RESUMO
Resumen Los tumores de células pequeñas extrapulmonares pueden aparecer en múltiples órganos y forman una rara afección clínico-patológica de tumores neuroendocrinos, con gran proliferación epitelial y con comportamiento biológico agresivo. El tubo gastrointestinal es la fuente más común de tumores de células pequeñas extrapulmonares. Nuestro caso clínico describe un paciente con carcinoma de células pequeñas en la unión gastroesofágica, que fue diagnosticado en el contexto de sangrado de tubo digestivo alto. Se excluyó un tumor pulmonar primario; el paciente recibió quimioterapia, quimiorradioterapia y radioterapia cerebral profiláctica, con buena evolución clínica. Nuestro caso se trata de una rara afección clínica, lo que evidencia la importancia de diagnosticar enferemedades poco frecuentes. Existe poca evidencia en la bibliografía de cómo deben tratarse estos pacientes.
Abstract Extrapulmonary small cell carcinomas (EPSCC) can arise in multiple organ sites and form a rare clinicopathological entity of high proliferative epithelial neuroendocrine tumors with aggressive biological behavior. Gastrointestinal is the most common source of EPSCC. We report a case of gastroesophageal junction small cell carcinoma, which was diagnosed in the context of upper gastrointestinal bleeding. A primary small cell lung carcinoma was excluded. Chemotherapy, neoadjuvant chemoradiotherapy and prophylactic cranial radiotherapy were given, with good clinical outcome. Our case of a very rare condition highlights the importance of recognizing atypical pathologic diagnoses. More research needs to be conducted with EPSCC patients in order to better characterize disease pathogenesis, and an optimal disease management.
RESUMO
OBJECTIVE: To ascertain the prevalence of Hepatitis-B, Hepatitis-C and Human-Immunodeficiency-Virus (HIV) markers among altruistic blood donors. PLACE: Blood bank of a third-level-hospital belonging to the Instituto Mexicano del Seguro Social (IMSS) system. SUBJECTS: Written records of the blood bank were reviewed, including charts of all risk free potential altruistic donors who between 1994 and 1995 had determination of: Hepatitis-B surface antigen (HBsAg), Hepatitis-B core antibodies (anti-HBc), Hepatitis-C antibodies (anti-HCV) and Human-Immunodeficiency-Virus (HIV). RESULTS: Of 78,566 potential blood donors studied 2,187 (2.8%) reacted to one or more markers, 2% were anti-HBc positive, 0.47% anti-HCV positive, 0.16% HBsAg positive and 0.12% anti-HIV positive. CONCLUSIONS: Prevalence of virus markers examined is equal or lower than reported worldwide as well as in our country in the 90; this reflects improved education and selection of potential donors and encourages the use of subsequent donation.
Assuntos
Doadores de Sangue , Anticorpos Anti-HIV/análise , Anticorpos Anti-Hepatite B/análise , Antígenos de Superfície da Hepatite B/análise , Anticorpos Anti-Hepatite C/análise , Adolescente , Adulto , Western Blotting , Feminino , Infecções por HIV/epidemiologia , Hepatite B/epidemiologia , Hepatite C/epidemiologia , Humanos , Técnicas Imunoenzimáticas , Masculino , México/epidemiologia , Pessoa de Meia-Idade , PrevalênciaRESUMO
Considering that hepatitis B infection prevalence is high in our hospital, we felt it necessary to determine the frequency of the delta hepatitis. We studied 85 consecutive patients who were HBsAg positive analyzing the delta antibody through the immunoenzymatic method. We found 2 cases (2.3%); one being coinfection and other one an superinfection. Because delta virus not only influences the prognosis but also the therapeutic response total treatment of hepatitis B we recommended the routine detection of delta virus.
Assuntos
Infecção Hospitalar/epidemiologia , Hepatite D/epidemiologia , Criança , Estudos Transversais , Feminino , Anticorpos Anti-Hepatite/análise , Vírus Delta da Hepatite/imunologia , Unidades Hospitalares , Humanos , Masculino , México , Pessoa de Meia-IdadeRESUMO
A multicenter open study aimed at evaluating the effect of famotidine in the treatment of duodenal ulcer was performed in several institutions located in 15 different cities of Mexico. One-hundred-and-fourteen patients with duodenal ulcer demonstrated by endoscopy were given 40 mg. of famotidine daily, administered as a single dose at night. After 4 and 6 weeks of treatment, healing of the ulcer was observed in 81.6% and 95.6% of patients, respectively. Side-effects were very unusual. In only one patient, who experienced vertigo during the treatment, administration of the drug had to be stopped.
Assuntos
Antiulcerosos/uso terapêutico , Úlcera Duodenal/tratamento farmacológico , Tiazóis/uso terapêutico , Adolescente , Adulto , Antiulcerosos/efeitos adversos , Avaliação de Medicamentos , Famotidina , Feminino , Humanos , Masculino , México , Pessoa de Meia-Idade , Estudos Multicêntricos como Assunto , Tiazóis/efeitos adversosRESUMO
A multicentric open study designed to evaluate the effect of famotidine in the treatment of gastric ulcer was performed in several institutions located in 15 different cities of Mexico. 54 patients with gastric ulcer demonstrated by endoscopy were given 40 mg of famotidine daily, administered as a single dose at night. After 6 and 8 weeks of treatment, healing of the ulcer was observed in 63% and 88.9%, respectively. Side-effects were very unusual.