productividad científica, colaboración, consumo e impacto, así como variables estructurales y de contenido. Aunque el número de artículos no sea muy alto, los resultados mostraron un aumento en las publicaciones científicas recientes centradas en procesos de aprendizaje mediados por estudiantes de alta capacidad y una concentración de publicaciones en revistas de ciencias sociales y psicología, además de mostrar los patrones emergentes en estos artículos, publicaciones y temas de interés en este campo. Finalmente, se sugiere una revisión de las prácticas de diseminación de resultados y un enfoque de cuestiones relacionadas con los efectos de la tecnología en el aprendizaje, en relación con el sexo, la edad, el papel de las familias y la formación inicial y continua.
ABSTRACT: This paper is a review of a research regarding technology-mediated learning for gifted students. The study was carried out through a bibliometric analysis of the scientific production in the well-known Scopus database. Thirty-five articles published between 1993 and 2018 were evaluated without a time filter, from which a selection of indicators of scientific productivity, collaboration, consumption and impact, as well as structural and content variables were analyzed. Although the number of articles is not very high, the results showed an increase in recent scientific publications focused on learning processes mediated by high-capacity students and a concentration of publications in Social Science and Psychology journals, in addition to showing, in these articles, the emerging patterns of authorship, publication and topics of interest in this field. Finally, it is suggested to review the practices for disseminating findings and addressing issues related to the effects of technology on learning in terms of gender, age, family role, and initial and continuing education.
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Introducción: la Dra. Jean Watson afirma que la Enfermería consiste en conocimientos, pensamientos, valores, filosofía y compromiso. La Unidad de Cuidados Intensivos Neonatales (UCIN) es una de las áreas más complejas y precisas, debido a las necesidades de los neonatos que se encuentran en ella, por lo que el ejercicio del personal de enfermería que labora en este servicio debe ser competente en el cuidado del neonato y su familia. Desarrollo: para el gremio de enfermería es importante seguir contribuyendo de manera positiva a su evolución mediante la innovación, por lo que ante las crecientes demandas de salud surge la Enfermera de Práctica Avanzada (EPA). La EPA requiere emplear modelos en la práctica clínica que permitan fomentar la autonomía y dignidad de la persona, así como fortalecer la práctica profesional. El presente artículo de reflexión tiene como objetivo desarrollar la Enfermería de Práctica Avanzada en las Unidades de Cuidados Intensivos Neonatales mediante la implementación del modelo de Enfermera de Cabecera creado por Marie Manthey. Conclusiones: el modelo de Enfermera de Cabecera, en conjunto con la Enfermería de Práctica Avanzada, contribuye a mejorar la calidad del cuidado, el mejoramiento de la comunicación y la relación entre el profesional de enfermería-paciente, profesional de enfermería-familia y profesional de enfermería-equipo multidisciplinar.
Introduction: Dr. Jean Watson affirms that Nursing consists of knowledge, thoughts, valúes, philosophy and commitment. The Neonatal Intensive Care Unit (NICU) is one of the most complex and precise areas, due to the needs of the neonates who are in it, so the practice of the nursing staff working in this Service must be competent in the care of the newborn and his family. Development: For the nursing unión it is important to continué contributing positively to its evolution through innovation, which is why, due to the growing demands for health, the Advanced Practice Nurse (APN) appears. The APN requires the use of models in clinical practice that promote the autonomy and dignity of the person, as well as strengthen professional practice. This article aims to develop Advanced Practice Nursing in Neonatal Intensive Care Units through the implementation of the Primary Nursing Care Model created by Marie Manthey. Conclusions: The Primary Nursing Care Model, together with the Advanced Practice Nursing, contributes to improve the quality of care, ¡mproving communication and the relationship between the nursing professional-patient, nursing professional-family and professional of multidisciolinarv nursing-team.
