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Objetivo Comparar el nivel de adaptación del autoconcepto (NAA) en las personas que viven con Diabetes mellitus tipo 2 (DT2), en dos escenarios de una unidad de primer nivel. Metodología Investigación descriptiva, correlacional, comparativa y transversal con muestreo por conveniencia; se conformó por adultos con DT2 que asisten a control mensual y al grupo de ayuda mutua (GAM) en una unidad de primer nivel. Se aplicó cédula de datos generales e instrumento Viveros03 (a=.85); se realizó valoración antropométrica y glucemia capilar. El análisis de datos fue con SPSS v. 20. La comprobación de hipótesis fue mediante Shapiro-Wilk, T-student y Ji cuadrada. Resultados Se trabajó con 50 sujetos, 25 del GAM (Grupo A) y 25 de control ambulatorio (Grupo B). El NAA del grupo A fue 60% integrado y del B fue de 68% compensatorio, con diferencia significativa entre ambos grupos (p=0.02). Los estímulos contextuales como control glucémico, años de diagnóstico y tratamiento no demostraron dependencia (p >.05), contrario a los antecedentes familiares con diabetes y pertenecer al GAM en donde sí hubo relación (p= <.05). Conclusión El NAA fue mejor en el GAM, la valoración positiva del autoconcepto tuvo un mayor impacto, así mismo en el GAM, los antecedentes familiares son estímulos contextuales que permiten la adaptación de manera positiva.
Objective To compare the level of Adaptation of the Self-Concept (ASC) in persons suffering from Diabetes mellitus type 2 (DT2) in two locations at a first level unit. Methodology This is a descriptive, correlational, comparative, and transversal research with a sample by convenience of adults with DT2 attending to a monthly control, and to a Mutual Support Group MSG, both in a first level unit. The general data register and the Viveros03 instrument (a =.85) were used. Anthropometric and capillary glycemic level assessments were performed. Data were analyzed through SPSS v.20. The hypothesis was verified using Shapiro-Wilk, T-student and Chi square tests. Results There were 50 participants, the 25 in the MSG were assigned to group A, while the other 25 constituted the ambulatory and group B. ASC in group A was 60% while 68% in group B; the difference was significant at p = 0.002. Contextual stimuli such as capillary glycemic level, and years of diagnosis and treatment did not show dependence (p > .05) contrary to family diabetes background, and belonging to the MSG, which did show an association (p=<.05). Conclusion ASC was better among those in the MSG, while family background promoted a better adaptation as well.
Objetivo Comparar o nível de adaptação do autoconceito (NAA) nas pessoas que vivem com Diabetes mellitus tipo 2 (DT2), em dois cenários de uma unidade de primeiro nível. Metodologia Pesquisa descritiva, correlacional, comparativa e transversal com amostragem por conveniência; conformou-se por adultos com DT2 que assistem a controle mensal e ao grupo de ajuda mutua (GAM) em uma unidade de primeiro nível. Aplicou-se cédula de dados generais e instrumento Viveros03 (a=.85); realizou-se valorização antropométrica e glicemia capilar. A análise de dados foi com SPSS v. 20. A comprobação de hipótese foi mediante Shapiro-Wilk, T-student e Ji cuadrada. Resultados Trabalhou-se com 50 indivíduos, 25 do GAM (Grupo A) e 25 de controle ambulatório (Grupo B). O NAA do grupo A foi 60% integrado e do B foi de 68% compensatório, com diferença significativa entre ambos os grupos (p=0.02). Os estímulos contextuais como controle glicêmico, anos de diagnóstico e tratamento não demonstraram dependência (p > .05), contrário aos antecedentes familiares com diabetes e pertencer ao GAM onde houve uma relação (p=< 05). Conclusão O NAA foi melhor no GAM, a avaliação positiva do autoconceito teve um maior impacto, assim mesmo no GAM, os antecedentes familiares são estímulos contextuais que permitem a adaptação de maneira positiva.
Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Autocuidado , Adulto , Diabetes Mellitus Tipo 2RESUMO
O objetivo do trabalho foi avaliar a efetividade da ivermectina a 4% e o levamisol a 15% no controle de parasitas gastrointestinais. Foi realizada uma amostragem de 20 ovinos entre 3 a 6 meses de idade em uma propriedade no município de Sabana de Torres, Santander, Colômbia em 2011. Os animais foram divididos em dois grupos e permaneceram nas mesmas condições ambientais, nutricionais e de manejo durante 115 dias de experimento. Um dos grupos recebeu Ivermectina a 4% via subcutânea, na dose de 800 μg/kg em dose única (dia 0). O outro grupo, por sua vez, recebeu 3 doses de Levamisol a 15%, na dose de 7.5 mg/kg administrados nos dias 0, 31 e 80. Foi avaliada a influência dos tratamentos no controle dos parasitas gastrointestinais, ganho de peso e custos dos tratamentos em cada grupo. Em relação à redução dos ovos, observou-se que os dois tratamentos foram efetivos até o dia 17, sendo mais eficaz a ivermectina, que manteve os níveis toleráveis de parasitas nos primeiros 94 dias. Além disso, o ganho de peso teve diferenças significativas (p<0.05) entre tratamentos, pois o grupo tratado com ivermectina obteve um maior ganho de peso final, com média de 8,4kg enquanto o
RESUMO
O objetivo do trabalho foi avaliar a efetividade da ivermectina a 4% e o levamisol a 15% no controle de parasitas gastrointestinais. Foi realizada uma amostragem de 20 ovinos entre 3 a 6 meses de idade em uma propriedade no município de Sabana de Torres, Santander, Colômbia em 2011. Os animais foram divididos em dois grupos e permaneceram nas mesmas condições ambientais, nutricionais e de manejo durante 115 dias de experimento. Um dos grupos recebeu Ivermectina a 4% via subcutânea, na dose de 800 μg/kg em dose única (dia 0). O outro grupo, por sua vez, recebeu 3 doses de Levamisol a 15%, na dose de 7.5 mg/kg administrados nos dias 0, 31 e 80. Foi avaliada a influência dos tratamentos no controle dos parasitas gastrointestinais, ganho de peso e custos dos tratamentos em cada grupo. Em relação à redução dos ovos, observou-se que os dois tratamentos foram efetivos até o dia 17, sendo mais eficaz a ivermectina, que manteve os níveis toleráveis de parasitas nos primeiros 94 dias. Além disso, o ganho de peso teve diferenças significativas (p<0.05) entre tratamentos, pois o grupo tratado com ivermectina obteve um maior ganho de peso final, com média de 8,4kg enquanto o
RESUMO
SUBJECT: To determinate the frecuency and the time of development of the gallbladder stones in gastrectomy post-operated patients with stomach adenocarcinoma at The National Cancer Institute in Lima, Peru. METHODS: In an observational, descriptive and retrospective case series design, 148 patiens' files who underwent gastrectomy for stomach adenocarcinoma in the National Cancer Institue of Lima during 1990 and 2000, have been reviewed looking for the development of gallbladder stones. RESULTS: A total de 148 patients were involved in this study. 29 of them (19.6%) develop gallbladder stones during the (x years of) follow up vs 119 (80.9%) . The mean age ot the 29 patients with gallbladder stones were 59.9 years ans 18 of them were female and 11 male.\The mean time of develop gallbladder stones was 3.1 years.According to the type of surgery, 14 patient wiht gallbladder stones underwent to subtotal gastrectomy and 15 to total gastrectomy. CONCLUSIONS: The frecuency of gallbladder stones post gastrectomy in this study was 19.6%. The mean time of the develop and diagnosis of litiasis was 3.1 years.To perform the colecistectomy at the same time of the gastrectomy could be an important decision in patients with high risk of gallstones and gallbladder cancer.We need furthermore studies to have conclusions about the risk factors.
