RESUMO
An in-situ experiment was performed to study metabolic responses of the freshwater mussel Diplodon chilensis to water contaminated by leachates from an open dump and cattle activity, in order to analyze both the effects of those contaminants on aquatic environments and the potential use of a native bivalve to evaluate the effects of anthropic influence and eutrophication. Bivalves from a reference site were cage-transplanted to a control site (site A) and to a temporal water pond (site B) over 30 and 60 periods. Water quality analyses revealed that the site B was affected by anthropogenic influence. Mussel's hemocytes from site B showed 50% lower reactive oxygen species production and 130% higher lysosomal membrane stability in the site B mussels. In addition, no oxidative stress was evident in gills, despite the elevated copper and iron concentrations recorded in the site B water samples (CuB = 0.3350 ± 0.0636 mg. L-1vs. CuA = 0.0045 ± 0.0007 mg. L-1; FeB = 3.8650 ± 0.4031 mg. L-1vs. FeA = 0.0365 ± 0.0049 mg. L-1). In contrast, the adductor muscle accumulated more Fe (~10-20-fold) than the gills and showed signs of oxidative stress, e.g. superoxide dismutase activity and TBARS levels were increased by 10% were 34%, respectively, in the site B compared with the site A after 60 days of exposure. Additionally, the adductor muscle showed signs of anaerobic metabolism activation. Cu is accumulated in gills from both sites' individuals, at 60 days, in concordance with the increase in the activity of the cu-containing enzyme cytochrome-c-oxidase. There was a reduction in the overall condition and digestive gland index in bivalves exposed at site B, associated with diminished levels of lipid and protein contents. Metal-pollution and eutrophication affects D. chilensis metabolism and is associated to tissue-specific exposure, anaerobic metabolism and general energetic condition depletion.
Assuntos
Bivalves/efeitos dos fármacos , Eutrofização , Metais Pesados/toxicidade , Poluentes Químicos da Água/toxicidade , Animais , Bivalves/enzimologia , Bivalves/metabolismo , Bovinos , Cobre/metabolismo , Água Doce , Brânquias/efeitos dos fármacos , Brânquias/metabolismo , Hemócitos/efeitos dos fármacos , Hemócitos/metabolismo , Metais Pesados/metabolismo , Estresse Oxidativo , Espécies Reativas de Oxigênio/metabolismo , Superóxido Dismutase/metabolismo , Substâncias Reativas com Ácido Tiobarbitúrico/metabolismo , Poluentes Químicos da Água/metabolismo , Qualidade da ÁguaRESUMO
NTPDases are enzymes that hydrolyse diphosphate and triphosphate nucleosides, regulating purinergic signalling in many organisms. The Schistosoma mansoni NTPDases, SmATPDases 1 and 2, are antigenic proteins and display a significant homology with the isoforms found in mammalian cells. In this work, we investigated whether anti-SmATPDase antibodies from S. mansoni-infected mice sera show cross-reactivity with the NTPDase 1 isoform from macrophages and how this event affects the cell proliferation. By Western blot, anti-SmATPDase antibodies present in serum from infected mice recognized 2 bands with approximately 53 and 58 kDa, corresponding to NTPDase 1. Additionally, the enzyme was identified in macrophages by immunofluorescence and the anti-SmATPDase antibodies were able to reduce activity enzyme (22%). Macrophages incubated with commercial polyclonal antibodies reactive with NTPDase 1 (anti-CD39) showed a reduction of 40% of the enzyme activity. In proliferation assays, macrophage proliferation was inhibited 11% and 90% by pooled sera from infected animals and anti-CD39, respectively. The results suggest that inhibition of NTPDase 1 in macrophages by antibodies produced against the isoforms of the S. mansoni ATPDases could be a mechanism of regulation in the immune response during experimental schistosomiasis.
