RESUMO
PURPOSE: To evaluate the impact of systemic cyclophosphamide treatment on the rat uterus and investigate the potential therapeutic effects of natural antioxidant preparations curcumin and capsaicin against cyclophosphamide side effects. METHODS: A 40 healthy adult female Wistar albino rats were used in this study. Rats were randomly divided into four groups to determine the effects of curcumin and capsaicin against Cyclophosphamide side effects on the uterus (n=10 in each group); Group 1 was the control group (sham-operated), Group 2 was the cyclophosphamide group, Group 3 was the cyclophosphamide + curcumin (100mg/kg) group, and Group 4 was the cyclophosphamide + capsaicin (0.5 mg/kg) group. RESULTS: Increased tissue oxidative stress and histological damage in the rat uterus were demonstrated due to the treatment of systemic cyclophosphamide chemotherapy alone. The level of tissue oxidant and antioxidant markers and histopathological changes were improved by the treatment of curcumin and capsaicin. CONCLUSION: Cytotoxic effects of natural alkylating chemotherapeutic agents like cyclophosphamide on the uterus can be prevented by curcumin and capsaicin.
Assuntos
Antineoplásicos Alquilantes/efeitos adversos , Antioxidantes/farmacologia , Capsaicina/farmacologia , Curcumina/farmacologia , Ciclofosfamida/efeitos adversos , Útero/efeitos dos fármacos , Animais , Catalase/análise , Feminino , Glutationa/análise , Glutationa Peroxidase/análise , Malondialdeído/análise , Estresse Oxidativo/efeitos dos fármacos , Distribuição Aleatória , Ratos Wistar , Reprodutibilidade dos Testes , Superóxido Dismutase/análise , Doenças Uterinas/induzido quimicamente , Doenças Uterinas/prevenção & controle , Útero/patologiaRESUMO
Abstract Purpose: To evaluate the impact of systemic cyclophosphamide treatment on the rat uterus and investigate the potential therapeutic effects of natural antioxidant preparations curcumin and capsaicin against cyclophosphamide side effects. Methods: A 40 healthy adult female Wistar albino rats were used in this study. Rats were randomly divided into four groups to determine the effects of curcumin and capsaicin against Cyclophosphamide side effects on the uterus (n=10 in each group); Group 1 was the control group (sham-operated), Group 2 was the cyclophosphamide group, Group 3 was the cyclophosphamide + curcumin (100mg/kg) group, and Group 4 was the cyclophosphamide + capsaicin (0.5 mg/kg) group. Results: Increased tissue oxidative stress and histological damage in the rat uterus were demonstrated due to the treatment of systemic cyclophosphamide chemotherapy alone. The level of tissue oxidant and antioxidant markers and histopathological changes were improved by the treatment of curcumin and capsaicin. Conclusion: Cytotoxic effects of natural alkylating chemotherapeutic agents like cyclophosphamide on the uterus can be prevented by curcumin and capsaicin.
Assuntos
Animais , Feminino , Útero/efeitos dos fármacos , Capsaicina/farmacologia , Antineoplásicos Alquilantes/efeitos adversos , Curcumina/farmacologia , Ciclofosfamida/efeitos adversos , Antioxidantes/farmacologia , Superóxido Dismutase/análise , Doenças Uterinas/induzido quimicamente , Doenças Uterinas/prevenção & controle , Útero/patologia , Catalase/análise , Distribuição Aleatória , Reprodutibilidade dos Testes , Ratos Wistar , Estresse Oxidativo/efeitos dos fármacos , Glutationa/análise , Glutationa Peroxidase/análise , Malondialdeído/análiseRESUMO
Purpose: To evaluate the impact of systemic cyclophosphamide treatment on the rat uterus and investigate the potential therapeutic effects of natural antioxidant preparations curcumin and capsaicin against cyclophosphamide side effects. Methods: A 40 healthy adult female Wistar albino rats were used in this study. Rats were randomly divided into four groups to determine the effects of curcumin and capsaicin against Cyclophosphamide side effects on the uterus (n=10 in each group); Group 1 was the control group (sham-operated), Group 2 was the cyclophosphamide group, Group 3 was the cyclophosphamide + curcumin (100mg/kg) group, and Group 4 was the cyclophosphamide + capsaicin (0.5 mg/kg) group. Results: Increased tissue oxidative stress and histological damage in the rat uterus were demonstrated due to the treatment of systemic cyclophosphamide chemotherapy alone. The level of tissue oxidant and antioxidant markers and histopathological changes were improved by the treatment of curcumin and capsaicin. Conclusion: Cytotoxic effects of natural alkylating chemotherapeutic agents like cyclophosphamide on the uterus can be prevented by curcumin and capsaicin.(AU)
Assuntos
Animais , Feminino , Adulto , Ratos , Ciclofosfamida/efeitos adversos , Neoplasias Uterinas/terapia , Curcumina/uso terapêutico , Capsaicina/uso terapêutico , Ratos WistarRESUMO
PURPOSE: To determine the toxic effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on reproductive system and the beneficial effects of Montelukast (ML) with histological and biochemical analysis. METHODS: Rats were randomly divided into four equal groups (control, TCDD, ML and TCDD+ML). Tissue samples were collected on day 60 and oxidative status and histological alterations were analyzed. RESULTS: The results showed a significant increase in oxidative and histological damage on uterine and ovarian tissues. Otherwise, the oxidative and histological damages caused by TCDD were prevented with ML treatment. CONCLUSION: The toxic effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on female reproductive system were reversed with Montelukast treatment. Therefore, we claimed that ML treatment might be useful for TCDD toxicity.
Assuntos
Acetatos/farmacologia , Antioxidantes/farmacologia , Ovário/efeitos dos fármacos , Estresse Oxidativo/efeitos dos fármacos , Dibenzodioxinas Policloradas/toxicidade , Quinolinas/farmacologia , Teratogênicos/toxicidade , Útero/efeitos dos fármacos , Animais , Catalase/metabolismo , Ciclopropanos , Feminino , Glutationa/metabolismo , Folículo Ovariano/efeitos dos fármacos , Ovário/patologia , Distribuição Aleatória , Ratos , Ratos Wistar , Sulfetos , Superóxido Dismutase/metabolismo , Útero/patologiaRESUMO
PURPOSE: To investigate the protective effect of Bg on cisplatin (CP)-induced neurotoxicity in rats. METHODS: Twenty eight rats were randomly distributed into four groups. The first group was kept as a control. In the second group, CP was given at the single dose of 7 mg/kg intraperitoneally. In the third group, ßg was orally administered at the dose of 50 mg/kg/day for 14 days. In the fourth group, CP and ßg were given together at the same doses. RESULTS: CP treatment caused significant oxidative damage via induction of lipid peroxidation and reductions antioxidant defense system potency in the brain tissue. In addition, histopathological damage increased with CP treatment. On the other hand, ßg treatment largely prevented oxidative and histopathological negative effects of CP. CONCLUSIONS: Cisplatin has severe neurotoxic effects in rats and ßg supplementation has significant beneficial effects against CP toxicity depending on its antioxidant properties. Thus, it appears that ßg might be useful against CP toxicity in patients with cancer in terms of nervous system.