Assuntos
Adenocarcinoma/cirurgia , Colelitíase/epidemiologia , Gastrectomia/métodos , Síndromes Pós-Gastrectomia/epidemiologia , Neoplasias Gástricas/cirurgia , Adenocarcinoma/epidemiologia , Adulto , Idoso , Institutos de Câncer/estatística & dados numéricos , Colecistectomia , Colelitíase/etiologia , Colelitíase/prevenção & controle , Feminino , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Peru , Síndromes Pós-Gastrectomia/etiologia , Síndromes Pós-Gastrectomia/prevenção & controle , Estudos Retrospectivos , Neoplasias Gástricas/epidemiologiaRESUMO
OBJETIVO: Determinar la frecuencia de litiasis vesicular en pacientes post-operados con gastrectomía por adenocarcinoma gástrico, determinar el tiempo de aparición de litiasis vesicular en pacientes gastrectomizados por Adenocarcinoma Gástrico. MÉTODOS: Se realizo un estudio observacional, descriptivo retrospectivo. Se revisó un total de 148 historias clínicas de pacientes sometidos a gastrectomía por adenocarcinoma gástrico en el Instituto Nacional de Enfermedades Neoplásicas en el periodo de 1990 al 2000. RESULTADOS: De los 148 casos de pacientes post gastrectomizados por adenocarcinoma gástrico que fueron enrolados, 29(19.6 por ciento) presentaron litiasis vesicular versus 119(80.9 por ciento) que no presentaron litiasis vesicular como complicación post gastrectomía. La media de edad de 29 pacientes con litiasis vesicular post gastrectomía por adenocarcinoma gástrico fue de 59.9años (min. 39años máx.74años). La distribución de la litiasis vesicular en relación al sexo fue, femenino 18(62.1 por ciento) casos y masculino 11(37.9 por ciento) casos. La media del tiempo de aparición de la litiasis vesicular post gastrectomía fue de 3.1 años, para el sexo masculino 2.7años y para el sexo femenino de 3.3 años. Según el tipo de cirugía se presento litiasis vesicular en 14 pacientes que fueron sometidos a Gastrectomía Subtotal Distal y a 15 pacientes a los que se les practicó Gastrectomía Total. CONCLUSIONES: la Frecuencia de litiasis vesicular post gastrectomía fue de 19.6 por ciento. El periodo de aparición de colelitiasis fue de 3.1 años. La colecistectomía podría ser una toma de decisión importante en pacientes con alto riesgo de litiasis y cáncer vesicular post gastrectomía. El presente trabajo de investigación invita a realizar otros estudios de tipo cohorte en el cual se determine el factor de riesgo principal para la aparición de esta complicación.
SUBJECT: To determinate the frecuency and the time of development of the gallbladder stones in gastrectomy post-operated patients with stomach adenocarcinoma at The National Cancer Institute in Lima, Peru. METHODS: In an observational, descriptive and retrospective case series design, 148 patiens' files who underwent gastrectomy for stomach adenocarcinoma in the National Cancer Institue of Lima during 1990 and 2000, have been reviewed looking for the development of gallbladder stones. RESULTS: A total de 148 patients were involved in this study. 29 of them (19.6 percent) develop gallbladder stones during the (x years of) follow up vs 119(80.9 percent). The mean age ot the 29 patients with gallbladder stones were 59.9 years ans 18 of them were female and 11 male./The mean time of develop gallbladder stones was 3.1 years. According to the type of surgery, 14 patient wiht gallbladder stones underwent to subtotal gastrectomy and 15 to total gastrectomy. CONCLUSIONS The frecuency of gallbladder stones post gastrectomy in this study was 19.6 percent. The mean time of the develop and diagnosis of litiasis was 3.1 years. To perform the colecistectomy at the same time of the gastrectomy could be an important decision in patients with high risk of gallstones and gallbladder cancer. We need furthermore studies to have conclusions about the risk factors.