Assuntos
Anticorpos Antiprotozoários/imunologia , Antígenos CD/imunologia , Antígenos de Protozoários/imunologia , Apirase/imunologia , Reações Cruzadas/imunologia , Macrófagos/imunologia , Schistosoma mansoni/imunologia , Esquistossomose/imunologia , Animais , Anticorpos Antiprotozoários/sangue , Western Blotting , Linhagem Celular , Proliferação de Células/fisiologia , Feminino , Camundongos , Camundongos Endogâmicos C57BL , Células RAW 264.7 , Esquistossomose/parasitologia , Caramujos/parasitologiaRESUMO
The aims of the study were to determine (1) whether the presence of High blood pressure (HBP) states in the youth associate a steeper rate of age-related change in arterial geometrical and wall properties with respect to subjects with no previous cardiovascular risk factor (CRF) exposure, (2) in which parameters and in what magnitude, and (3) the existence of a gender-related difference in the impact of this condition on arterial properties. 300 individuals (mean/range: 15/4-29 years; 133 females) were included. Two groups were assembled: (1) Reference: nonprevious exposure to traditional CRF and (2) HBP: subjects with arterial hypertension and/or elevated blood pressure (BP) levels during the study. Additionally, HBP subjects were separated in BP-related subgroups. Measured parameters were (1) central (aortic) arterial BP and aortic pulse wave analysis parameters, (2) carotid and femoral artery local (pressure-strain elastic modulus) and regional (pulse wave velocity; PWV) stiffness, and (3) arterial diameters and carotid intima-media thickness (CIMT). Age-related changes in these parameters (absolute values and z-scores) were explored by obtaining simple linear regression models for each group. HBP presented a steeper rate of change (accelerated vascular aging; VA) for most of the parameters assessed, mainly in central (aortic) hemodynamics. VA increased as the HBP level got higher. Both males' and females' aging rates were affected by this condition, but females presented a more marked relative age-related increase with HBP exposure. HBP states in the youth gradually associate accelerated VA, with a progressive hemodynamic-structural-functional onset of damage, with females presenting a more marked relative HBP-associated arterial repercussion.
Assuntos
Envelhecimento , Artérias/fisiopatologia , Hipertensão/fisiopatologia , Doenças Vasculares/fisiopatologia , Adolescente , Adulto , Aorta/fisiopatologia , Pressão Arterial , Artérias Carótidas/fisiopatologia , Espessura Intima-Media Carotídea , Criança , Pré-Escolar , Feminino , Artéria Femoral/fisiopatologia , Hemodinâmica , Humanos , Masculino , Análise de Onda de Pulso , Fluxo Sanguíneo Regional , Fatores de Risco , Fatores Sexuais , Rigidez Vascular , Adulto JovemRESUMO
Children with acute lymphoblastic leukemia (ALL) often present fever. Febrile states are usually associated with infectious processes that generate an inflammatory response involving various molecules, including cytokines. However, an inflammatory response may also occur in the absence of infection. We hypothesized that the levels of inflammatory cytokines are increased in children with ALL without apparent infection. The serum levels of 13 cytokines in 99 patients with ALL and 48 non-oncological patients without apparent infection were measured using multiplex analyte profiling technology (Luminex®). The concentration of circulating pro-inflammatory cytokines associated with fever was similar between patients with ALL and fever at diagnosis and those without fever. The levels of tumor necrosis factor α, interleukin (IL)-6, IL-8, monocyte chemoattractant protein-1 (MCP-1) and IL-10 were higher in patients with ALL vs. the control group (P<0.05). Moreover, the levels of the T helper 1 (interferonγ and IL-12) cytokines were higher in patients with ALL vs. the control group. Transforming growth factor ß was lower in patients with ALL vs. the control group (P<0.05). The levels of IL-1ß, IL-2, IL-4, IL-13, and IL-17 were similar in the two groups. Our results indicate that the circulating levels of seven of the important studied cytokines are elevated in patients with newly diagnosed ALL without apparent infection, reflecting a strong and deregulated inflammatory state in this disease, with a Th1-polarization profile.
Assuntos
Leucemia-Linfoma Linfoblástico de Células Precursoras/imunologia , Células Th1/fisiologia , Adolescente , Polaridade Celular , Quimiocinas/sangue , Criança , Pré-Escolar , Feminino , Febre/sangue , Febre/imunologia , Humanos , Lactente , Masculino , Leucemia-Linfoma Linfoblástico de Células Precursoras/sangueRESUMO
Avaliaram-se os efeitos dos tipos de suplementação sobre o desempenho produtivo e o comportamento ingestivo diurno de cordeiros mestiços Santa Inês mantidos em pastagem de capim-aruana (Panicum maximum cv. Aruana) sobressemeado com aveia branca (Avena sativa L.) e azevém (Lolium multiflorum Lam.), em um delineamento inteiramente ao acaso, com três tratamentos e três repetições. Os cordeiros foram distribuídos aleatoriamente em três sistemas alimentares, com seis animais cada, sendo: PAST - cordeiros mantidos exclusivamente a pasto; SIL - cordeiros mantidos em pastagem recebendo suplementação (1,0% do peso vivo) com silagem de milho; CONC - cordeiros mantidos em pastagem recebendo suplementação (1,0% do peso vivo) com concentrado. Os cordeiros suplementados com concentrado apresentaram ganho de peso médio diário 37,5% superior aos mantidos em pastagem, mas não diferiram da suplementação com silagem de milho. O tempo de pastejo foi superior para os animais não suplementados quando comparados aos animais suplementados. Cordeiros mantidos a pasto e suplementados com silagem de milho ou concentrado ganham mais peso do que os cordeiros não suplementados.
