RESUMO

Scirrhous eosinophilic gastritis (SEG) is characterized by diffuse infiltration of eosinophils and concomitant fibrovascular tissue proliferation in the stomach wall. The condition is a rare occurrence with an unknown cause. Two dogs were examined with a history of progressive weight loss, emesis, melena and anorexia. Complete blood cell counts of both cases revealed anemia and eosinophilia, while ultrasonography examination revealed thickening of the stomach wall. Due to suspected gastric neoplasia and a poor clinical prognosis, the dogs were euthanized. At necropsy, both had markedly distended stomachs with a diffusely thickened and firm wall. The spleens of both dogs were enlarged with a nodular surface. Histological evaluation revealed diffuse infiltrate of eosinophils, fibrovascular tissue proliferation and fibrinoid degeneration in blood vessel walls of stomach and spleen. SEG is a rare pathological condition that must be considered as a possible diagnosis in dogs presenting gastrointestinal signs and eosinophilia.(AU)

A gastrite eosinofílica esquirrosa (GEE) é caracterizada por infiltrado inflamatório difuso de eosinófilos e concomitante proliferação de tecido fibrovascular no estômago. A condição apresenta ocorrência rara e causa desconhecida. Dois cães foram examinados com histórico de emagrecimento progressivo, êmese, melena e anorexia. O hemograma de ambos os casos revelou anemia e eosinofilia, enquanto o exame ultrassonográfico evidenciou espessamento da parede do estômago. Diante de suspeita de neoplasia gástrica e devido ao prognóstico desfavorável, foi realizada a eutanásia dos cães. Na necropsia, ambos apresentavam estômago acentuadamente aumentado, com parede difusamente espessada e firme. O baço dos dois cães apresentava-se aumentado e com superfície nodular. O exame histopatológico revelou infiltrado difuso de eosinófilos, proliferação de tecido fibrovascular e degeneração fibrinoide na parede de vasos sanguíneos no estômago e baço. A GEE é uma condição patológica rara que deve ser considerada no diagnóstico em cães que apresentem sinais gastrointestinais e eosinofilia.(AU)

Assuntos

RESUMO

Scirrhous eosinophilic gastritis (SEG) is characterized by diffuse infiltration of eosinophils and concomitant fibrovascular tissue proliferation in the stomach wall. The condition is a rare occurrence with an unknown cause. Two dogs were examined with a history of progressive weight loss, emesis, melena and anorexia. Complete blood cell counts of both cases revealed anemia and eosinophilia, while ultrasonography examination revealed thickening of the stomach wall. Due to suspected gastric neoplasia and a poor clinical prognosis, the dogs were euthanized. At necropsy, both had markedly distended stomachs with a diffusely thickened and firm wall. The spleens of both dogs were enlarged with a nodular surface. Histological evaluation revealed diffuse infiltrate of eosinophils, fibrovascular tissue proliferation and fibrinoid degeneration in blood vessel walls of stomach and spleen. SEG is a rare pathological condition that must be considered as a possible diagnosis in dogs presenting gastrointestinal signs and eosinophilia.

A gastrite eosinofílica esquirrosa (GEE) é caracterizada por infiltrado inflamatório difuso de eosinófilos e concomitante proliferação de tecido fibrovascular no estômago. A condição apresenta ocorrência rara e causa desconhecida. Dois cães foram examinados com histórico de emagrecimento progressivo, êmese, melena e anorexia. O hemograma de ambos os casos revelou anemia e eosinofilia, enquanto o exame ultrassonográfico evidenciou espessamento da parede do estômago. Diante de suspeita de neoplasia gástrica e devido ao prognóstico desfavorável, foi realizada a eutanásia dos cães. Na necropsia, ambos apresentavam estômago acentuadamente aumentado, com parede difusamente espessada e firme. O baço dos dois cães apresentava-se aumentado e com superfície nodular. O exame histopatológico revelou infiltrado difuso de eosinófilos, proliferação de tecido fibrovascular e degeneração fibrinoide na parede de vasos sanguíneos no estômago e baço. A GEE é uma condição patológica rara que deve ser considerada no diagnóstico em cães que apresentem sinais gastrointestinais e eosinofilia.