Assuntos
Adulto , Pessoa de Meia-Idade , Adenocarcinoma , Colelitíase , Cálculos , Gastrectomia , Litíase , Neoplasias Gástricas , Síndromes Pós-Gastrectomia , Epidemiologia Descritiva , Estudos Retrospectivos , Estudos Observacionais como AssuntoRESUMO
Activated carbons were developed by phosphoric acid activation of sawdust from Prosopis ruscifolia wood, an indigenous invasive species of degraded lands, at moderate conditions (acid/precursor ratio=2, 450 degrees C, 0.5h). For in situ modification of their characteristics, either a self-generated atmosphere or flowing air was used. The activated carbons developed in the self-generated atmosphere showed higher BET surface area (2281m2/g) and total pore volume (1.7cm3/g) than those obtained under flowing air (1638m2/g and 1.3cm3/g). Conversely, the latter possessed a higher total amount of surface acidic/polar oxygen groups (2.2meq/g) than the former (1.5meq/g). To evaluate their metal sorption capability, adsorption isotherms of Cu(II) ion from model solutions were determined and properly described by the Langmuir model. Maximum sorption capacity (Xm) for the air-derived carbons (Xm=0.44mmol/g) almost duplicated the value for those obtained in the self-generated atmosphere (Xm=0.24mmol/g), pointing to a predominant effect of the surface functionalities on metal sequestering behaviour. The air-derived carbons also demonstrated a superior effectiveness in removing Cd(II) ions as determined from additional assays in equilibrium conditions. Accordingly, effective phosphoric acid-activated carbons from Prosopis wood for toxic metals removal from wastewater may be developed by in situ modification of their characteristics operating under flowing air.
Assuntos
Carbono/análise , Carbono/química , Metais/análise , Prosopis/química , Poluentes Químicos da Água/isolamento & purificação , Purificação da Água/métodos , Madeira/química , Metais/toxicidade , Modelos Químicos , Espectroscopia de Infravermelho com Transformada de FourierRESUMO
Objetivos: (1) diseñar y evaluar una técnica de angiorresonancia 3D contrastada (ARM 3D) para el diagnóstico de la estenosis carotídea y compararla con la ecografía triplex (eco triplex) y la arteriografía por sustracción digital (ASD), esta última como estándar de referencia. (2) Evaluar la factibilidad de adicionar a la técnica anterior secuencias anatómicas y angiográficas del cerebro. Materiales y métodos: en 39 pacientes (78 carótidas) se estudió la bifurcación carotídea con ASD, angiorresonancia 3D con doble inyección y eco triplex. Se utilizó el método descrito en el estudio NASCET para cuantificar el grado de estenosis. Cada examen fue evaluado por observadores diferentes que no conocían el resultado de los otros métodos. Adicionalmente, se obtuvieron imágenes del cerebro y se describieron dichos hallazgos. Resultados: la angiorresonancia 3D con técnica de doble inyección detectó el 98 por ciento del grupo de carótidas clasificadas como normal-leves, el 83 por ciento de las estenosis moderadas, el 88 por ciento de las estenosis graves y el 100 por ciento de las oclusiones. Adicionalmente, dos errores diagnósticos (oclusiones falsas) de la ASD fueron identificados efectivamente por la ARM 3D. La eco triplex detectó el 92 por ciento del grupo normal-leve, el 33 por ciento de las estenosis moderadas, el 86 por ciento de las graves y todas las oclusiones encontradas con la ASD, pero la ecografía sobrestimó una estenosis leve a oclusión (falsa oclusión). La correlación estadística entre el estándar de referencia ASD y la ARM 3D fue buena a excelente, para los diferentes grados de estenosis (K>0,7 y K>0,9, respectivamente). En todos los pacientes se logró una evaluación adecuada del cerebro con resonancia. Conclusión: esta investigación sugiere que la ARM 3D con técnica de doble inyección tiene el potencial para remplazar la ASD en el diagnóstico y seguimiento de la enfermedad carotídea
Assuntos
Espectroscopia de Ressonância Magnética/métodos , Espectroscopia de Ressonância Magnética , Trombose das Artérias Carótidas/diagnóstico , Trombose das Artérias CarótidasRESUMO