The aim of this work was to evaluate the types of supplementation on performance and the diurnal feeding behavior of crossbred Santa Inês lambs maintained in aruana (Panicum maximum cv. Aruana) pasture grass overseeding with oat (Avena sativaL.) and Italian ryegrass (Lolium multiflorum Lam.) pasture in a completely randomized design with three treatments and three replications. The lambs were randomly assigned to three food systems of six animals each, PAST - lambs fed only pasture; SIL - lambs fed pasture and supplemented (1% of live weight) with corn silage; CONC - lambs fed pasture and supplemented with concentrate. Animals supplemented with concentrate presented average daily gain 37,5% higher, but did not differ from supplementation with corn silage. Grazing time was higher for non-supplemented animals compared with supplemented animals. Lambs maintained in pasture and supplemented with corn silage or concentrate gain more weight than non-supplemented lambs.
Assuntos
Animais , Avena , Lolium , Panicum/metabolismo , Ovinos , Silagem/análise , Aumento de Peso , Ração Animal/análise , Fenômenos Fisiológicos da Nutrição do LactenteRESUMO
Avaliaram-se os efeitos dos tipos de suplementação sobre o desempenho produtivo e o comportamento ingestivo diurno de cordeiros mestiços Santa Inês mantidos em pastagem de capim-aruana (Panicum maximum cv. Aruana) sobressemeado com aveia branca (Avena sativa L.) e azevém (Lolium multiflorum Lam.), em um delineamento inteiramente ao acaso, com três tratamentos e três repetições. Os cordeiros foram distribuídos aleatoriamente em três sistemas alimentares, com seis animais cada, sendo: PAST - cordeiros mantidos exclusivamente a pasto; SIL - cordeiros mantidos em pastagem recebendo suplementação (1,0% do peso vivo) com silagem de milho; CONC - cordeiros mantidos em pastagem recebendo suplementação (1,0% do peso vivo) com concentrado. Os cordeiros suplementados com concentrado apresentaram ganho de peso médio diário 37,5% superior aos mantidos em pastagem, mas não diferiram da suplementação com silagem de milho. O tempo de pastejo foi superior para os animais não suplementados quando comparados aos animais suplementados. Cordeiros mantidos a pasto e suplementados com silagem de milho ou concentrado ganham mais peso do que os cordeiros não suplementados.(AU)
The aim of this work was to evaluate the types of supplementation on performance and the diurnal feeding behavior of crossbred Santa Inês lambs maintained in aruana (Panicum maximum cv. Aruana) pasture grass overseeding with oat (Avena sativaL.) and Italian ryegrass (Lolium multiflorum Lam.) pasture in a completely randomized design with three treatments and three replications. The lambs were randomly assigned to three food systems of six animals each, PAST - lambs fed only pasture; SIL - lambs fed pasture and supplemented (1% of live weight) with corn silage; CONC - lambs fed pasture and supplemented with concentrate. Animals supplemented with concentrate presented average daily gain 37,5% higher, but did not differ from supplementation with corn silage. Grazing time was higher for non-supplemented animals compared with supplemented animals. Lambs maintained in pasture and supplemented with corn silage or concentrate gain more weight than non-supplemented lambs.(AU)
Assuntos
Animais , Ovinos , Panicum/metabolismo , Lolium , Silagem/análise , Aumento de Peso , Avena , Ração Animal/análise , Fenômenos Fisiológicos da Nutrição do LactenteRESUMO
Toxocara canis and Toxocara cati are nematode parasites in dogs and cats, respectively, transmitted by ingestion of embryonated eggs, transmammary and transplacental (T. canis) routes and paratenic host predation. Many parasites use mechanisms that change the behaviour of their hosts to ensure continued transmission. Several researchers have demonstrated behavioural changes in mouse models as paratenic hosts for T. canis. However, there have been no studies on behavioural changes in laboratory rats (Rattus norvegicus) experimentally infected with T. cati. This study investigated behavioural changes and muscle strength in male and female rats experimentally infected with T. cati or T. canis in acute and chronic phases of infection. Regardless of sex, rats infected with T. cati showed a greater decrease in muscle strength 42 days post infection compared to rats infected with T. canis. However, behavioural changes were only observed in female rats infected with T. canis.