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Humanos , Competência Profissional , Recém-Nascido Prematuro , Unidades de Terapia Intensiva Neonatal , Modelos de Enfermagem , Prática Avançada de Enfermagem , MéxicoRESUMO
Introducción: las enfermedades crónicas no transmisibles causan gran morbilidad y mortalidad a nivel mundial por lo que se requiere de estrategias innovadoras que impacten en el autocuidado, adopción de estilos de vida saludables y manejo de ellas. En la actualidad, las Tecnologías de la información y la comunicación constituyen un recurso para mejorar la efectividad y la eficacia de programas dirigidos a pacientes con enfermedades crónicas, superar las limitaciones estructurales y la disponibilidad de recursos humanos existentes en los sistemas de salud. Objetivo: evaluar el impacto de las Tecnologías de la información y la comunicación como herramienta educativa para promover estilos de vida saludables y adherencia a la medicación, conocer la percepción de los usuarios frente a la intervención y observar el efecto sobre variables clínicas. Materiales y Métodos: estudio longitudinal, donde se incluyeron 90 pacientes de la consulta externa de una institución prestadora de salud de Manizales para recibir mensajes de texto. Fueron seleccionados hombres y mujeres mayores de 18 años con diagnóstico de hipertensión arterial o diabetes mellitus con teléfono celular propio o de un cuidador cercano que aceptaran recibir los mensajes de texto en su teléfono móvil. Los mensajes contenían información sobre estilos de vida saludable y fueron enviados entre agosto y diciembre de 2014 durante 29 semanas. 68 sujetos completaron el seguimiento. Al final de la intervención, se evaluó la aceptación, utilidad y efectos sobre parámetros de laboratorio y clínicos. Resultados: el 100% de los pacientes que confirmaron la recepción de los mensajes percibieron una mejoría en su autocuidado; evidenciándose cambios en la dieta (95,16%) y mejoría en la adherencia a la medicación (59%), además de calificarse la utilidad del servicio como excelente por el 61,5% de los sujetos. Sin embargo no se encontraron cambios estadísticamente significativos en variables clínicas y de laboratorio. Conclusiones: la percepción de los pacientes frente al uso de las Tecnologías de la información y la comunicación es positiva y genera cambios en aspectos como la alimentación y la adherencia a la medicación, por lo que constituye una herramienta en la promoción de estilos de vida saludables y manejo de enfermedades crónicas no transmisibles. Se requiere de estudios controlados estandarizados mediante un seguimiento a largo plazo para determinar el impacto real sobre variables clínicas y su costo-beneficio. Además se deberá individualizar el tipo de población que obtendría mayor beneficio. MÉD. UIS. 2016;29(2):59-70.
Introduction: chronic noncommunicable diseases cause high morbidity and mortality worldwide so it requires innovative strategies that impact on self-care, adoption of healthy lifestyles and the diseases treatment. Nowadays, the information and communication technologies compose a resource in order to improve the effectiveness and efficiency of the patient's programs with chronic diseases, overcome structural limitations and the availability of human resources in the health system. Objective: to evaluate the impact of the information and communication technologies to promote healthy lifestyles and adherence to medication, to know the perception of users about the usefulness of the intervention and also their effect on clinical variables. Methods: longitudinal study, in which 90 patients outpatient health institution in Manizales were included to receive text messages, was made. There were chosen over-age-18 men and women, with arterial hypertension diagnosis or diabetes mellitus who owned a cell phone or were with a near carer assistant who would accept receiving text massages in its own mobile. The massages were about their healthy lifestyle, and these were sent between august and december during 29 weeks. 68 subject completed the follow up. At the end of the intervention, acceptance, usefulness and effects on laboratory and clinical parameters were evaluated. Results: it was found that 100% of the patients who confirmed receiving the messages perceived an improvement in self care; showing changes in diet (95.16%) and the amelioration of medication adherence (59%). Besides, the service utility was qualified as excellent. Conclusions: the patient's perceptions about the use of the information and communication technologies was positive and it could generates changes in areas such as alimentary habits and medication adherence, in promoting healthy lifestyles and management of chronic noncommunicable diseases. However, it requires controlled studies using a standardized long-term monitoring to determine the actual impact on clinical variables and cost-effective. In addition, it should identify the type of population would get greater benefit. MÉD.UIS. 2016;29(2):59-70.