OBJECTIVE: Determine the clinical features and the survival of patients with gastric cancer invading the muscularis propia. MATERIAL AND METHODS: We reviewed the clinical records of the patients with gastric cancer invading the muscularis propia, that had undergone surgical treatment at the National Cancer Institute (INEN) between 1950 and 1999. We considered age, sex, location of the tumor, regional lymph node metastases (N), distant metastases (M), TNM stage and survival. RESULTS: 202 patients had gastric cancer invading the muscularis propia, the mean age was 60.03 years, 105 (52%) were females, in 69% the neoplasm was in the antrum and in 22% in the body. We found regional lymph node metastases in 48% and distant metastases in 1%; 52.1% was in the IB TNM stage and 3.1% in the IV. The five year survival rate using Kaplan Meier was 66%, patients with N0, N1, N2 and N3 had 78%, 70%, 25% and 0% respectively.
Assuntos
Neoplasias Gástricas/patologia , Estômago/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Interpretação Estatística de Dados , Feminino , Humanos , Metástase Linfática , Masculino , Pessoa de Meia-Idade , Metástase Neoplásica , Antro Pilórico/patologia , Neoplasias Gástricas/mortalidade , Análise de SobrevidaRESUMO
OBJECTIVE: To determine if the morbidity and postoperative mortality after a full gastrectomy for gastric cancer performed on patients of more than 70 years of age were different from those of younger patients. MATERIAL AND METHODS: Between 1980 and 1999, a total of 411 gastrectomies for gastric adenocarcinoma were performed at the Institute of Cancer Diseases (INEN). Of these, 87 were inpatients older than 70 years of age (elderly group) and 92 were inpatients between 50 and 59 years of age (young group). The clinical record of both groups were studied and the clinical-pathological features, morbidity and postoperative mortality, staying time in hospital and survival rate were compared. RESULTS: There was no significant difference between the two groups regarding clinical-pathological features except in the TNM stage. In the elderly group 23.0% had stage IV and 43.5% in the young group (p=0.007). The average operating time in the elderly group was shorter than in the young group (5.5 hours versus 6.0 hours, p=0.015). The morbidity for the elderly group was 29.9% and that of the young group was 34.8%, whereas the postoperative mortality for the elderly and young groups was 4.6% and 2.2%, respectively. Pneumonia was the most frequent postoperative complication (14.8%) and the primary cause of postoperative death in the elderly group. Time in hospital and survival were similar between both groups. CONCLUSIONS: The morbidity and postoperative mortality after a full gastrectomy for cancer of the stomach in the elderly is no different from those found in younger patients.
Assuntos
Adenocarcinoma/cirurgia , Gastrectomia , Neoplasias Gástricas/cirurgia , Adenocarcinoma/mortalidade , Fatores Etários , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Complicações Pós-Operatórias/epidemiologia , Neoplasias Gástricas/mortalidadeRESUMO
AIM: To compare the leakage rate of esophagojejunal anastomosis performed with stapler or hand sutures. MATERIAL AND METHODS: We studied a series of 367 patients who underwent total gastrectomy for gastric cancer at the Instituto de Enfermedades Neoplásicas (Lima-Peru) from 1986 to 1999. RESULTS: In 197 patients esophagojejunal anastomosis was performed with stapler and in 170 with manual sutures. There were no differences between both groups with regard to age, TNM stage, operating time and hospital stay. There were 8 anastomotic leakage (4.1%) in the stapler group and 4 (2.4%) in the hand sutures group (p> 0.05). Of these 12 cases, 2 patients (16%) died of causes directly related to the leak of the esophagojejunal anastomosis. CONCLUSION: There were no statistical differences in the rate of leakage of the esophagojejunal anastomosis performed with stapler or hand sutures, thus both techniques should be accepted as standard procedures.
