RESUMO
Pitiose gástrica canina é uma afecção crônica granulomatosa causada pelo pseudo-fungo Pythium insidiosum que ocasiona espessamento trasnsmural do estômago. Relata-se um caso de gastrite fúngica em um canino dobermann de 1 ano, macho, atendido no Hospital Veterinário da Universidade Federal do Mato Grosso, campus Sinop-MT, com sinais clínicos de diarreia escura intermitente, regurgitação, êmese e anorexia progressiva por cerca de três meses. No exame ultrassonográfico, observou espessamento gástrico difuso. Devido ao prognóstico ruim, foi realizado eutanásia. Na macroscopia, havia espessamento difuso da parede do estômago e petéquias multifocais por toda a mucosa. Na microscopia havia acentuado infiltrado inflamatório granulomatoso por toda a submucosa e muscular. Foi realizado coloração de metenamina nitrato de prata de Grocott (GMS), com evidenciação de hifas cenocíticas, raras septação e diâmetro de 6-10µm. A confirmação do diagnóstico e identificação do agente foi realizado através Imuno-histoquímica com anticorpo primário para Pythium insidiosum.
Canine gastric pythiosis is a chronic granulomatous infection caused by the insidious pythi fungus that causes stomach thickening. We report a case of fungal gastritis in a 1-year-old male progressive Doberman canine treated at the Veterinary Hospital of the Federal University of Mato Grosso, Sinop-MT campus, with clinical signs of intermittent diarrhea, regurgitation, vomiting and anorexia for about three months. On ultrasound examination, diffuse gastric thickening was observed. Due to the poor prognosis, euthanasia was performed. Macroscopically, there was diffuse thickening of the stomach wall and multifocal petechiae throughout the mucosa. On microscopy, there was a marked granulomatous inflammatory infiltrate throughout the submucosa and muscle Production of Grocott silver nitrate methenamine (GMS) was performed with evidence of cenocytic hyphae, rare septation and diameter of 6-10µm. Confirmation of the diagnosis and identification of the agent was performed through Immunohistochemistry with primary antibody to Pythium insidiosum.
Assuntos
Animais , Masculino , Cães , Pythium , Pitiose/diagnóstico , Gastrite/veterinária , Doença Granulomatosa Crônica/veterináriaRESUMO
The dexamethasone suppression test (DST) and the clonidine stimulation test (CST) were studied in 47 depressed patients. Issues addressed included (1) the usefulness of both tests as markers of major depression; (2) the relationship between the two tests and the pathophysiology underlying this relationship; and (3) the psychopathological correlates of both tests. The widely reported link between abnormal DST results and melancholic depression was confirmed. The DST and the CST showed extensive overlap, suggesting a relationship in major depression between the biological abnormalities indexed by each test (i.e., hypothalamic-pituitary-adrenal axis and noradrenergic system). Finally, the psychopathological correlates of various subgroups categorized on the basis of test responses (e.g., normal test results, blunted CST results, and both abnormal DST and CST results) confirmed significant differences between groups on two items of the Hamilton Rating Scale for Depression: psychic anxiety and somatic anxiety. The results suggest that particular patterns of neuroendocrine abnormalities may be associated with particular profiles of depressive symptomatology.