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Humanos , Adulto , Pessoa de Meia-Idade , Idoso , Idoso de 80 Anos ou mais , Prevenção Primária , Doença Crônica , Tecnologia , Telefone Celular , Diabetes Mellitus , Educação , Envio de Mensagens de Texto , HipertensãoRESUMO
En la actualidad, la enfermedad cardiovascular y la depresión constituyen problemas de salud pública importantes y se consideran las primeras causas de discapacidad en los países de altos ingresos. Esta asociación entre ambas entidades se ha descrito desde hace varios años, entendiéndose la depresión como un factor de riesgo para el desarrollo de eventos cardiovasculares, peores desenlaces clínicos e incremento de la mortalidad. Se efectuó una revisión de la literatura con el fin de exponer los aspectos más relevantes en cuanto a epidemiología, fisiopatología, clínica, pronóstico y estrategias terapéuticas de la depresión en el contexto de la enfermedad cardiovascular, con especial énfasis en las mujeres y en la importancia de implementar medidas para su detección y tratamiento oportunos, con la finalidad de disminuir el impacto negativo de esta enfermedad sobre la salud cardiovascular de dicho género.
Nowadays, cardiovascular disease and depression pose important public health problems and are considered the main causes of disability in high-income countries. This association between both entities has been described over several years, understanding depression as a risk factor for developing cardiovascular events, worsening clinical outcomes and raising mortality. Literature review was carried out with the objective of exposing most relevant aspects regarding epidemiology, pathophysiology, clinical, prognostic and therapeutic strategies towards depression in the context of cardiovascular disease, with a focus on women and the importance of implementing measures for early detection and treatment so as to reduce the negative impact of this condition on cardiovascular health.
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Humanos , Depressão , Doenças Cardiovasculares , Fatores de Risco , MulheresRESUMO
Antecedentes: el cáncer de próstata (CP) ocupa el primer lugar de ocurrencia en USA y en los países en desarrollo, está entre el cuarto y sexto puesto excepto en Brasil, donde es el primer cáncer en hombres. En los registros de Oncólogos del Occidente S.A. de Colombia ocupa el sexto lugar en la población general y la segunda neoplasia en el sexo masculino. Material y métodos: se llevó a cabo un seguimiento de los pacientes tratados en Oncólogos del Occidente -Sede de Caldas- con una población de influencia de 1 100 000 habitantes y un total de 12 000 registros analizados desde enero de 1997 hasta junio de 2012, para un informe final de 404 pacientes con cáncer de próstata. Resultados: la media de edad fue 69 años, 73% entre 61 y 80 años; 56% en estadio clínico II (II-A: 22% y II-B:34%) y 18% estadio IV. Escala de Gleasson menor a 6 en 37%, el 33% igual a 7 (4+3:49% y 3+4:51%). El 30% con PSA entre 4 y 10 ng/mL y 13% PSA mayor a 100 ng/mL. El 36% con algún tipo de tratamiento previo (prostatectomía:17% y orquiectomía:9%); 90% con Karnofsky >80%; 29% presentaron recaída y de éstos, 73% con recaída bioquímica; la radioterapia se usó en 92% (60% dirigida al tumor primario y 16% a metástasis); el estadio T1c se encontró en 41%. La sobrevida a 10 años fue 94% entre 61 y 70 años (p=0.001). En pacientes con Gleasson
Background: prostate cancer (PC) occupies the first place of occurrence in the US; in developing countries it is between the fourth and sixth place, except in Brazil where it is the first cancer in men. In the West Oncologists S.A. of Colombia records, it ranks sixth in the general population and is the second malignancy in males. Materials and methods: a follow-up of patients treated in the West Oncologists -headquarters of Caldas- was carried out, with an influence population of 1.1 million inhabitants and a total of 12 000 records analyzed from January 1997 to June 2012, for a final report of 404 patients with prostate cancer. Results: the mean age was 69 years, 73% between 61 and 80 years; 56% in clinical stage II (II-A: 22% and II-B: 34%) and 18% stage IV. Gleason Scale less than 6 in 37%, 33% equal to 7 (4 + 3: 49% and 3 + 4: 51%). 30% with PSA between 4 and 10 ng / mL and 13% greater than 100 ng / mL PSA. 36% with some type of prior treatment (prostatectomy and orchiectomy 17%: 9%); 90% with Karnofsky > 80%; 29% relapsed and 73% of those with biochemical relapse; radiotherapy was performed in 92% (60% directed to the primary tumor and 16% to metastasis); stage T1c was found in 41%. The 10-year survival was 94% between 61 and 70 years (p = 0.001). In patients with Gleason