Assuntos

RESUMO

Background: Feline dysautonomia is a rare autonomic neuropathy of unknown cause, that has already been reported in Europe, the United States and Brazil. Cats usually show nonspecific clinical signs that are associated with autonomic dysfunction of the nervous system. The diagnosis is based on the clinical signs and imaging tests, and confirmed by necropsy and histopathological findings. The prognosis is poor and there is no definitive treatment. The aim of this report is to describe a case of feline dysautonomia with emphasis in the clinical, diagnostic imaging and histopathological findings. Feline dysautonomia must always be considered as a differential diagnosis in cases of megaesophagus in cats.Case: A mixed-breed young male cat was evaluated for anorexia, regurgitation, bilateral nasal discharge and dyspnoea for 24 h. The animal was dehydrated and had pale mucous membranes, abdominal distension and keratoconjunctivitis sicca. The neurological examination was normal. Abdominal ultrasound showed a distended bladder and normal intestinal motility. Chest radiography and esophageal contrast study exhibited megaesophagus in the intrathoracic region. Blood work showed mild neutrophilic leukocytosis and the presence of toxic neutrophils. The cat remained hospitalized for supportive care, including fluidtherapy, broad spectrum antibiotics, antiemetic and mucosal protective drugs. [...](AU)

Assuntos

RESUMO

Background: Feline dysautonomia is a rare autonomic neuropathy of unknown cause, that has already been reported in Europe, the United States and Brazil. Cats usually show nonspecific clinical signs that are associated with autonomic dysfunction of the nervous system. The diagnosis is based on the clinical signs and imaging tests, and confirmed by necropsy and histopathological findings. The prognosis is poor and there is no definitive treatment. The aim of this report is to describe a case of feline dysautonomia with emphasis in the clinical, diagnostic imaging and histopathological findings. Feline dysautonomia must always be considered as a differential diagnosis in cases of megaesophagus in cats.Case: A mixed-breed young male cat was evaluated for anorexia, regurgitation, bilateral nasal discharge and dyspnoea for 24 h. The animal was dehydrated and had pale mucous membranes, abdominal distension and keratoconjunctivitis sicca. The neurological examination was normal. Abdominal ultrasound showed a distended bladder and normal intestinal motility. Chest radiography and esophageal contrast study exhibited megaesophagus in the intrathoracic region. Blood work showed mild neutrophilic leukocytosis and the presence of toxic neutrophils. The cat remained hospitalized for supportive care, including fluidtherapy, broad spectrum antibiotics, antiemetic and mucosal protective drugs. [...]

Assuntos

RESUMO

Coristomas são tecidos normais maduros e posições anatômicas anormais. Relatos em animais domésticos são incomuns a raros, restringindo-se geralmente à espécie bovina, com proliferação de diferentes tecidos em várias localizações, como tecido subcutâneo, cavidade torácica, região retroperitoneal e ocular. Não há uma faixa etária predominantemente afetada, porém há mais relatos em bovinos jovens. O Laboratório de Patologia Veterinária da Universidade Federal do Rio Grande do Sul recebeu uma amostra de tronco encefálico de um bovino Nelore, macho, cinco anos de idade, vinculado ao projeto de Complementação de Métodos Diagnósticos de Encefalopatias Espongiformes Transmissíveis (EETs). O animal apresentava-se no momento do abate em decúbito; estava alerta, com uma fratura completa no fêmur direito e sem sinais neurológicos. No exame macroscópico, observou-se uma massa branca oval, firme, localizada caudalmente ao colículo caudal esquerdo, sobre o pedúnculo cerebelar esquerdo. No exame microscópico, observou-se uma área bem delimitada, não encapsulada, composta predominantemente por fibras de tecido conjuntivo fibroso (colágeno). O exame imuno-histoquímico para proteína ácida fibrilar glial foi negativo. Devido às características macroscópicas e microscópicas, o diagnóstico de coristoma colagenoso foi estabelecido, visto que a presença

 Choristomas are mature normal tissues in abnormal anatomical positions. Reports in domestic animals are uncommon to rare, usually restricted to cattle, with the proliferation of different tissues in various locations, such as subcutaneous tissue, thoracic cavity, retroperitoneal and ocular regions. No age range is predominantly affected, but there are more reports in young cattle. The Laboratory of Veterinary Pathology at the Universidade Federal do Rio Grande do Sul received a brainstem sample of a bull, Nelore breed, 5 years old, from the project of Supplementary Diagnostic Methods of Transmissible Spongiform Encephalopathies (TSEs). The animal presented recumbency at the time of slaughter; was alert, with a complete fracture to the right femur and without neurological signs. On gross examination, there was a white oval firm mass, located caudally to the left caudal colliculus, on the left cerebellar peduncle. In the microscopic examination, there was a well-demarcated area, unencapsulated and composed predominantly of connective tissue fibers (collagen). Immunohistochemical examination for glial fibrillary acidic protein was negative. Due to the gross and microscopic characteristics, a diagnosis of collagenous choristoma at the cerebellar peduncle was established, since the presence of collagen within the brain tissue itself is abnormal.   