Assuntos
Adenocarcinoma/cirurgia , Esôfago/cirurgia , Gastrectomia , Jejuno/cirurgia , Neoplasias Gástricas/cirurgia , Grampeadores Cirúrgicos , Técnicas de Sutura , Anastomose Cirúrgica , Feminino , Humanos , MasculinoRESUMO
OBJECTIVE: To measure gastrointestinal hormonal response (GHR) with minimal enteral feeding (MEF) in sick premature infants. METHODS: Forty-one babies birth weight < 1800 g receiving total parenteral nutrition or intravenous solutions entered the study. They were distributed in two groups: group I: 26 infants (early enteral feeding < or = 5 d) and group II = 15 infants (late enteral feeding = 10-14 d). A diluted special formula was used as MEF starting with 1 mL hourly with daily increments of 1 mL up to 120 mL. Basal and final determinations of GHR were done before and after the MEF. RESULTS: Both groups were similar in birth weight, postnatal age, and trophism. There were intragroup differences between basal and final GHR for all hormones in both groups. Subgroups by gestational age (< or = 32 vs > 32 weeks) and trophism (< or = 1250 vs > 1250 g) also showed basal-final differences. There were no complications related to the MEF. CONCLUSIONS: MEF favors secretion of gastrointestinal hormones in sick premature infants. Early MEF seems to be preferable to late one since it allows a faster secretion related to volume of the formula. MEF did not increase abdominal complications in our infants.
Assuntos
Nutrição Enteral , Hormônios Gastrointestinais/metabolismo , Doenças do Prematuro/fisiopatologia , Peso ao Nascer , Polipeptídeo Inibidor Gástrico/metabolismo , Gastrinas/metabolismo , Idade Gestacional , Humanos , Alimentos Infantis , Recém-Nascido de Baixo Peso , Recém-Nascido , Doenças do Prematuro/terapia , Motilina/metabolismo , Neurotensina/metabolismo , Nutrição Parenteral Total , Estudos Prospectivos , Taxa Secretória , Fatores de TempoRESUMO
Usually primary cancer originating in the hepatic duct confluence (Klatskin Tumor) is regarded as unresectable at diagnosis and therefore percutaneously or endoscopically placed stents have been advocated. Unfortunately with these palliative modalities the median survival is only 3-6 months. However with aggressive surgical resection of the tumor 17% of five year survival have been obtained. The present paper summarizes our experience from three patients with Klatskin tumor which underwent surgery. The Klatskin tumors were Type II (one case), Type IIIa (one case) and Type IIIb (one case). The patient with tumor Type II had wide tumor excision and extrahepatic bile duct resection at the liver hilum. The patients with tumor Type III had extrahepatic bile duct resection at the liver hilum with left and right hepatectomy respectively. Reconstruction was made with Roux-en-Y biliary enteric anastomosis, the mean post operative stay was 9 days. The mean post operative survival of two patients undergoing surgery with curative intent was 21 months, in contrast to 10 months for the patient with palliative surgery. One patient is alive 22 months with no evidence of disease. Our results supports an aggressive surgical approach in patients with Klatskin tumor which should include Hepatectomy to obtain free resection margins.
