RESUMO
The ambulatory arterial stiffness index (AASI) is a recently proposed index derived from 24-h ambulatory blood pressure monitoring (ABPM) for the evaluation of arterial stiffness. In this cross-sectional study we investigated whether AASI reflects arterial stiffness in patients with resistant hypertension by comparing AASI and ambulatory pulse pressure (PP) with aortic pulse wave velocity (PWV), a measure of arterial stiffness, in 391 resistant hypertensives. Clinical, laboratory and echocardiographic variables, 24-h ABPM and aortic PWV (measured using the Complior device) were obtained. AASI was calculated as 1--the regression slope of 24-h diastolic on systolic blood pressure (BP). Statistical analysis involved single and multiple linear regressions to assess the correlations between the two ABPM variables and PWV, both unadjusted and adjusted for potential confounders (age, gender, body height, presence of diabetes, 24-h mean arterial pressure [MAP], heart rate, and nocturnal BP reduction). Ambulatory PP and aortic PWV were independently associated with age, gender, presence of diabetes, and 24-h MAP, whereas AASI was associated with age, diabetes, and nocturnal diastolic BP reduction. PP showed stronger unadjusted (r=0.39, p<0.001) and adjusted (r=0.22, p<0.001) correlations with aortic PWV than AASI (r=0.12, p=0.032 and r= -0.04, p=0.47, respectively). In the analysis of subgroups stratified by gender, age, presence of atherosclerotic diseases and diabetes, dipping pattern, and ambulatory BP control, the superiority of PP over AASI was apparent in all subgroups. In conclusion, 24-h ambulatory PP was better correlated to arterial stiffness, as evaluated by aortic PWV, than the novel AASI, in patients with resistant hypertension.
Assuntos
Monitorização Ambulatorial da Pressão Arterial , Pressão Sanguínea , Hipertensão/diagnóstico , Hipertensão/fisiopatologia , Fluxo Pulsátil , Idoso , Aorta/diagnóstico por imagem , Aorta/fisiologia , Doenças da Aorta/diagnóstico , Doenças da Aorta/diagnóstico por imagem , Doenças da Aorta/fisiopatologia , Estudos Transversais , Feminino , Humanos , Hipertensão/diagnóstico por imagem , Modelos Lineares , Masculino , Pessoa de Meia-Idade , Índice de Gravidade de Doença , UltrassonografiaRESUMO
Os autores apresentam um caso de síndrome poliglandular auto-imune (SPA) tipo II, caracterizada pela associaçao de insuficiência adrenal, hipotireoidismo subclínico, hipofunçao gonadal e vitiligo. Discutem a prevalência das doenças auto-imunes associadas a esta síndrome e a conseqüente importância de classificar em tipo I e II as pacientes com SPA.