RESUMO

Coristomas são tecidos normais maduros e posições anatômicas anormais. Relatos em animais domésticos são incomuns a raros, restringindo-se geralmente à espécie bovina, com proliferação de diferentes tecidos em várias localizações, como tecido subcutâneo, cavidade torácica, região retroperitoneal e ocular. Não há uma faixa etária predominantemente afetada, porém há mais relatos em bovinos jovens. O Laboratório de Patologia Veterinária da Universidade Federal do Rio Grande do Sul recebeu uma amostra de tronco encefálico de um bovino Nelore, macho, cinco anos de idade, vinculado ao projeto de Complementação de Métodos Diagnósticos de Encefalopatias Espongiformes Transmissíveis (EETs). O animal apresentava-se no momento do abate em decúbito; estava alerta, com uma fratura completa no fêmur direito e sem sinais neurológicos. No exame macroscópico, observou-se uma massa branca oval, firme, localizada caudalmente ao colículo caudal esquerdo, sobre o pedúnculo cerebelar esquerdo. No exame microscópico, observou-se uma área bem delimitada, não encapsulada, composta predominantemente por fibras de tecido conjuntivo fibroso (colágeno). O exame imuno-histoquímico para proteína ácida fibrilar glial foi negativo. Devido às características macroscópicas e microscópicas, o diagnóstico de coristoma colagenoso foi estabelecido, visto que a presença

 Choristomas are mature normal tissues in abnormal anatomical positions. Reports in domestic animals are uncommon to rare, usually restricted to cattle, with the proliferation of different tissues in various locations, such as subcutaneous tissue, thoracic cavity, retroperitoneal and ocular regions. No age range is predominantly affected, but there are more reports in young cattle. The Laboratory of Veterinary Pathology at the Universidade Federal do Rio Grande do Sul received a brainstem sample of a bull, Nelore breed, 5 years old, from the project of Supplementary Diagnostic Methods of Transmissible Spongiform Encephalopathies (TSEs). The animal presented recumbency at the time of slaughter; was alert, with a complete fracture to the right femur and without neurological signs. On gross examination, there was a white oval firm mass, located caudally to the left caudal colliculus, on the left cerebellar peduncle. In the microscopic examination, there was a well-demarcated area, unencapsulated and composed predominantly of connective tissue fibers (collagen). Immunohistochemical examination for glial fibrillary acidic protein was negative. Due to the gross and microscopic characteristics, a diagnosis of collagenous choristoma at the cerebellar peduncle was established, since the presence of collagen within the brain tissue itself is abnormal.   

RESUMO

Coristomas são tecidos normais maduros e posições anatômicas anormais. Relatos em animais domésticos são incomuns a raros, restringindo-se geralmente à espécie bovina, com proliferação de diferentes tecidos em várias localizações, como tecido subcutâneo, cavidade torácica, região retroperitoneal e ocular. Não há uma faixa etária predominantemente afetada, porém há mais relatos em bovinos jovens. O Laboratório de Patologia Veterinária da Universidade Federal do Rio Grande do Sul recebeu uma amostra de tronco encefálico de um bovino Nelore, macho, cinco anos de idade, vinculado ao projeto de Complementação de Métodos Diagnósticos de Encefalopatias Espongiformes Transmissíveis (EETs). O animal apresentava-se no momento do abate em decúbito; estava alerta, com uma fratura completa no fêmur direito e sem sinais neurológicos. No exame macroscópico, observou-se uma massa branca oval, firme, localizada caudalmente ao colículo caudal esquerdo, sobre o pedúnculo cerebelar esquerdo. No exame microscópico, observou-se uma área bem delimitada, não encapsulada, composta predominantemente por fibras de tecido conjuntivo fibroso (colágeno). O exame imuno-histoquímico para proteína ácida fibrilar glial foi negativo. Devido às características macroscópicas e microscópicas, o diagnóstico de coristoma colagenoso foi estabelecido, visto que a presença de colágeno no encéfalo é anormal.