Assuntos
Comportamento Animal , Força Muscular , Toxocara/fisiologia , Toxocaríase/patologia , Animais , Feminino , Masculino , RatosRESUMO
Oportunamente, en publicaciones dedicadas a la prótesis híbrida (PH), la definimos como la conjunción de dos especies, la prótesis total removible (PTR) y la prótesis parcial fija (PPF). Decíamos en aquella oportunidad, que utilizamos tres tipos de PH, a las que denominamos de baja, media y alta complejidad. Este tipo de prótesis está indicada en rebordes exiguos no reconstruidos parcialmente y con implantes no distribuidos en posición ideal. Antes de realizar nuestro enfoque actual del tema, nos parece oportuno hacer una síntesis de aquellos capítulos en los que desarrollamos las técnicas constructivas de las híbridas de maxilar inferior y cuestionábamos la utilización de las híbridas para el maxilar superior. Finalmente, daremos los motivos por los cuales, en la actualidad, indicamos la PH en el maxilar superior, y desarrollaremos dos nuevos recursos, diseñados por nosotros, para facilitar la eficiencia de la PH: uno para mejorar la fijación de las partes de la clásica PH de alta complejidad y otro para obtener mayor precisión en la fijación de la PH de maxilar superior.
Assuntos
Planejamento de Dentadura , Prótese Parcial Fixa , Prótese Parcial Removível , Prótese Dentária Fixada por Implante/classificação , Dente Suporte , Prótese Total Inferior , Prótese Total Superior , Mandíbula , Maxila , Reabilitação BucalRESUMO
Oportunamente, en publicaciones dedicadas a la prótesis híbrida (PH), la definimos como la conjunción de dos especies, la prótesis total removible (PTR) y la prótesis parcial fija (PPF). Decíamos en aquella oportunidad, que utilizamos tres tipos de PH, a las que denominamos de baja, media y alta complejidad. Este tipo de prótesis está indicada en rebordes exiguos no reconstruidos parcialmente y con implantes no distribuidos en posición ideal. Antes de realizar nuestro enfoque actual del tema, nos parece oportuno hacer una síntesis de aquellos capítulos en los que desarrollamos las técnicas constructivas de las híbridas de maxilar inferior y cuestionábamos la utilización de las híbridas para el maxilar superior. Finalmente, daremos los motivos por los cuales, en la actualidad, indicamos la PH en el maxilar superior, y desarrollaremos dos nuevos recursos, diseñados por nosotros, para facilitar la eficiencia de la PH: uno para mejorar la fijación de las partes de la clásica PH de alta complejidad y otro para obtener mayor precisión en la fijación de la PH de maxilar superior.(AU)
Assuntos
Prótese Dentária Fixada por Implante/classificação , Prótese Parcial Fixa , Prótese Parcial Removível , Planejamento de Dentadura , Reabilitação Bucal , Maxila , Mandíbula , Dente Suporte , Prótese Total Superior , Prótese Total InferiorRESUMO
Valvular Heart Disease (VHD) is an important cardiovascular problem in the adult population. The knowledge of the physiology involved, prompt recognition and diagnosis are of paramount importance for the primary care physician who is in the front line of patient care. This article is the second of a series of two that deals with valvular problems in the adults in concise and practical form (11). Each topic will be presented using the following format: description, etiology, pathophysiology, natural history, essential of diagnosis and management. In this second and final article we will discuss aortic valve disorders.
Assuntos
Humanos , Adulto , Estenose da Valva Aórtica/terapia , Insuficiência da Valva Aórtica/terapia , Ensaios Clínicos como Assunto , Ecocardiografia , Eletrocardiografia , Estenose da Valva Aórtica/diagnóstico , Estenose da Valva Aórtica/fisiopatologia , Insuficiência da Valva Aórtica/diagnóstico , Insuficiência da Valva Aórtica/fisiopatologiaRESUMO
ABSTRACT Samples of faeces from domiciliated dogs of Guarulhos, SP, were analyzed to determine the occurrence of zoonotic parasitic agents. From 166 samples examined, 54 (32.53%) were positive, with a frequency of Giardia duodenalis (13.25%), followed by Ancylostoma spp. (10.84%), Dipylidium caninum (2.41%) and Toxocara canis (1.81%).