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Humanos , Masculino , Feminino , Neoplasias da Próstata , Prognóstico , Prostatectomia , Sobrevida , Colômbia , Tomada de Decisões , SobrevivênciaRESUMO
OBJETIVO: Presentar nuestra experiencia en artrodesis posterolateral vs circunferencial (360º) en columna lumbosacra, en 2000-2010. MÉTODOS: Serie clínica de 132 pacientes (61 pacientes: artrodesis 360º y 71 pacientes: artrodesis posterolateral). RESULTADOS: Predominio del sexo femenino 51,5%, promedio de edad de 45,5 años, seguimiento de 60 meses, nivel más intervenido en artrodesis 360º L4-L5 (54,5%) y posterolateral L5-S1 (38,5%) se observó semejanza entre el test de Oswestry y la escala visual análoga del dolor pre y posoperatorio. Radiológicamente se evidenció síndrome transicional en 15,5% en artrodesis posterolateral y 3,2% en artrodesis 360º, 5 casos de fatiga de implante en artrodesis posterolateral y 2 casos en artrodesis 360º, 2 casos de pseudoartrosis en artrodesis posterolateral y circunferencial, 1 caso de infección para cada grupo en estudio. CONCLUSIÓN: Nuestros resultados no reflejan discrepancias funcionales, sin embargo, evidenciamos menos complicaciones en cuanto a síndrome transicional (11 vs 2) y migración del implante (5 vs 2) en artrodesis posterolateral vs artrodesis 360º, aunque sin significancia desde el punto de vista estadístico.
OBJETIVO: Apresentar nossa experiência em artrodese póstero-lateral em comparação com circunferencial (360º) na parte lombossacral da coluna durante o período de 2000 a 2010. MÉTODOS: Série clínica de 132 pacientes (61 pacientes com atrodese de 360º e 71 pacientes com artrodese póstero-lateral). RESULTADO: Predominância do sexo feminino (51,5%); média de idade de 45,5 anos; acompanhamento de 60 meses; nível mais instrumentado com artrodese 360º, L4-L5 (54.5%) e com procedimento póstero-lateral L5-S1 (38.5%); observou-se semelhança entre o questionário de Oswestry e a escala analógica visual de dor no pré e pós-operatório. Em termos radiológicos, demonstrou-se síndrome de transição em 15,5% em artrodese póstero-lateral e em 3,2% em artrodese 360º; 5 casos da fadiga dos implantes na artrodese póstero-lateral e em 2 casos de artrodese 360º; 2 casos do pseudoartrose com artrodese póstero-lateral e circunferencial; 1 caso de infecção em cada grupo do estudo. CONCLUSÃO: Nossos resultados não refletem discrepâncias funcionais; contudo, evidenciamos menos complicações na síndrome de transição (11 vs 2) e migração dos implantes (5 vs 2) com artrodese póstero-lateral com relação à artrodese 360º, embora sem significância do ponto de vista estatístico.
OBJECTIVE: To present our experience in posterolateral vs circumferential (360º) arthrodesis in the lumbosacral spine during the period 2000-2010. METHODS: 132 patients (61 patients with arthrodesis 360º and 71 patients with posterolateral arthrodesis). RESULTS: Female predominance (51.5%); mean age 45.5 years, follow-up of 60 months; instrumented level with arthrodesis 360º, L4-L5 (54.5%) and posterolateral, L5-S1 (38.5%); there was similarity between the Oswestry Quesionnaire and Visual Analog Pain Scale in the pre- and postoperative period. Radiologically it was demonstrated transition syndrome in 15.5% posterolateral and arthrodesis 360º in 3.2%; 5 cases of fatigue of the implants in the posterolateral arthrodesis and 2 cases of arthrodesis 360º; 2 cases of pseudoartrose with posterolateral and circumferential fusion; 1 case of infection in each study group. CONCLUSION: Our results do not reflect functional differences; however we found fewer complications in the transitional syndrome (11 vs 2) and migration of the implants (5 vs 2) fusion with posterolateral arthrodesis vs 360º arthrodesis, although without statistical significance.