Choristomas are mature normal tissues in abnormal anatomical positions. Reports in domestic animals are uncommon to rare, usually restricted to cattle, with the proliferation of different tissues in various locations, such as subcutaneous tissue, thoracic cavity, retroperitoneal and ocular regions. No age range is predominantly affected, but there are more reports in young cattle. The Laboratory of Veterinary Pathology at the Universidade Federal do Rio Grande do Sul received a brainstem sample of a bull, Nelore breed, 5 years old, from the project of Supplementary Diagnostic Methods of Transmissible Spongiform Encephalopathies (TSEs). The animal presented recumbency at the time of slaughter; was alert, with a complete fracture to the right femur and without neurological signs. On gross examination, there was a white oval firm mass, located caudally to the left caudal colliculus, on the left cerebellar peduncle. In the microscopic examination, there was a well-demarcated area, unencapsulated and composed predominantly of connective tissue fibers (collagen). Immunohistochemical examination for glial fibrillary acidic protein was negative. Due to the gross and microscopic characteristics, a diagnosis of collagenous choristoma at the cerebellar peduncle was established, since the presence of collagen within the brain tissue itself is abnormal.

RESUMO

Choristomas are mature normal tissues in abnormal anatomical positions. Reports in domestic animals are uncommon to rare, usually restricted to cattle, with the proliferation of different tissues in various locations, such as subcutaneous tissue, thoracic cavity, retroperitoneal and ocular regions. No age range is predominantly affected, but there are more reports in young cattle. The Laboratory of Veterinary Pathology at the Universidade Federal do Rio Grande do Sul received a brainstem sample of a bull, Nelore breed, 5 years old, from the project of Supplementary Diagnostic Methods of Transmissible Spongiform Encephalopathies (TSEs). The animal presented recumbency at the time of slaughter; was alert, with a complete fracture to the right femur and without neurological signs. On gross examination, there was a white oval firm mass, located caudally to the left caudal colliculus, on the left cerebellar peduncle. In the microscopic examination, there was a well-demarcated area, unencapsulated and composed predominantly of connective tissue fibers (collagen). Immunohistochemical examination for glial fibrillary acidic protein was negative. Due to the gross and microscopic characteristics, a diagnosis of collagenous choristoma at the cerebellar peduncle was established, since the presence of collagen within the brain tissue itself is abnormal.(AU)

Coristomas são tecidos normais maduros e posições anatômicas anormais. Relatos em animais domésticos são incomuns a raros, restringindo-se geralmente à espécie bovina, com proliferação de diferentes tecidos em várias localizações, como tecido subcutâneo, cavidade torácica, região retroperitoneal e ocular. Não há uma faixa etária predominantemente afetada, porém há mais relatos em bovinos jovens. O Laboratório de Patologia Veterinária da Universidade Federal do Rio Grande do Sul recebeu uma amostra de tronco encefálico de um bovino Nelore, macho, cinco anos de idade, vinculado ao projeto de Complementação de Métodos Diagnósticos de Encefalopatias Espongiformes Transmissíveis (EETs). O animal apresentava-se no momento do abate em decúbito; estava alerta, com uma fratura completa no fêmur direito e sem sinais neurológicos. No exame macroscópico, observou-se uma massa branca oval, firme, localizada caudalmente ao colículo caudal esquerdo, sobre o pedúnculo cerebelar esquerdo. No exame microscópico, observou-se uma área bem delimitada, não encapsulada, composta predominantemente por fibras de tecido conjuntivo fibroso (colágeno). O exame imuno-histoquímico para proteína ácida fibrilar glial foi negativo. Devido às características macroscópicas e microscópicas, o diagnóstico de coristoma colagenoso foi estabelecido, visto que a presença de colágeno no encéfalo é anormal.(AU)

Assuntos

RESUMO

Choristomas are mature normal tissues in abnormal anatomical positions. Reports in domestic animals are uncommon to rare, usually restricted to cattle, with the proliferation of different tissues in various locations, such as subcutaneous tissue, thoracic cavity, retroperitoneal and ocular regions. No age range is predominantly affected, but there are more reports in young cattle. The Laboratory of Veterinary Pathology at the Universidade Federal do Rio Grande do Sul received a brainstem sample of a bull, Nelore breed, 5 years old, from the project of Supplementary Diagnostic Methods of Transmissible Spongiform Encephalopathies (TSEs). The animal presented recumbency at the time of slaughter; was alert, with a complete fracture to the right femur and without neurological signs. On gross examination, there was a white oval firm mass, located caudally to the left caudal colliculus, on the left cerebellar peduncle. In the microscopic examination, there was a well-demarcated area, unencapsulated and composed predominantly of connective tissue fibers (collagen). Immunohistochemical examination for glial fibrillary acidic protein was negative. Due to the gross and microscopic characteristics, a diagnosis of collagenous choristoma at the cerebellar peduncle was established, since the presence of collagen within the brain tissue itself is abnormal.