RESUMO Foram analisadas amostras fecais de cães domiciliados provenientes de Guarulhos, SP, para se determinar a ocorrência de agentes parasitários de zoonoses. Das 166 amostras examinadas, 54 (32,53%) apresentaram-se positivas, com uma maior freqüência de Giardia duodenalis (13,25%), seguido de Ancylostoma spp. (10,84%), Dipylidium caninum (2,41%) e Toxocara canis (1,81%).
RESUMO
Valvular Heart Disease (VHD) is an important cardiovascular problem in the adult population. The knowledge of the physiology involved, prompt recognition and diagnosis are of paramount importance for the primary care physician who is in the front line of patient care. This article is the first of a series of two that will discuss valvular problems in the adults in concise and practical form. Each topic will be presented using the following format: description, etiology, pathophysiology, natural history, essential of diagnosis and management. In this first article we will discuss mitral valve disorders including mitral valve prolapse (MVP)
Assuntos
Humanos , Adulto , Idoso , Insuficiência da Valva Mitral , Prolapso da Valva Mitral , Estenose da Valva Mitral , Fatores Etários , Progressão da Doença , Cateterismo , Ecocardiografia , Ecocardiografia Doppler , Eletrocardiografia , Estenose da Valva Mitral/cirurgia , Implante de Prótese de Valva Cardíaca , Atenção Primária à Saúde , Radiografia TorácicaRESUMO
The microalga Scenedesmus incrassatulus was grown under continuous regime in the presence of chromium(VI), cadmium(II) and copper(II), as single metal species and as mixtures of two or three metals, in a laboratory scale system. We used an artificial wastewater with low free ion activities (as determined by MINEQL+) due to the presence of EDTA (a strong chelating agent) but with total concentrations not suitable for acceptable environments. Chromium(VI) and cadmium(II) had positive interaction that increased the removal percentages of both these metals; we could not, however, detect any interaction with copper(II). S. incrassatulus was able to remove all the tested metals to some extent (25-78%), but bivalent metals were not removed as efficiently as reported in batch cultures, probably due to the high pH values there recorded. Chromium(VI) was more efficiently removed in continuous cultures than in batch culture, because the uptake of chromate could be favored by actively growing algae.
Assuntos
Metais Pesados/farmacocinética , Scenedesmus/metabolismo , Poluentes Químicos da Água/análise , Biodegradação Ambiental , Modelos Teóricos , Análise EspectralRESUMO
Angiomyolipoma is a rare benign mesenchymal tumor of the liver. We present the case of a 32-year-old female patient that seeks medical consultation to confirm pregnancy. Ultrasound was performed and a hyperechoic lesion was detected in the left lobe of the liver. CT scan showed a heterogenic mass arising from the left lobe of the liver, fine needle aspiration biopsy was performed and diagnosis of liposarcoma was made. A laparotomy was done and a left lateral segmentectomy performed, postoperative course was uneventful. Histology and immunohistochemical analysis of the tumor revealed classical findings of primary angiomyolipoma of the liver. This case shows the difficulty often found when a preoperative diagnosis of fatty liver lesions is made. A literature review is presented and the diagnosis and management of these lesions is discussed.
Assuntos
Angiomiolipoma/patologia , Neoplasias Hepáticas/patologia , Adulto , Angiomiolipoma/diagnóstico por imagem , Angiomiolipoma/cirurgia , Feminino , Humanos , Laparoscopia , Neoplasias Hepáticas/diagnóstico por imagem , Neoplasias Hepáticas/cirurgia , Gravidez , Radiografia , Esclerose Tuberosa/patologiaRESUMO
To provide optimum protection against classical and El Tor biotypes of Vibrio cholerae O1, a single-dose, oral cholera vaccine was developed by combining two live, attenuated vaccine strains, CVD 103-HgR (classical, Inaba) and CVD 111 (El Tor, Ogawa). The vaccines were formulated in a double-chamber sachet; one chamber contained lyophilized bacteria, and the other contained buffer. A total of 170 partially-immune American soldiers stationed in Panama received one of the following five formulations: (a) CVD 103-HgR at 10(8) CFU plus CVD 111 at 10(7) CFU, (b) CVD 103-HgR at 10(8) CFU plus CVD 111 at 10(6) CFU, (c) CVD 103-HgR alone at 10(8) CFU, (d) CVD 111 alone at 10(7) CFU, or (e) inactivated Escherichia coli placebo. Among those who received CVD 111 at the high or low dose either alone or in combination with CVD 103-HgR, 8 of 103 had diarrhea, defined as three or more liquid stools. None of the 32 volunteers who received CVD 103-HgR alone or the 35 placebo recipients had diarrhea. CVD 111 was detected in the stools of 46% of the 103 volunteers who received it. About 65% of all persons who received CVD 103-HgR either alone or in combination had a fourfold rise in Inaba vibriocidal titers. The postvaccination geometric mean titers were comparable among groups, ranging from 450 to 550. Ogawa vibriocidal titers were about twice as high in persons who received CVD 111 as in those who received CVD 103-HgR alone (600 versus 300). The addition of CVD 111 improved the overall seroconversion rate and doubled the serum Ogawa vibriocidal titers, suggesting that the combination of an El Tor and a classical cholera strain is desirable. While CVD 111 was previously found to be well tolerated in semiimmune Peruvians, the adverse effects observed in this study indicate that this strain requires further attenuation before it can be safely used in nonimmune populations.