Assuntos
Artrodese , Dor Lombar , Plexo Lombossacral , Região Lombossacral , Fusão Vertebral , Coluna VertebralRESUMO
Antecedentes: Los diagnósticos de cáncer son cada vez mayores y ello está asociado con el aumento de la expectativa de vida, la exposición a carcinógenos, la cobertura en salud, el tamizaje y la búsqueda activa de casos. En Estados Unidos se diagnostican 1000,000 de casos nuevos y más de 500,000 muertes por año. Los costos de la atención y la incapacidad laboral son muy altos. En Colombia, el patrón de ocurrencia de esta enfermedad se constituye en un problema de salud pública. En Manizales, en el año 2004, se diagnosticaron 653 casos nuevos.Objetivo: Describir la población con diagnóstico de cáncer atendida en el Instituto Oncológico (ION SA) deManizales, Colombia, desde su fundación en el año 1995, hasta diciembre de 2004. Métodos: Se incluyeron 5,000 pacientes tratados durante 1995 a 2004. Las variables demográficas y clínicas seanalizaron para establecer las frecuencias de presentación y los principales aspectos del manejo y los resultados del tratamiento.Resultados: Edad promedio 57 años +17.3; sexo femenino (65.6%); procedencia urbana (90.2%). La principal categoría ocupacional fue ®Oficios varios¼ (61%) seguida de ®Técnico¼ (12.1%). Los diagnósticos con mayor frecuencia fueron cáncer de mama (18.7%), cáncer de cérvix (13.1%), linfomas (7.7%), cáncer colorectal (6.4%) y cáncer gástrico (4.7%). La mayoría de los pacientes (69.1%) consultó después de dos meses de presentar síntomas.Las etapas clínicas III y IV fueron las más frecuentes en el momento de la consulta. Según la escala de Karnofsky, la capacidad funcional era buena al inicio del tratamiento. El manejo general se hizo con cirugía, quimioterapia yradioterapia. La toxicidad medicamentosa se presentó en 11.3% (567/5,000). La supervivencia a 5 años para hombres y mujeres fue de 61.2% y 72.3%, respectivamente (p<0.05).
Assuntos
Humanos , Terapia Combinada , Neoplasias , SobrevidaRESUMO
Objetiv determinar el estado de salud oral de pacientes con enfermedad renal crónica atendidos en un centro de terapia renal y su relación con marcadores nutricionales, inflamatorios y dosis de eritropoyetina. Pacientes: todos los pacientes con enfermedad renal crónica atendidos en RTS sucursal Caldas en programas predialítico, postrasplante renal, hemodiálisis y diálisis peritoneal, con más de tres meses ininterrumpidos de asistencia en uno de esos programas, haber aceptado su participación en el estudio, contar con los paraclínicos necesarios para el estudio y registro de dosis administrada de eritropoyetina. Métodos: trescientos treinta y seis pacientes cumplieron con los criterios de inclusión: 24 (7%) en prediálisis, 164 (49%) en hemodiálisis, 114 (34%) en diálisis peritoneal y 34 (10%) en postrasplante renal. Se establecieron los datos demográficos y se evaluaron los índices de placa (higiene oral), salud periodontal, experiencia en caries COP-D (cariados, obturados, perdidos - diente), y diagnóstico estomatológico. También resultados de exámenes paraclínicos indicadores de estado inflamatorio tales como albúmina, ferritina y porcentaje de saturación de transferrina, además la dosis administrada de eritropoyetina. Resultados: la población de pacientes en prediálisis y postrasplante renal no arrojó datos suficientes para ser incluida en el análisis estadístico. De los pacientes en diálisis 63% presentaban buena higiene oral, 33% regular, y sólo 3% tenían mala higiene oral, a pesar de ello la prevalencia de enfermedad periodontal fue alta afectando a 75% de los pacientes llegándose a presentar gingivitis severa en 35-38% de los pacientes. Por el índice COP-D se observó que la prevalencia en caries fue alta. Por lo disperso de los resultados de laboratorio de marcadores inflamatorios no fue posible determinar correlación alguna entre ellos y salud periodontal o dosis de eritropoyetina. Conclusiones: la higiene oral de los pacientes ...
