RESUMO

The background of prodrug design is presented herein as the basis for introducing new and advanced latent systems, taking into account mainly the versatility of polymers and other macromolecules as carriers. PDEPT (Polymer-Directed Enzyme Prodrug Therapy); PELT (Polymer-Enzyme Liposome Therapy); CDS (Chemical Delivery System); ADEPT(Antibody-Directed Enzyme Prodrug Therapy); GDEPT/VDEPT (Gene-Directed Enzyme Prodrug Therapy/Virus-Directed Enzyme Prodrug Therapy); ODDS (Osteotropic Drug Delivery System) and LEAPT (Lectin-directed enzyme-activated prodrug therapy) are briefly described and some examples are given.

Assuntos

Portadores de Fármacos , Sistemas de Liberação de Medicamentos , Desenho de Fármacos , Substâncias Macromoleculares/administração & dosagem , Pró-Fármacos/administração & dosagem , Animais , Anticorpos/uso terapêutico , Terapia Genética , Humanos , Lectinas/uso terapêutico , Substâncias Macromoleculares/metabolismo , Osteoporose/tratamento farmacológico , Pró-Fármacos/metabolismo , Pró-Fármacos/uso terapêutico , Vírus/imunologia