Assuntos
Vacinas contra Cólera/imunologia , Cólera/prevenção & controle , Militares , Qualidade de Produtos para o Consumidor , Humanos , Panamá , Estados Unidos , Vacinas Atenuadas/imunologiaRESUMO
Semen infected experimentally with infectious bovine rhinotracheitis virus (BHV-1) was treated with trypsin at concentrations of 0.30%, 0.25% and 0.15%, with or without (w or w/o) trypsin inhibitor in order to render the semen virus free. The trypsin treatments (at 0.30% and 0.25% by concentration) inactivating the virus up to 10(4) TCID50/ml, and its effects on semen quality were assessed weekly from the 1st to 20th week after being frozen. The following parameters were determined using a computerized semen analysis system (Hamilton Thorn motility analyzer, HTM): total motility, progressive motility and linearity of sperm cells. The results showed that the total and progressive motility of sperm cells were reduced in frozen/thawed semen, principally in the semen treated with trypsin at concentrations of 0.30%. Moreover, the plasma membranes were damaged by trypsin treatments (0.30% by concentration), as determined by the hypoosmotic swelling test (HOS test). These findings suggest that trypsin treatments were effective against the virus however the effects on semen quality and the possibility of a decrease in semen fertility were clear. Trypsin treatment could be recommended at a maximum concentration of 0.25% (w/o trypsin inhibitor) on semen with a high concentration and high motility values of spermatozoa before freezing.
Assuntos
Criopreservação/veterinária , Herpesvirus Bovino 1/fisiologia , Preservação do Sêmen/veterinária , Sêmen/fisiologia , Motilidade dos Espermatozoides , Tripsina/farmacologia , Animais , Bovinos , Criopreservação/métodos , Herpesvirus Bovino 1/efeitos dos fármacos , Herpesvirus Bovino 1/isolamento & purificação , Masculino , Sêmen/efeitos dos fármacos , Sêmen/virologia , Preservação do Sêmen/métodos , Software , Motilidade dos Espermatozoides/efeitos dos fármacos , Latência ViralRESUMO
Contiene: 1.Los Proyectos, la racionalización de inversiones, el sistema nacional de inversión pública 2.El ciclo de vida de los proyectos 3.Identificación de problemas-identificación y priorización de proyectos...
RESUMO
Foram utilizados 19 cabritos machos e fêmeas, mestiços, com idade de 4 dias e peso médio de 3,09 kg, com o objetivo de avaliar a utilizaçäo de sucedâneos de leite sobre o desenvolvimento ponderal de animais desmamados precocemente. O delineamento experimental utilizado foi o inteiramente casualizado, em arranjo fatorial (3x2) em que os tratamentos foram: leite de cabra (T1), sucedâneo com proteínas lácteas (T2), e sucedâneo com proteínas de soja (T3), aplicados a machos e fêmeas. Em todos os tratamentos os animais recebiam mistura de concentrados com 14,0 por cento de proteína bruta e feno de coast-cross. O consumo de leite e sucedâneos foi restrito a 1,0 litro/animal/dia. Os ganhos diários de peso em T1 (130 g) foram significativamente maiores (p<0,01) que nos demais tratamentos: T2 (55 g) e T3 (60 g). Os cabritos foram desmamados aos 56 dias de idade, com pesos médios de 9,51; 6,61 e 6,30 kg (respectivamente para T1, T2 e T3). O presente trabalho mostrou que o emprego de sucedâneos com leite de vaca com proteína de soja é inferior ao leite de cabra, dentro de um sistema de aleitamento artificial