RESUMO

Langerhans cell histiocytosis may be seen with goiter and histiocytic infiltration of the thyroid. We report a 2 1/2-year-old boy who had goiter and primary hypothyroidism develop, later had pulmonary disease, and died of neurologic involvement. Autopsy lesions suggested a transitional dendritic cell precursor of the epidermal Langerhans cell. Of the reported cases of Langerhans cell histiocytosis with goiter in children and adolescents, 82% were male when the relative incidence of Langerhans cell histiocytosis is two males to one female.

Assuntos

Células Dendríticas , Bócio/complicações , Histiocitose de Células de Langerhans/complicações , Hipotireoidismo/complicações , Pré-Escolar , Evolução Fatal , Bócio/patologia , Histiocitose de Células de Langerhans/patologia , Humanos , Hipotireoidismo/patologia , Masculino , Glândula Tireoide/patologia