Objective: to establish the oral health condition of patients with chronic kidney disease (CKD) who received care in a center for renal therapy, as well as its relationship with nutritional and inflammatory markers and doses of erythropoietin received. Patients: patients with chronic kidney disease treated at RTS Caldas, in the following programs: predialysis, post-renal transplant, hemodialysis, and peritoneal dialysis. All these patients had attended any of these programs uninterruptedly for at least three months; they agreed to participate in the study and had the necessary laboratory studies, as well as registered doses of erythropoietin. Methods: three hundred thirty-six patients met the inclusion criteria: 24 (7%) in predialysis, 164 (49%) in hemodialysis, 114 (34%) in PD and 34 (10%) in post-renal transplant. The following demographic data were established and assessed: Silness and Loe plaque indices (oral Health) and Loe and Silness gingival indices, caries experience in Decayed-Missing-Filled Teeth Index (DMFT) and stomatologic diagnosis. Additionally, laboratory reports were recorded indicating the infammation state of the patients: albumin, ferritin, transferrin saturation and erythropoietin dosage. Results: pre-dialysis and post-renal transplant populations did not give suffIcient information to be included in the statistical analysis. The following information was obtained from dialysis patients: 63% had good oral hygiene, 33% fair, and only 3% had poor oral hygiene. The prevalence of periodontal disease was high, affecting 75% of patients. Severe gingivitis was present in 35-38% of patients. The DMFT index showed a high prevalence of caries. No relationship was found between laboratory results for infammatory markers, periodontal health, and doses of erythropoietin. Conclusions: the oral hygiene of dialysis patients is satisfactory. However, they have a high prevalence of periodontal disease and tooth decay. This suggests ...
RESUMO
Siringomielia, cavidades quísticas dentro del cordón espinal. Con incidencia baja de 8.4 por 100000 por año, Presentamos nuestra experiencia en tratamiento quirúrgico de 5 casos de siringomielia. Se presenta serie clínica, sin distinción de edad ni sexo, con diagnostico de siringomielia y que cumplan con los criterios quirúrgicos establecidos por el grupo. Estudiamos 5 pacientes, la totalidad de los casos presentaron síndrome disociativo medular por siringomielia, 4 casos sexo femenino, promedio de edad de 40,8 años, rango de seguimiento de 6 años a 6 meses, 5 casos procedentes del estado Mérida, 100% diagnostico por resonancia, 3 caso localización cervical, 1 caso la etiología es hemangioma capilar, a los 5 se les realizo derivación siringosubaracnoidea con mejoría clínica y en el postoperatorio tardío un 20% presento recidiva, manejada conservadoramente.
Syringomyelia, cystic cavities within the spinal cord. With low incidence of 8.4 per 100000 per year, present our experience in surgical treatment of 5 cases of syringomyelia. We present clinical series, regardless of age, sex diagnosed with syringomyelia and meet surgical criteria established by the grupo. We studied 5 patients, all cases had spinal cord syndrome and syringomyelia dissociative 4 cases female, mean age of 40.8 years, range 6-year follow-up to 6 months, 5 cases from the state of Merida, 100% resonance diagnosis, 3 cases cervical lesion, 1 case of capillary hemangioma etiology, to 5 were conducted with clinical improvement siringosubaracnoidea bypass and postoperative period by 20% for 1 case of recurrent, conservatively managed.