Coristomas são tecidos normais maduros e posições anatômicas anormais. Relatos em animais domésticos são incomuns a raros, restringindo-se geralmente à espécie bovina, com proliferação de diferentes tecidos em várias localizações, como tecido subcutâneo, cavidade torácica, região retroperitoneal e ocular. Não há uma faixa etária predominantemente afetada, porém há mais relatos em bovinos jovens. O Laboratório de Patologia Veterinária da Universidade Federal do Rio Grande do Sul recebeu uma amostra de tronco encefálico de um bovino Nelore, macho, cinco anos de idade, vinculado ao projeto de Complementação de Métodos Diagnósticos de Encefalopatias Espongiformes Transmissíveis (EETs). O animal apresentava-se no momento do abate em decúbito; estava alerta, com uma fratura completa no fêmur direito e sem sinais neurológicos. No exame macroscópico, observou-se uma massa branca oval, firme, localizada caudalmente ao colículo caudal esquerdo, sobre o pedúnculo cerebelar esquerdo. No exame microscópico, observou-se uma área bem delimitada, não encapsulada, composta predominantemente por fibras de tecido conjuntivo fibroso (colágeno). O exame imuno-histoquímico para proteína ácida fibrilar glial foi negativo. Devido às características macroscópicas e microscópicas, o diagnóstico de coristoma colagenoso foi estabelecido, visto que a presença de colágeno no encéfalo é anormal.

Assuntos

RESUMO

Background: Gastric dilatation volvulus syndrome (GDV) is an acute and severe disease affecting specially dogs of big breeds. It is a severe illness, which may have a high risk of death if not treated quickly. GDV consists in stomach acute dilatation and rotation, resulting in decrease of gastric and splenic infusion, in addition to the obstruction of abdominal venous return. The aim of this research was to analyze clinical pathological findings of dogs with GDV diagnosis in which necropsy was performed. Materials, Methods & Results: The necropsy records were reviewed from January 2001 to December 2011 to identify these cases. In the period, 4877 autopsies were performed by the Setor de Patologia Veterinária from Universidade Federal do Rio Grande do Sul (UFRGS), being 55 cases (1.15%) of GDV. Four main breeds were identified: Fila Brasileiro (43.6%), Great Dane (12.7%), German Shepherd (10.9%) and Boxer (5.4%). Clinical signs such as bloating, lethargy and dyspnoea were reported. At necropsy, the findings that consisted with gastric alterations were stomach distention due to accumulation of gas, dark red mucosa, and rotations of 90° to 360° especially clockwise. Splenomegaly was observed in 96.36% of dogs and V-shaped spleen in 60%. There was compressive atelectasis in 38.18% of autopsies. The main histological findings in the stomach were characterized by congestion, hemorrhage and necrosis of the mucosa. In the spleen, congestion and necrosis of lymphoid follicles were found. Discussion: When GDV's casuistic is analyzed, our results were similar to other studies, with 0.7% and 2.5%. What is concerned about the breed and age of the animals affected is the high number of GDV in breeds such as Great Dane and German Shepherd. However, we also found high numbers of Fila Brasileiro, a Brazilian breed, that hasn't been mentioned in other studies about this illness before. Similar clinical signs were described by other authors, between them, vomit, a previous sign of acute GDV, which is expected as while there is a gastric rotation, gastric-oesophageal obstruction happens. However, vomit is described as GVD predisposing factor associated to aerophagia, and should be considered a previous sign to the dislocation. The observation of gastric clockwise rotation in most cases is described as the most frequent. Gastric pathologic findings are characteristics of a circulatory compromising due to the rotation, leading to ischemic areas and necrosis. Splenomegaly and the identification of the V-shaped spleen were commonly observed, because when GDV happens, the spleen follows the gastric displacement by the presence of the gastrosplenic ligament. These findings cause splenic congestion by obstruction of venous return, which may lead it to twist too. It is concluded that the GDV was responsible for a low number of necropsies, reaching large and giant breeds. The identification of a large number of Fila breed dogs suggests that this breed is predisposed to the GDV. The gastric lesions indicated circulatory injury by vascular obstruction due to the rotation. Lung compressive atelectasis occurs secondary to gastric distention, also, compression of the caudal vena cava and of the portal vein can occur, decreased venous return, less displacement of blood from the right ventricle to be oxygenated by the lungs leading to breathing recrudescence.

Assuntos