Assuntos
Neoplasias dos Ductos Biliares/cirurgia , Ducto Hepático Comum , Tumor de Klatskin/cirurgia , Anastomose em-Y de Roux , Neoplasias dos Ductos Biliares/diagnóstico por imagem , Neoplasias dos Ductos Biliares/patologia , Colangiopancreatografia Retrógrada Endoscópica , Feminino , Seguimentos , Hepatectomia , Ducto Hepático Comum/patologia , Ducto Hepático Comum/cirurgia , Humanos , Tumor de Klatskin/diagnóstico por imagem , Tumor de Klatskin/patologia , Masculino , Pessoa de Meia-Idade , Fatores de TempoRESUMO
OBJECTIVE: Determination of the postoperative morbidity and mortality after gastroenterostomy in patients with unresectable gastric cancer. STUDY DESIGN: Retrospective review of clinical records of all patients with obstructive distal gastric cancer who underwent gastroenterostomy at the Instituto de Enfermedades Neoplásicas between 1980 and 1993. The following factors were analyzed: age, sex, hemoglobin, albumin, preoperative risk, ascites, extent of disease, operative time, hospital stay, morbidity and mortality. RESULTS: 198 gastroenterostomy were done with a morbidity and mortality rates of 20% and 10%, respectively. Pneumonia was the principal cause of postoperative morbidity and mortality. High operative risk, adjacent organ invasion by the tumor and peritoneal metastasis were factors associated with increased postoperative morbidity (p > 0.05). High operative risk was the only prognostic factor for postoperative mortality (p < 0.01). CONCLUSIONS: Because of high postoperative morbidity and mortality, gastroenterostomy should not be done in patients with unresectable gastric cancer and high preoperative risk.
Assuntos
Gastroenterostomia , Complicações Pós-Operatórias , Neoplasias Gástricas/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Gastroenterostomia/mortalidade , Humanos , Neoplasias Hepáticas/secundário , Masculino , Pessoa de Meia-Idade , Cuidados Paliativos , Neoplasias Peritoneais/secundário , Prognóstico , Estudos Retrospectivos , Fatores de RiscoRESUMO
Thirty one patients with diagnosis of Gastric Cancer were admitted in this study. Median age was 71 years (range 24-82). Twenty two were male. No one had previous chemotherapy. Functional capacity was 0-1 in 26/31 (60.6%). More common symptoms were: loss of weight 21/31 (75.1%) and abdominal pain in 13/31 (40.3%). Ten patients were Borrmann III and nine Borrmann IV. Twenty one had surgery: 12 palliative gastrectomy and 9 exploratory laparatomy. Twenty three cases were adenocarcinoma and 8 undifferentiated carcinoma. FEM regimen was administered (5 Fluoruracil 600 mg/m2/day 1 and 8, Epidoxorubicin 30 mg/m2/day 1 and Mitomycin 10 mg/m2/day 1). Ten of 24 patients (41.7%) achieved partial remission with a median survival of 10.5 months. Three patients achieved subjective response with a median survival of 6 months. Median survival for the non response was 3 months (range 2-7 months). Survival difference between responders and no responders was statistically significant. Survival among the adjuvent group was 5.7 months (range 2-16 months). One out of three patients survived without evidence of disease at the end of this study. Twenty three patients died and 5 were lost to follow up. Alopecia was the most common secondary effect in 74%, nausea and vomiting in 60% and leukopenia below 3000 x mm3 in 54%. Cardiotoxicity was not documented in any case.
Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Neoplasias Gástricas/tratamento farmacológico , Adulto , Idoso , Idoso de 80 Anos ou mais , Epirubicina/administração & dosagem , Feminino , Fluoruracila/administração & dosagem , Humanos , Masculino , Pessoa de Meia-Idade , Mitomicina/administração & dosagem , Estadiamento de Neoplasias , Neoplasias Gástricas/patologiaRESUMO
Cyclin/PCNA (auxiliary protein of DNA polymerase delta) is a proliferation sensitive DNA replication protein whose synthesis is modulated during the cell cycle. All available information suggests that cyclin/PCNA may trigger DNA replication following the formation of pre-replicative complexes at the G1/S transition border.