Assuntos
Humanos , Masculino , Feminino , Canal Medular/cirurgia , Siringomielia/cirurgia , Siringomielia/diagnóstico , Traumatismos da Coluna Vertebral/patologia , Traumatismos da Medula Espinal/cirurgia , Traumatismos da Medula Espinal/patologia , OrtopediaRESUMO
La cirugía endoscópica de columna, resultado de la inquietud de múltiples investigadores en encontrar técnicas menos invasivas para el tratamiento de problemas quirúrgicos. Serie clínica de 33 pacientes, sometidos a cirugía lumbar endoscópica y evolución clínica (20092011). 33 pacientes, el 91% mínimo 6 meses de evolución, 100% fueron manejados ambulatorio, 52% femenino, 48% masculinos, promedio de 49 años de edad, 60% diagnostico de Lumbalgia discogenica y 40% síndrome de receso lateral y radiculalgia, 30% empleados públicos, 50% Discectomía endoscopia un nivel, 30% dos niveles, 17% tres niveles y 3% cuatro niveles, 21% tenía signos radiculares preoperatorios, un paciente (3%) espondilodiscitis, 37% reagudización clínica e inestabilidad lumbar, 15% requirió otra cirugía y 9% se le plantea nueva cirugía. Se evaluaron con la escala visual análoga del dolor, test de incapacidad de Oswestry, criterios de Macnab. La cirugía endoscópica lumbar, técnica atractiva, al reducir la vía de abordaje, reduce las complicaciones de cicatrización y la temprana incorporación a sus actividades. En nuestra experiencia, obtuvimos un 76% entre buenos y aceptables resultados y 24% malos según Macnab, lo que obliga a ser acuciosos para seleccionar al paciente.
Endoscopic surgery of the spine, resulting from the concern of many researchers to find less invasive techniques for the treatment of surgical problems. A case series of 33 patients who underwent lumbar endoscopic surgery and clinical course (2009 - 2011). 33 patients, 91% at least 6 months duration, 100% were ambulatory, 52% female, 48% male, average age 49 years, 60% diagnosis of discogenic low back pain and 40% lateral recess syndrome and radiculalgia, 30% civil servants, 50% endoscopic discectomy level, 30% two levels, three levels 17% and 3% four levels, 21% had preoperative radicular findings, one patient (3%) spondylodiscitis, 37% and clinical worsening lumbar instability, 15% required another surgery and 9% is facednew surgery. Were evaluated with visual analog pain scale, Oswestry Disability test, Macnab criteria. The lumbar endoscopic surgery, technically attractive, reducing the surgical approach, reduces the complications of early healing and incorporation into its activities. In our experience, we obtained 76% between good and acceptable and 24% poor results according to Macnab, making it necessary to be diligent to select the patient.
Assuntos
Humanos , Cirurgia Endoscópica por Orifício Natural/métodos , Canal Medular/cirurgia , Dor Lombar/cirurgia , Dor Lombar/diagnóstico , Endossonografia/métodos , Laparoscopia/métodos , Região Lombossacral/cirurgia , Região Lombossacral/lesões , Traumatismos da Medula Espinal/cirurgia , OrtopediaRESUMO
INTRODUCTION: It has been reported in some series that gsp+ somatotropinomas are more sensitive to somatostatin analogues (SA) and dopamine's actions which may be related to their somatostatin receptor (SSTR) and dopamine receptor (DR) profile. No previous studies have been undertaken to evaluate the SSTR and DR profile related with the gsp status in somatotropinomas. OBJECTIVES: To determine if (1) gsp status is correlated with response to octreotide LAR (LAR) and tumor expression patterns of SSTR1-5 and DR1-5 and (2) cAMP level can directly modulate SSTR and DR mRNA levels. METHODS: Response to SA was evaluated by GH and IGF-I percent reduction after 3 and 6 months of treatment with LAR. Conventional PCR and sequencing were used to identify gsp+ tumors. Quantitative real-time PCR was used to determine SSTR and DR tumor expression. Primary pituitary cell cultures of primates were used to study whether SSTR and DR expression is regulated by forskolin. RESULTS: The response to LAR did not significantly differ between patients with gsp+ and gsp- tumors; however, gsp+ tumors expressed higher levels of SSTR1, SSTR2, DR2 and a lower level of SSTR3. Forskolin increased SSTR1, SSTR2, DR1 and DR2 expression in cell cultures. CONCLUSION: Elevated SSTR1, SSTR2, and DR2 tumor expression may help improve responsiveness to SA and DA therapy; however, this study may not have been appropriately powered to observe significant effects in the clinical response. Elevated cAMP levels could be directly responsible for the upregulation in SSTR1, SSTR2 and DR2 mRNA levels observed in gsp+ patients.